CN106338498A - Water content distribution detection device and application thereof - Google Patents
Water content distribution detection device and application thereof Download PDFInfo
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- CN106338498A CN106338498A CN201610998291.7A CN201610998291A CN106338498A CN 106338498 A CN106338498 A CN 106338498A CN 201610998291 A CN201610998291 A CN 201610998291A CN 106338498 A CN106338498 A CN 106338498A
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- terahertz
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/59—Transmissivity
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N2021/0106—General arrangement of respective parts
- G01N2021/0112—Apparatus in one mechanical, optical or electronic block
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N2021/1765—Method using an image detector and processing of image signal
Abstract
The invention relates to a water content distribution detection device and application thereof. The device comprises a terahertz radiation device, a first dimming lens assembly, a carrying shelf assembly, a second dimming lens assembly and a terahertz detection assembly; the carrying shelf assembly comprises a movable carrying table; the first dimming lens assembly is arranged between the terahertz radiation device and the carrying shelf assembly, the second dimming lens assembly is arranged between the carrying shelf assembly and the terahertz detection assembly, and the terahertz detection assembly is connected with a signal analysis device; terahertz light beams radiated from the terahertz radiation device are focused to a to-be-detected sample on the carrying table through the first dimming lens assembly, the terahertz light beams transmitted from the to-be-detected sample are focused to the terahertz detection assembly through the second dimming lens assembly, and terahertz signals detected by the terahertz detection assembly are input into the signal analysis device for water content distribution detection of the sample. By means of the scheme, the tedious procedures of tissue slices can be avoided, and the sensitivity and the accuracy of water content determination can be improved.
Description
Technical field
The present invention relates to the present invention relates to Terahertz detection technique field, more particularly to a kind of water content distribution detection dress
Put and its apply.
Background technology
In carrying out biological tissue's analysis, often using tissue section method, biological tissue is cut into slices, subsequently using light
Learn microscope and carry out observation analysis, be distributed to identify normal structure and pathology group in biological tissue by observing water content therein
The distribution knitted and position.But this kind of method needs professional to carry out loaded down with trivial details artificial operation and tediously long data analysis, institute
Need are relatively costly, step is relatively complicated, latent period is longer.
Additionally, carrying out water content analysis using ordinary optical microscope, only in accordance with the image contrast in different water content regions
Differentiated, the sensitivity of Water content determination is relatively low.
Content of the invention
It is an object of the invention to provide a kind of water content distribution detecting device and its application, histotomy can be avoided
Complicated procedures, and sensitivity and the accuracy of Water content determination can be improved.
The purpose of the present invention is achieved through the following technical solutions:
A kind of water content distribution detecting device, comprising: terahertz emission device, the first light modulation lens subassembly, luggage carrier group
Part, the second light modulation lens subassembly and terahertz detection assembly, described luggage carrier assembly includes moveable objective table；
Described first light modulation lens subassembly is arranged between described terahertz emission device, described second light modulation lens subassembly
It is arranged between described luggage carrier assembly and described terahertz detection assembly, described terahertz detection assembly connects signal analysis dress
Put；
The thz beam that described terahertz emission device gives off focuses to described loading through the first light modulation lens subassembly
Testing sample on platform, the thz beam of described testing sample transmission through the described second light modulation lens subassembly focus to described in too
Hertz probe assembly, the terahertz signal that described terahertz detection assembly detects is input to described signal analysis device and carries out institute
State the water content distribution detection of testing sample.
A kind of application in biological tissue's analysis, material tests for water content distribution detecting device as above.
According to the scheme of the invention described above, its device includes terahertz emission device, the first light modulation lens subassembly, luggage carrier
Assembly, the second light modulation lens subassembly and terahertz detection assembly, luggage carrier assembly includes moveable objective table, and the first light modulation is thoroughly
Mirror assembly is arranged between terahertz emission device, and the second light modulation lens subassembly is arranged on luggage carrier assembly and terahertz detection group
Between part, terahertz detection assembly connects signal analysis device, and the thz beam that terahertz emission device gives off is through first
Light modulation lens subassembly focuses to the testing sample on objective table, and the thz beam of testing sample transmission is through the second light modulation lens group
Part focuses to terahertz detection assembly, and the terahertz signal that terahertz detection assembly detects is input to signal analysis device to be carried out
The water content distribution detection of testing sample, on the one hand, due to including terahertz emission device, the first light modulation lens subassembly, loading
Frame assembly, the second light modulation lens subassembly and terahertz detection assembly, luggage carrier assembly includes moveable objective table, the first light modulation
Lens subassembly is arranged between terahertz emission device, and the second light modulation lens subassembly is arranged on luggage carrier assembly and terahertz detection
Between assembly, terahertz detection assembly connects signal analysis device, and the terahertz light being given off due to terahertz emission device
Bundle focuses to the testing sample on objective table through the first light modulation lens subassembly, and the thz beam of testing sample transmission is through the second tune
Optical lens assembly focuses to terahertz detection assembly, make use of Laser Scanning Confocal Microscope principle, and Terahertz can be greatly improved
The accuracy to lift detection for the spatial resolution of imaging, on the other hand, because objective table may move, is moved in objective table
When can drive the testing sample being placed on objective table to move, it is possible to achieve to testing sample both horizontally and vertically
Scanning, further, since hydrone has powerful absorbability to terahertz emission, can carry out highly sensitive water content inspection
Survey, thus, it is possible to obtain the structural representation of the three-dimensional water content distribution of testing sample, thus the method using Histopathology
The lesion degree of tissue is analyzed, it is to avoid the complicated procedures of histotomy in traditional pathology, improves Water content determination
Sensitivity and accuracy, this water content distribution detecting device is applied in biological tissue's analysis, in material tests, is had extensively
Using value.
Brief description
Fig. 1 is the composition structural representation one of the water content distribution detecting device of the embodiment of the present invention one；
Fig. 2 is the refinement structural representation in the terahertz emission device in Fig. 1 wherein an embodiment；
Fig. 3 is the refinement structure in the first light modulation lens subassembly in Fig. 1 wherein an embodiment and its light path is illustrated
Figure；
Fig. 4 is the refinement structural representation in the luggage carrier assembly in Fig. 1 wherein an embodiment；
Fig. 5 is the refinement structure in the second light modulation lens subassembly in Fig. 1 wherein an embodiment and its light path is illustrated
Figure；
Fig. 6 is the refinement structure in the terahertz detection assembly in Fig. 1 wherein an embodiment and its light path schematic diagram；
Fig. 7 is the composition structural representation two of the water content distribution detecting device of the embodiment of the present invention one；
Fig. 8 is the refinement structural representation in the embodiment wherein of signal analysis device in Fig. 1 or Fig. 7；
Fig. 9 be the embodiment of the present invention two a specific example in the composition structure of water content distribution detecting device and its
Light path schematic diagram.
Specific embodiment
In order that the objects, technical solutions and advantages of the present invention become more apparent, below in conjunction with drawings and Examples, right
This is further elaborated using new.It should be appreciated that specific embodiment described herein is used only for explaining this
Bright, it is not intended to limit the present invention.
Unless otherwise defined, all of technology used herein and scientific terminology and the technical field belonging to the present invention
The implication that technical staff is generally understood that is identical.The term being used in the description of the invention herein is intended merely to description tool
The purpose of the embodiment of body is it is not intended that in limiting the present invention.Term as used herein " or/and " include one or more phases
The arbitrary and all of combination of the Listed Items closing.
Terahertz emission refers to electromagnetic radiation between 0.1thz to 10thz for the frequency.Due in Terahertz frequency range, metal
Object shows as the feature of extremely strong reflection, and complicated organic molecule shows as spectral characteristic and absorbs, nonpolar nonmetallic materials performance
For highly transmissive the features such as, terahertz imaging is respectively provided with important application valency in fields such as Non-Destructive Testing, materialogy, national defense safeties
Value.Because water is polar molecule, hydrone has powerful absorbability to terahertz emission, and either laboratory assembles too
Hertz system, or business type Terahertz product, rush nitrogen or dry air be all vapor in conventional removal system method,
To reduce loss in free space for the THz wave.Also just because of this, terahertz imaging can easily differentiate hydrate
Matter and anhydrous substances, carry out the mensure of high sensitivity water content.This point is particularly important in biosystem, because water content
Minor alteration will reflect the key change of biological tissue.People damage formula detection method (as pathological tissue is cut not using
Piece) in the case of, remain to make a distinction normal structure and pathological tissues (as cancerization tissue) exactly, and sensitivity is higher.
The terahertz imaging mainly absorption to terahertz emission according to moisture, therefore can carry out highly sensitive water content detection.Too
Hertz micro-imaging technique is a very ergastic INVENTIONMedical diagnostic technology, is devoted to improving current terahertz imaging system
Spatial resolution, thus obtain the micro tomography image of tested testing sample in Terahertz frequency range.Below to the present invention program's
Each embodiment is described in detail.
Embodiment one
Shown in Figure 1, it is the composition structural representation one of the water content distribution detecting device of the embodiment of the present invention one.As
Shown in Fig. 1, the water content distribution detecting device of the present embodiment one includes terahertz emission device 101, first light modulation lens subassembly
102nd, luggage carrier assembly 103, second light modulation lens subassembly 104 and terahertz detection assembly 105, luggage carrier assembly 103 includes can
The objective table 1031 of movement；
First light modulation lens subassembly 102 is arranged between terahertz emission device 101 and luggage carrier assembly 103, the second tune
Optical lens assembly 104 is arranged between luggage carrier assembly 103 and terahertz detection assembly 105, and terahertz detection assembly 105 connects
Signal analysis device 106；
The thz beam that terahertz emission device 101 gives off focuses on 102 to objective table through the first light modulation lens subassembly
Testing sample on 1031, the thz beam of described testing sample transmission focuses to terahertz through the second light modulation lens subassembly 104
Hereby probe assembly 105, the terahertz signal that terahertz detection assembly 105 detects is input to signal analysis device 106 and carries out institute
State the water content distribution detection of testing sample.
Wherein it is contemplated that testing sample is located on objective table 1031 in detection, in order to realize to be measured
The 3-D scanning of sample, generally requiring objective table 1031 can both horizontally and vertically (direction of vertical level) move
Dynamic.
Wherein, signal analysis device 106 can be external module or the water content of water content distribution detecting device
The intraware of distribution detecting device.
Wherein, the first light modulation lens subassembly 102 and the second light modulation lens subassembly 104 can include one or more respectively
Optical component, for example, convex lens, aperture diaphragm etc., and the quantity of each optical component can be one respectively, also may be used
Think multiple.
Accordingly, the scheme according to above-mentioned the present embodiment, because terahertz emission device 101, first dims lens subassembly
102nd, luggage carrier assembly 103, second light modulation lens subassembly 104 and terahertz detection assembly 105, the first light modulation lens subassembly 102
It is arranged between terahertz emission device 101 and luggage carrier assembly 103, the second light modulation lens subassembly 104 is arranged on luggage carrier group
Between part 103 and terahertz detection assembly 105, terahertz detection assembly 105 connects signal analysis device 106, and due to terahertz
The thz beam that hereby radiation appliance 101 gives off focuses on to be measured on 102 to objective table 1031 through the first light modulation lens subassembly
Sample, the thz beam of described testing sample transmission focuses to terahertz detection assembly through the second light modulation lens subassembly 104
105, make use of Laser Scanning Confocal Microscope principle, the spatial resolution that terahertz imaging can be greatly improved is to lift detection
Accuracy, on the other hand, because objective table 1031 may move, can drive testing sample to enter when objective table 1031 is moved
Row moves, it is possible to achieve to testing sample scanning both horizontally and vertically, further, since hydrone has to terahertz emission
Powerful absorbability, can carry out highly sensitive water content detection, thus, it is possible to obtain the three-dimensional water content of testing sample
The structural representation of distribution, thus be analyzed to the lesion degree of tissue using the method for Histopathology, it is to avoid tradition disease
In Neo-Confucianism, the complicated procedures of histotomy, improve sensitivity and the accuracy of Water content determination.
Wherein in an embodiment, as shown in Fig. 2 terahertz emission device 101 can include Terahertz quantum cascaded
Laser instrument 1011.Or, as shown in Fig. 2 terahertz emission device 101 can include Terahertz quantum cascaded laser 1011 He
The TEC 1012 being connected with this Terahertz quantum cascaded laser 1011.
Wherein, terahertz emission device 101 is used for radiation thz beam, TEC 1012 and Terahertz quantum
Cascaded laser 1011 connects (thermal coupling) generally by heat transfer, thus effectively eliminating Terahertz quantum cascaded laser 1011
The heat itself producing is it is ensured that the operation reliably and with long-term of terahertz emission device 101 or even whole device；Terahertz quantum cascaded
Laser instrument 1011 is usually driven in the pulsing mode.Terahertz emission source is the key determining terahertz imaging sensitivity
Device；In the producing method of numerous terahertz emissions, had based on all solid state Terahertz quantum cascaded laser of semiconductor
Energy conversion efficiency height, small volume, light, easy of integration the features such as；Using all solid state Terahertz quantum cascaded based on semiconductor
Laser instrument it is ensured that device Water content determination high sensitivity performance.
Wherein in an embodiment, as shown in figure 3, the first light modulation lens subassembly 102 can include setting gradually the
Collimating lens 1021, the first condenser lens 1022, the first aperture diaphragm 1023, the second collimation lens 1024 and second focus on thoroughly
Mirror 1025；The thz beam that terahertz emission device 101 gives off collimates through described first collimation lens 1021, the first focusing
Lens 1022 focus to the first aperture diaphragm 1023, and the thz beam of the first aperture diaphragm 1023 outgoing is through the second collimation lens
1024 collimations, the second condenser lens 1025 focus to the testing sample on described objective table.
Wherein, each optical component in the first light modulation lens subassembly 102 can be arranged in free space；First collimation
Lens 1021, the first condenser lens 1022 are used for collimating and focus on thz beam to the first aperture diaphragm 1023；First aperture
Diaphragm 1023 as spatial filter, for obtaining uniform thz beam profile, to improve micro-imaging quality；Additionally,
First aperture diaphragm 1023 must be sufficiently small as copolymerization Jiao's aperture diaphragm, can choose submillimeter level pore size to reduce terahertz
Hereby radiate the power attenuation in the first aperture diaphragm 1023, ensure imaging resolution simultaneously；Second collimation lens 1024, second gathers
Focus lens 1025 are used for the thz beam of the first aperture diaphragm 1023 outgoing being collimated and focusing on；Due to submillimeter level
First aperture diaphragm 1023 will produce the larger outgoing beam angle of divergence, and therefore, the second collimation lens 1024 need to have larger
Lens diameter, that is, the lens diameter of the second collimation lens 1024 be more than the lens diameter of the first collimation lens 1021, received with effective
Collect the thz beam of the first aperture diaphragm 1023 outgoing；Second condenser lens 1025 removes needs to have larger diameter, and that is, second
The lens diameter of condenser lens 1025 is more than the lens diameter of the first condenser lens 1022, also needs to have the high light gathering of friendship, such as
Have large-numerical aperture, that is, the numerical aperture of the second condenser lens 1025 is more than the numerical aperture of the first condenser lens 1022, with
Larger-diameter thz beam is focused on testing sample a bit, thus moving stage 1031 is to drive testing sample to enter
Row scanning imagery.It should be noted that the structure composition not limited to this of the first light modulation lens subassembly 102.Submillimeter level refers to 0.1 milli
Rice is to 1 millimeter.
Wherein in an embodiment, as shown in figure 4, luggage carrier assembly 103 can also include stepper motor 1032 and control
Device 1033 processed, wherein, stepper motor 1032 is connected with objective table 1031, controller 1033 respectively；Controller 1033 is used for controlling
Stepper motor 1032 band dynamic object stage 1031 carries out step motion on direction initialization, and feeds back stepping position information.
After water content distribution detecting device in the present embodiment comes into operation, testing sample is placed and is fixed on objective table
On 1031, objective table 1031 need to keep level, additionally, the objective table 1031 placing testing sample typically need to carry out hollowing out of part
Process or using high-transmission rate in Terahertz frequency range, low absorption material (or perhaps using the transmissivity to Terahertz frequency range
Higher than the material of transmissivity threshold value, that is, meet the material that certain transmission requirement or absorptivity require, wherein, transmissivity threshold value
Can select according to actual needs), to ensure that the thz beam inciding testing sample can be from the transmission of testing sample bottom
Go out, reach terahertz detection assembly 105 through propagating, complete the detection of Terahertz transmitted light beam.
Wherein, stepper motor 1032 is typically mechanically connected with objective table 1031, and stepper motor 1032 is general and controller
1033 electrical connections；Controller 1033 is used for controlling testing sample and objective table 1031 both horizontally and vertically carrying out walking in high precision
Enter motion, digital feedback stepping position information, adjust the sample area of microscopical visual field or required monitoring, sweep as microscope
Retouch the auxiliary machinery of imaging.
It should be noted that stepper motor 1032 is only illustrative with the position relationship in the diagram of objective table 1031,
Do not represent the side that stepper motor 1032 must be positioned at objective table 1031, implementing, can set according to actual needs
Both position relationships.
As imaging system, microscopical main performance index is exactly its spatial resolution, and the water of the embodiment of the present invention
First aperture diaphragm 1023 of the submillimeter level that content distribution detection means is used and the second condenser lens of large-numerical aperture
1025 will greatly enhance spatial resolution.Because this water content distribution detecting device carries out two dimension or graphics using scan mode
Scanning accuracy (the i.e. stepping every time of the foundation of picture, the spatial resolution of this water content distribution detecting device and stepper motor 1032
Displacement) have certain relation, according to nyquist sampling theorem, the scanning accuracy of stepper motor 1032 need to be that microscope itself is empty
Between more than 2 times of resolution ratio, just can ensure that the acquisition of spatial resolution, otherwise can reduce the original spatial discrimination of microscope
Rate.Therefore, wherein in an embodiment, the scanning accuracy of stepper motor 1032 is that the space of water content distribution detecting device is divided
More than the twice of resolution.
Wherein in an embodiment, as shown in figure 5, the second light modulation lens subassembly 104 can include setting gradually the
Three collimation lenses 1041, tertiary focusing lens 1042, the second aperture diaphragm 1043, the first off axis paraboloidal mirror 1044 and second from
Axis paraboloidal mirror 1045；After the thz beam of described testing sample transmission is collected, collimated through the 3rd collimation lens 1041, through
Three condenser lenses 1042 focus to described second aperture diaphragm 1043；The thz beam of the second aperture diaphragm 1043 outgoing is through
One off axis paraboloidal mirror 1044, the second off axis paraboloidal mirror 1045 are projected to terahertz detection assembly 105.
Wherein, each optical component in the second light modulation lens subassembly 104 can be arranged in free space.3rd collimation
Lens 1041 are used for the thz beam collected, collimate from the transmission of testing sample bottom and dissipate, and the 3rd collimation lens 1041 needs
Have the numerical aperture identical or bigger with the second condenser lens 1025, that is, the numerical aperture of the 3rd collimation lens 1041 be more than or
Person is equal to the numerical aperture of the second condenser lens 1025, to optimize the spatial resolution of detection means.Tertiary focusing lens
1042 are used for for thz beam after collimation focusing to the second aperture diaphragm 1043.Second aperture diaphragm 1043 is as common focal aperture
Footpath diaphragm, the aperture of the second aperture diaphragm 1043 equally need to be sufficiently small, to obtain high-resolution image, can choose and first
The aperture of aperture diaphragm 1023 similar size, that is, the aperture of the second aperture diaphragm 1043 is also submillimeter level, to ensure Terahertz
The low-power consumption of light beam and high imaging resolution.The thz beam of the second aperture diaphragm 1043 outgoing is thrown from axle via first
Object plane mirror 17, the second off axis paraboloidal mirror 18 are projected to terahertz detection assembly, the focusing of the wherein second off axis paraboloidal mirror 18
Light beam and visual field need to be matched with the incident cone-shaped beam of terahertz detection assembly 105 and visual field, to ensure maximized light biography
Broadcast coupling efficiency.
Wherein, the first collimation lens 1031, the first condenser lens 1032, the second collimation lens 1034, the second condenser lens
1035th, the 3rd collimation lens 1041 and tertiary focusing lens 1042 are typically convex lens, when implementing, can select
First collimation lens 1031 of identical lens diameter and the first condenser lens 1032, the second collimation lens of identical lens diameter
1034 and second condenser lens 1035, the 3rd collimation lens 1041 of identical lens diameter and tertiary focusing lens 1042.
Wherein in an embodiment, as shown in fig. 6, terahertz detection assembly 105 can include setting in free space
Hyper-hemispherical lens 1051 and calorimetric radiation gauge 1052, wherein, calorimetric radiation gauge 1052 is placed on hyper-hemispherical lens 1052 back side,
Hyper-hemispherical lens 1051 is used for strengthening the coupling efficiency of calorimetric radiation gauge 1052；Calorimetric radiation gauge 1052 is also electrically connected with signal
Analytical equipment 106, signal analysis device 106 is used for collection and the process being scanned being imaged.
Wherein in an embodiment, as shown in fig. 7, the water content distribution detecting device of the present invention can also include signal
Analytical equipment 106.
Wherein in an embodiment, as shown in figure 8, the signal that signal analysis device can include being sequentially connected amplifies electricity
Road 1061, signal acquisition circuit 1062 and image analysis apparatus 1063.Wherein, signal amplification circuit 1061, signal acquisition circuit
Connected mode between 1062 and image analysis apparatus 1063 can be electrically connected with.Image analysis apparatus 1063 can be using online
Analysis and off-line analysis two ways.
Wherein, image analysis apparatus 1063 can also connect with controller 1033, and image analysis apparatus 1063 can be used for
Obtain controller 1033 feedback stepping position information, in conjunction with each stepping position corresponding testing sample positional information and
During each stepping position, the measured signal of testing sample obtains water content distribution map.
Additionally, signal amplification circuit 1061 can include a lock-in amplifier and the copped wave being connected with this lock-in amplifier
Device, before this chopper is arranged on terahertz detection assembly 105, here, before chopper is arranged on terahertz detection assembly 105
Refer to that chopper is arranged on the Terahertz light velocity and is incident to certain position before terahertz detection assembly 105, this position can root
According to being actually needed selection.Wherein, lock-in amplifier can significantly suppress useless noise and improve detection sensitivity, and chopper is used
There is the reference signal of same frequency and phase relation in acquisition and measured signal.
Embodiment two
For the ease of understanding the solution of the present invention, below by way of a specific example, the present invention program is illustrated.
As shown in figure 9, the composition structural representation in a specific example for the water content distribution detecting device for the present invention.
The composition structural representation of preferable examples of water content distribution detecting device is shown in Fig. 9.According to different considerations because
Element, when implementing the water content distribution detecting device of the present invention it is also possible to make some changes to some parts or assembly
Shape and improvement, are described in detail below taking the water content distribution detecting device in Fig. 9 as a example.
Shown in Figure 9, the water content distribution detecting device of the present embodiment two includes terahertz emission device, the first light modulation
Lens subassembly, luggage carrier assembly, the second light modulation lens subassembly, terahertz detection assembly and signal analysis device 217.
Wherein, terahertz emission device includes the QCL 202 of integrated thermal electric refrigerator 201, wherein hot
Electric refrigerator and QCL are to connect (thermal coupling) by heat transfer；First light modulation lens subassembly is arranged on Terahertz spoke
Between injection device and luggage carrier assembly；First light modulation lens subassembly includes the first collimation lens setting gradually in free space
203rd, the first condenser lens 204, the first aperture diaphragm 205, the second collimation lens 206 and the second condenser lens 207 is a series of
Optical component；Luggage carrier assembly includes the objective table 208 with stepper motor, here, the objective table with stepper motor is referred to as
Stepping objective table, wherein, testing sample 218 is positioned on stepping objective table 208, and stepping objective table 208 is electrically connected with control
Device 209, for controlling testing sample 218 both horizontally and vertically carrying out high accuracy step motion and scanning imagery；Second tune
Optical lens assembly is arranged between luggage carrier assembly and terahertz detection assembly；Second light modulation lens subassembly includes free space and sets
The 3rd collimation lens 210 put, tertiary focusing lens 211, the second aperture diaphragm 212, the first off axis paraboloidal mirror 213 and second
A series of optical components of off axis paraboloidal mirror 214；Terahertz detection assembly includes the hyper-hemispherical lens of free space setting
215 and calorimetric radiation gauge 216, wherein calorimetric radiation gauge is placed on the hyper-hemispherical lens back side and is electrically connected with signal analysis dress
Put 217.
Wherein, signal analysis device 217 may include signal amplification circuit, signal acquisition circuit, image analysis apparatus；Wherein
Signal amplification module, signal acquisition module and image analysis apparatus are electrically connected with；Image analysis apparatus can using on-line analysis and
Off-line analysis two ways.In signal analysis device, signal amplification circuit can include a lock-in amplifier, can significantly press down
Make useless noise and improve detection sensitivity；This lock-in amplifier need to connect a chopper, and this chopper need to be arranged on Terahertz
Before probe assembly, thus obtaining the reference signal having same frequency and phase relation with measured signal.
Water content distribution detecting device in this specific example make use of Laser Scanning Confocal Microscope principle, is greatly improved
The spatial resolution of terahertz imaging, the other application field extending to terahertz imaging includes medical imaging, material tests
Deng.On the other hand, scanning sample being carried out both horizontally and vertically using copolymerization Jiao's Terahertz flying-spot microscope, it is possible to obtain
The structural representation of the three-dimensional water content distribution of sample, thus carried out to the lesion degree of tissue using the method for Histopathology
Analysis, it is to avoid the complicated procedures of histotomy in traditional pathology, improves sensitivity and the accuracy of Water content determination.
Embodiment three
According to the water content distribution detecting device of the invention described above, the embodiment of the present invention three improves a kind of water content distribution
The application of detection means.As above the water content distribution detecting device described in any one embodiment can be applied in biological tissue
In analysis, material tests.
Specifically, in biological tissue's analysis, testing sample can be put on objective table 1031, by controlling objective table
1031 both horizontally and vertically move, and can complete the 3-D scanning to testing sample, obtain testing sample three-dimensional water
Content distribution figure, according to the water content value of each point in three-dimensional water content distribution map and the method for the Histopathology disease to tissue
Change degree is analyzed.For example, it is possible in inquiry testing sample, water content value is in a certain region setting interval, to this region
The water content value of interior each point is averaged, according to the corresponding relation of this mean value and default lesion degree and water content value
Determine the lesion degree of respective organization.Wherein, set interval can choose according to actual needs.This mode, can avoid passing
In system pathology, the complicated procedures of histotomy, improve sensitivity and the accuracy of Water content determination.
Specifically, in material tests, testing sample can be put on objective table 1031, by controlling objective table 1031
Both horizontally and vertically move, the 3-D scanning to testing sample can be completed, obtain testing sample three-dimensional water content
Distribution map, according to the corresponding relation of default material type and water content value, inquiry and each point in three-dimensional water content distribution map
The material type that water content value matches.
" level ", " vertical " described in above-described embodiment is only relative concept or normally use shape with device each other
State is reference, and should not be regarded as restrictive.
It should be noted that when an element is referred to as " connection " another element, as needed, it can directly be connected
It is connected to another element or be indirectly connected on this another element.Term " first ", " second ", " the 3rd ", " the 4th " are only
For descriptive purposes, and it is not intended that indicating or hint relative importance.
Each technical characteristic of embodiment described above can arbitrarily be combined, for making description succinct, not to above-mentioned reality
The all possible combination of each technical characteristic applied in example is all described, as long as however, the combination of these technical characteristics is not deposited
In contradiction, all it is considered to be the scope of this specification record.
Embodiment described above only have expressed the several embodiments of the present invention, and its description is more concrete and detailed, but simultaneously
Can not therefore be construed as limiting the scope of the patent.It should be pointed out that coming for those of ordinary skill in the art
Say, without departing from the inventive concept of the premise, some deformation can also be made and improve, these broadly fall into the protection of the present invention
Scope.Therefore, the protection domain of patent of the present invention should be defined by claims.
Claims (10)
1. a kind of water content distribution detecting device it is characterised in that include: terahertz emission device, first light modulation lens subassembly,
Luggage carrier assembly, the second light modulation lens subassembly and terahertz detection assembly, described luggage carrier assembly includes moveable objective table；
Described first light modulation lens subassembly is arranged between described terahertz emission device and described luggage carrier assembly, and described second
Light modulation lens subassembly is arranged between described luggage carrier assembly and described terahertz detection assembly, and described terahertz detection assembly is even
Connect signal analysis device；
The thz beam that described terahertz emission device gives off focuses on described objective table through the first light modulation lens subassembly
Testing sample, the thz beam of described testing sample transmission focuses to described Terahertz through the described second light modulation lens subassembly
Probe assembly, the terahertz signal that described terahertz detection assembly detects be input to described signal analysis device carry out described in treat
The water content distribution detection of test sample product.
2. water content distribution detecting device according to claim 1 is it is characterised in that described first dims lens subassembly bag
Include the first collimation lens setting gradually, the first condenser lens, the first aperture diaphragm, the second collimation lens and second to focus on thoroughly
Mirror；The thz beam that described terahertz emission device gives off is through described first collimation lens collimation, described first focusing thoroughly
Mirror focuses to described first aperture diaphragm, and the thz beam of described first aperture diaphragm outgoing is accurate through described second collimation lens
Directly, described second condenser lens focuses to the testing sample on described objective table.
3. water content distribution detecting device according to claim 2 is it is characterised in that described second dims lens subassembly bag
Include the 3rd collimation lens setting gradually, tertiary focusing lens, the second aperture diaphragm, the first off axis paraboloidal mirror and second from axle
Paraboloidal mirror；After the thz beam of described testing sample transmission is collected, collimated through described 3rd collimation lens, through the described 3rd
Condenser lens focuses to described second aperture diaphragm；The thz beam of described second aperture diaphragm outgoing is through first from axle parabolic
Face mirror, the second off axis paraboloidal mirror are projected to described terahertz detection assembly.
4. water content distribution detecting device according to claim 3 is it is characterised in that the lens of described second collimation lens
With diameter greater than the lens diameter of described first collimation lens, and/or the lens diameter of described second condenser lens is more than described the
The lens diameter of one condenser lens, and/or the numerical aperture of described second condenser lens is more than the number of described first condenser lens
Value aperture；And/or the numerical aperture of described 3rd collimation lens is more than or equal to the numerical aperture of described second condenser lens；
And/or the aperture of described first aperture diaphragm is submillimeter level；And/or the aperture of described second aperture diaphragm is submillimeter level.
5. water content distribution detecting device according to claim 1 is it is characterised in that also include signal analysis device, institute
State signal amplification circuit, signal acquisition circuit and the image analysis apparatus that signal analysis device includes being sequentially connected.
6. water content distribution detecting device according to claim 5 is it is characterised in that described signal amplification circuit includes locking
Phase amplifier and the chopper being connected with described lock-in amplifier, described chopper be arranged on described terahertz detection assembly it
Before.
7. water content distribution detecting device according to claim 1 it is characterised in that:
Described terahertz emission device includes Terahertz quantum cascaded laser, or described terahertz emission device includes terahertz
Hereby QCL and the TEC being connected with this Terahertz quantum cascaded laser；
Or/and
Described terahertz detection assembly includes hyper-hemispherical lens and calorimetric radiation gauge, and described calorimetric radiation gauge is placed on described super half
The back side of globe lens and being connected with described signal analysis device.
8. water content distribution detecting device according to claim 1 is it is characterised in that described luggage carrier assembly also includes walking
Stepper motor and controller, described controller is used for controlling described stepper motor to drive described objective table to be walked on direction initialization
Enter motion, and feed back stepping position information.
9. water content distribution detecting device according to claim 1 it is characterised in that described objective table include cavern part or
It is higher than to set the material of transmissivity that person uses the transmissivity to Terahertz frequency range.
10. the water content distribution detecting device as described in a kind of any one as claim 1 to 9 is in biological tissue's analysis, material
Application in detection.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610998291.7A CN106338498A (en) | 2016-11-11 | 2016-11-11 | Water content distribution detection device and application thereof |
| PCT/CN2017/110379 WO2018086574A1 (en) | 2016-11-11 | 2017-11-10 | Apparatus for testing water content distribution and use thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610998291.7A CN106338498A (en) | 2016-11-11 | 2016-11-11 | Water content distribution detection device and application thereof |
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| CN106338498A true CN106338498A (en) | 2017-01-18 |
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| CN201610998291.7A Pending CN106338498A (en) | 2016-11-11 | 2016-11-11 | Water content distribution detection device and application thereof |
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| CN (1) | CN106338498A (en) |
| WO (1) | WO2018086574A1 (en) |
Cited By (4)
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| WO2018086574A1 (en) * | 2016-11-11 | 2018-05-17 | 华讯方舟科技有限公司 | Apparatus for testing water content distribution and use thereof |
| CN109799042A (en) * | 2017-11-17 | 2019-05-24 | 现代自动车株式会社 | Device and method for waterproof test |
| CN109946262A (en) * | 2017-12-21 | 2019-06-28 | 深圳先进技术研究院 | A kind of detection device and detection system based on THz wave |
| WO2020029691A1 (en) * | 2018-08-07 | 2020-02-13 | 京东方科技集团股份有限公司 | Lens assembly, terahertz tomography system, method, and filter |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112327476B (en) * | 2020-11-12 | 2022-05-03 | 中国电子技术标准化研究院 | Method for preparing terahertz double-telecentric lens antenna group and lens antenna group |
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| WO2020029691A1 (en) * | 2018-08-07 | 2020-02-13 | 京东方科技集团股份有限公司 | Lens assembly, terahertz tomography system, method, and filter |
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|---|---|
| WO2018086574A1 (en) | 2018-05-17 |
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