CN206219482U - The process units of liquaemin - Google Patents
The process units of liquaemin Download PDFInfo
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- CN206219482U CN206219482U CN201621309044.3U CN201621309044U CN206219482U CN 206219482 U CN206219482 U CN 206219482U CN 201621309044 U CN201621309044 U CN 201621309044U CN 206219482 U CN206219482 U CN 206219482U
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- exchange column
- ion exchange
- retort
- tank
- liquaemin
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Abstract
The utility model is related to a kind of process units of liquaemin, the process units includes retort, adsorption tanks, ion exchange column, preparation of reagents tank and settling tank, order is arranged from top to bottom for the retort, adsorption tanks, ion exchange column and settling tank, the retort, adsorption tanks, are connected between ion exchange column and settling tank by pipeline, and opening/shutting valve is provided with pipeline；The upper end of the ion exchange column is provided with blast pipe, and liquid discharging tube is provided with the lateral wall of ion exchange column；The preparation of reagents tank is located at ion exchange column top, and the bottom of the preparation of reagents tank is provided with two drain pipes, and drain pipe I is connected with the inlet I of ion exchange column, and drain pipe II is connected with the inlet II of ion exchange column, and the drain pipe II is provided with electric pump；Opening/shutting valve is also equipped with the drain pipe I and drain pipe II.The process units of the liquaemin of this new offer can effectively remove impurity in liquaemin, to prepare the liquaemin of low impurity high-quality.
Description
Technical field
The utility model is related to a kind of biochemical reaction device, especially a kind of process units of liquaemin.
Background technology
Liquaemin (Heparin Sodium) liquaemin is mucopolysaccharide sulfuric acid ester anticoagulant.Liquaemin is by pig or ox
Intestinal mucosa in extract CSSO3 sodium salt, belong to mucopolysaccharide material.It is many with liquaemin-albumen in animal body
The form of matter compound is present.Medically, liquaemin has blood coagulation resisting function in vivo and in vitro, can extend clotting time, fibrin ferment
Former time and thrombin time, prevention blood clotting and blood bank preserve the external anti-coagulants such as blood when being usually used in blood transfusion.Clinically
Increase with anticoagulation, reducing blood lipid, protection endothelial cell, antiplatelet accumulation and release, rush fibrinolytic, suppression arterial smooth muscle cell
Grow, reduce the effect such as blood viscosity, reducing blood lipid and anti-inflammatory, can be used to treat various diseases concurrent disseminated intravascular coagulation (DIC) morning
Phase, prevent artery and vein thrombus and pulmonary embolism, treat artery and vein thrombus and pulmonary embolism, cerebral arterial thrombosis, the instability mode heart is twisted
(mitigate symptom, prevention miocardial infarction) bitterly, acute myocardial infarction (prevents from early stage from blocking again to extend with infarct, reduction is died of illness
Rate)；In artificial heart-lung, peritoneal dialysis or haemodialysis as anticoagulation medicine.
The method for extracting liquaemin at present has many kinds, and existing preparation facilities also has a lot, but in current extraction process by
It is incomplete in liquaemin dissociation so that certain amount is remained in liquaemin with the protein of Covalent bonding together and with electrostatical binding
Positively charged protein, could apply the problems such as the chondroitin polysulfate in liquaemin can not be efficiently separated, it is necessary to further refine
In clinic, so obtained liquaemin nucleic acid and protein-based Impurity removal low degree at present, product potency is low.
Utility model content
For above-mentioned technical problem, the utility model provides a kind of process units of liquaemin, and the device can have
Impurity in effect removal liquaemin, to prepare the liquaemin of low impurity high-quality.
The technical solution adopted in the utility model is：
The process units of liquaemin, the process units includes retort 1, adsorption tanks 2, ion exchange column 3, preparation of reagents
Order is arranged from top to bottom for tank 4 and settling tank 5, the retort 1, adsorption tanks 2, ion exchange column 3 and settling tank 5, described anti-
Answer tank 1, adsorption tanks 2 to be connected by pipeline between ion exchange column 3 and settling tank 5, opening/shutting valve 6 is provided with pipeline；It is described
The upper end of ion exchange column 3 is provided with blast pipe 31, and liquid discharging tube 32 is provided with the lateral wall of ion exchange column 3；The reagent
Preparing tank 4 is located at the top of ion exchange column 3, and the bottom of the preparation of reagents tank 4 is provided with two drain pipes, drain pipe I41 with from
The inlet I33 connections of sub- exchange column 3, drain pipe II42 is connected with the inlet II34 of ion exchange column 3, the drain pipe
II42 is provided with electric pump 7；Opening/shutting valve 6 is also equipped with the drain pipe I41 and drain pipe II42.
The weight of itself is leaned in transfer of the process units major part feed liquid of the liquaemin of this new offer between each tank body
Power effect be can reach, and the purpose of investment, energy saving is reduced so as to reach；The arrangement of space from top to down that device is used
Form, takes plant area and is substantially reduced.
This new ion exchange column 3 can carry out positive and negative washing, and gradient can be successively configured in this new preparation of reagents tank 4
Washing reagent and elution reagent, can effectively go the removal of impurity, and removal of impurity is high.
Further, the bottom in the retort 1 and adsorption tanks 2 is provided with filter screen 11；The top of the retort 1 is provided with
Inlet 12 and charging aperture 13.
Further, the both sides of the settling tank 5 are symmetrically arranged with discharging tube 51, and the bottom of the settling tank 5 is additionally provided with discharging
Mouth 52.The discharging tube is symmetrically arranged with several, uniform using liquid and effectively exclude.
Further, temperature inductor is provided with the retort 1, adsorption tanks 2, preparation of reagents tank 4 and settling tank 5 and is stirred
Mix device 8.
Further, the paddle of the agitator 8 points to the corner of pot bottom.The structure design can be sufficiently stirred for, no
Easily remain.
Further, watch window 9 is provided with the retort 1, adsorption tanks 2, preparation of reagents tank 4 and settling tank 5.
Further, the retort 1, adsorption tanks 2 and ion exchange column 3 are detachably replaced.Retort and adsorption tanks are replaced
Be easy to replace and clean, retort and adsorption tanks can also used interchangeably, ion exchange column sets at least 4 and is easy to resin to maintain.
The beneficial effects of the utility model are：Retort in the process units of the liquaemin of this new offer, absorption
The transfer of tank, ion exchange column, and settling tank feed liquid feed liquid between each tank body is that can reach by the Action of Gravity Field of itself, from
And reached reduction investment, the purpose of energy saving；The space arrangement form from top to down that device is used, takes plant area
It is substantially reduced；Ion exchange column can carry out positive and negative washing, can effectively go the removal of impurity, and removal of impurity is high, be obtained using the present apparatus
Product quality it is high.
Brief description of the drawings
Fig. 1 is structural representation of the present utility model.
Reference lexical or textual analysis：1. retort, 11. filter screens, 12. inlets, 13 charging apertures；2. adsorption tanks；3. ion exchange
Post, 31. blast pipes, 32. liquid discharging tubes, 33. inlet I, 34. inlet II；4. preparation of reagents tank, 41. drain pipe I, 42. go out liquid
Pipe II；5. settling tank, 51. discharging tubes, 52. discharging openings；6. opening/shutting valve；7. electric pump；8. agitator；9. watch window.
Specific embodiment
Below in conjunction with the accompanying drawings, the utility model is described in detail.In order that the purpose of this utility model, technical scheme
And advantage becomes more apparent, below in conjunction with drawings and Examples, the utility model is further elaborated.Should manage
Solution, specific embodiment described herein is only used to explain the utility model, is not used to limit the utility model.
Embodiment 1
The process units of liquaemin, the process units includes retort 1, adsorption tanks 2, ion exchange column 3, preparation of reagents
Order is arranged from top to bottom for tank 4 and settling tank 5, the retort 1, adsorption tanks 2, ion exchange column 3 and settling tank 5, described anti-
Answer tank 1, adsorption tanks 2 to be connected by pipeline between ion exchange column 3 and settling tank 5, opening/shutting valve 6 is provided with pipeline；It is described
The upper end of ion exchange column 3 is provided with blast pipe 31, and liquid discharging tube 32 is provided with the lateral wall of ion exchange column 3；The reagent
Preparing tank 4 is located at the top of ion exchange column 3, and the bottom of the preparation of reagents tank 4 is provided with two drain pipes, drain pipe I41 with from
The inlet I33 connections of sub- exchange column 3, drain pipe II42 is connected with the inlet II34 of ion exchange column 3, the drain pipe
II42 is provided with electric pump 7；Opening/shutting valve 6 is also equipped with the drain pipe I41 and drain pipe II42；The retort 1 and suction
Bottom in attached tank 2 is provided with filter screen 11；The top of the retort 1 is provided with inlet 12 and charging aperture 13.
Retort 1 in the process units of the liquaemin of this new offer, adsorption tanks 2, ion exchange column 3, and settling tank 5
Transfer of the feed liquid between each tank body is that can reach by the Action of Gravity Field of itself, and investment, energy saving are reduced so as to reach
Purpose；The space arrangement form from top to down that device is used, takes plant area and is substantially reduced.
Producing liquaemin key step with the process units of liquaemin includes：
1) dissolve：To add that add aqueous medium to be miscible to its after mucous membrane or primary liquaemin and sodium chloride complete in the retort 1
Dissolve to obtain solution in portion；
2) digest：Dissolving completely after in retort 1 add protease digested, after inactivation enzymolysis liquid, filtering or
Adsorption tanks 2 are transferred to after insoluble impurity is centrifuged；
3) adsorb：The enzymolysis liquid is into carrying out insulation absorption 4-24 hours in upper ion exchange column 3 after adsorption tanks 2；
4) wash：Prepare gradient wash reagent control upper prop speed, upper ion exchange column 3 successively in preparation of reagents tank 4
Positive and negative washing is carried out, cleaning solution is derived；
5) elute：Step 4) washing after alkalescence anion-exchange resin is eluted twice with elution reagent；
6) drying is precipitated：The eluent for collecting and combining enters into settling tank 5, adds ethanol precipitation, removes right after supernatant
Precipitation is dried, and obtains the crude heparin sodium of high-purity.
Embodiment 2
Used as optimal technical scheme, in addition to the structure of embodiment 1 is retained, the both sides of the settling tank 5 are symmetrically arranged with embodiment 2
Discharging tube 51, the bottom of the settling tank 5 is additionally provided with discharging opening 52.The discharging tube is symmetrically arranged with several, using liquid
Uniform and effectively exclusion.
Embodiment 3
Used as optimal technical scheme, embodiment 3, also in the retort 1, is adsorbed in addition to the structure of embodiment 1 or 2 is retained
Watch window 9 is provided with tank 2, preparation of reagents tank 4 and settling tank 5, feelings in device can in time be observed by watch window 9
Condition；The paddle of the agitator 8 points to the turning of pot bottom；So setting can be equal by each local material stirring in tank
It is even, it is difficult residual.
Embodiment 4
Used as optimal technical scheme, embodiment 3 in addition to the structure of embodiment 1 or 2 or 3 is retained, adsorb by the retort 1
Tank 2 and ion exchange column 3 are detachably replaced.Retort and adsorption tanks are replaced to be easy to replace and cleaned, and retort and adsorption tanks also may be used
With used interchangeably, ion exchange column sets at least 4 and is easy to resin to maintain.
Preferred embodiment of the present utility model is the foregoing is only, is not used to limit the utility model, it is all at this
Any modification, equivalent and improvement made within the spirit and principle of utility model etc., should be included in the utility model
Protection domain within.
Claims (7)
1. the process units of liquaemin, it is characterised in that the process units includes retort (1), adsorption tanks (2), ion is handed over
Change post (3), preparation of reagents tank (4) and settling tank (5), the retort (1), adsorption tanks (2), ion exchange column (3) and precipitation
Tank (5) from top to bottom arrange by order, and the retort (1), adsorption tanks (2) lead between ion exchange column (3) and settling tank (5)
Piping is connected, and opening/shutting valve (6) is provided with pipeline；The upper end of the ion exchange column (3) is provided with blast pipe (31), from
Liquid discharging tube (32) is provided with the lateral wall of sub- exchange column (3)；The preparation of reagents tank (4) positioned at ion exchange column (3) top,
The bottom of the preparation of reagents tank (4) is provided with the inlet I (33) of two drain pipes, drain pipe I (41) and ion exchange column (3)
Connection, drain pipe II (42) is connected with the inlet II (34) of ion exchange column (3), and the drain pipe II (42) is provided with electric pump
(7)；Opening/shutting valve (6) is also equipped with the drain pipe I (41) and drain pipe II (42).
2. the process units of liquaemin according to claim 1, it is characterised in that the retort (1) and adsorption tanks (2)
Interior bottom is provided with filter screen (11)；Retort (1) top is provided with inlet (12) and charging aperture (13).
3. the process units of liquaemin according to claim 1, it is characterised in that settling tank (5) both sides symmetrically set
Discharging tube (51) is equipped with, settling tank (5) bottom is additionally provided with discharging opening (52).
4. the process units of liquaemin according to claim 1, it is characterised in that the retort (1), adsorption tanks (2),
Temperature inductor and agitator (8) are provided with preparation of reagents tank (4) and settling tank (5).
5. the process units of liquaemin according to claim 4, it is characterised in that the paddle of the agitator (8) refers to
To the corner of pot bottom.
6. the process units of liquaemin according to claim 1, it is characterised in that the retort (1), adsorption tanks (2),
Watch window (9) is provided with preparation of reagents tank (4) and settling tank (5).
7. the process units of liquaemin according to claim 1, it is characterised in that the retort (1), adsorption tanks (2)
Detachably replaced with ion exchange column (3).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201621309044.3U CN206219482U (en) | 2016-11-29 | 2016-11-29 | The process units of liquaemin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201621309044.3U CN206219482U (en) | 2016-11-29 | 2016-11-29 | The process units of liquaemin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN206219482U true CN206219482U (en) | 2017-06-06 |
Family
ID=58783834
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201621309044.3U Active CN206219482U (en) | 2016-11-29 | 2016-11-29 | The process units of liquaemin |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN206219482U (en) |
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2016
- 2016-11-29 CN CN201621309044.3U patent/CN206219482U/en active Active
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