CN207646111U - A kind of alcohol precipitation device of crude heparin sodium - Google Patents
A kind of alcohol precipitation device of crude heparin sodium Download PDFInfo
- Publication number
- CN207646111U CN207646111U CN201721479370.3U CN201721479370U CN207646111U CN 207646111 U CN207646111 U CN 207646111U CN 201721479370 U CN201721479370 U CN 201721479370U CN 207646111 U CN207646111 U CN 207646111U
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- Prior art keywords
- tank
- settling tank
- heparin sodium
- alcohol precipitation
- alcohol
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Abstract
The utility model discloses a kind of alcohol precipitation devices of crude heparin sodium, including settling tank, again sink tank, the bottom of the settling tank is equipped with discharge port, the top for sinking tank again is equipped with feed inlet, the discharge port is connected to the feed inlet by pipeline, the settling tank is equipped with blender, and the blocking plate for making agitated liquid convection current is equipped in the settling tank.When heparin sodium eluent and alcohol stir in settling tank, the blocking plate in settling tank can play the role of making agitating solution convection current, keep stirring more abundant, be conducive to remove the impurity in heparin sodium, obtained titer of heparin sodium is high.
Description
Technical field
The utility model is related to heparin sodium production fields, are filled more particularly, to a kind of alcohol precipitation of crude heparin sodium
It sets.
Background technology
Heparin sodium is the mucopolysaccharide sulfuric acid ester anticoagulative substance extracted from animal tissue, is most effective and face in the world
The bed maximum anticoagulation medicine of dosage, is mainly used in cardiovascular and cerebrovascular disease and hemodialysis.Heparin is in the world so far
Until the most complicated compound of known molecular structure, in a short time can not artificial chemistry synthesis, only derive from chitterlings at present
The heparin of mucous membrane can be used in clinical treatment.China is pig-breeding big country, possesses abundant pig slaughtering by-product small intestine, can
Abundant raw material is provided for heparin sodium, China is the major producing country of global heparin sodium crude and bulk pharmaceutical chemicals, and the whole world
Maximum heparin sodium bulk pharmaceutical chemicals exported country.
Crude heparin sodium is to extract to be made from the mucous membrane of small intestine etc. of fresh healthy live pig, is heparin sodium bulk pharmaceutical chemicals
Raw material.Chitterlings are dried by raw material pulverization process, salt solution enzymolysis and extraction, ion exchange adsorption, resin washing desorption, alcohol precipitation
Crude heparin sodium is obtained after dry and etc..Alcohol precipitation is the alcohol that resin eluent is added to high concentration, is made in eluent
The process of precipitation is precipitated in heparin sodium, is a vital step in crude heparin sodium production.In actual production, crude heparin sodium
Alcohol precipitation device generally comprise settling tank and sink tank again, settling tank is equipped with blender, heparin sodium eluent and alcohol heavy
Enter again heavy tank after being stirred in the tank of shallow lake, crude heparin sodium sediment is obtained after alcohol precipitation again in heavy tank again.But it is existing
Some settling tank stirrings are not enough, and are unfavorable for removing the impurity in crude heparin sodium precipitation, are influenced the potency of heparin sodium.
Utility model content
The utility model is the defect overcome described in the above-mentioned prior art, provides a kind of alcohol precipitation dress of crude heparin sodium
It sets.
In order to solve the above technical problems, the technical solution adopted in the utility model is：
A kind of alcohol precipitation device of crude heparin sodium, including settling tank, the tank that sinks again, the bottom of the settling tank is equipped with out
Material mouth, the top for sinking tank again are equipped with feed inlet, and the discharge port is connected to the feed inlet by pipeline, the settling tank
The blocking plate for making agitated liquid convection current is equipped with equipped with blender, in the settling tank.
Heparin sodium eluent and alcohol stir in settling tank, and the blocking plate in settling tank, which can play, makes agitating solution pair
The effect of stream keeps stirring more abundant, is conducive to remove the impurity in heparin sodium, obtained titer of heparin sodium is high.
Preferably, the blocking plate is set on the tank skin of the settling tank.
Preferably, the blocking plate extends along the radial section of the settling tank.Radial section of the blocking plate along settling tank
Extend so that settling tank is more convenient in actual use, and convection effects are more preferable.
Preferably, the blender includes telescopic stirring rod.Blender generally comprises stirring rod and agitating paddle, carries out
When stirring, the agitating paddle of blender is deep by scalable stirring rod in liquid, and after the completion of stirring, agitating paddle is recoverable to,
The space of settling tank will not be accounted for；By the stirring rod that stretches, the liquid of different height can be stirred.
Preferably, the bottom for sinking tank again is exported equipped with sediment.The heparin sodium sediment being finally prepared is from heavy
It takes out starch outlet.
Preferably, the tank that sinks again is equipped with vacuum pump.By vacuum pump, change the pressure between settling tank and again heavy tank
Difference so that heparin sodium sediment automatically flows into again heavy tank from settling tank.
Preferably, the top of the settling tank is equipped with the first alcohol entrance.
Preferably, the lower part of the settling tank is exported equipped with the first alcohol.After the completion of precipitation, heparin sodium is deposited on lower layer,
Alcohol can export the alcohol on discharge settling tank upper layer by the first alcohol on upper layer.
Preferably, the settling tank is equipped with the first observation window.By the first observation window, the precipitation in settling tank can be observed
Object interface.
Preferably, the top for sinking tank again is equipped with the second alcohol entrance.
Preferably, the lower part for sinking tank again is exported equipped with the second alcohol.After the completion of precipitation, heparin sodium is deposited on lower layer,
Alcohol the alcohol on heavy tank upper layer can be discharged again by the outlet of the second alcohol on upper layer.
Preferably, the tank that sinks again is equipped with the second observation window.By the second observation window, the precipitation in sinking tank again can be observed
Object interface.
Preferably, the settling tank or the tank heavy again or the vacuum pump are equipped with the moving parts for shift position,
The moving parts includes movable pulley.By movable pulley, the alcohol precipitation device of the utility model can be moved to needs
Place, operating flexibility is big, saves space and manpower.
It is highly preferred that the moving parts further includes the brake for checking movable pulley.Brake can be checked and consolidate
Movable pulley is determined, convenient for fixed alcohol precipitation device.
Compared with prior art, the utility model has the beneficial effects that：
The alcohol precipitation device of the crude heparin sodium of the utility model includes settling tank, again heavy tank, and resistance is equipped in settling tank
Disconnected plate, when heparin sodium eluent and alcohol stir in settling tank, the blocking plate in settling tank, which can play, makes agitating solution pair
The effect of stream keeps stirring more abundant, is conducive to remove the impurity in heparin sodium, obtained titer of heparin sodium is high.
Description of the drawings
Fig. 1 is the schematic diagram of the alcohol precipitation device of the crude heparin sodium of embodiment 1.
Specific implementation mode
The utility model is further described With reference to embodiment.
Embodiment 1
A kind of alcohol precipitation device of crude heparin sodium, including settling tank 1, the tank 3 that sinks again, settling tank 1 are equipped with blender 2,
Blender 2 is located at the top of settling tank 1, and blender 2 includes agitating paddle and scalable stirring rod 21, and blender 2 is by scalable
Agitating paddle is declined and is put in settling tank 1 by stirring rod 21, and the agitating paddle rises and withdraws after use；
Tank skin in settling tank 1 is equipped with blocking plate 11, and blocking plate 11 extends along the radial section of settling tank 1, blocking plate
11 extend to lower part from the top of settling tank 1；The top of settling tank 1 is equipped with eluent import 12 and the first alcohol entrance 14, sinks
The bottom of shallow lake tank 1 is equipped with discharge port 13, and the lower part of settling tank is equipped with the first alcohol and exports 15, and settling tank 1 is additionally provided with the first observation
Window 16；
The top of heavy tank 3 is equipped with feed inlet 31 again, and discharge port 13 is connected to feed inlet 31 by pipeline, and heavy tank 3 is upper again
Portion is additionally provided with the second alcohol entrance 33 and vacuum pump interface 35, sinks the bottom of tank 3 again and is equipped with sediment and exports 32, sinks tank 3 again
Lower part is equipped with the second alcohol and exports 34, and the tank 3 that sinks again is additionally provided with the second observation window 36；
The tank 3 that sinks again is equipped with vacuum pump 4, and vacuum pump 4 is connect with vacuum pump interface 35；
Settling tank 1, again heavy tank 3 and vacuum pump 4 are equipped with support leg, and support leg lower end is equipped with movable pulley 5 and for checking
The brake 6 of movable pulley 5.
Obviously, above-described embodiment of the utility model is only intended to clearly illustrate the utility model example, and
It is not the restriction to the embodiment of the utility model.For those of ordinary skill in the art, in above description
On the basis of can also make other variations or changes in different ways.There is no need and unable to give all embodiments
It is exhaustive.All any modification, equivalent and improvement made within the spirit and principle of the present invention etc., should be included in
Within the protection domain of the utility model claims.
Claims (9)
1. a kind of alcohol precipitation device of crude heparin sodium, including settling tank（1）, again sink tank（3）, the settling tank（1）Bottom
Portion is equipped with discharge port（13）, the top for sinking tank again is equipped with feed inlet（31）, the discharge port（13）With the feed inlet
（31）It is connected to by pipeline, the settling tank（1）Equipped with blender（2）, which is characterized in that the settling tank（1）Interior be equipped with is used
In the blocking plate for making agitated liquid convection current（11）.
2. alcohol precipitation device according to claim 1, which is characterized in that the blocking plate（11）It is set to the precipitation
Tank（1）Tank skin on.
3. alcohol precipitation device according to claim 1 or 2, which is characterized in that the blocking plate（11）Along the precipitation
Tank（1）Radial section extend.
4. alcohol precipitation device according to claim 1, which is characterized in that the blender（2）It is stirred including telescopic
Mix bar（21）.
5. alcohol precipitation device according to claim 1, which is characterized in that the tank that sinks again（3）Equipped with vacuum pump（4）.
6. alcohol precipitation device according to claim 1, which is characterized in that the settling tank（1）Lower part be equipped with first
Alcohol exports（15）.
7. alcohol precipitation device according to claim 1, which is characterized in that the tank that sinks again（3）Lower part be equipped with second
Alcohol exports（34）.
8. alcohol precipitation device according to claim 5, which is characterized in that the settling tank（1）Or the tank that sinks again（3）
Or the vacuum pump（4）Equipped with the moving parts for shift position, the moving parts includes movable pulley（5）.
9. alcohol precipitation device according to claim 8, which is characterized in that the moving parts further includes for checking
State movable pulley（5）Brake（6）.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201721479370.3U CN207646111U (en) | 2017-11-08 | 2017-11-08 | A kind of alcohol precipitation device of crude heparin sodium |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201721479370.3U CN207646111U (en) | 2017-11-08 | 2017-11-08 | A kind of alcohol precipitation device of crude heparin sodium |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN207646111U true CN207646111U (en) | 2018-07-24 |
Family
ID=62885530
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201721479370.3U Expired - Fee Related CN207646111U (en) | 2017-11-08 | 2017-11-08 | A kind of alcohol precipitation device of crude heparin sodium |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN207646111U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112274968A (en) * | 2020-10-21 | 2021-01-29 | 东莞市德鸿肠衣有限公司 | Alcohol precipitation device of crude heparin sodium |
-
2017
- 2017-11-08 CN CN201721479370.3U patent/CN207646111U/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112274968A (en) * | 2020-10-21 | 2021-01-29 | 东莞市德鸿肠衣有限公司 | Alcohol precipitation device of crude heparin sodium |
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| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20180724 Termination date: 20201108 |