CN208594226U - A kind of animal heparin sodium extraction collection device - Google Patents
A kind of animal heparin sodium extraction collection device Download PDFInfo
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- CN208594226U CN208594226U CN201821178067.4U CN201821178067U CN208594226U CN 208594226 U CN208594226 U CN 208594226U CN 201821178067 U CN201821178067 U CN 201821178067U CN 208594226 U CN208594226 U CN 208594226U
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- production tank
- heparin sodium
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Abstract
The utility model discloses a kind of animal heparin sodiums to extract collection device, including archenteron-scrapping machine, first production tank and the second production tank, postcibal diarrhea motor spindle is equipped with motor, control panel is equipped with above motor, complex enzyme plate is equipped in first production tank, filter screen is equipped with below complex enzyme plate, cavity inner wall is equipped with pH sensor and temperature sensor below filter screen, first production tank top is equipped with hydrochloric acid holding vessel and buck holding vessel, first production pot bottom is connect by conduit with the second production tank, resin and temperature sensor are equipped with inside second production tank, salting liquid holding vessel is equipped with above second production tank, first production tank and the second production pot bottom are equipped with heater.It is digested with complex enzyme, so as to effectively improve the efficiency of enzymolysis processing, is conducive to the acquirement rate for improving heparin sodium；By to absorption and elution and etc. condition control, so that the absorption to heparin sodium product and eluting rate are further increased, so as to further increase the acquirement rate of heparin sodium.
Description
Technical field
The utility model relates to a kind of extraction collection device, in particular to a kind of animal heparin sodium extracts collection device, belongs to
In biotechnology technical field.
Background technique
Heparin sodium is a kind of sulfuric acid ester substance of acid mucopolysaccharide that the mast cell by animal connective tissue generates, because
It, with strong anticoagulation, is the choice drug that prevention and treatment deep-vein thrombosis forms equal thrombotic diseases, with research
Deeply, it has been found that heparin sodium not only plays the role of anticoagulant, antithrombus formation and adjustment blood lipid, and there are also anti-inflammatory, antiallergies, disease-resistant
The multiple biological functions such as poison, anticancer.Though history of the heparin sodium for clinical existing more than 60 years, there are no one kind so far can
Completely instead of its product, so it is still the biochemical drug of most important anticoagulation and antithrombotic, and at present can only be driven
It is extracted in the portion of tissue of object, it cannot be artificial synthesized.China is pig-breeding, butchers and consume big country, and even more casing processing is big
State.Intestinal mucosa is the optimum feed stock for extracting heparin sodium, and there is the producer for being largely dedicated to that heparin sodium is extracted from intestinal mucosa in the country, greatly
Some Enterprises salting out method or enzyme salt combined techniques extract heparin sodium.The main program of enzyme salt combined techniques is first to carry out to intestinal mucosa object
Enzymatic hydrolysis, filtering, then with resin adsorption, elution, then use alcohol precipitation, after purification dry.Heparin sodium recovery rate is mostly one
Between hundred million IU/2300-2500 root small intestines (for best level in 100,000,000 IU/2000 root small intestines, only individual enterprises can reach this level),
The purity of mentioned heparin sodium is lower, Chang 70-90IU/mg, wherein containing a large amount of protein, color is dark brown, gives clinical application
Preparation increase difficulty.
In recent years, with the emergence of the progress of biotechnology and novel high polymer material, and new results go out
It is existing.Assisted extraction heparin sodium is digested, it is present corporate boss technology to be used that ion-exchange chromatography, which separates heparin technology,.Egg is added
White hydrolase, it is possible to reduce hydrolysis time and the pollution for reducing microorganism.But zymolysis technique is limited to the control of temperature, pH, mentions
Enzyme deactivation is also wanted after taking heparin sodium and is removed, while using ion-exchange from enzymolysis liquid when adsorbing liquaemin, due to inhaling
It is attached incomplete, so will lead to still containing the heparin sodium of higher amount in Liquid Residue, to influence heparin sodium acquirement rate.Further
, since the conditions such as absorb-elute are not effectively adjusted and are optimized, also further affect heparin sodium efficiently separate and
It obtains, affects the acquirement rate of heparin sodium.
Utility model content
The technical problems to be solved in the utility model is to overcome prior art absorption not exclusively, and the conditions such as absorb-elute are not
It is effectively adjusted and is optimized, affect the defect of the acquirement rate of heparin sodium, a kind of animal heparin sodium extraction collection dress is provided
It sets.
In order to solve the above-mentioned technical problem, the utility model provides the following technical solution:
The utility model provides a kind of animal heparin sodium extraction collection device, including archenteron-scrapping machine, the first production tank and second
Tank is produced, feed hopper is equipped at the top of the archenteron-scrapping machine, big rubber tire is equipped with inside the archenteron-scrapping machine, the big rubber tire is equipped with and scrapes greatly
Knife, the big scraper lower section are equipped with pallet, small wheel and small scraper are equipped with below the pallet, the small wheel lower section is equipped with sieve
Net, the sieve left and right ends are equipped with spray head, crushing knife are equipped with below the sieve, and the postcibal diarrhea motor spindle is equipped with motor,
Control panel is equipped with above the motor, the archenteron-scrapping machine outlet at bottom is connected by conduit with the first production tank, and described first
It produces and is equipped with complex enzyme plate in tank, filter screen is equipped with below the complex enzyme plate, cavity inner wall is equipped with below the filter screen
PH sensor and temperature sensor, it is described first production tank top be equipped with hydrochloric acid holding vessel and buck holding vessel, described first
Production pot bottom is connect by conduit with the second production tank, is equipped with resin and temperature sensor, institute inside the second production tank
It states and is equipped with salting liquid holding vessel above the second production tank, the first production tank and the second production pot bottom are equipped with heater, institute
The second production pot bottom lower right is stated equipped with outfall.
As a kind of optimal technical scheme of the utility model, the control panel and pH sensor, temperature sensor,
Heater is electrically connected.
As a kind of optimal technical scheme of the utility model, the complex enzyme plate is alkali protease and trypsase.
As a kind of optimal technical scheme of the utility model, the resin is macroreticular resin.
As a kind of optimal technical scheme of the utility model, the salting liquid holding vessel is sodium chloride solution.
The utility model beneficial effect achieved is: the utility model is digested with complex enzyme, so as to effective
The efficiency for improving enzymolysis processing is conducive to the acquirement rate for improving heparin sodium；By to absorption and elution and etc. condition control
System, so that the absorption to heparin sodium product and eluting rate are further increased, so as to further increase the acquirement rate of heparin sodium.
Detailed description of the invention
Attached drawing is used to provide a further understanding of the present invention, and constitutes part of specification, practical with this
Novel embodiment is used to explain the utility model together, does not constitute limitations of the present invention.In the accompanying drawings:
Fig. 1 is the structural schematic diagram of the utility model；
In figure: 1, archenteron-scrapping machine；2, feed hopper；3, big rubber tire；4, big scraper；5, pallet；6, small wheel；7, small scraper；8,
Spray head；9, sieve；10, motor；11, the first production tank；12, complex enzyme plate；13, filter screen；14, salting liquid holding vessel；15,
Two production tanks；16, resin；17, outfall；18, pH sensor；19, temperature sensor；20, control panel；21, salt
Sour storage tank；22, buck storage tank；23, heater；24, crushing knife.
Specific embodiment
It is illustrated below in conjunction with preferred embodiment of the attached drawing to the utility model, it should be understood that described herein excellent
It selects embodiment to be only used for describing and explaining the present invention, is not used to limit the utility model.
Embodiment:
As shown in Figure 1, the utility model, which provides the utility model, provides a kind of animal heparin sodium extraction collection device, including
Archenteron-scrapping machine 1, first produces tank 11 and the second production tank 15, and feed hopper 2 is equipped at the top of archenteron-scrapping machine 1, is equipped with big glue inside archenteron-scrapping machine 1
Wheel 3, big rubber tire 3 are equipped with big scraper 4, and pallet 5 is equipped with below big scraper 4, is equipped with small wheel 6 and small scraper 7 below pallet 5,
Sieve 9 is equipped with below small wheel 6,9 left and right ends of sieve are equipped with spray head 8, are equipped with crushing knife 24,1 bottom of archenteron-scrapping machine below sieve 9
Portion is equipped with motor 10, and control panel 20 is equipped with above motor 10, and 1 outlet at bottom of archenteron-scrapping machine passes through conduit and the first production 11 phase of tank
Even, it is equipped with complex enzyme plate 12 in the first production tank 11, is equipped with filter screen 13 below complex enzyme plate 12, in 13 lower section cavity of filter screen
Wall is equipped with pH sensor 18 and temperature sensor 19, is equipped with hydrochloric acid holding vessel 21 at the top of the first production tank 11 and buck stores
Tank 22, the first production 11 bottom of tank are connect by conduit with the second production tank 15, are equipped with 16 He of resin inside the second production tank 15
Temperature sensor 19, second produces above tank 15 equipped with salting liquid holding vessel 14, the first production tank 11 and the second production 15 bottom of tank
Portion is equipped with heater 23, is equipped with outfall 17 below the second production 15 bottom, right of tank.
Control panel 20 and pH sensor 18, temperature sensor 19, heater 23 are electrically connected.Complex enzyme plate 12 is alkali
Property protease and trypsase.Resin 16 is macroreticular resin.Salting liquid holding vessel 14 is sodium chloride solution.
Specifically, raw material chitterlings are put into archenteron-scrapping machine 1 and are handled, pig intestinal mucosa, pig intestinal mucosa are obtained when work
It filtering out from sieve 9, is crushed into crushing knife 24 is crossed, the water excluded with spray head 8 mixes, reach mixed solution to be processed, into
Enter into the first production tank 11, the numerical value that pH sensor 18 and temperature sensor 19 will test is transmitted to control panel 20, when mixed
When closing the pH value of solution not between 8.5-9, mixed solution is adjusted by control hydrochloric acid holding vessel 21 and buck holding vessel 22
PH, while controlling heater and mixed solution heated, stop heating when temperature reaches 65 degree, and temperature is made to maintain 55-
65 degree, enzyme digestion reaction control is controlled the pH value of the solution at into 7.5-8.5 after 2-4 hours, 2-4 hours, temperature is controlled in 35-
55 degree, then the solution after enzyme digestion reaction is discharged in the second production tank 15, by resin adsorption, temperature is kept in adsorption process
Degree is in 35-55 degree, after 4.5 hours, by other fluid removals, salting liquid is then added and is eluted, finally with alcohol pair
Liquid precipitate is eluted, after separation of solid and liquid, heparin sodium that solid content is dried to obtain.
The utility model beneficial effect achieved is: the utility model is digested with complex enzyme, so as to effective
The efficiency for improving enzymolysis processing is conducive to the acquirement rate for improving heparin sodium；By to absorption and elution and etc. condition control
System, so that the absorption to heparin sodium product and eluting rate are further increased, so as to further increase the acquirement rate of heparin sodium.
Finally, it should be noted that the above descriptions are merely preferred embodiments of the present invention, it is not limited to this
Utility model, although the utility model is described in detail with reference to the foregoing embodiments, for those skilled in the art
For, it is still possible to modify the technical solutions described in the foregoing embodiments, or to part of technical characteristic
It is equivalently replaced.Within the spirit and principle of the utility model, any modification, equivalent replacement, improvement and so on,
It should be included within the scope of protection of this utility model.
Claims (5)
1. a kind of animal heparin sodium extracts collection device, including archenteron-scrapping machine (1), the first production tank (11) and the second production tank
(15), which is characterized in that be equipped with feed hopper (2) at the top of the archenteron-scrapping machine (1), big rubber tire is equipped with inside the archenteron-scrapping machine (1)
(3), the big rubber tire (3) is equipped with big scraper (4), pallet (5) is equipped with below the big scraper (4), below the pallet (5)
Equipped with small wheel (6) and small scraper (7), sieve (9) are equipped with below the small wheel (6), sieve (9) left and right ends are all provided with
Have spray head (8), be equipped with crushing knife (24) below the sieve (9), archenteron-scrapping machine (1) bottom is equipped with motor (10), the electricity
Control panel (20) are equipped with above machine (10), archenteron-scrapping machine (1) outlet at bottom is connected by conduit with the first production tank (11),
Complex enzyme plate (12) are equipped in first production tank (11), are equipped with filter screen (13) below the complex enzyme plate (12), it is described
Cavity inner wall is equipped with pH sensor (18) and temperature sensor (19), first production tank (11) below filter screen (13)
Top is equipped with hydrochloric acid holding vessel (21) and buck holding vessel (22), and first production tank (11) bottom is raw by conduit and second
Tank (15) connection is produced, resin (16) and temperature sensor (19), second production are equipped with inside second production tank (15)
Salting liquid holding vessel (14) are equipped with above tank (15), first production tank (11) and the second production tank (15) bottom are equipped with heating
Device (23), the second production tank (15) bottom, right lower section are equipped with outfall (17).
2. a kind of animal heparin sodium according to claim 1 extracts collection device, which is characterized in that the control panel
(20) it is electrically connected with pH sensor (18), temperature sensor (19), heater (23).
3. a kind of animal heparin sodium according to claim 1 extracts collection device, which is characterized in that the complex enzyme plate
It (12) is alkali protease and trypsase.
4. a kind of animal heparin sodium according to claim 1 extracts collection device, which is characterized in that the resin (16) is
Macroreticular resin.
5. a kind of animal heparin sodium according to claim 1 extracts collection device, which is characterized in that the salting liquid storage
Tank (14) is sodium chloride solution.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201821178067.4U CN208594226U (en) | 2018-07-25 | 2018-07-25 | A kind of animal heparin sodium extraction collection device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201821178067.4U CN208594226U (en) | 2018-07-25 | 2018-07-25 | A kind of animal heparin sodium extraction collection device |
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| Publication Number | Publication Date |
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| CN208594226U true CN208594226U (en) | 2019-03-12 |
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| CN201821178067.4U Active CN208594226U (en) | 2018-07-25 | 2018-07-25 | A kind of animal heparin sodium extraction collection device |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112812202A (en) * | 2020-12-28 | 2021-05-18 | 黄金时代股份有限公司 | Heparin crude production system of processing |
-
2018
- 2018-07-25 CN CN201821178067.4U patent/CN208594226U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112812202A (en) * | 2020-12-28 | 2021-05-18 | 黄金时代股份有限公司 | Heparin crude production system of processing |
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