CN207641300U - A kind of classified concentration device of heparin sodium eluent - Google Patents
A kind of classified concentration device of heparin sodium eluent Download PDFInfo
- Publication number
- CN207641300U CN207641300U CN201721480091.9U CN201721480091U CN207641300U CN 207641300 U CN207641300 U CN 207641300U CN 201721480091 U CN201721480091 U CN 201721480091U CN 207641300 U CN207641300 U CN 207641300U
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- Prior art keywords
- filter column
- level
- dalton
- heparin sodium
- concentration device
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Abstract
The utility model discloses a kind of classified concentration devices of heparin sodium eluent, it include at least three-level filter column by placed in series, the filter column is equipped with inlet, filtrate (liquid and concentrated solution outlet, the molecular cut off of at least three-level filter column is sequentially reduced, it is 80k dalton wherein at least to have the molecular cut off of level-one filter column, it is 6k dalton wherein at least to have the molecular cut off of level-one filter column, and it is 500 dalton wherein at least to have the molecular cut off of level-one filter column.The multistage filtering of each component, separation, concentration in heparin sodium eluent are realized, heparin sodium active ingredient is made to be fully used；The concentrate for producing heparin sodium bulk pharmaceutical chemicals and low molecular sodium heparin bulk pharmaceutical chemicals is obtained, sensitization impurity has been effectively removed, is conducive to the potency and quality and safety that improve heparin sodium bulk pharmaceutical chemicals.
Description
Technical field
The utility model is related to heparin sodium production fields, more particularly, to a kind of multi-stage PCE of heparin sodium eluent
Device.
Background technology
Heparin sodium is the most effective in the world and maximum anticoagulation medicine of quantity, is mainly used in cardiovascular and cerebrovascular disease
And hemodialysis.Heparin sodium can only be extracted from the portion of tissue of animal at present, cannot be artificial synthesized.Heparin sodium first from
The mucous membrane of small intestine etc. of fresh healthy live pig extracts and is made crude heparin sodium, and crude heparin sodium contains virus and albumen
Matter is not directly applicable clinical treatment, need to further purify so that heparin sodium bulk pharmaceutical chemicals are made.Heparin sodium bulk pharmaceutical chemicals can direct quilt
For being made standard heparin preparation of sodium, or low molecular sodium heparin bulk pharmaceutical chemicals are made in further processing, then low molecular sodium heparin is made
Preparation.Standard heparin preparation of sodium and low molecular weight heparin preparation of sodium may be directly applied to clinical treatment.
In heparin sodium production, chitterlings are by raw material pulverization process, salt solution enzymolysis and extraction, ion exchange adsorption, resin
Washing desorption, alcohol precipitation drying and etc. after obtain crude heparin sodium.If the eluent after resin washing desorption directly carries out
Alcohol precipitation, first, the easy sensitization impurity of a variety of heparans such as dermatan sulfate, such heparan knot can be mixed into heparin sodium product
Structure impurity is the principal risk source of heparin sodium Clinical practice formulation products, second is that using traditional alcohol precipitation process, in eluent
Low molecular sodium heparin fails effective extraction and application, results in waste of resources.
Utility model content
The utility model is the defect overcome described in the above-mentioned prior art, provides a kind of multi-stage PCE of heparin sodium eluent
Device.Using the filter column of different molecular weight cut off, multistage filtering, separation, concentration are carried out to each component in heparin sodium eluent.
In order to solve the above technical problems, the technical solution adopted in the utility model is：
A kind of classified concentration device of heparin sodium eluent includes at least three-level filter column by placed in series, the filter
Column is equipped with inlet, filtrate (liquid and concentrated solution outlet, and the molecular cut off of at least three-level filter column is sequentially reduced, wherein extremely
The molecular cut off of rare level-one filter column is 80k dalton, and it is 6k dalton wherein at least to have the molecular cut off of level-one filter column,
It is 500 dalton wherein at least to have the molecular cut off of level-one filter column.
Using multistage by the filter column of placed in series, realize the multistage filtering of each component in heparin sodium eluent, separation,
Concentration, makes heparin sodium active ingredient be fully used；By the multistage filtering of filter column, it is 80k ~ 6k dalton to obtain molecular weight
Concentrate and molecular weight be the dalton of 6k ~ 500 concentrate；
Molecular weight is heparin sodium molecule and liver between the key component of 80k dalton to the concentrate between 6k dalton
Element-protein residues, active group is relatively fully more free in heparin sodium molecular structure, and eliminates dermatan sulfate etc. easily
Sensitization quasi-heparin substance is the optimal components for producing heparin sodium bulk pharmaceutical chemicals；
Molecular weight is low molecular sodium heparin, warp between the key component of 6k dalton to the concentrate between 500 dalton
Low molecular sodium heparin bulk pharmaceutical chemicals can be done by crossing after refining, and realize the utilization of low molecular sodium heparin, improve the valence of heparin sodium extraction
Value.
Preferably, molecular weight is used to recycle NaCl less than the filtrate of 500 dalton.Obtained NaCl is recycled to can be used in matching
Resin processed washs brine, saves production cost, and reduce discharge of wastewater, reduces pollution.
Preferably, the classified concentration device includes three-level filter column, and the molecular cut off of the three-level filter column is followed successively by 80k
Dalton, 6k dalton, 500 dalton.
Preferably, the filter column includes high pressure resistant sleeve and hollow fiber ultrafiltration membrane.
Preferably, the hollow fiber ultrafiltration membrane is detachable.Hollow fiber ultrafiltration membrane disassembling cleaning is replaced.
Preferably, the inlet is equipped with force (forcing) pump.So that eluent is entered filter column by force (forcing) pump, filter column is applied and is pressed
Power, make hollow fiber ultrafiltration membrane in filter column to by heparin sodium eluent be filtered, detach, concentrate.
It is highly preferred that the inlet is additionally provided with flowmeter, pressure gauge is equipped between the force (forcing) pump and the inlet,
The filtrate (liquid is equipped with the first valve, and the concentrated solution outlet is equipped with the second valve.It is shown according to flowmeter and pressure gauge
Numerical value adjusts the startup and closing of the first valve, the second valve and force (forcing) pump, to realize to heparin sodium quickly and efficiently
Filtering, separation, concentration.
It is further preferred that the classified concentration device further includes automatic control system, first valve is the first electricity
Magnet valve, second valve are second solenoid valve, the force (forcing) pump, the flowmeter, the pressure gauge, first electromagnetism
Valve, the second solenoid valve are electrically connected with the automatic control system.Automatic control system respectively with force (forcing) pump, flowmeter,
Pressure gauge, the first solenoid valve, second solenoid valve electrical connection, by the way that pressure, flow parameter is arranged, the first electromagnetism is opened in interruption control
Valve, second solenoid valve, force (forcing) pump are automatically filtered heparin sodium eluent, detach, concentrate, without excessive manual operation.
Preferably, the inlet is equipped with check (non-return) valve.
Preferably, the inlet is equipped with liquid feed valve.
Compared with prior art, the utility model has the beneficial effects that：
The utility model realizes the multistage of each component in heparin sodium eluent using the multistage filter column by placed in series
Filtering, separation, concentration, make heparin sodium active ingredient be fully used；It obtains for producing heparin sodium bulk pharmaceutical chemicals and low point
The concentrate of sub- heparin sodium bulk pharmaceutical chemicals, has effectively removed sensitization impurity, is conducive to the potency and quality that improve heparin sodium bulk pharmaceutical chemicals
Safety.
Description of the drawings
Fig. 1 is the schematic diagram of the classified concentration device of the heparin sodium eluent of embodiment 1.
Fig. 2 is the schematic diagram of the classified concentration device of the heparin sodium eluent of embodiment 2.
Fig. 3 is the schematic diagram of the filter column of the classified concentration device of the heparin sodium eluent of embodiment 1 and embodiment 2.
Fig. 4 is the flow chart of the classified concentration device of the heparin sodium eluent of embodiment 1 and embodiment 2.
Specific implementation mode
The utility model is further described With reference to embodiment.
Embodiment 1
A kind of heparin sodium takes off the classified concentration device of liquid, as shown in figures 1 and 3, including filter that three-level passes through placed in series
The molecular cut off of column 1, three-level filter column 1 is followed successively by 80k dalton, 6k dalton, 500 dalton, is respectively designated as the first filter
Column 1, the second filter column 1, third filter column 1, filter column 1 are external high pressure resistant sleeve 11, contain dismountable hollow fiber ultrafiltration membrane 12
Component, 1 inside both ends of filter column are that pressure resistance blocks, and filter column 1 is additionally provided with inlet 13, filtrate (liquid 14 and concentrated solution outlet 15；
Heparin sodium elution liquid storage tank 10 is connect with the inlet 13 of the first filter column 1 by pipeline, the filtrate (liquid 14 of the first filter column 1 and the
The inlet 13 of two filter columns 1 is connected by filtrate collection vessel with pipeline, filtrate (liquid 14 and the third filter column 1 of the second filter column 1
Inlet 13 connected with pipeline by filtrate collection vessel.
The molecular weight of the concentrate of first filter column 1 is more than or equal to 80k dalton, and the filtrate of the first filter column 1 is less than 80k dongles
, the filtrate of the first filter column 1 enters the second filter column 1 and carries out ultrafiltration；The molecular weight of the concentrate of second filter column 1 is 80k ~ 6k dongles
, the molecular weight of the filtrate of the second filter column 1 is less than 6k dalton, and the filtrate of the second filter column 1 enters third filter column and 1 surpassed
Filter；The molecular weight of the concentrate of third filter column 1 is the dalton of 6k ~ 500, and the molecular weight of the filtrate of third filter column 1 is less than 500 dongles
.
As shown in figure 4, the concentrate needs of the first filter column 1 are digested again after recycling, adsorption treatment, the reason is that the first filter
The key component of the concentrate of column 1 is to digest incomplete heparin-albumen long-chain and big molecular impurity polypeptide；Second filter column 1
Concentrate for refining heparin sodium bulk pharmaceutical chemicals；The concentrate of third filter column 1 is for refining low molecular sodium heparin bulk pharmaceutical chemicals；Third
For recycling NaCl, the NaCl recycled can be used in preparing resin washing brine the filtrate of filter column 1, save production cost,
And discharge of wastewater is reduced, reduce pollution.
Embodiment 2
The present embodiment is the second embodiment that the heparin sodium of the utility model takes off the classified concentration device of liquid, with embodiment 1
Unlike, force (forcing) pump 2, flowmeter 3, pressure gauge 4, check (non-return) valve 8 and feed liquor are equipped on the pipeline being connect with inlet 13 successively
Valve 9, filtrate (liquid 14 are equipped with the first solenoid valve 5, and concentrated solution outlet 15 is equipped with second solenoid valve 6, and the present embodiment further includes automatic
Control system 7, automatic control system 7 are electrically connected with force (forcing) pump 2, flowmeter 3, pressure gauge 4, the first solenoid valve 5 and second solenoid valve 6
It connects, by the way that pressure, flow parameter is arranged, the first solenoid valve 5, second solenoid valve 6 and force (forcing) pump 2 are opened in interruption control, automatic right
Heparin sodium eluent is filtered, detaches, concentrates.
Obviously, above-described embodiment of the utility model is only intended to clearly illustrate the utility model example, and
It is not the restriction to the embodiment of the utility model.For those of ordinary skill in the art, in above description
On the basis of can also make other variations or changes in different ways.There is no need and unable to give all embodiments
It is exhaustive.All any modification, equivalent and improvement made within the spirit and principle of the present invention etc., should be included in
Within the protection domain of the utility model claims.
Claims (8)
1. a kind of classified concentration device of heparin sodium eluent, which is characterized in that include being filtered by at least three-level of placed in series
Column（1）, the filter column（1）Equipped with inlet（13）, filtrate (liquid（14）And concentrated solution outlet（15）, at least three-level filter column
（1）Molecular cut off be sequentially reduced, wherein at least have level-one filter column（1）Molecular cut off be 80k dalton, wherein at least
There is level-one filter column（1）Molecular cut off be 6k dalton, wherein at least have level-one filter column（1）Molecular cut off be 500
Er Dun.
2. classified concentration device according to claim 1, which is characterized in that the classified concentration device includes three-level filter column
（1）, the three-level filter column（1）Molecular cut off be followed successively by 80k dalton, 6k dalton, 500 dalton.
3. classified concentration device according to claim 1, which is characterized in that the filter column（1）Including high pressure resistant sleeve
（11）And hollow fiber ultrafiltration membrane（12）.
4. classified concentration device according to claim 1, which is characterized in that the inlet（13）Equipped with force (forcing) pump（2）.
5. classified concentration device according to claim 4, which is characterized in that the inlet（13）It is additionally provided with flowmeter
（3）, the force (forcing) pump（2）With the inlet（13）Between be equipped with pressure gauge（4）, the filtrate (liquid（14）Equipped with the first valve
Door, the concentrated solution outlet（15）Equipped with the second valve.
6. classified concentration device according to claim 5, which is characterized in that further include automatic control system（7）, described
One valve is the first solenoid valve（5）, second valve is second solenoid valve（6）, the force (forcing) pump（2）, the flowmeter
（3）, the pressure gauge（4）, first solenoid valve（5）, the second solenoid valve（6）With the automatic control system（7）
Electrical connection.
7. according to claim 1 ~ 6 any one of them classified concentration device, which is characterized in that the inlet（13）Equipped with only
Inverse valve（8）.
8. according to claim 1 ~ 6 any one of them classified concentration device, which is characterized in that the inlet（13）Equipped with into
Liquid valve（9）.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201721480091.9U CN207641300U (en) | 2017-11-08 | 2017-11-08 | A kind of classified concentration device of heparin sodium eluent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201721480091.9U CN207641300U (en) | 2017-11-08 | 2017-11-08 | A kind of classified concentration device of heparin sodium eluent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN207641300U true CN207641300U (en) | 2018-07-24 |
Family
ID=62884713
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201721480091.9U Expired - Fee Related CN207641300U (en) | 2017-11-08 | 2017-11-08 | A kind of classified concentration device of heparin sodium eluent |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN207641300U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109758912A (en) * | 2019-03-06 | 2019-05-17 | 康哲(湖南)制药有限公司 | A kind of dedicated ultrafiltration apparatus of protein hydrolysate concentrate |
-
2017
- 2017-11-08 CN CN201721480091.9U patent/CN207641300U/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109758912A (en) * | 2019-03-06 | 2019-05-17 | 康哲(湖南)制药有限公司 | A kind of dedicated ultrafiltration apparatus of protein hydrolysate concentrate |
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| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20180724 Termination date: 20201108 |
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| CF01 | Termination of patent right due to non-payment of annual fee |