CN206184034U - Apparatus for preparing instant type traditional chinese medicine anticancer product - Google Patents

Abstract

The utility model discloses an apparatus for preparing instant type traditional chinese medicine anticancer product, equipment mainly including heating ultrasonic extraction ware, heat exchanger, distillation column, condenser, compounding room, spray drier and medicine film -making ware, be connected with the distillation column through heat exchanger, condenser by the ultrasonic extraction ware of heating, and the distillation column is connected with the compounding room, and the compounding room is connected with spray drier, and spray drier is connected with medicine film -making ware. The utility model discloses an apparatus for preparing instant type traditional chinese medicine anticancer product, having integrateed of novelty heat supersound extraction technique, hot exchange technology, distilling Recycle technique, spray drying is technological and medicine film -making technique, has guaranteed the traditional chinese medicine efficiency of optimization, has made non - crystal formation, fast water -soluble medicine product, has improved water -soluble, the human absorption rate of product, has strengthened the curative effect of anticancer traditional chinese medicine product, and has realized high -efficient, energy -conserving, practical production procedure.

Description

A kind of equipment for preparing Instant Traditional Chinese Drug Anticancer product

Technical field

The utility model belongs to medicine preparation field, and in particular to a kind of equipment for preparing Instant Traditional Chinese Drug Anticancer product.

Background technology

Chinese herbal medicine for preventing, such as ganoderma lucidum, Taxus, toad, Cordyceps sinensis, American Ginseng, scorpio, Radix Angelicae Sinensis, the Radix Astragali, pseudo-ginseng, strand Indigo plant etc., due to direct anticancer or indirect anticancer（The collaboration such as anti-aging, antibacterial, antiviral, regulation endocrine, enhancing be immune Anticancer effect）Ability, is often processed to preparation, powder or tablet, is used in anticancer health-care and medically.

It is prepared by existing various tcm products for non-treatment of cancer on the market, the mode frequently with direct medicine milling Into medicine, price is cheap and curative effect is preferable, but the method is not suitable for Chinese herbal medicine for preventing product；Having in due to Chinese herbal medicine for preventing product Effect anticancer component is mostly non-water soluble substance, and degree is relatively low, it is necessary to can be made using the method that medicine is concentrated High potency drugs.

The method for concentration of the antineoplastic product that prior art is recorded, continues to use the ancient method to Chinese medicine cooking to obtain medicine soup, by In boiling for a long time at high temperature, very big a part of water-insoluble anticancer component is also dispersed in water, is then dried Concentration, is obtained product；These methods for extract green tea, soybean, mushroom, broccoli, wild cabbage, sea-tangle, ginger, turmeric, garlic, The nontoxicity edible material such as blackberry, blueberry, Cranberry, hickory nut, pomegranate, walnut, matrimony vine, raspberry is feasible, but such as sago cycas The Chinese herbal medicine for preventing material such as leaf, toad, scorpio, rosemary, due to drug side-effect（Toxicity）It is larger, and toxic component is mostly water-soluble Property material, the method for the water concentrated traditional Chinese medicine not science, it is necessary to concentrated to toxic anticancer Chinese medicine using organic solvent, by poison Property minimize, evade side effects on the body.

Further, since the water-insoluble Chinese herbal medicine for preventing composition of concentration is water insoluble or is insoluble in water, directly by organic solvent Extract processing pharmacy is unpractical, therefore, water solubility, the human absorptivity for improving water-insoluble Chinese herbal medicine for preventing composition, with Strengthen the curative effect of Chinese herbal medicine for preventing product, and be the problem for being currently needed for solving using the production technology of energy-saving and environmental protection.

The content of the invention

In view of the shortcomings of the prior art, the purpose of this utility model is to provide one kind to prepare Instant Traditional Chinese Drug Anticancer product Equipment, the active drug composition for slightly being carried by way of energy-conserving and environment-protective, being concentrated out in Chinese herbal medicine for preventing, while improving its non-aqueous Property the dissolubility of Chinese herbal medicine for preventing product, biologic applications rate and effect, and use cheap, practical production technology.

To achieve these goals, the utility model uses following technical measures：One kind prepares Instant Traditional Chinese Drug Anticancer product The equipment of product, it is characterised in that：The equipment of described preparation Instant Traditional Chinese Drug Anticancer product mainly include heating ultrasonic extractor, Heat exchanger, destilling tower, condenser, weighing area, spray dryer and pharmaceutical tableting device, heat the liquid outlet pipe of ultrasonic extractor Road is connected through over-heat-exchanger with destilling tower liquid inlet, and the top gas outlet pipeline of destilling tower is connected with the entrance of heat exchanger, The outlet conduit of heat exchanger is connected by condenser with heating ultrasonic extractor bottom liquid inlet, the bottom discharging pipe of destilling tower Road is connected with weighing area feeding mouth, and weighing area discharge pipe is connected with spray dryer top feeding mouth, the bottom of spray dryer Portion's discharge pipe is connected with pharmaceutical tableting device.

Heating ultrasonic extractor as described above is internally provided with micropore grenadine and the ultrasonic rod of heating, and fills for Chinese medicine The organic solvent of extraction, the mesh of the micropore grenadine is preferably sized to 0.1-10 microns, and the temperature of the ultrasonic rod of heating sets Surely 30~80 degree, preferably 20~60 hertz of ultrasound setting are preferably.

The high-temperature-phase that heat exchange is carried out in heat exchanger as described above is to be steamed from the organic solvent in destilling tower separate Gas, low-temperature phase is the pharmaceutical extraction liquid in the liquid outlet pipeline from heating ultrasonic extractor.

Destilling tower as described above is in hot environment, and temperature is preferably 80~150 degree, wherein boiling volatilization at high temperature Organic solvent steam out is discharged into heat exchanger by top gas outlet pipeline, and the water-insoluble Traditional Chinese Drug Anticancer composition of precipitation leads to Cross bottom discharging pipeline to weighing area.

The solvent that dispensing is carried out in weighing area as described above is water, and solute is the concentrated traditional Chinese medicine composition and medicine for extracting Product excipient；The medicine excipient is one or more in sugar, alcohol, amino acid, albumen powder, milk powder, ground coffee, and in water Mass fraction in solution is 3~30%.

Spray dryer as described above is made up of heated nozzle, hothouse, cyclone separator and aspiration pump, the heating The temperature setting of nozzle is preferably 130~230 degree, and the lower size limit that cyclone separator separates solid particle is 1 micron.

Pharmaceutical tableting device as described above is internally provided with pressurization hammer and mould, and the pressure of the pressurization hammer sets and is preferably 1~3 ton, mold shape is the one kind in circular, oval, spherical, square, rectangle or star.

The utility model compared with prior art, with advantages below：The integrated heating ultrasonic extraction technology of novelty, heat Switching technology, Distillation recovery technology, spray drying technology and pharmaceutical tableting technology, realize efficient, energy-conservation, practical production stream Journey；Wherein, water-insoluble Chinese herbal medicine for preventing uniformly mixes with organic solvent molecule during ultrasonic extraction is heated, it is ensured that optimal The medicine extraction efficiency of change；System improves efficiency of energy utilization by with hot swapping；It is organic during Distillation recovery Solvent vapour is condensed recovery, is back to heating ultrasonic extraction；With spray drying method to concentrate water-insoluble anticancer Traditional Chinese medicine ingredients are dried granulation, and drug powder that is armorphous, being instantly dissolved in water has been obtained, and improve product water solubility, human body and inhale Yield, enhances the curative effect of Chinese herbal medicine for preventing product；Pharmaceutical tableting technology will the obtained Instant medicine powder pressing, side Just transport and oral, it is more practical.

Brief description of the drawings

Fig. 1 is structural representation of the present utility model.

In figure：1- heatings ultrasonic extractor, 1-1- micropores grenadine, the ultrasonic rod of 1-2- heating, 2- heat exchangers, 3- distillations Tower, 4- condensers, 5- weighing areas, 6- spray dryers, 6-1- heated nozzles, 6-2- hothouses, 6-3- cyclone separators, 6-4- Aspiration pump, 7- pharmaceutical tabletings device, 7-1- pressurizations hammer, 7-2- moulds.

Specific embodiment

Below in conjunction with the utility model embodiment and accompanying drawing, the technical scheme in the utility model embodiment is retouched State, it is clear that described embodiment is only a part of embodiment of the utility model, rather than whole embodiments.Based on this Embodiment in utility model, those of ordinary skill in the art obtained under the premise of creative work is not made it is all its His embodiment, belongs to the scope of the utility model protection.

Embodiment 1：As shown in figure 1, a kind of equipment for preparing Instant Traditional Chinese Drug Anticancer product, including heating ultrasonic extractor （1）, heat exchanger（2）, destilling tower（3）, condenser（4）, weighing area（5）, spray dryer（6）With pharmaceutical tableting device（7）, plus Warm ultrasonic extractor（1）Liquid outlet pipeline through over-heat-exchanger（2）With destilling tower（3）Liquid inlet is connected, destilling tower（3）Top Portion gas outlet pipeline and heat exchanger（2）Entrance connection, heat exchanger（2）Outlet conduit by condenser（4）With heating Ultrasonic extractor（1）Bottom liquid inlet connection, destilling tower（3）Bottom discharging pipeline and weighing area（5）Feeding mouth is connected, dispensing Between（5）Discharge pipe and spray dryer（6）Top feeding mouth connection, spray dryer（6）Bottom discharge pipeline and medicine Film-making device（7）Connection.

Further, described heating ultrasonic extractor（1）It is internally provided with the micropore grenadine that mesh size is 1 micron（1- 1）With the ultrasonic rod of heating（1-2）, and the alcohol for Chinese medicine extraction is filled as solvent, the heating ultrasound rod（1-2）Temperature Degree be set as 50 degree, ultrasound be set as 30 hertz.It should be noted that preferably ethanol as extractant because the valency of alcohol Lattice are cheap, environmental pollution is small, recovery is convenient, and it is also feasible as extract to substitute alcohol using other organic solvents, is belonged to In the description content of the present embodiment；The temperature and ultrasound intensity parameter of the present embodiment are most preferred, improve temperature and ultrasound is strong Degree is also feasible, but energy consumption is higher；It is also feasible to reduce temperature and ultrasound intensity, and energy consumption is relatively low, but extraction time is more long.

Further, choose 100 grams of Chinese lobelia of chopping, 100 grams of selfheals, 80 grams of Poria cocos, 50 grams of paris polyphyllas, 20 grams Ginseng is thrown to micropore grenadine as Chinese herbal medicine for preventing composition（1-1）In, heating ultrasonic extraction 2 hours.It should be noted that anti- Cancer Chinese medicine also belongs to retouching for the present embodiment in addition to above-mentioned Chinese medicine species using other Chinese herbal medicine for preventing or the dosage for changing Chinese medicine State content.

Further, by the heating ultrasonic extractor（1）In extract by liquid outlet pipeline through heat exchanger（2）It is logical Toward destilling tower（3）In, the heat exchanger（2）In to carry out the high-temperature-phase of heat exchange be from destilling tower（3）Middle separation it is organic Solvent vapour, low-temperature phase is from heating ultrasonic extractor（1）Liquid outlet pipeline in pharmaceutical extraction liquid.

Further, in destilling tower（3）In carry out solution heating distillation, the temperature setting of distillation is 100 degree, wherein in high temperature The lower alcohol vapor for evaporating of seething with excitement passes through heat exchanger（2）, condenser（4）Cooling under re-form liquid alcohol, return With extremely heating ultrasonic extractor（1）In；The concentrated traditional Chinese medicine anticancer component of precipitation is by bottom discharging pipeline to weighing area （5）.

Further, in the weighing area（5）In carry out dispensing, it is solvent to use 1L water, and solute is 50 grams for extracting Concentrated traditional Chinese medicine composition and 100 grams of milk powder of extra addition are used as medicine excipient.It should be noted that medicine excipient is main Purposes be strengthen medicine water solubility and human absorptivity, the medicine excipient higher due to adding glass transition temperature, be sugar, One or more in alcohol, amino acid, albumen powder, milk powder, ground coffee, the obtained medicine of spray drying is amorphous structure, point Active force between son is smaller, causes integral material soluble in water.

Further, in spray dryer（6）In ingredients solution is spray-dried, the spray dryer（6）By adding Hot nozzle（6-1）, hothouse（6-2）, cyclone separator（6-3）And aspiration pump（6-4）Composition, the heated nozzle（6-1）'s Temperature is set as 170 degree, hothouse（6-2）The solid vapour mixing air of middle formation is in aspiration pump（6-4）In the presence of in whirlwind point From device（6-3）In carry out solid vapour separation, and based on cyclone separator（6-3）Shape-designing, its separate solid particle size Lower limit is 1 micron.

Further, by spray dryer（6）In obtained drug powder be placed in the pharmaceutical tableting device（7）Circular die （7-2）In, hammered into shape with pressurization（7-1）Pressurization film-making is carried out to every 0.3 gram of medicinal powder under 1 ton of pressure, tablet product is obtained.

The preparation method of embodiment 1 can be by changing chinese medicine material, solvent, medicine excipient and product pattern, with cancer In the medicine of disease preventing and treating.

Embodiment 2：Described heating ultrasonic extractor（1）It is internally provided with the micropore grenadine that mesh size is 2 microns（1- 1）With the ultrasonic rod of heating（1-2）, and fill for the ethyl acetate for extracting as solvent, the heating ultrasound rod（1-2）Temperature Degree be set as 40 degree, ultrasound be set as 20 hertz.

Further, 100 grams of jujubes, 100 grams of green tea, 80 grams of raspberries, 10 grams of Grape Skins of chopping are chosen as food-grade Cancer therapy drug composition, is thrown to micropore grenadine（1-1）In, heating ultrasonic extraction 1 hour.Because various conventional foods have necessarily Anticancer function, can be used as non-drug health products using the anticancer component of such food-grade, with wider array of applicable model Enclose.

Further, in the weighing area（5）In carry out dispensing, it is solvent to use 1L water, and solute is 50 grams for extracting Concentrated traditional Chinese medicine composition and 140 grams of medicine excipient of extra addition（80 grams of starch and 60 grams of mixtures of lactose）.

Further, in spray dryer（6）In ingredients solution is spray-dried, the heated nozzle（6-1）Temperature Degree is set as 150 degree.

Further, by spray dryer（6）In obtained drug powder be placed in the pharmaceutical tableting device（7）Elliptical mode Tool（7-2）In, hammered into shape with pressurization（7-1）Pressurization film-making is carried out to every 0.5 gram of medicinal powder under 1.5 tons of pressure, oval medicine is obtained Flake products.

Other processes not outlined in embodiment 2 are identical with described in embodiment 1, and the preparation method of embodiment 2 can pass through Change anticancer food material, solvent, medicine excipient and product pattern, with the medicine of prevention and control of cancer, health products and daily material In reason.

Finally illustrate, preferred embodiment above is merely to illustrate the technical solution of the utility model and unrestricted, to the greatest extent Pipe is described in detail by above preferred embodiment to the utility model, but those skilled in the art should manage Solution, can be variously modified to it in the form and details, be limited without departing from the utility model claims Scope.

Claims (8)

1. a kind of equipment for preparing Instant Traditional Chinese Drug Anticancer product, it is characterised in that：Described preparation Instant Traditional Chinese Drug Anticancer is produced The equipment of product mainly includes heating ultrasonic extractor（1）, heat exchanger（2）, destilling tower（3）, condenser（4）, weighing area（5）、 Spray dryer（6）With pharmaceutical tableting device（7）, heat ultrasonic extractor（1）Liquid outlet pipeline through over-heat-exchanger（2）With steaming Evaporate tower（3）Liquid inlet is connected, destilling tower（3）Top gas outlet pipeline and heat exchanger（2）Entrance connection, heat exchanger （2）Outlet conduit by condenser（4）With heating ultrasonic extractor（1）Bottom liquid inlet connection, destilling tower（3）Bottom row Pipe material and weighing area（5）Feeding mouth is connected, weighing area（5）Discharge pipe and spray dryer（6）Top feeding mouth connection, spray Mist drier（6）Bottom discharge pipeline and pharmaceutical tableting device（7）Connection.

2. a kind of equipment for preparing Instant Traditional Chinese Drug Anticancer product according to claim 1, it is characterised in that：Described adds Warm ultrasonic extractor（1）It is internally provided with micropore grenadine（1-1）With the ultrasonic rod of heating（1-2）, and fill for Chinese medicine extraction Organic solvent, the micropore grenadine（1-1）Mesh be preferably sized to 0.1-10 microns, the ultrasonic rod of heating（1-2）Temperature Preferably 30~80 degree of degree setting, ultrasound setting are preferably 20~60 hertz.

3. a kind of equipment for preparing Instant Traditional Chinese Drug Anticancer product according to claim 1, it is characterised in that：The heat is handed over Parallel operation（2）In to carry out the high-temperature-phase of heat exchange be from destilling tower（3）The organic solvent steam of middle separation, low-temperature phase be from plus Warm ultrasonic extractor（1）Liquid outlet pipeline in pharmaceutical extraction liquid.

4. a kind of equipment for preparing Instant Traditional Chinese Drug Anticancer product according to claim 1, it is characterised in that：The distillation Tower（3）In hot environment, temperature is preferably 80~150 degree, wherein the organic solvent steam for evaporating that seethes with excitement at high temperature Heat exchanger is discharged into by top gas outlet pipeline（2）, the water-insoluble Traditional Chinese Drug Anticancer composition of precipitation is by bottom discharging pipeline It is delivered to weighing area（5）.

5. a kind of equipment for preparing Instant Traditional Chinese Drug Anticancer product according to claim 1, it is characterised in that：The dispensing Between（5）In carry out the solvent of dispensing for water, solute is the concentrated traditional Chinese medicine composition and medicine excipient for extracting.

6. a kind of equipment for preparing Instant Traditional Chinese Drug Anticancer product according to claim 5, it is characterised in that：The medicine Excipient is one or more in sugar, alcohol, amino acid, albumen powder, milk powder, ground coffee, and the mass fraction in the aqueous solution It is 3~30%.

7. a kind of equipment for preparing Instant Traditional Chinese Drug Anticancer product according to claim 1, it is characterised in that：The spraying Drier（6）By heated nozzle（6-1）, hothouse（6-2）, cyclone separator（6-3）And aspiration pump（6-4）Composition, it is described to add Hot nozzle（6-1）Temperature setting be preferably 130~230 degree, cyclone separator（6-3）Separate solid particle lower size limit be 1 micron.

8. a kind of equipment for preparing Instant Traditional Chinese Drug Anticancer product according to claim 1, it is characterised in that：The medicine Film-making device（7）It is internally provided with pressurization hammer（7-1）And mould（7-2）, the pressurization hammer（7-1）Pressure set be preferably 1~3 Ton, mould（7-2）It is shaped as the one kind in circular, oval, spherical, square, rectangle or star.