CN206109376U - Reaction plate, reaction platform and nucleic acid molecules hybridization appearance - Google Patents
Reaction plate, reaction platform and nucleic acid molecules hybridization appearance Download PDFInfo
- Publication number
- CN206109376U CN206109376U CN201621072420.1U CN201621072420U CN206109376U CN 206109376 U CN206109376 U CN 206109376U CN 201621072420 U CN201621072420 U CN 201621072420U CN 206109376 U CN206109376 U CN 206109376U
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- Prior art keywords
- reaction
- positive displacement
- plate
- plate body
- displacement pump
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Abstract
The utility model relates to the technical field of medical equipment, a reaction plate is disclosed, include: plate body and a plurality of reactions of formation on the plate body still include: positive displacement pump and control circuit, every be equipped with the weeping hole in the reaction, every weeping jogged joint has the weeping pipe, installs automatically controlled valve on every weeping pipe, weeping union coupling positive displacement pump, automatically controlled valve with the positive displacement pump is connected control circuit, control circuit is used for opening automatically controlled valve to liquid in the control positive displacement pump suction institute reaction. A reaction platform and nucleic acid molecules hybridization appearance is still disclosed. The utility model discloses a reaction plate adopts the liquid of remaining in the mode discharge reaction of weeping for quick discharge of waste liquid in the reaction is not just remained, can not influence reaction precision next time.
Description
Technical field
This utility model is related to technical field of medical instruments, more particularly to a kind of Sptting plate, reaction platform and nucleic acid molecules
Hybridization instrument.
Background technology
At present industry, chemical laboratory and molecular biosciences laboratory are widely used in full-automatic liquid relief platform, to participating in
The most of the liquid of reaction adopts syringe principle pin or tip heads to reactive tank fluid injection, or siphons away the waste liquid in reactive tank.
If fluid injection and imbibition are same pin, simultaneously detergent line is wanted in imbibition process, that is, when increasing operational
Between expense.And because needle point is little with the contact area at reactive tank bottom, be not easy to blot in net reactive tank when with pin imbibition
Liquid, easily affects the precision tested next time.
Utility model content
This utility model provides a kind of Sptting plate and nucleic acid molecular cross instrument, and solving traditional syringe needle imbibition cannot blot
Net problem.
A kind of Sptting plate of the present utility model, including：Plate body and some reactive tanks being formed on plate body, also include：Row
Liquid pump and control circuit, in each described reactive tank liquid-leaking nozzle is provided with, and each liquid-leaking nozzle is connected with leakage pipe, on each leakage pipe
Electrically-controlled valve, the leakage pipe connected drainage pump, the electrically-controlled valve and the positive displacement pump connection control circuit are installed.
Wherein, the number of the positive displacement pump is identical with the reactive tank number, and each leakage pipe connects different positive displacement pumps.
Wherein, each leakage pipe is connected to same positive displacement pump.
Wherein, the liquid-leaking nozzle is located at the reaction tank bottom or side wall.
Wherein, the cover plate for covering the reactive tank is also removably provided with the plate body.
Wherein, the plate body is made using PC, PP, PE material.
This utility model additionally provides a kind of reaction platform, including the Sptting plate described in any of the above-described and with the plate body
Connection for the agitating device that waves the plate body.
Wherein, the agitating device includes：Gripper shoe, bearing, rocking arm, shaft coupling, position sensor and motor, the plate
Body is located in gripper shoe, and one end of gripper shoe is rotatably coupled bearing, and the other end is rotatably coupled the rocking arm, and rocking arm leads to
Cross the shaft coupling and connect the motor, the motor and the position sensor connect the control circuit.
This utility model additionally provides a kind of nucleic acid molecular cross instrument, including the reaction platform described in any of the above-described.
Sptting plate of the present utility model discharges the residual liquid in reactive tank by the way of leakage so that in reactive tank
Waste liquid is quickly discharged and not remained, and reaction next time is more accurate.
Description of the drawings
In order to be illustrated more clearly that this utility model embodiment or technical scheme of the prior art, below will be to embodiment
Or the accompanying drawing to be used needed for description of the prior art is briefly described, it should be apparent that, drawings in the following description are only
It is some embodiments of the present utility model, for those of ordinary skill in the art, before creative labor is not paid
Put, can be with according to these other accompanying drawings of accompanying drawings acquisition.
Fig. 1 is a kind of structural representation of Sptting plate of the present utility model；
Fig. 2 is the structural representation of another kind of Sptting plate of the present utility model；
Fig. 3 is to add a cover plate structure schematic diagram on the Sptting plate of Fig. 1；
Fig. 4 is a kind of structural representation of reaction platform of the present utility model.
Fig. 5 is the nucleic acid molecular cross instrument structural representation of the reaction platform for including Fig. 3.
Description of reference numerals is as follows：
1st, plate body；2nd, reactive tank；3rd, small opening；4th, leakage pipe；5th, electrically-controlled valve；6th, positive displacement pump；7th, cover plate；8th, gripper shoe；9、
Bearing；10th, rocking arm；11st, shaft coupling；12nd, motor；13rd, position sensor；14th, refrigerating plant；15th, casing；16th, topping-up pump；
17th, the electrically-controlled valve between topping-up pump and injection needle；18th, three-dimensional moving mechanism；19th, injection needle；20th, controller；21st, fluid reservoir；
22nd, waste liquid pool；23rd, the electrically-controlled valve between topping-up pump and fluid reservoir.
Specific embodiment
Below in conjunction with the accompanying drawing in this utility model embodiment, the technical scheme in this utility model embodiment is carried out
Clearly and completely describe, it is clear that described embodiment is only a part of embodiment of this utility model, rather than whole
Embodiment.Based on the embodiment in this utility model, those of ordinary skill in the art are not under the premise of creative work is made
The every other embodiment for being obtained, belongs to the scope of this utility model protection.
The Sptting plate of the present embodiment as shown in Figures 1 to 3, including：Plate body 1 and some reactive tanks 2 being formed on plate body 1,
Also include：Liquid-leaking nozzle 3 is provided with positive displacement pump 6 and control circuit (not shown), each reactive tank 2, each liquid-leaking nozzle 3 connects
There is leakage pipe 4, electrically-controlled valve 5 is installed on each leakage pipe 4, the connected drainage pump 6 of leakage pipe 4, electrically-controlled valve 5 and positive displacement pump 6 connect
Control circuit, control circuit is used to open electrically-controlled valve 5, and so as to connecting reactive tank 2 and positive displacement pump 6, and controlling positive displacement pump 6 institute is suctioned out
Liquid in reactive tank 2.Wherein, reactive tank 2 can also be test tube shape, and leakage pipe 4 is flexible pipe.
After the completion of reactant liquor reaction in the Sptting plate of the present embodiment, positive displacement pump 6 is started by control circuit, while opening
Electrically-controlled valve 5, positive displacement pump 6 suctions out the residual liquid in reactive tank 2 from liquid-leaking nozzle 3 so that waste liquid in reactive tank quickly discharge and
Do not remain, do not interfere with reaction precision next time.
Positive displacement pump is connected with the following two kinds mode with leakage pipe：
Mode one：The number of positive displacement pump 6 is identical with the number of reactive tank 2, and each leakage pipe 4 connects different positive displacement pumps 6, often
Individual positive displacement pump 6 is all connected with control circuit, and control circuit can simultaneously open all of electrically-controlled valve 5, and it is simultaneously right to control positive displacement pump 6
Each reactive tank 2 carries out discharge opeing, and drain age velocity is faster.
Mode two：As illustrated in fig. 1 and 2, each leakage pipe 4 is connected to same positive displacement pump 6, i.e. only one of which positive displacement pump 6.
In theory control circuit can also open all of electrically-controlled valve 5, and the positive displacement pump 6 carries out discharge opeing to each reactive tank 2 simultaneously, but
After all electrically-controlled valves 5 are opened, the liquid-leaking nozzle of each reactive tank 2 is connected, and is not in each reactive tank 2 due to the relation of air pressure
Waste liquid can exclude.It is therefore preferred that control circuit is used to once open an electrically-controlled valve 5, and the row of control by scheduled timing
Liquid pump 6 suctions out the waste liquid in reactive tank 2 corresponding with the electrically-controlled valve 5.This mode draining mode relative to the cost of mode one more
It is low.
In the present embodiment, liquid-leaking nozzle 3 may be located at the bottom of reactive tank 2 (as shown in Figure 2) or side wall (as shown in Figure 1),
During the wall of side, liquid-leaking nozzle is more beneficial for fluid removal near the position of bottom land.
In the present embodiment, the cover plate 7 for covering reactive tank 2 is also removably provided with plate body 1.Cover plate 7 can not be complete
Cover reactive tank 2 entirely, leave small gap, in order to fluid injection in reactive tank 2, and avoid as far as possible in reaction dust or
Other impurities fall into reactive tank 2 and cause to react precision is forbidden, while and can as far as possible reduce reactant liquor (volatile reaction
Liquid) volatile zone come differential responses groove 2 cross-contamination.Wherein, cover plate 7 can be a monoblock or the lid of a groove one.
Plate body 1 is made using PP, PC, PE material.On nucleic acid molecular cross instrument, metal material is replaced using PP, PC, PE
Sptting plate, it is to avoid there is chemical reaction in metal itself and reactant, while such material is easy to do into medical disposable material, reduce
The pollution that Reusability brings.
As shown in figure 4, this utility model additionally provides a kind of reaction platform, including above-mentioned Sptting plate and it is connected with plate body 1
For the agitating device that waves the body of plate 1, plate body 1 is shaken in reaction so that reactant liquor mixes evenly, reaction
More thoroughly, more rapidly.
The agitating device is specifically included：Gripper shoe 8, bearing 9, rocking arm 10, shaft coupling 11, motor 12 and position sensor
13.Plate body 1 is located in gripper shoe 8, and one end of gripper shoe 8 is rotatably coupled bearing 9, and the other end is rotatably coupled rocking arm
10, rocking arm 10 connects motor 12, motor 12 and the connection control circuit of position sensor 13 by shaft coupling 11.Control circuit passes through
The rotating speed and rotation direction of controlled motor 12 to control sway velocity and amplitude, the agitating device simple structure low cost.In row
During liquid, control circuit controlled motor 12 drives plate body 1 to rotate, and position sensor 13 detects plate body 1 and goes to after default angle,
There is halt instruction to control circuit, control circuit receives stopping motor 12 after halt instruction.The predetermined angular is caused Lou
Fluid apertures 3 is in low level, is so more beneficial for waste liquid and discharges more quickly, does not remain, and reduces experiment risk, increased experiment accurate
Degree.The angle can be according to practical situation (such as：Bottom land is located at according to liquid-leaking nozzle 3 or Sidewall angles is different) in position sensor
Set in 13.
Wherein, gripper shoe 8 can be the gripper shoe (heating wire is arranged in Heat Conduction Material) with heating function, with control electricity
Road connects, and some reactions are needed when carrying out under higher than ambient temperature, can control gripper shoe 8 by control circuit and generate heat.This is anti-
Answer and can also include in platform refrigerating plant 14, connect control circuit, the connection gripper shoe 8 of refrigerating plant 14.Some reactions need
When carrying out at temperatures below ambient, refrigerating plant 14 can be controlled by control circuit and be freezed, because gripper shoe 8 is Heat Conduction Material
Make, according to heat transfer principle, the temperature of reactant liquor in reactive tank 2 can be reduced.Temperature sensor is coordinated to realize to anti-
Answer the precise control of liquid temp, specifically, temperature sensor connection control circuit, by the reacting liquid temperature of real-time monitoring send to
Control circuit, stopping gripper shoe 8 is heated or refrigerating plant 14 freezes when control circuit judges that reacting liquid temperature reaches predetermined value.
Reaction platform also includes waste liquid pool 22, the connected drainage pump 6 of waste liquid pool 22, for containing the waste liquid of the exclusion of reactive tank 2.
This utility model additionally provides a kind of nucleic acid molecular cross instrument as shown in figure 5, including above-mentioned reaction platform, also wrapping
Include：Topping-up pump 16, electrically-controlled valve 17, three-dimensional moving mechanism 18 (have only indicated the structure of the X-axis of transverse shifting, Y-axis and Z in figure
Axle is repeated no more), injection needle 19, controller 20 and fluid reservoir 21.Fluid reservoir 21 connects injection needle 19, fluid injection by topping-up pump 16
Pipeline between pump 16 and injection needle 19 is provided with the pipeline of electrically-controlled valve 17, topping-up pump 16 and fluid reservoir 21 and is provided with electrically-controlled valve
23.Injection needle 19 is fixed on the slip-on head of three-dimensional moving mechanism 18, and the reaction platform is located at the casing of nucleic acid molecular cross instrument
In 15, and positioned at the lower section of injection needle 19.The connection electrically-controlled valve 17 of controller 20, topping-up pump 16 and three-dimensional moving mechanism 18, for pressing
Preset value controls the position of reservoir quantity and control slip-on head, and controller 20 is by topping-up pump 16, electrically-controlled valve 17 and electricity during fluid injection
The control of control valve 23, makes the liquid in fluid reservoir 21 enter injection needle 19 from infusion, while controlling the alignment reactive tank 2 of injection needle 19.
When Sptting plate and reaction platform are used for nucleic acid molecular cross instrument, its control circuit is desirably integrated in controller 20, realizes concentrating
Control.
Nucleic acid molecular cross instrument discharge opeing including the reaction platform is faster more thorough, and cost is lower.
Preferred embodiment of the present utility model is the foregoing is only, it is all in this practicality not to limit this utility model
Within new spirit and principle, any modification, equivalent substitution and improvements made etc. should be included in guarantor of the present utility model
Within the scope of shield.
Claims (9)
1. a kind of Sptting plate, including：Plate body and some reactive tanks being formed on plate body, it is characterised in that also include：Positive displacement pump
And control circuit, liquid-leaking nozzle is provided with each described reactive tank, each liquid-leaking nozzle is connected with leakage pipe, installs on each leakage pipe
There are electrically-controlled valve, the leakage pipe connected drainage pump, the electrically-controlled valve and the positive displacement pump connection control circuit.
2. Sptting plate as claimed in claim 1, it is characterised in that the number of the positive displacement pump and the reactive tank number phase
Together, each leakage pipe connects different positive displacement pumps.
3. Sptting plate as claimed in claim 1, it is characterised in that each leakage pipe is connected to same positive displacement pump.
4. the Sptting plate as any one of claims 1 to 3, it is characterised in that the liquid-leaking nozzle is located at the reactive tank
Bottom or side wall.
5. the Sptting plate as any one of claims 1 to 3, it is characterised in that be also removably provided with the plate body
For covering the cover plate of the reactive tank.
6. the Sptting plate as any one of claims 1 to 3, it is characterised in that the plate body adopts PC, PP, PE material
Make.
7. a kind of reaction platform, it is characterised in that include Sptting plate as any one of claim 1～6 and with it is described
Plate body connection for the agitating device that waves the plate body.
8. it is as claimed in claim 7 to react platform, it is characterised in that the agitating device includes：Gripper shoe, bearing, rocking arm,
Shaft coupling, position sensor and motor, the plate body is located in gripper shoe, and one end of gripper shoe is rotatably coupled bearing, separately
One end is rotatably coupled the rocking arm, and rocking arm connects the motor by the shaft coupling, and the motor and the position pass
Sensor connects the control circuit.
9. a kind of nucleic acid molecular cross instrument, it is characterised in that including reaction platform as claimed in claim 7 or 8.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201621072420.1U CN206109376U (en) | 2016-09-22 | 2016-09-22 | Reaction plate, reaction platform and nucleic acid molecules hybridization appearance |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201621072420.1U CN206109376U (en) | 2016-09-22 | 2016-09-22 | Reaction plate, reaction platform and nucleic acid molecules hybridization appearance |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN206109376U true CN206109376U (en) | 2017-04-19 |
Family
ID=58521429
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201621072420.1U Expired - Fee Related CN206109376U (en) | 2016-09-22 | 2016-09-22 | Reaction plate, reaction platform and nucleic acid molecules hybridization appearance |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN206109376U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106281968A (en) * | 2016-09-22 | 2017-01-04 | 周江 | Sptting plate, reaction platform and nucleic acid molecular cross instrument |
| CN111197002A (en) * | 2018-11-19 | 2020-05-26 | 武汉菲思特生物科技有限公司 | High-throughput hybridization recognizing and reading integrated machine |
-
2016
- 2016-09-22 CN CN201621072420.1U patent/CN206109376U/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106281968A (en) * | 2016-09-22 | 2017-01-04 | 周江 | Sptting plate, reaction platform and nucleic acid molecular cross instrument |
| CN106281968B (en) * | 2016-09-22 | 2019-06-14 | 周江 | Reaction plate, reaction platform and nucleic acid molecular cross instrument |
| CN111197002A (en) * | 2018-11-19 | 2020-05-26 | 武汉菲思特生物科技有限公司 | High-throughput hybridization recognizing and reading integrated machine |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20170419 Termination date: 20200922 |