CN206103132U - High strength focus ultrasound therapy device of magnetic resonance guide - Google Patents
High strength focus ultrasound therapy device of magnetic resonance guide Download PDFInfo
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- CN206103132U CN206103132U CN201620762861.8U CN201620762861U CN206103132U CN 206103132 U CN206103132 U CN 206103132U CN 201620762861 U CN201620762861 U CN 201620762861U CN 206103132 U CN206103132 U CN 206103132U
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- magnetic resonance
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- ultrasonic transducer
- pallet
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Abstract
The utility model belongs to magnetic resonance guide focus supersound field especially relates to a high strength focus ultrasound therapy device of magnetic resonance guide. Follow X direction, Y direction and the removal of Z direction through displacement drive mechanism drive tray, conveniently adjust the position of being fixed in the ultrasonic transducer on the tray automatically, realize the accurate positioning and the supersound wave propagation of ultrasonic transducer focus in the finite space, realization real time monitoring treatment process and security detection. In addition, displacement drive mechanism passes through the connecting rod and will export the displacement and transmit to the tray to driving ultrasonic transducer and removing, this process animal keeps the transfixion, avoids prior art to arouse at the easy awake of removal objective table in -process animal and produces the condition of disturbing and delaying the experiment process to the magnetic resonance imaging quality. When carrying out high strength focus supersound animal experiment, this high strength focus ultrasound therapy device of magnetic resonance guide need not to reform transform low cost to the MRI bed body on can directly arranging the MRI bed body in.
Description
Technical field
This utility model belongs to guided by magnetic resonance and focuses on ultrasound field, more particularly to a kind of high intensity of guided by magnetic resonance is gathered
Burnt ultrasonic therapeutic apparatus.
Background technology
Glioma is intracranial common cancer, accounts for the 40%-50% of all brain sections tumor, with sickness rate
The characteristics of height, high recurrence rate, mortality rate are high and cure rate is low " three high and one low ".At present in glioma treatment clinical course, face
The subject matter faced be topically effective antitumor medicine concentration it is low and cannot real-time monitoring medicine metabolic process and causing
Treat failure.
In terms of the metabolism of real-time monitoring medicine, nuclear magnetic resonance (MRI) is swept with three-dimensional high definition imaging and multiparameter
The ability retouched, therefore MRI molecular images become disease early diagnosiss, the important means of drug metabolism tracking.Imaging for Monitoring is real
The basic guarantee of existing safe treatment, and efficient, the basis of fine and personalized treatment of image guiding.Nuclear magnetic resonance it is excellent
Point is, with high tissue resolution capability, to be easier to distinguish normal structure and tumor tissues, therefore be well suited for for carrying out
Monitoring in high-strength focusing ultrasonic therapy.
High intensity focused ultrasound (High Intensity Focused Ultrasound, HIFU) treatment is a kind of emerging
The good malignant entity tumor of Noninvasive therapy new method, its mechanism is at short notice by focusing on ultrasound by tumor tissues
(therapy target) temperature moment brings up to more than 60 DEG C, cause tumor cell produce it is irreversible necrosis, tissue coagulation necrosis and
Protein denaturation.The key of focused ultrasound therapy is that ultrasonic energy is focused on deep target tissue and coagulation necrosiss are formed,
And on surrounding harmony passage normal structure is unaffected or acceptable impact, i.e., ensure the safety of focused ultrasound therapy simultaneously
And high efficiency.
Based on MRI high-resolution and the characteristic of non-invasive real-time monitoring, the HIFU developed under MRI guiding in real time and monitoring is controlled
Treatment technology has become an important development direction of HIFU Treatment with equipment.The high-strength focusing ultrasonic therapy of guided by magnetic resonance is moved
Thing tumor device is that mr imaging technique (MRI) is combined together with high intensity focused ultrasound technology (HIFU), becomes one
Integrated system, in the integrated system is carried out diagnosing to animal focus, is positioned, monitored with MRI, thermometric, curative effect evaluation, uses HIFU
Implement tumour ablation treating, realize magnetic resonance guiding focused ultrasound tumor treatment technology truly.Transmitting focusing ultrasound
The ultrasonic transducer of ripple and the accuracy of the positioning relation of tumor locus, directly influence the safety and treatment of integrated system
Effectiveness.
In the prior art, the high-strength focusing ultrasonic therapy animal tumor device of guided by magnetic resonance be primarily present it is following not
Foot：
(1) the dynamic moving stage of armrest, realizes HIFU targeted therapies, and kinematic accuracy is poor, and error is big, troublesome poeration；
(2) motion cannot be automatically controlled, it is impossible to realize that monitor in real time is treated；
(3) during moving stage, animal easily revives, and can produce interference to resonance image quality, while can drag
Prolong experiment process, can seriously lead to not proceed.
Utility model content
The purpose of this utility model is the high-strength focusing ultrasonic therapy equipment for providing a kind of guided by magnetic resonance, it is intended to solved
The dynamic moving stage troublesome poeration of the high-strength focusing ultrasonic therapy animal tumor device armrest of certainly existing guided by magnetic resonance, cannot
Automatically control motion and the easy technology for causing resonance image quality to produce interference of reviving of animal during moving stage
Problem.
This utility model is achieved in that a kind of high-strength focusing ultrasonic therapy equipment of guided by magnetic resonance, including uses
In holding the water tank of fluid, the ultrasonic transducer in the fluid of the water tank and above the ultrasonic transducer and use
In the object stage for carrying animal, also include in the water tank and pallet and use for fixedly mounting the ultrasonic transducer
In drive the pallet in X direction, the moving drive mechanism of Y-direction and Z-direction movement, the X-direction, the Y-direction and institute
State Z-direction to be mutually perpendicular to two-by-two, connected by connecting rod between the moving drive mechanism and the pallet.
Further, the moving drive mechanism includes X to mobile actuator, from the X to mobile actuator drives edge
The Z-direction movement that the Y-direction movement actuator and the Y-direction by described in the Y-direction moves actuator drives edge of the X-direction movement is moved
Actuator, is connected by the connecting rod between the Z-direction movement actuator and the pallet.
Further, the X is pressure to mobile actuator, Y-direction movement actuator and Z-direction movement actuator
Electroceramics motor.
Further, the quantity of the moving drive mechanism is two with the quantity of the connecting rod, two connections
One end of bar connects one to one in two moving drive mechanisms, and the other end of two connecting rods is all connected to the support
On disk, the pallet is located between two moving drive mechanisms, and two connecting rods are positioned opposite.
Further, the via passed through for the connecting rod is offered on the side wall of the water tank, be provided with the via
For the sealing member for making to seal between the periphery of the outer wall and the via of the connecting rod.
Further, it is provided with the moving drive mechanism for detecting the light of the output displacement of the moving drive mechanism
Grid.
Further, the object stage offers an installing hole, the installation corresponding to the position of the ultrasonic transducer
Coupling water pocket for the ultrasonic propagation produced for the ultrasonic transducer is installed at hole.
Further, water hole is offered on the water tank.
Further, it is provided with the pallet for positioning the labelling part of the ultrasonic transducer.
Further, also include for fixedly mounting the base of the water tank and the moving drive mechanism.
This utility model having the technical effect that relative to prior art, by moving drive mechanism drive pallet in X direction,
Y-direction is moved with Z-direction, is conveniently adjusted automatically the position of the ultrasonic transducer being fixed on pallet, in confined space interior-excess
The propagation being accurately positioned with ultrasound wave of existing ultrasonic transducer focus, realizes monitor in real time therapeutic process and safety detection.Also
Have, output displacement is transferred to pallet by connecting rod by moving drive mechanism, to drive ultrasonic transducer to move, the process animal
Remains stationary is motionless, it is to avoid prior art animal during moving stage easily revives to cause and resonance image quality is produced
Raw interference and the situation of delay experiment process.When high intensity focused ultrasound zoopery is carried out, the guided by magnetic resonance it is high-strength
Degree focusing ultrasonic therapeutic apparatus can be placed directly within MRI bed bodies, without the need for transforming to MRI bed bodies, with low cost.
Description of the drawings
Fig. 1 is the three-dimensional dress of the high-strength focusing ultrasonic therapy equipment of the guided by magnetic resonance that this utility model embodiment is provided
Figure；
Fig. 2 is the three-dimensional exploded view of the high-strength focusing ultrasonic therapy equipment of the guided by magnetic resonance of Fig. 1；
Fig. 3 is the further three-dimensional exploded view of the high-strength focusing ultrasonic therapy equipment of the guided by magnetic resonance of Fig. 2；
Fig. 4 is the sectional view of the high-strength focusing ultrasonic therapy equipment of the guided by magnetic resonance of Fig. 1.
10 installing hole of water tank, 31 grating 55
11 pallet of via, 40 connecting rod 60
12 moving drive mechanism of sealing member 50 couples water pocket 70
13 X of water hole is to 51 labelling part 80 of mobile actuator
20 Y-direction of ultrasonic transducer moves 52 base 90 of actuator
21 Z-direction of drive signal line moves 53 handle 91 of actuator
30 support 54 of object stage
Specific embodiment
In order that the purpose of this utility model, technical scheme and advantage become more apparent, below in conjunction with accompanying drawing and enforcement
Example, is further elaborated to this utility model.It should be appreciated that specific embodiment described herein is only to explain
This utility model, is not used to limit this utility model.
Fig. 1 to Fig. 4 is referred to, the high-strength focusing ultrasonic therapy of the guided by magnetic resonance that this utility model embodiment is provided sets
It is standby, including for holding the water tank 10 of fluid, the ultrasonic transducer 20 in the fluid of water tank 10 and located at ultrasonic transducer
Above in the of 20 and for carrying the object stage 30 of animal, also include in water tank 10 and for fixedly mounting ultrasonic transducer 20
Pallet 40 and for drive pallet 40 in X direction, Y-direction and Z-direction movement moving drive mechanism 50, X-direction, Y-direction and Z
Direction is mutually perpendicular to two-by-two, is connected by connecting rod 60 between moving drive mechanism 50 and pallet 40.
By moving drive mechanism 50 drive pallet 40 in X direction, Y-direction and Z-direction movement, be conveniently adjusted automatically solid
The position of the ultrasonic transducer 20 on the pallet 40, confined space interior-excess 20 focus of existing ultrasonic transducer be accurately positioned and
The propagation of ultrasound wave, realizes monitor in real time therapeutic process and safety detection.Further, moving drive mechanism 50 passes through connecting rod 60
Output displacement is transferred to into pallet 40, to drive ultrasonic transducer 20 to move, the process animal remains stationary is motionless, it is to avoid existing
Technology animal during moving stage easily revives to cause and interference is produced to resonance image quality and delays experiment process
Situation.When high intensity focused ultrasound zoopery is carried out, the high-strength focusing ultrasonic therapy equipment of the guided by magnetic resonance can
It is placed directly within MRI bed bodies, it is without the need for transforming to MRI bed bodies, with low cost.
Ultrasonic transducer 20 is used for transmitting focusing ultrasonic energy.The drive signal line 21 of ultrasonic transducer 20 is using without magnetic
Property screen layer parcel, it is to avoid MRI imaging in introduce electromagnetic interference.In the ultrasound wave Jing water tanks 10 that ultrasonic transducer 20 is produced
Fluid, and then arrival therapy target realizes therapeutic purposes, in whole transmittance process, ultrasound wave does not enter into air, it is ensured that ultrasound
The therapeutic effect of transducer 20.Vehicle of the fluid as ultrasonic propagation.Preferably, fluid is the deionization of degassed process
Pure water.The high-strength focusing ultrasonic therapy equipment of the guided by magnetic resonance can carry out tumor heating ablation, Opening Blood Brain Barrier, targeting
The high intensity focused ultrasound zooperies such as administration.
Further, moving drive mechanism 50 includes X to mobile actuator 51, from X to mobile 51 drives edge X side of actuator
The Z-direction movement actuator 53, Z of 52 drives edge Y-direction of actuator movement is moved to mobile Y-direction movement actuator 52 and by Y-direction
Connected by connecting rod 60 between actuator 53 and pallet 40 to moving.The program can automatically control X, Y, Z three degree of freedom and put down
It is steady to move.It is to be appreciated that X can also be mutual with 53 position of Z-direction movement actuator to mobile actuator 51, Y-direction movement actuator 52
Change, can automatically control X, Y, Z three degree of freedom easy motion.Such as, X is driven to mobile actuator from Y-direction movement actuator
Move along Y-direction, drive Z-direction movement actuator along X to movement from X to mobile actuator, actuator drive connection bar is moved by Z-direction
Move along Z-direction.
Further, X is piezoelectric ceramics to mobile actuator 51, Y-direction movement actuator 52 and Z-direction movement actuator 53
Motor.Piezoelectric ceramic motor can provide driving force, be capable of achieving to automatically control, and kinematic accuracy is high, stable movement, and nonmagnetic,
Ensure that the compatibility with magnetic resonance imaging system, it is to avoid electromagnetic interference is introduced in MRI imagings.Specifically, X is to mobile driving
Part 51 is stacked with Y-direction movement actuator 52, and Z-direction moves actuator 53 and is installed on Y-direction movement actuator 52 by support 54
On, the configuration is easily assembled, compact conformation, and the program is prior art.Each piezoelectric ceramic motor includes guide rail and slip
The slide block being installed on guide rail.Slide and slide block is ceramic member, it is to avoid electromagnetic interference is introduced in MRI imagings.It is appreciated that
Ground, X to mobile actuator 51, Y-direction movement actuator 52 and Z-direction movement actuator 53 can also for hydraulic cylinder or other can export
Straight-line displacement and be avoided that MRI imaging in introduce electromagnetic interference mobile actuator.
Further, the quantity of moving drive mechanism 50 is two, the one of two connecting rods 60 with the quantity of connecting rod 60
End connects one to one in two moving drive mechanisms 50, and the other end of two connecting rods 60 is all connected on pallet 40, support
Disk 40 is located between two moving drive mechanisms 50, and two connecting rods 60 are positioned opposite.In the both sides of water tank 10 using mobile drive
Motivation structure 50 carries out bi-directional drive, and driving force is big, stable movement.Structural stability is good, and the depth of parallelism is high, and targeting accurate positioning can
Realize monitor in real time treatment damage effect and safety detection.
Further, offer the via 11 passed through for connecting rod 60 on the side wall of water tank 10, be provided with via 11 for
The sealing member 12 sealed between the periphery for making the outer wall and via 11 of connecting rod 60.Specifically, with garment bag isolating water tank 10
With connecting rod 60, the fluid leakage in water tank 10 is prevented.
Further, it is provided with moving drive mechanism 50 for detecting the light of the output displacement of the moving drive mechanism 50
Grid 55.Move distance feeds back to processor (not shown), grating 55, moving drive mechanism 50, processor using 55 reading of grating
Composition closed loop system, kinematic accuracy can reach micron order, and high precision improves treatment precision and safety.
Further, object stage 30 offers an installing hole 31 corresponding to the position of ultrasonic transducer 20, at installing hole 31
Coupling water pocket 70 for the ultrasonic propagation produced for ultrasonic transducer 20 is installed.Specifically, couple water pocket 70 to be cylindrical in shape,
As the sound passage for focusing on ultrasonic propagation, focused ultrasound energy is made smoothly to reach the area for treatment of object stage 30.
Further, water hole 13 is offered on water tank 10.For being input into water tank 10 or exporting fluid.
Further, it is provided with pallet 40 for positioning the labelling part 80 of ultrasonic transducer 20.Labelling part 80 is used for fixed
Position position of the ultrasonic transducer 20 in magnetic resonance image (MRI).Specifically, labelling part 80 includes plate body and multiple is located on tabular
Cylinder on body, the plate body of labelling part 80 are located between ultrasonic transducer 20 and pallet 40, the compact conformation.
Further, also include for fixedly mounting the base 90 of water tank 10 and moving drive mechanism 50.The program is easy
Assembling.
Further, handle 91 is provided with base 90, facilitate haulage equipment.
Further, all components such as water tank 10, object stage 30, moving drive mechanism 50, base 90 and screw are all adopted
Magnetic compatibility or non-magnetic material, it is ensured that magnetic resonance image (MRI) is not affected, overall structure is stable.Screw is used to connect two neighboring
Component.
Preferred embodiment of the present utility model is these are only, it is not to limit this utility model, all in this practicality
Any modification, equivalent and improvement for being made within new spirit and principle etc., should be included in guarantor of the present utility model
Within the scope of shield.
Claims (10)
1. the high-strength focusing ultrasonic therapy equipment of a kind of guided by magnetic resonance, including for holding the water tank of fluid, located at described
Ultrasonic transducer in the fluid of water tank and the object stage above the ultrasonic transducer and for carrying animal, its feature
It is also to include in the water tank and for fixedly mounting the pallet of the ultrasonic transducer and being used to drive the pallet
In X direction, the moving drive mechanism of Y-direction and Z-direction movement, the X-direction, the Y-direction are mutual two-by-two with the Z-direction
Vertically, connected by connecting rod between the moving drive mechanism and the pallet.
2. the high-strength focusing ultrasonic therapy equipment of guided by magnetic resonance as claimed in claim 1, it is characterised in that the movement
Drive mechanism includes that X is driven to mobile actuator, the Y-direction movement of X-direction movement from the X to mobile actuator drives edge described in
Part and by described in the Y-direction moves actuator drives edge Y-direction movement Z-direction movement actuator, Z-direction movement actuator with
Connected by the connecting rod between the pallet.
3. the high-strength focusing ultrasonic therapy equipment of guided by magnetic resonance as claimed in claim 2, it is characterised in that the X to
Mobile actuator, Y-direction movement actuator are piezoelectric ceramic motor with Z-direction movement actuator.
4. the high-strength focusing ultrasonic therapy equipment of guided by magnetic resonance as claimed in claim 1, it is characterised in that the movement
The quantity of drive mechanism is two with the quantity of the connecting rod, and one end of two connecting rods connects one to one in two
The moving drive mechanism, the other end of two connecting rods are all connected on the pallet, and the pallet is positioned at described in two
Between moving drive mechanism, two connecting rods are positioned opposite.
5. the high-strength focusing ultrasonic therapy equipment of guided by magnetic resonance as claimed in claim 1, it is characterised in that the water tank
Side wall on offer the via passed through for the connecting rod, be provided with the via for making outer wall and the institute of the connecting rod
The sealing member sealed between the periphery for stating via.
6. the high-strength focusing ultrasonic therapy equipment of the guided by magnetic resonance as described in any one of claim 1 to 5, its feature exist
In being provided with the moving drive mechanism for detecting the grating of the output displacement of the moving drive mechanism.
7. the high-strength focusing ultrasonic therapy equipment of the guided by magnetic resonance as described in any one of claim 1 to 5, its feature exist
An installing hole is offered corresponding to the position of the ultrasonic transducer in, the object stage, be provided with the installing hole for
The coupling water pocket of the ultrasonic propagation produced for the ultrasonic transducer.
8. the high-strength focusing ultrasonic therapy equipment of the guided by magnetic resonance as described in any one of claim 1 to 5, its feature exist
In offering water hole on the water tank.
9. the high-strength focusing ultrasonic therapy equipment of the guided by magnetic resonance as described in any one of claim 1 to 5, its feature exist
In being provided with the pallet for positioning the labelling part of the ultrasonic transducer.
10. the high-strength focusing ultrasonic therapy equipment of the guided by magnetic resonance as described in any one of claim 1 to 5, its feature exist
In also including for fixedly mounting the base of the water tank and the moving drive mechanism.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201620762861.8U CN206103132U (en) | 2016-07-19 | 2016-07-19 | High strength focus ultrasound therapy device of magnetic resonance guide |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201620762861.8U CN206103132U (en) | 2016-07-19 | 2016-07-19 | High strength focus ultrasound therapy device of magnetic resonance guide |
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| CN206103132U true CN206103132U (en) | 2017-04-19 |
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| CN201620762861.8U Active CN206103132U (en) | 2016-07-19 | 2016-07-19 | High strength focus ultrasound therapy device of magnetic resonance guide |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109173100A (en) * | 2018-10-17 | 2019-01-11 | 无锡海鹰医疗科技股份有限公司 | Have the focused ultrasound devices of two-dimensional imaging and HIFU Treatment one for toy |
| CN115399749A (en) * | 2022-07-25 | 2022-11-29 | 中国人民解放军总医院第一医学中心 | Fixing device and magnetic resonance inspection device of rodent experimental animals |
-
2016
- 2016-07-19 CN CN201620762861.8U patent/CN206103132U/en active Active
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109173100A (en) * | 2018-10-17 | 2019-01-11 | 无锡海鹰医疗科技股份有限公司 | Have the focused ultrasound devices of two-dimensional imaging and HIFU Treatment one for toy |
| CN109173100B (en) * | 2018-10-17 | 2024-03-08 | 无锡海鹰医疗科技股份有限公司 | Focusing ultrasonic device for small animals with two-dimensional imaging and HIFU treatment |
| CN115399749A (en) * | 2022-07-25 | 2022-11-29 | 中国人民解放军总医院第一医学中心 | Fixing device and magnetic resonance inspection device of rodent experimental animals |
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