WO2007056905A1 - Hifu tumor ablating system - Google Patents

Hifu tumor ablating system Download PDF

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Publication number
WO2007056905A1
WO2007056905A1 PCT/CN2006/000322 CN2006000322W WO2007056905A1 WO 2007056905 A1 WO2007056905 A1 WO 2007056905A1 CN 2006000322 W CN2006000322 W CN 2006000322W WO 2007056905 A1 WO2007056905 A1 WO 2007056905A1
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WO
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Patent type
Prior art keywords
hifu
treatment device
mounted
tumor ablation
hifu treatment
Prior art date
Application number
PCT/CN2006/000322
Other languages
French (fr)
Chinese (zh)
Inventor
Jiwei Jiang
Jiaxian Dong
Haijin Ma
Yisheng Chen
Yong Zhou
Original Assignee
Shanghai A & S Science Technology Development Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00Ultrasound therapy
    • A61N7/02Localised ultrasound hyperthermia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/225Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for for extracorporeal shock wave lithotripsy [ESWL], e.g. by using ultrasonic waves
    • A61B17/2256Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for for extracorporeal shock wave lithotripsy [ESWL], e.g. by using ultrasonic waves with means for locating or checking the concrement, e.g. X-ray apparatus, imaging means
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00Arrangements or instruments for measuring magnetic variables
    • G01R33/20Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/38Systems for generation, homogenisation or stabilisation of the main or gradient magnetic field
    • G01R33/3806Open magnet assemblies for improved access to the sample, e.g. C-type or U-type magnets
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00Arrangements or instruments for measuring magnetic variables
    • G01R33/20Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00Arrangements or instruments for measuring magnetic variables
    • G01R33/20Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48NMR imaging systems
    • G01R33/4808Multimodal MR, e.g. MR combined with positron emission tomography [PET], MR combined with ultrasound or MR combined with computed tomography [CT]
    • G01R33/4814MR combined with ultrasound
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/225Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for for extracorporeal shock wave lithotripsy [ESWL], e.g. by using ultrasonic waves
    • A61B17/2256Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for for extracorporeal shock wave lithotripsy [ESWL], e.g. by using ultrasonic waves with means for locating or checking the concrement, e.g. X-ray apparatus, imaging means
    • A61B17/2258Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for for extracorporeal shock wave lithotripsy [ESWL], e.g. by using ultrasonic waves with means for locating or checking the concrement, e.g. X-ray apparatus, imaging means integrated in a central portion of the shock wave apparatus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/36Image-producing devices or illumination devices not otherwise provided for
    • A61B90/37Surgical systems with images on a monitor during operation
    • A61B2090/374NMR or MRI

Abstract

A HIFU tumor ablating system comprises at least a HIFU treatment means and an open-type MRI system. The magnetic material of the open-type MRI system is arranged vertical to the ground, and the HIFU treatment means is arranged between the magnetic materials. The MRI technology is combined with the HIFU technology; the common ground-parallel arrangement of the magnetic materials is changed to be a vertical arrangement.

Description

HIFU tumor ablation FIELD

The present invention relates to the field of treating tumor, particularly cancer relates HIFU ablation system. technical background

MRI (Magnetic Resonance Imaging Magnetic Resonance Imaging) system, an image is reconstructed using imaging signal generated by the resonance phenomenon collected. After human tissues nuclei (protons or neutrons containing base, generally refers to hydrogen protons), a strong magnetic field in the magnetic gradient field given spatial orientation, the RF excitation pulse a specific proton precession frequency, accepting excited hydrogen proton relaxation released during the relaxation energy is magnetic resonance signals. The magnetic resonance signals collected by the computer up, different conversion into black and white gray scale intensity signal, by the position of two or three dimensional form of the composition, the final composition of the magnetic resonance image (MRI). It has no radiation damage, no bone artifacts may be many advantages of the ability of soft tissue multi-parametric imaging, Gao degree resolution. Further, using MRI proton resonance parameters of temperature-related change in frequency and the spin-lattice relaxation time, can realize real-time non-invasive temperature measurement for the patient.

The basic components of the MRI system magnets, spectrometer, patients carrying device, computer analysis software. MRI systems currently used, which substantially magnet structure has two, one for the open structure, the upper and lower disposed a magnetic material, a magnetic field generated by the main constant perpendicular to the ground, called open MRI system; other species MRI system has an annular structure, generating a main magnetic field is constant in a closed annular space, in use, patients need to be placed within the annular space.

The basic components of HIFU (High Intensity Focused Ultrasound HIFU) ablation system tumors are: HIFU treatment device (also known as an ultrasonic transducer, a transducer group, the wave source, the treatment class), a patient carrying the patient support means , computer control software, power generators and the like.

The basic principle is treatment of a single or a plurality of ultrasound transducers emit an ultrasound beam is focused to a target outside the patient's body through an intermediary, such that the ultrasonic acoustic intensity at the focus target reach thousands or even tens of W / cm2, target biological tissue at the focus produce severe mechanical vibration (relaxation) at an energy superposition effect, keep the ordered molecular vibration energy is converted into kinetic energy of random molecular heat, i.e., mechanical energy is converted to heat medium the target temperature of the biological tissue at the focus at the moment (0.1-ls) rises above 65 ° C, the protein rapidly irreversible coagulation necrosis occurs. Because in such a short period of time, non-target tissue is hardly damaged by HIFU, we are able to achieve a non-invasive "ablation" The purpose (ablation) tumors. HIFU tumor ablation therapy is a noninvasive, non-toxic side effects of cancer treatment in recent years has become a hot topic in the international academic community, and has been increasingly widely used in the medical profession. HIFU therapy has been a certain clinical application and promotion, has confirmed that China is the world's first clinical application of HIFU treatment technology, the largest number of countries, but also the manufacturing enterprise systems products than any other country.

HIFU treatment system currently on the market are used in embodiment B-mode image guided positioning system, there is no clear imaging, tumor localization accuracy is not accurate, relatively poor reliability, security and other fatal flaw. In addition, not non-invasive temperature measurement, real-time imaging to evaluate the efficacy, but also become its troubled clinical applications.

Israel INSIGHTEC produced EXABLTE type 2000 ultrasonic therapy system preclude guide for positioning US company GE 1.5T magnetic resonance imaging system, the image is clear, accurate tumor localization. But due to the high field MRI system, the choice of which superconducting magnet material, and the need to use liquid nitrogen circulating cooling means, so that the whole system is too dilated, the operation is relatively cumbersome, expensive to manufacture. HIFU system and their use in the MRI system using a conventional ring-shaped structure portion. SUMMARY

Object of the present invention is to overcome the drawbacks of the prior art, to provide a new tumor HIFU ablation system.

Object of the present invention is achieved by the following technical solution:

One kind HIFU tumor ablation system, comprising at least one HIFU treatment apparatus further includes an open MRI system, a magnetic material is perpendicular to the open MRI system is provided on the ground, between the HIFU treatment device disposed in the magnetic material.

Wherein the main direction of the constant magnetic field MRI system parallel to the ground.

Wherein the HIFU treatment means is mounted on a HIFU treatment device is provided between an upper portion of the magnetic material in an open MRI system.

Further, the HIFU treatment device may also be mounted under a HIFU treatment device is provided between the lower portion of the magnetic system of an open MI.

Alternatively, the HIFU tumor ablation system comprises a top-mounted apparatus HIFU treatment and HIFU treatment means mounted at a lower portion disposed between the magnetic Jian discharge type MRI system provided at the upper portion of the material between an open MRI system of .

Wherein mounted on the HIFU treatment device disposed in an upper portion between preclude the magnetic material suspended or supported manner.

The lower HIFU treatment device carrier mounted on the base of the HIFU tumor ablation system.

Additionally, the system further comprises a patient support means, which is connected to the base by means of a lifting device, and connected to the lower-mounted HIFU treatment device by the sealing material.

Then, the patient is provided with the device-under HIFU treatment device corresponding bearing openings.

The positive effect of the present invention is characterized in progress: the MRI technique of the present invention for the integrated and HIFU technique, pioneered the magnetic material from a conventional MRI system level down disposed perpendicularly to a horizontal plane, so that the magnetic material is more convenient to install between HIFU treatment device, precise positioning by using the MRI system, real-time detection temperature, high-resolution real-time imaging technology, solve the problems of the development and application of formula B-HIFU precise positioning system, the fundamental problem of non-invasive temperature measurement, efficacy evaluation , breaking the HIFU tumor ablation technology development bottleneck, the HIFU therapy more security, reliability, availability and credibility, and it also has a low manufacturing cost and ease of use. BRIEF DESCRIPTION

Example 1 Fig 1 a schematic front embodiment of the present invention.

Example 1 FIG 2 a schematic side view of the embodiment of the present invention. detailed description

Example 1

Figure 1-2 shows a HIFU tumor ablation system, comprising an open MRI system, the magnetic material 5 of the open MRI system, 6 disposed perpendicular to the ground, the main direction of the constant magnetic field of MRI system parallel to the ground mounted on the HIFU treatment apparatus further comprises a magnetic material disposed between the upper portion of the open MRI system 1 and HIFU treatment device mounted under a magnetic material disposed between the lower portion of the open MRI system 2, further comprising a patients carrying means for carrying a patient 3.

A. 4, a magnetic resonance imaging MRI system using the magnetic material 5, 6 placed horizontally in a vertically disposed ground base open structure, which opens upward, the HIFU High Intensity Focused Ultrasound opening of the MRI system in a magnetic resonance imaging system.

Wherein the overhead type HIFU treatment using the apparatus 1 is suspended or supported in an upper portion disposed between the magnetic material 5 of the 6,, the patient is located above the carrier means 3, i.e. positioned above the patient.

In this embodiment, mounted on the HIFU treatment device 18, is connected to the two magnetic material 6 via a bracket 5 suspended from the upper bearing device 3 patients. Mounted on the HIFU treatment device 1 via the control along the patient can carry axial and radial positioning device 3 do <90 ° swing.

The home-style HIFU treatment device 2 is located below the patient support means 3, provided on the base 4, by a sealing material (not shown) is connected to the carrier device 3 and the patient. Patients carrying apparatus 3 carried on the lifting device with a base HIFU tumor ablation system 4 connected to 9. The lifting device 9 is provided on the base 4, the patient 3 is provided with bearing means mounted for use during the HIFU therapy treatment device 2 corresponding to the opening means 2 mounted HIFU treatment.

A specific application, the control of the patient support means 3 up and down, left and right, back and forth movement of the patient 7 in the central field MRI magnetic resonance imaging system 5, 6 is formed, constitutes a tumor in MRI guided HIFU integration ablation system, so as to achieve the purpose of treatment of tumor.

Example 2

Example 2 differs from an embodiment wherein: the HIFU treatment means is located on the mounted HIFU treatment apparatus above devices patient carries, not shown, embodiment of another configuration example 2 are the same as in Example 1, which is not do repeat.

Example 3

Example 3 differs from the first embodiment in that: the HIFU treatment means is located under the home HIFU treatment device below the device the patient bearing, not shown, embodiments other configurations of Example 3 are the same as in Example 1, which is not do repeat.

Claims

Rights request
A HIFU tumor ablation system, comprising at least one HIFU treatment device, characterized in that: it further comprises an open MRI system, a magnetic material is perpendicular to the MRI system Jian-place is provided on the ground, the HIFU treatment device is disposed between the magnetic material.
2. The HIFU tumor ablation system according to claim 1, wherein: the main direction of the stationary magnetic field of MRI system parallel to the ground.
. 3, HIFU tumor ablation system according to claim 1, wherein: the HIFU treatment apparatus is mounted on a HIFU treatment device is provided between an upper portion of the magnetic material in an open MRI system.
4. The system of claim HIFU tumor ablation according to claim 1, wherein: the HIFU treatment device is mounted HIFU treatment device between a magnetic material disposed in a lower portion of the open MRI system.
5, according to claim HIFU tumor ablation system according to claim 1, characterized in that: it comprises HIFU treatment device mounted on a magnetic material disposed between the upper portion of the open MRI system and the one in an open MRI system between the lower portion of the magnetic material mounted HIFU treatment device.
6, HIFU tumor ablation system according to claim 3 or claim 5, wherein: the upper way mounted HIFU treatment using suspension or support means disposed between the upper portion of the magnetic material.
7, HIFU tumor ablation system according to claim 4 or claim 5, wherein: the lower HIFU treatment device carrier mounted on the base of the HIFU tumor ablation system.
8, according to claim HIFU tumor ablation system according to claim 7, characterized in that it further comprises a patient support means, which is connected to the base by means of a lifting device, and connected to the lower-mounted HIFU treatment device by the sealing material.
9, according to claim HIFU tumor ablation system according to claim 8, characterized in that the HIFU treatment device mounted under the corresponding aperture means provided on the carrier patient.
PCT/CN2006/000322 2005-11-16 2006-03-03 Hifu tumor ablating system WO2007056905A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN200510110387.7 2005-11-16
CN 200510110387 CN1966108A (en) 2005-11-16 2005-11-16 Hifu tumor ablation system

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WO2007056905A1 true true WO2007056905A1 (en) 2007-05-24

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Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2268361A1 (en) 2008-04-09 2011-01-05 Julian Itzcovitz A medical system comprising a percutaneous probe
EP2223719A1 (en) * 2009-02-27 2010-09-01 Koninklijke Philips Electronics N.V. Therapeutic apparatus for treating a subject using magnetic nanoparticles
CN101947129B (en) * 2010-10-12 2012-03-21 上海交通大学 Phase-control high-intensity focusing ultrasonic transducer and magnetic resonance breast coil integrating device

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US5275165A (en) * 1992-11-06 1994-01-04 General Electric Company Magnetic resonance guided ultrasound therapy system with inclined track to move transducers in a small vertical space
US5443068A (en) * 1994-09-26 1995-08-22 General Electric Company Mechanical positioner for magnetic resonance guided ultrasound therapy
EP0938913A2 (en) * 1993-03-10 1999-09-01 Kabushiki Kaisha Toshiba Ultrasonic wave medical treatment apparatus suitable for use under guidance of magnetic resonance imaging
CN1257414A (en) * 1997-05-23 2000-06-21 外科器械股份有限公司 MRI-guided therapeutic unit and method
CN1466476A (en) * 2000-07-31 2004-01-07 观察技术-特克斯松尼克斯有限公司 Mechanical positioner for mri guided ultrasound therapy system
WO2005030330A1 (en) * 2003-09-30 2005-04-07 Koninklijke Philips Electronics, N.V. Target tracking method and apparatus for radiation treatment planning and delivery

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5247935A (en) * 1992-03-19 1993-09-28 General Electric Company Magnetic resonance guided focussed ultrasound surgery
US5275165A (en) * 1992-11-06 1994-01-04 General Electric Company Magnetic resonance guided ultrasound therapy system with inclined track to move transducers in a small vertical space
EP0938913A2 (en) * 1993-03-10 1999-09-01 Kabushiki Kaisha Toshiba Ultrasonic wave medical treatment apparatus suitable for use under guidance of magnetic resonance imaging
US5443068A (en) * 1994-09-26 1995-08-22 General Electric Company Mechanical positioner for magnetic resonance guided ultrasound therapy
CN1257414A (en) * 1997-05-23 2000-06-21 外科器械股份有限公司 MRI-guided therapeutic unit and method
CN1466476A (en) * 2000-07-31 2004-01-07 观察技术-特克斯松尼克斯有限公司 Mechanical positioner for mri guided ultrasound therapy system
WO2005030330A1 (en) * 2003-09-30 2005-04-07 Koninklijke Philips Electronics, N.V. Target tracking method and apparatus for radiation treatment planning and delivery

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