CN100425199C - Extracorporeal high energy focusing ultrasonic system guided by permanent magnet type magnetic resonance image and method thereof - Google Patents

Extracorporeal high energy focusing ultrasonic system guided by permanent magnet type magnetic resonance image and method thereof Download PDF

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CN100425199C
CN100425199C CNB2006101113943A CN200610111394A CN100425199C CN 100425199 C CN100425199 C CN 100425199C CN B2006101113943 A CNB2006101113943 A CN B2006101113943A CN 200610111394 A CN200610111394 A CN 200610111394A CN 100425199 C CN100425199 C CN 100425199C
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magnet
energy focusing
focusing ultrasonic
magnetic
ultrasonic
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CN1903121A (en
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赵明
吴晓东
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Haifuning Strength Ultrasonic Technology (Beijing) Co., Ltd.
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Yuande Biological Medicine Engineering Co Ltd Beijing
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N7/02—Localised ultrasound hyperthermia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/36—Image-producing devices or illumination devices not otherwise provided for
    • A61B90/37—Surgical systems with images on a monitor during operation
    • A61B2090/374—NMR or MRI

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Abstract

A high energy focusing ultrasonic system based on permanent-magnet magnetic resonance imaging system is composed of a U-shaped 0.35T/0.45T permanent-magnet magnetic resonance imaging system consisting of permanent magnet, gradient coil, RF receiving emitting coil, and high-energy focusing ultrasonic emitter, and an examining bed (or chair) for patient. It can perform real-time tumor examination, therapy and temp control.

Description

Guided by permanent magnet type magnetic resonance image extracorporeal high energy focusing ultrasonic system and method
Technical field
The invention belongs to medical imaging diagnosis and interventional therapy instrument and equipment field, relate to a kind of nuclear magnetic resonance (Magnetic Resonance Imaging, hereinafter to be referred as MRI) guiding diagnosis and interventional therapeutic technique, extracorporeal high energy focusing ultrasonic (High Intensity FocusedUltrasound is hereinafter to be referred as HIFU) treatment technology.
The present invention is specifically related to a kind ofly adopt high openness permanent magnet type magnetic resonance imaging system to carry out the extracorporeal high energy focusing ultrasonic therapy system of the monitoring of image guided and therapeutic process, curative effect inspection and use the method for this system.
Background technology
Background technology 1:
The extracorporeal high energy focusing ultrasonic therapy system be with the external supersonic energy accumulating at human body deep destination organization, reach the purpose of accurate thermal damage selected target tissue.At present, the extracorporeal high energy focusing ultrasonic therapy system is one of focus of domestic and international medical research, and clinical practice has obtained good effect.Extracorporeal high energy focusing ultrasonic has been proved to be the tumor and the treatment of diseases at positions such as can being applied to liver, kidney, pancreas, rectum, prostate, mammary gland, bone, skin, uterus.Wherein extensive at the per-rectum Therapeutic Method of carcinoma of prostate.In the clinical practice of energy focusing ultrasonic-high oncotherapy technology, China medical personnel uses home-made all kinds extracorporeal high energy focusing ultrasonic tumor treatment equipment to do a large amount of work from the nineties in last century, accumulated valuable clinical experience in treatment fields such as hepatocarcinoma, renal carcinoma, breast carcinoma and hysteromyoma, by world colleague is attracted attention.
Common extracorporeal high energy focusing ultrasonic therapy system generally is made of following components: in order to produce the emitter and the drive circuit thereof of high-energy concentration ultrasonic; Be used to seek real-time imaging inspection, the monitoring system (mostly being B ultrasound imaging inspection instrument) in therapeutic goal district; According to the real-time imaging check result, the therapeutic goal district is moved to the focus ultrasonic transmitter multi-freedom posture control system that focuses on burnt territory and carries the therapeutic bed system that patient's (also claiming those who are investigated or inspected object) is in the appropriate therapeutic position; System's operating console; High-energy concentration ultrasonic conducting structure and transmitting medium processing system.The high-energy concentration ultrasonic conducting structure mainly is to be provided with one to hold airtight water pocket, airtight water tank of purifying waste water as the degassing of transmitting medium or the tank with relief function in the place ahead of the high-energy concentration ultrasonic surface of emission.The transmitting medium processing system is for above-mentioned airtight water pocket, airtight water tank or has the complete equipment that the tank supply degassing of relief function is purified waste water, comprises water source, degassing blood processor, high-efficiency water purifying treatment device, filtration treatment device, delivery pipeline system etc.
Background technology 2:
Many array element phased array formula (Phase Array) energy focusing ultrasonic-high emitter is characterized in that it can adopt polytype phased array formula energy focusing ultrasonic-high emitters such as many array element sphere phase array row formula energy focusing ultrasonic-high emitter, many array element cambered surface phased array formula energy focusing ultrasonic-high emitter and many array element planar phased array row formula energy focusing ultrasonic-high emitter.
Phased array formula focus ultrasonic transmitter main characteristics is to produce flexible and changeable single focus and the multiple-point focusing focus mode of while that is fit to treatment.Compare with the single focus of single array element, multiple spot focuses on can increase the single therapy volume of focus, reduces treatment time significantly, accelerates treatment speed.Phased array formula focus ultrasonic transmitter can also adopt the submatrix technology to avoid some barriers (as rib) and treat.
Need complicated multi-freedom posture control to compare with common non-phased array formula focus ultrasonic transmitter, many array element phased array formula energy focusing ultrasonic-high emitter is in the process of the patient being carried out the treatment of many positions, and its required motion number of axle is few, attitude control is simple, treatment time shortens dramatically.It is few to make motion used parts and components and parts number, and component structural is simple, can all adopt nonmetal and non-magnetic material manufacturing is finished, and satisfies its instructions for use under the magnet environment.
Background technology 3:
Common permanent magnet type magnetic resonance imaging system generally is made of following subsystem: magnet subsystem, gradient subsystem, Radio Frequency Subsystem, computer and image processing subsystem, patient are carried positioning subsystem and scanning room subsystem.
Design has the magnetic gap space that fore-and-aft direction perforation, upper and lower or left and right directions open wide and places uniform magnetic field sample area in the magnetic gap space in the permanent-magnet; Gradient subsystem comprises parts such as the gradient power-supply system that is used to produce the gradient coil of gradient fields and matches with it, gradient coil cooling system, noise absorption control system; Radio Frequency Subsystem comprises that radio-frequency transmissions and radio frequency receive two parts, comprise being used to implement the radio-frequency sending coil of radio-frequency (RF) excited and the power-supply system supporting, be used to receive the radiofrequency signal receiving coil and the signal processing system supporting of nuclear magnetic resonance information with it with it; Computer and image processing subsystem comprise the spectrometer subsystem that is used for data acquisition, image reconstruction subsystem, master computer, operating console etc.; The patient is carried positioning subsystem and is comprised and be used to carry examinating couch/inspection chair that the patient is scanned location and scanning motion requirement; The scanning room subsystem comprises electromagnetic shielding scanning room and the inside and outside signal transducting system of scanning room, inside and outside communication, surveillance etc.
The permanent-magnet that U type of the present invention is arranged is compared with the permanent magnet system that common middle low field intensity, perpendicualr field are arranged, difference is that permanent-magnet that the U type is arranged has the magnetic field openness high characteristics in both sides about layouts, the patient body that are the level of state.Compare with the magnet that existing U type structure, level field are arranged, difference is that it is to make for two the special development and Design of emitter work up and down that cooperate energy focusing ultrasonic-high, has advantages such as the magnetic gap spacing dimension is big.Compare with existing magnetic resonance guiding energy focusing ultrasonic-high equipment, difference is the permanent-magnet of low field intensity in its employing rather than the superconducting magnet of high field intensity.Magnet openness height, pleasant property is good, is applicable to two energy focusing ultrasonic-high emitters up and down.
Background technology 4:
It is image guided that the extracorporeal high energy focusing ultrasonic therapy system of clinical practice at present adopts B ultrasound imaging inspection instrument to implement more, utilizes the B ultrasound image to seek the therapeutic goal district, carry out real-time imaging inspection, therapeutic process monitoring etc.Be limited to the deficiency of present existing B ultrasound imaging ultrasound technology aspect guiding in real time and accurate diagnosis, utilize magnetic resonance imaging system to carry out the monitoring of image guided and therapeutic process, curative effect inspection, become the main direction of extracorporeal high energy focusing ultrasonic therapy system technical development.
Why magnetic resonance guiding extracorporeal high energy focusing ultrasonic therapy system becomes the developing direction of extracorporeal high energy focusing ultrasonic therapy system of new generation, mainly based on magnetic resonance equipment in the accurate advantage aspect the diagnosis of real time imaging guiding, noinvasive thermometric and clinical tumor, these advantages mainly show following some:
(1) image detection aspect, nuclear magnetic resonance is better than ultra sonic imaging
Nuclear magnetic resonance is safety, the non-invasive tumor image diagnostic equipment, and it utilizes multiple pulse train integrated imaging, the pathological change of complete observation neoplastic lesion.Three-dimensional high definition rate image accurately can be provided, and resolution can reach below the 1mm.Clear picture, accurate, especially very clear for the boundary of tumor locus and normal surrounding tissue.Magnetic resonance utilizes benign tumor and malignant tumor completely different this characteristic aspect blood supply, can carry out dynamic contrast enhancement, observe the enhanced ratio of pathological changes signal, the sensitivity and the specificity of diagnosis of malignant tumor are reached about 95%. magnetic resonance will be used the radio frequency transmit and receive coil in testing process, but does not directly contact patient's body.The interference factor that is subjected in the checking process is fewer, and the repdocutbility of image is very good, stable image quality.
And B ultrasound imaging inspection instrument majority commonly used at present can only provide two dimensional image, and resolution is clear not as magnetic resonance, and some trickle part of lesions position tissue is not easy in sight.Ultrasonoscopy is subjected to the influence of factors such as human body Endoskeleton, gas easily.Must consider pendulum position, posture, the location status of human body during detection, the applying between ultrasonic probe and the skin, multiple factors such as the angle of probe.Because interference factor is many, in ultrasonic real-time testing process, the picture quality instability.
(2) guiding aspect in real time, nuclear magnetic resonance is better than ultra sonic imaging
Present common extracorporeal high energy focusing ultrasonic therapy system, the control of its focus point locus obtains by the motion of focus ultrasonic transmitter.The used focus supersonic of extracorporeal high energy focusing ultrasonic therapy system is that three-dimensional energy focuses on.Promptly in a sense cycle, focus on emitted energy with the energy focusing ultrasonic-high emitter earlier, stop the back and guide the ultrasound detection therapentic part, obtain reflecting the image of therapeutic effect with two dimensional image.A sense cycle is followed another sense cycle, goes round and begins again. and in a sense cycle, generally being used for the energy focusing ultrasonic-high emitter, to focus on time of emission long and time two dimension guiding ultrasound detection image is short.In the practical work process, the interference ratio between three-dimensional energy focus supersonic and two dimensional image guiding are ultrasonic is more serious, and some image does not really reflect therapeutic effect, and two dimensional image is guided the ultrasonic real real-time guiding that do not reach.
And the magnetic resonant imaging examination process is different with the energy emission process principle of focus supersonic, does not disturb mutually during work.The therapeutic effect of focus area can be observed and judge to the image taking speed of magnetic resonance fast-pulse sequence especially can at little region of interest (ROI) slice rapidly and accurately than very fast, helps the evaluation to tumor tissues irreversible transition (necrocytosis).By magnetic resonance can interactive real time the energy and action time in the burnt territory of control energy focusing ultrasonic-high.Reach and promptly destroy tumor tissues, do not damage the purpose of normal surrounding tissue again.
In the process of magnetic resonance guiding extracorporeal high energy focusing ultrasonic therapy system, magnetic resonance provides the supervision of focal position and the control of ultrasonic energy.Have only slight temperature rise when focus place energy is relatively low, the bootable focus of magnetic resonance image (MRI) that obtain this moment is positioned on the tumor tissues.After finishing, the focus location improves ultrasonic energy, the kill tumor cell.Tissue protein degeneration after the tumor cell thermocoagulation, reach uniform temperature after, in-house moisture content has gasification, thereby causes tissue density and other changes of properties.These variations can be caught and reflect to nuclear magnetic resonance sensitivity, clear quickly and accurately.Multipath information extraction, monitoring in real time.
(3) real-time noinvasive thermometric aspect, magnetic resonance is better than ultrasonic temperature measurement
The parameter of nuclear magnetic resonance (for example T1, disperse and chemical shift etc.) changes responsive to tissue temperature, the real-time three-dimensional high-definition picture of variations in temperature in the time of can providing heat effect.When temperature surpasses 41 ℃ of high temperature, but the signal of magnetic resonance record organization protein denaturation (solidifying).Realization is to the measurement of target normal surrounding tissue transient temperature.The thermometric of magnetic resonance equipment is very sensitive, and temperature measurement accuracy can reach 1 ℃, and the information of the temperature field that can accurately be reflected distribution.And ultrasonicly be difficult to accomplish this point at present.
Background technology 5:
U.S. Pat 6,582,381 B1, title is that " mechanical positioner of nuclear magnetic resonance guiding supersonic therapeutic system " is by proposing because of plug Tyke-Insightec Txsonics Ltd, this Patent publish the structural design of the underneath type energy focusing ultrasonic-high emitter that under the magnet environment, uses and the motion of compact multi-freedom posture thereof and controlling organization, high-energy concentration ultrasonic conduction device, introduced by motor-driven mechanism of piezoelectric vibration and the use under magnetic field environment thereof.But, this patent adopts the cartridge type nuclear magnetic resonance, limited and checked the space of object, thereby can't more effectively arrange ultrasonic therapeutic facility (as settling more than one transmitting probe), also do not had to propose under the magnet environment, to use the more effective measures or the improvement of energy focusing ultrasonic-high emitter.
Summary of the invention
The invention provides and a kind ofly adopt high openness permanent magnet type magnetic resonance imaging system to carry out extracorporeal high energy focusing ultrasonic tumor system and relevant implementation method that the monitoring of image guided and therapeutic process, curative effect are checked.
Put it briefly, the present invention is aspect system design: the high openness horizontal magnetic resonance imaging of the 0.35T/0.45T permanent magnetism system that uses U type structure.Carrying positioner (examinating couch or chair) permanent-magnet, gradient coil, radio frequency reception/transmitting coil, energy focusing ultrasonic-high emitter, patient's (those who are investigated or inspected object) compound is functions such as an incorporate system, compound real time imaging inspection, oncotherapy, temperature control.Use phased array formula focus ultrasonic transmitter, and visual in conjunction with real-time damaged tissue, and the number of times of the repetitive therapy that the minimizing patient needs shortens treatment time.Use the magnetic resonance rapid serial to carry out the real time scan imaging, the variation of real-time clear observation lesions position before art and in the art.From the parameter (for example T1, disperse and chemical shift etc.) of nuclear magnetic resonance, extract the temperature information of therapentic part, accurately control therapeutic process.
Put it briefly, the present invention has realized the integrated of the monitoring of image guided and therapeutic process, curative effect inspection treatment, has brought into play the advantage separately of different system.The present invention is comprising the complete high openness magnetic resonance imaging system of permanent magnetism of a cover aspect system's composition, with the energy focusing ultrasonic-high therapy system (containing upper and lower two focus ultrasonic transmitters) of the composite design that matches with magnetic resonance imaging system of cover, comprise the custom-designed subsystem of the numerous both sides of linking functions.
The main subsystem of device of the present invention has: the permanent-magnet subsystem that is used to build a uniform magnetic field sample area; Be used for producing the gradient subsystem of gradient fields at sample area; Be used to launch the Radio Frequency Subsystem that radio-frequency field activates the purpose aspect of inspected object; The top focus ultrasonic transmitter subsystem that comprises top energy focusing ultrasonic-high emitter; The bottom focus ultrasonic transmitter subsystem that comprises bottom energy focusing ultrasonic-high emitter; Inspected object carrying positioning subsystem with top focus ultrasonic transmitter adapted; Inspected object carrying positioning subsystem with bottom focus ultrasonic transmitter adapted; With computer and image processing subsystem,
In addition, also can comprise/bottom focus ultrasonic transmitter multi-freedom posture control subsystem supportingly, high-energy concentration ultrasonic conducting structure and transmitting medium processing subsystem, scanning room subsystem.
Requirement according to cartesian coordinate system, the coordinate system of the whole system after compound is provided with as follows: the corresponding patient's of the x axle of system and z axial plane transverse section (Axial Plane), the y axle of system and the corresponding patient's sagittal plane (Sagittal Plane) of z axial plane, the corresponding patient's of the x axle of system and y axial plane coronalplane (Coronal Plane).
In a specific embodiment, whole system comprises following specific technical characterictic:
The structure of the permanent-magnet of U type structure is: adopt the high open magnet structure of U type of arranging about magnetic pole, yoke is made of left side yoke, right side yoke, bottom yoke three parts, left side yoke and right side yoke symmetric arrangement, be fixed on the yoke of bottom, the bottom yoke is the basis of whole magnet; Right side Ci Duo (the N utmost point) is positioned at the left side of right side yoke, and left side magnetic buttress (the S utmost point) is positioned at the right side of left side yoke, and two magnetic buttress is parallel relatively; Magnetic flux is sent by right side Ci Duo, crosses the magnetic gap space between two buttress, penetrates left side magnetic buttress, returns right side Ci Duo by the bottom yoke again, forms the closed-loop path;
Be furnished with first and second gradient coils at above-mentioned magnet right side magnetic buttress and left side magnetic buttress towards patient's a side, two gradient coils are parallel relative; Gradient coil requires to manufacture and design according to the distribution and the gradient field intensity of gradient magnetic, and the magnetic gap size after enlarging between the magnetic pole adapts.
U type with characteristics such as available magnetic gap spacing is big, magnetic field intensity is high, no eddy current, high openness is arranged permanent-magnet, it is characterized in that described magnetic buttress is made of the permanent magnet material of single kind.Permanent magnet material can be selected sintered NdFeB, samarium-cobalt alloy of the different trades mark etc. for use.Obtain on the basis of the available magnetic gap spacing of required maximum, maximum usbale field strength and full-size uniform magnetic field sample area guaranteeing, the realization in its magnetic field is guaranteed by many-sides such as the design of the selecting for use of permanent magnet material, magnet structure, manufacturing technologies.
The permanent magnet system that the U type is arranged is custom-designed in order to match with the clinical practice of energy focusing ultrasonic-high system of tumor treatment and development and the many requirements of the thing followed.Permanent-magnet for U type layout, regardless of its at present concrete magnet structure constitute, the type of permanent magnet material and the trade mark, manufacturing process technology, regardless of its following possible technical development and technological break-through, be exactly the magnet that meets the demands as long as meet following four conditions.
These four conditions are: promptly build a larger-size elliposoidal uniform magnetic field sample area at himself center, the front and back of a channel-type connect, upper and lower is opened wide magnetic gap space, a large-sized available magnetic gap spacing and maximum usbale field strength.
The permanent-magnet of U type structure places the position, central back partially in the electromagnetic shielding scanning room, design has fore-and-aft direction to connect (along the y of system axle) in the permanent-magnet, magnetic gap space that upper and lower (along the z of system axle) is opened wide and the spheroid-like uniform magnetic field sample area that places in the magnetic gap space, direction to the S utmost point is identical with the x axle negative direction of system from the N utmost point in magnetic field, two gradient coils and temperature control equipment thereof are symmetricly set in the left and right sides magnetic buttress of magnet, magnetic gap between the magnetic pole can be preferably 600mm with spacing, whole magnet adopts no eddy-current technique design, has very high openness.
In one embodiment, the elliposoidal uniform magnetic field sample area of described permanent-magnet, (three radius values of ellipsoid are respectively 400mm to it is characterized in that it the bulk that satisfies instructions for use being arranged, 400mm and 380mm), can hold two phased array formula energy focusing ultrasonic-high emitter motions in its zone up and down, work, holding the dual-purpose radio-frequency coil of magnetic resonance signal reception/emission is provided with in its zone, hold patient and location thereof, bearing system motion in its zone, work, and ecg-gating is with popping one's head in the respiration gate control probe, device work in its zone such as wound thermometric needle are arranged.All these components and parts and device all are to finish with satisfactory nonmetal and non-magnetic material manufacturing and assembling, can not produce interference, damage the uniform magnetic field sample area, or make the magnetic resonance imaging image produce pseudo-shadow.
Carrying patient's examinating couch first is sent into the good radio-frequency transmissions of health arranged outside/receive dual-purpose coil, the patient that is in dorsal position or ventricumbent position attitude uniform magnetic field sample area in the magnetic gap space along y axle positive direction outside magnet, carry out MRI scan and top focus ultrasonic transmitter emitting treatment after finish the location, finish treatment back carrying patient and shift out magnet areas; The top focus ultrasonic transmitter adopts many array element sphere phase array row formula structural design, and its movement mechanism with multiple degrees of freedom adopts motor-driven rail mounted hanger mechanism.Hanger mechanism is fixedly mounted on the position that there are enough usage spaces scanning room inner magnet top along the axial track of y, and this track is the basis of whole hanger mechanism.All the other motions of hanger mechanism are fixedly mounted on the slide plate below along this orbital motion.Whole top focus ultrasonic transmitter can be finished along x axle, y axle and z are axial and move and rotate, swing around the x direction of principal axis around the z direction of principal axis. and the place ahead of the ultrasonic transmitter surface of emission is provided with and is full of the airtight water pocket that the degassing is purified waste water, so that with the relevant position coupling of in the bottom body surface, the conduction focus beam enters in patient's body; Carrying patient's examinating couch second is sent into the good radio-frequency transmissions of health arranged outside/receive dual-purpose coil, the patient that is in dorsal position or ventricumbent position attitude uniform magnetic field sample area in the magnetic gap space along y axle positive direction outside magnet, carry out MRI scan and bottom focus ultrasonic transmitter emitting treatment after finish the location, finish treatment back carrying patient and shift out magnet areas; Bottom focus ultrasonic transmitter and relevant motion thereof, the design and installation of focus beam conducting structure are in the inside of the examinating couch second of adapted with it, this focus ultrasonic transmitter adopts many array element planar phased array row formula structural design, and the carrying emitter carries out the movement mechanism with multiple degrees of freedom of position and attitude levelling and emitter and is contained entirely within together and is full of in the airtight water tank that the degassing purifies waste water.Whole bottom focus ultrasonic transmitter can be finished along x axle, y axle and z are axial and move.The water tank upper surface is the fexible film structure, and upper surface is concordant with bed surface, heaves behind the fexible film water-filling, so that be coupled with the relevant position of the body surface that is in its top, the conduction focus beam enters in patient's body; In the position of the magnet outside near carrying patient's examinating couch, be provided with the manual overvide that subsidiary independently image shows LCD display and equipment emergency stop switch in real time, so that the clinical medical and nursing personnel Real Time Observation position relation between two energy focusing ultrasonic-high emitters and the patient and control and adjust up and down nearby.
In use, also be provided with patient treatment condition monitoring, ecg-gating device, respiration gate control device and nursing system etc. in the electromagnetic shielding scanning room, so that realize getting involved function and operation technique.
The electromagnetic shielding scanning room is furnished with gradient power-supply system regulator cubicle outward, the rf power system regulator cubicle, and focus ultrasonic transmitter driving power source system regulator cubicle as the degassing of the transmitting medium processing cabinet of purifying waste water, calculates rack, operating console.Operating console is provided with the up and down manual overvides of two energy focusing ultrasonic-high emitter motions of another set of control, and it and magnetic resonance operation control system, Flame Image Process and display system, area for treatment temperature display system, scanning room are inside and outside to lump together use to the image monitoring system of making peace etc.The whole operation control station is provided with the equipment emergency stop switch, in order to emergency processing.
The present invention solves the influence that problem of materials may cause MRI scan aspect following three in the design of whole system, comprising: make up and down the used material of two energy focusing ultrasonic-high ejector systems, the selection of components and parts; The maintenance of ultrasonic coupling material cleanliness factor; The purify waste water maintenance (following detailed description) of cleanliness factor of the degassing.
Problem of materials of the present invention mainly is meant because of containing ferromagnetism compositions such as ferrum, cobalt, nickel in the material of making relevant parts and causes uniformity to destroy, scanogram is caused the interferential problem of great pseudo-shadow to the uniform magnetic field sample area.
Compare with common extracorporeal high energy focusing ultrasonic system of tumor treatment, therapy system of the present invention is installed in the magnet scanning room that meets the electromagnetic shielding requirement, works under strong magnetic field circumstance.Mainly different on the design of coupling and device and hydraulic pipeline system is purified waste water in two energy focusing ultrasonic-high emitters and movement support device thereof, the degassing up and down.These improvement comprise:
Two energy focusing ultrasonic-high emitters and most of movement support device thereof, purify waste water coupling and device etc. of the degassing use in 5 gaussian line scopes of permanent-magnet up and down.Used parts and components and parts are made by non-conductive, nonmetal and non-magnetic material, can not influence the uniformity of magnetic field sample area, can not cause pseudo-shadow influence to the magnetic resonance imaging image.Meet safety requirements and picture quality assurance requirement that nuclear magnetic resonance image is checked fully.
Having only a bottom focus ultrasonic transmitter to work with existing superconducting magnet nuclear magnetic resonance guiding extracorporeal high energy focusing ultrasonic equipment compares, two energy focusing ultrasonic-high emitters up and down of the present invention can carry out work respectively independently, patient's body posture and the requirement of treatment position during at the treatment characteristics of different syndromes and treatment, select suitable focus ultrasonic transmitter by medical personnel, treat.
In a kind of preferred implementation, up and down two energy focusing ultrasonic-high emitters of the present invention all adopt many array element phased array formula focus ultrasonic transmitters, it is characterized in that it can adopt polytype phased array formula focus ultrasonic transmitters such as many array element sphere phase array row formula focus ultrasonic transmitter, many array element cambered surface phased array formula focus ultrasonic transmitter and many array element planar phased array row formula focus ultrasonic transmitter.
Need complicated multi-freedom posture control to compare with common non-phased array formula external focusing ultrasonic transmitter, phased array formula focus ultrasonic transmitter is in the process of the patient being carried out the treatment of many positions, and its required motion number of axle is few, attitude control is simple, treatment time shortens dramatically.It is few to make motion used parts and components and parts number, and component structural is simple, can all adopt nonmetal and non-magnetic material manufacturing is finished, and satisfies its instructions for use under the magnet environment.
Because up and down two energy focusing ultrasonic-high ejector systems adopt motor-driven, computer-controlled electromechanical integration mechanism to realize motion, adjustment, registration and the location of its locus, so the motor driver of each kinematic axis and some other influence the metallic mechanism of magnet shimming performance and scanning process, dynamo-electric components and parts are preferably located in beyond the 5 gaussian line scopes of magnet in the motion.5 gaussian line scopes preferably adopt engineering plastics with the interior mechanism that uses or other high strength is nonmetal and weak magnetic manufacturing assembling is finished to avoid the influence that problem of materials causes MRI scan, all need 5 gaussian line scopes with the mechanical movement of interior realization and transmission components and parts also in order to avoid because the influence that problem of materials causes MRI scan can be adopted nonmetal and weak magnetic parts.
Highstrenghtpiston that the present invention requires and nonmetal and weak magnetic material not only satisfy mechanics requirements such as intensity, rigidity, and satisfy the requirement of magnetic resonance system scanning process, and the uniform magnetic field sample area is not constituted influence, scanogram is not produced pseudo-shadow interference.Corrosion-resistant, aging resistance.Be easy to make, assemble and maintenance, the motion noiselessness can keep job stability and precision for a long time.
In actual use, be to improve or improve the airtight water pocket in focus ultrasonic transmitter surface of emission the place ahead, top and hold the acoustics coupling effect of fexible film of the airtight water tank upper surface of bottom focus ultrasonic transmitter, between hermetic flexible water pocket (or fexible film) that medical personnel generally need the material of water, ultrasonic conducting gel and similar performance to be coated on to heave behind the water-filling and patient's the skin.When carrying out similar operations, should be noted that in the acoustics coupling material, not to be mingled with metal particle that contains the ferromagnetism composition etc., in order to avoid influence the uniform magnetic field sample area, produce pseudo-shadow.
In one embodiment, the degassing of the present invention hydraulic pipeline system that purifies waste water, the cleaning that the de aerated water magnetization filtering adsorpting device of water source that the multilamellar de aerated water filtering and purifying that it is characterized in that using in the pipe-line system high density filter element to constitute is outer with being arranged in the magnet scanning room and water treatment cabinet keeps whole pipeline, strictness has prevented the ferrum that contains that those produce in the pipe-line system in manufacturing and work process, cobalt, the metal particle of ferromagnetism compositions such as nickel enters two corresponding coupling and devices of purifying waste water that outgas of energy focusing ultrasonic-high emitter up and down. and these microgranules not only can constitute influence to magnetic field homogeneity, scanogram is produced pseudo-shadow to be disturbed, but also might puncture coupling and the device of purifying waste water that outgas, cause de aerated water leakage accident, injure the patient who carries out the energy focusing ultrasonic-high treatment and damage magnetic resonance system.
In a preferred implementation, two energy focusing ultrasonic-high emitters adopt the same set of degassing to purify waste water to produce and delivery pipeline system production, filtration and the supply degassing are purified waste water up and down, are gone up water, draining and are stopped water supply by the control system decision according to instructions for use.Be used to supply the requirement that pipe-line system that the degassing purifies waste water should satisfy seal request and magnetic resonance imaging process, do not omit liquid corrosion magnet system, do not influence magnetic field homogeneity range and magnetic resonance imaging process.The degassing transfer pipeline of purifying waste water is communicated with and is positioned at the outer degassing of magnet scanning room and purifies waste water and handle two energy focusing ultrasonic-high emitters up and down of cabinet and magnet scanning room, passes the magnet scanning room and conducts panel and enter the magnet scanning room.Its pipeline in the magnet scanning room is divided into two parts, and a part of pipeline is attached in the hanger mechanism of top energy focusing ultrasonic-high emitter, and moves with hanger mechanism.The mechanical movement of hanger mechanism does not impact the purify waste water normal operation of pipe-line system of the degassing.Another part pipeline is attached in the examinating couch second of holding bottom energy focusing ultrasonic-high emitter, and moves with examinating couch second.The mechanical movement of examinating couch second should not impact the purify waste water normal operation of pipe-line system of the degassing.
Water circuit system keeps the cleaning of whole pipeline, prevent that those metal particles that contain ferromagnetism compositions such as ferrum, cobalt, nickel that produce in manufacturing and work process enter Water hermetic flexible water pocket (or water tank) in the pipe-line system.These microgranules not only can constitute influence, scanogram is produced pseudo-shadow interference magnetic field homogeneity, but also might puncture hermetic flexible water pocket (or fexible film), cause the leakage accident of purifying waste water that outgases, injure the patient who carries out the energy focusing ultrasonic-high treatment and damage magnetic resonance system.
Launch, the present invention has emphasized requirement of water circuit system cleanliness factor and relevant technology implementation measure.In an exemplary specific embodiment, the multilamellar degassing that the high density filter element the constitutes filtering and purifying of purifying waste water has obtained successful application.In addition, the degassing that is arranged in water source outside the magnet scanning room and the water treatment cabinet magnetization filtering adsorpting device of purifying waste water also is proved to be effective water treatment measure.These 2 have constituted the basis that the degassing is purified waste water and stablized, uses safely in the design.
According to the present invention, can use top or bottom focus ultrasonic transmitter separately, can image guidedly carry out dorsal position or ventricumbent position treatment to the patient down and therapeutic process is monitored, the curative effect inspection accurate.Thereby enlarged the treatable indication scope of extracorporeal high energy focusing ultrasonic.When not using focus ultrasonic transmitter, magnetic resonance system can also carry out independently carrying out image scanning.
With the examinating couch first that the top focus ultrasonic transmitter is used, it is characterized in that it is that one pair of height dimension is fixed, simple in structure, stretcher cheaply.The patient that it mainly carries the good radio-frequency transmissions/receiving coil of health arranged outside enters the even sample area of magnet and is fixed on the operating position.
In addition, as the more intense patient's bearing system of mobility, this can carry conversion and the prescription on individual diagnosis of the transfer in hospital environment, for example X-ray machine image check, gamma camera image check, radiotherapy, chemotherapy, microwave heat therapeutic, radio-frequency (RF) thermotherapeutic, surgical operation etc. that the patient carries out the inspection of different images section purpose, different therapeutic modalities.
This is to based on the magnet scanning room that meets the electromagnetic shielding requirement of the present invention, increase equipment, enlarged-area, the comprehensive consulting room that is improved to multiple diagnosis and treatment means such as comprising nuclear magnetic resonance image real-time inspection, extracorporeal high energy focusing ultrasonic treatment, surgical operation is very useful, is an important vehicle that constitutes this system.
With the examinating couch second that the bottom focus ultrasonic transmitter is used, it is characterized in that it has contained bottom energy focusing ultrasonic-high emitter and movement support device thereof, the degassing purify waste water coupling and device etc.When not needing to use bottom energy focusing ultrasonic-high emitter, examinating couch second can be released from the magnet working region, change the examinating couch first and cooperate top energy focusing ultrasonic-high emitter work or only the patient is done independently nuclear magnetic resonance image inspection.
When top energy focusing ultrasonic-high emitter is worked, can be used with the examinating couch first, the examinating couch second after also can quitting work with bottom energy focusing ultrasonic-high emitter is used.When bottom energy focusing ultrasonic-high emitter was worked, the top general integral body of energy focusing ultrasonic-high emitter shifted out magnet areas.To strengthen the openness of therapy system, reduce patient's fear of confined spaces sense.
The distribution of these motions and control device cable are drawn the magnet scanning room by conductive plate, and the power supply outer with scanning room is connected with control system.
High openness permanent magnet type magnetic resonance imaging system as image guided system, the present invention includes the examinating couch that two covers and two energy focusing ultrasonic-high emitters up and down be used respectively (the examinating couch first that is used with top energy focusing ultrasonic-high emitter and the examinating couch second that is used with bottom energy focusing ultrasonic-high emitter), they can remain working depth and fix, part in permanent-magnet 5 gaussian line scopes is by non-conductive, nonmetal and non-magnetic material is made. and bed panel is by high strength, the fiberglass reinforced plastics of anti-distortion (fiberglass) material is made, so not only can satisfy the strength and stiffness requirement of this bed surface, and, can not constitute influence to magnetic field homogeneity because glass-reinforced plastic material does not contain ferromagnetic particle, scanogram is produced pseudo-shadow to be disturbed.The design of bed panel also can be considered the layout of in place and fixing and coil signal transmission cable of the dual-purpose coil of signal reception/emission and fixing, and designs corresponding signaling interface.
For satisfying the requirement of some treatment position of patient, can comprise that also design has the liner of shapes such as wedge type, square and head rest, neck brace, arm holder etc. to cooperate patient's body big mattress down, with support the patient for a long time comfortable be in the treatment position.
Wide application of the present invention, according to general requirement, maybe should not carry out to carry out MRI scan the patient of nuclear magnetic resonance image inspection except that body contains metal rack, heart heartstart, thereby can benefit from Therapeutic Method and the system that the present invention describes and carry out oncotherapy.
According on the other hand, by system of the present invention and design can provide a kind of adopt the permanent magnet type magnetic resonance imaging system to extracorporeal high energy focusing ultrasonic treatment carry out image guided method, it may further comprise the steps:
(1) builds a uniform magnetic field sample area with permanent-magnet at himself center;
(2) by receiving/launch dual-purpose radio-frequency coil with signal, move the examinating couch of carrying those who are investigated and radio-frequency coil, make a purpose aspect that is subjected to the check point tissue be in the center of described sample area in the scanning of those who are investigated's health arranged outside;
(3) activate the above-mentioned purpose aspect with radio-frequency sending coil emission radio-frequency field;
(4) produce gradient fields at sample area, space encoding is carried out in the nuclear spin of purpose aspect;
(5) described purpose aspect is carried out nuclear magnetic resonance, the magnetic resonance signal with RF receiving coil reception purpose aspect through the processing of magnetic resonance imaging system, obtains reflecting the image of lesions position organization factors;
(6) adjust bed thickness by magnetic resonance imaging system;
(7) repeating step (3) carries out multiple slice imaging to (6), obtains reflecting the layered image of all organization factorses of check point;
(8) the emitter motion of control extracorporeal high energy focusing ultrasonic therapy equipment by observing the magnetic resonance image (MRI) of reflection emitter position real-time change, is positioned in the target site that needs to treat in the selected aspect the burnt territory of focusing.
In use, also comprise further and may further comprise the steps:
(9) start the concentration ultrasonic emission, observe the magnetic resonance image (MRI) that the selected aspect of real-time reflection inner tissue situation changes, extract the temperature distribution information of relevant focal zone.
Description of drawings
The present invention is described in detail below in conjunction with accompanying drawing and a specific embodiment, wherein:
Fig. 1 is the structural representation that the permanent magnet type magnetic resonance imaging system of the high openness level field layout of employing of the present invention is carried out a kind of embodiment of image guided and the extracorporeal high energy focusing ultrasonic system of tumor treatment that therapeutic effect is monitored, checked;
Fig. 2 is the structural representation of the U type permanent-magnet of high according to an embodiment of the invention openness level field layout;
Fig. 3 is that the system of whole system according to an embodiment of the invention constitutes block diagram;
Fig. 4 is the flow chart that carries out oncotherapy according to one embodiment of the present of invention;
Fig. 5 is the relation that focuses on burnt territory according to the nuclear magnetic resonance aspect of the embodiment of the invention and external focusing ultrasonic transmitter;
Fig. 6 is the structural representation of top extracorporeal high energy focusing ultrasonic emitter and hanger mechanism motor system thereof according to an embodiment of the invention;
Fig. 7 is other organization plan of top extracorporeal high energy focusing ultrasonic emitter and motor system thereof according to an embodiment of the invention;
Fig. 8 (a) and (b) are operation principle sketch maps of top extracorporeal high energy focusing ultrasonic emitter according to an embodiment of the invention;
Fig. 9 (a) and (b) are structural representations of bottom extracorporeal high energy focusing ultrasonic emitter and motor system thereof according to an embodiment of the invention;
Figure 10 is the operation principle sketch map of bottom extracorporeal high energy focusing ultrasonic emitter according to an embodiment of the invention;
Figure 11 is the operation principle sketch map that two energy focusing ultrasonic-high emitters adopt same set of de aerated water production and delivery pipeline system production, filtration and supply de aerated water;
Figure 12 is that whole system and electromagnetic shielding scanning room are main body according to an embodiment of the invention, makes up the sketch map of intervention diagnosis, treatment, operation integral system.
The specific embodiment
With reference to Fig. 1, this figure integral body shows the structure of whole permanent magnet type magnetic resonance imaging guiding extracorporeal high energy focusing ultrasonic system of tumor treatment and forms situation.Wherein 1 is permanent magnet system, 2 is top extracorporeal high energy focusing ultrasonic emitter and rail mounted hanger mechanism thereof, 3 is the examinating couch first, 4 for comprising the examinating couch second of bottom extracorporeal high energy focusing ultrasonic emitter, 5 is the emitter position manual overvide, 6 is the radio-frequency transmissions/receiving coil with top extracorporeal high energy focusing ultrasonic emitter adapted, 7 is the radio-frequency transmissions/receiving coil with bottom extracorporeal high energy focusing ultrasonic emitter adapted, 8 is the patient treatment condition monitoring system, 9 be ecg-gating in the respiration gate control device, 10 is with the bed nursing system, 11 is the electromagnetic shielding scanning room, 12 is the conductive plate system of electromagnetic shielding scanning room, 13 is gradient power-supply system regulator cubicle, 14 is the rf power system regulator cubicle, 15 is focus ultrasonic transmitter driving power source system regulator cubicle, 16 are the processing cabinet of purifying waste water that outgases, 17 is operating console, 18 for calculating rack.
With reference to Fig. 2, according to a preferred embodiment, the structure that illustrates the U type permanent-magnet of high openness level field layout is formed.Mainly for the supporting use of extracorporeal high energy focusing ultrasonic system of tumor treatment of two emitters designs with containing up and down, magnet adopts the structure of U type layout to magnet system.Wherein 1-1 is that right side yoke, 1-2 are that left side yoke, 1-3 are that bottom yoke, 1-4 are that right side Ci Duo (the N utmost point), 1-5 are that right side pole shoe, 1-7 are that left side pole shoe, 1-8 are that first gradient coil, 1-9 are that second gradient coil, 1-10 contain heat-insulation layer in interior magnet temperature control system for magnet shell body, the 1-11 that makes with fiberglass reinforced plastics (fiberglass) material for left side magnetic buttress (the S utmost point), 1-6.Because most of structure of U type permanent-magnet itself and coil etc. is a prior art, therefore its 1-1 is not done detailed description to the 1-9 item.
Magnet shell body 1-10 adopts the method manufacturing of piecemeal design, piecemeal manufacturing to form, and whole then chimeric, splicing fits together, and tightly wraps magnet system, and machinery that it is all and electric component and patient separate.
According to preferred embodiment, the magnet shell body made from fiberglass reinforced plastics (fiberglass) material, adopt the method manufacturing of piecemeal design, piecemeal manufacturing to form, whole then chimeric, the splicing fit together, tightly wrap magnet system, machinery that it is all and electric component and patient separate.
Bottom shell design in the magnet shell body 1-10 has special water collection system to leak and flow into magnet and cause the electrical safety accident to prevent to purify waste water as the degassing of couplings.
According to preferred embodiment, magnet temperature control system 1-11 contains the flame-retardant sponge material heat-insulation layer of particular design, it is characterized in that it is made up of the flame-retardant sponge material block of multiple difformity and size.These material block integral body are chimeric, overlap, laminate, splice and fit together, tightly wrap yoke and the reaction type temperature control system of forming by a plurality of temperature measuring equipments and electric heater unit disposed thereon, constitute tight magnet heat-insulation layer, can realize large-area insulation and guarantee uniformity, the stability that magnet temperature is controlled.
As shown in Figure 2, preferably, the magnetic gap between the magnetic pole can be 600mm with spacing.This realized safety hold the needs that the patient carries out magnetic resonant imaging examination and focus supersonic emitting treatment, have good ergonomics effect.Not only being of value to the patient overcomes the fear of confined spaces sense, also is of value to medical personnel's Real Time Observation patient's states, monitor therapy process.
With reference to block diagram shown in Figure 3, to have described according to an embodiment, the system of whole system constitutes, and can understand the relation between the main subsystem.These subsystems comprise:
The permanent-magnet subsystem;
Top focus ultrasonic transmitter subsystem;
Bottom focus ultrasonic transmitter subsystem;
Carry positioning subsystem with the patient of top focus ultrasonic transmitter adapted;
Carry positioning subsystem with the patient of bottom focus ultrasonic transmitter adapted; With
Computer and image processing subsystem,
Wherein the permanent-magnet subsystem adopts the magnet of U type arrangement, the architectural feature of the permanent-magnet of this U type structure is: build a larger-size elliposoidal uniform magnetic field sample area at himself center, the front and back of a channel-type connect, upper and lower is opened wide magnetic gap space, a large-sized available magnetic gap spacing and maximum usbale field strength.
In addition, also can comprise/bottom focus ultrasonic transmitter multi-freedom posture control subsystem high-energy concentration ultrasonic conducting structure and transmitting medium processing subsystem, scanning room and conductive plate subsystem in actual use.
Computer wherein and image processing subsystem control whole system operation and data acquisition etc., for example, can comprise the gradient controller of controlling gradient coil, the sequence that control RF signal transmits and receives takes place, amplifier, master computer passes through operation control, built-in operation control is to last/bottom focus ultrasonic transmitter multi-freedom posture control subsystem, high-energy concentration ultrasonic conducting structure and transmitting medium processing subsystem, on/bottom focus ultrasonic transmitter power-supply system etc. controls, by Data Detection filtering, data acquisition, image processor, image displays etc. carry out date processing and pictorial display.Those skilled in the art can readily design this control system, Fig. 3 has clearly illustrated wherein a kind of concrete allocation plan.In view of the present invention can adopt computer and the image processing subsystem that belongs to prior art, needn't make detailed description to it at this.
With reference to flow chart shown in Figure 4, can understand and use the present invention to carry out the process of oncotherapy.
This embodiment shows and adopts high openness permanent magnet type magnetic resonance imaging system that the extracorporeal high energy focusing ultrasonic oncotherapy is carried out a kind of method image guided and that therapeutic process monitoring, curative effect are checked, and it may further comprise the steps:
(1) builds a larger-size elliposoidal uniform magnetic field sample area with permanent-magnet at himself center.The constitutive characteristic of magnet is: the high open magnet structure of level field U type that adopts that the magnetic gap spacing is big, arranges about magnetic pole, yoke is made of left side yoke, right side yoke, bottom yoke three parts, left side yoke and right side yoke symmetric arrangement, the bottom yoke is the basis of whole magnet.Right side Ci Duo (the N utmost point) is positioned at the left side of right side yoke, and left side magnetic buttress (the S utmost point) is positioned at the right side of left side yoke, and two place's magnetic buttress are parallel relatively.Magnetic flux is sent by right side Ci Duo, crosses the magnetic gap space between two buttress, penetrates left side magnetic buttress, returns right side Ci Duo by the bottom yoke again, forms the closed-loop path;
(2) by receiving/launch dual-purpose radio-frequency coil with signal, move the examinating couch of carrying patient and radio-frequency coil, make and checked that a purpose aspect of lesions position tissue is in the center of described sample area in the scanning of patient body arranged outside;
(3) activate the above-mentioned purpose aspect with radio-frequency sending coil emission radio-frequency field;
(4) pile up neatly towards two gradient coils of patient's one side and produce gradient fields by being arranged on magnet right side magnetic buttress and left side magnetic, space encoding is carried out in the nuclear spin of purpose aspect at sample area;
(5) described purpose aspect being carried out nuclear magnetic resonance. the magnetic resonance signal with RF receiving coil reception purpose aspect through the processing of magnetic resonance imaging system, obtains reflecting the image of lesions position organization factors fast;
(6) adjust bed thickness by magnetic resonance imaging system, select another purpose aspect;
(7) repeating step (3) carries out multiple slice imaging to (6), obtains reflecting the layered image of all pathological tissues situations of lesions position; Determine operation plan then in view of the above;
(8), select the treatment aspect according to operation plan;
(9) determine the treatment aspect after, emitter motion by manual control extracorporeal high energy focusing ultrasonic therapeutic apparatus for treating tumor, the magnetic resonance image (MRI) of the emitter position of close observation reflection simultaneously real-time change is positioned in the focus target site that needs in the selected aspect to treat the burnt territory of focusing;
(10) start the concentration ultrasonic emitting treatment, observe and reflect the magnetic resonance image (MRI) that the pathological tissues situation changes in the selected aspect in real time, extract the temperature distribution information of relevant focal zone.Judge the therapeutic effect in the burnt territory of selected focusing and determine the extended treatment time or finish treatment;
(11) finish the focusing therapy of selected focus target site after, size according to selected treatment aspect inner disease foci position, by manual control volume exterior focusing ultrasonic tumor device emitter motion, make and move in the not area for treatment that focuses in the lesions position of burnt territory in selected aspect and reorientate.Repeating step (10), through repeatedly moving and the location, repeatable operation concentration ultrasonic emitting treatment makes the focus target site that needs in the selected aspect to treat all finish treatment and therapeutic effect inspection;
(12) select new treatment aspect;
(13) repeating step (9) arrives step (12), all therapeutic process and therapeutic effect inspections of focus target sites in finishing all treatment aspects.
Can understand nuclear magnetic resonance aspect and external focusing ultrasonic transmitter with reference to Fig. 5 and focus on relation between the burnt territory.
Requirement according to cartesian coordinate system, the coordinate system of the whole system after compound is provided with as follows: the corresponding patient's of the x axle of system and z axial plane transverse section (Axial Plane), the y axle of system and the corresponding patient's sagittal plane (Sagittal Plane) of z axial plane, the corresponding patient's of the x axle of system and y axial plane coronalplane (Coronal Plane).
With reference to Fig. 6, can understand the constitution state of top extracorporeal high energy focusing ultrasonic emitter and hanger mechanism thereof.
According to an embodiment, top energy focusing ultrasonic-high emitter 2-1 adopts motor-driven rail mounted hanger mechanism 2-2 to realize motion, adjustment, registration and the location of its locus, hanger mechanism 2-2 can realize top energy focusing ultrasonic-high emitter about the motion requirement of five kinematic axiss of rotation (the z axle of system for winding rotates) of the swing (the x axle swing of system for winding) of (the x axle of system), front and back (the y axle of system) and oscilaltion campaign (the z axle of system), energy focusing ultrasonic-high emitter and energy focusing ultrasonic-high emitter.
In an exemplary example, the axial motion of y realizes that by a cover motor-driven, rubber synchronous belt, the slide rail of synchronizing wheel traction, sled mechanism slide rail is fixed on the below of the aluminium section bar controlling the water circulation flat-topped ridge of scanning room inner magnet top; The axial motion of x is realized by another set of motor-driven, rubber synchronous belt, the slide rail of synchronizing wheel traction, sled mechanism; X axle slide rail is y axle slide plate below fixedly, and the below of x axle slide plate is a z axle elevating mechanism, and the z axial brake device is positioned at x axle slide plate, adopts the motor-driven rubber synchronous belt lifting haulage gear after gravitational equilibrium is provided with.The elevating movement of top energy focusing ultrasonic-high emitter is realized by the z axle rotation of system for winding and the x axle swing combination of system for winding.Z axle rotary system is made up of motor-driven gear pair mechanism, and x axle oscillation system is made of motor-driven rubber synchronous belt, synchronizing wheel drive mechanism.This two covers motion is installed on the body works, and integral body is positioned at the below of z axle elevating mechanism.Each kinematic axis all is provided with pulse codr with accurate measurement displacement and corner, travel switch is set to control its range of movement, electromechanical stop is set to prevent the motion surpassed distance.The motor control of top energy focusing ultrasonic-high emitter 2-1 and hanger mechanism 2-2 thereof adopts control mode step by step separate between each kinematic axis.Adopt subsidiary image real-time display device of two covers and equipment emergency stop switch manual overvide, one is set in the magnet scanning room, in the position of the magnet outside near carrying patient's examinating couch; Another set of manual overvide is arranged on the outer operating console of magnet scanning room and magnetic resonance operation control system, Flame Image Process and display system, area for treatment temperature display system, scanning room are inside and outside lumps together use to the image monitoring system of making peace etc.The whole operation control station is provided with the equipment emergency stop switch, in order to emergency processing.
Because whole motion and motor control are prior art, therefore except its material is required to some extent, it is not done detailed description.
In the present invention, since 5 gaussian line scopes with the interior mechanism that uses and form parts, components and parts and adopt satisfactory engineering plastics, nonmetal and weak magnetic material manufacturing to avoid the influence that problem of materials causes MRI scan.Therefore this hanger mechanism 2-2 has been different from present common diagnostic imaging equipment such as nose suspension type X-ray machine, similar rail mounted or the rotation-sliding formula hanger mechanism that operation is adopted with medical apparatus equipment such as shadowless lamp, monitor, respirator, anesthetic machines in fact.
Launch, the present invention the material application facet repeatedly emphasized the 5 gaussian line scopes that are positioned at the motion of top energy focusing ultrasonic-high emitter 2-1 finish this technical characterictic by the nonmetal of particular design and weak magnetic material manufacturing and assembling.With reference to shown in Figure 7, can understand the operation principle that articulated type operating robot clamping upper extracorporeal high energy focusing ultrasonic emitter 2-1 realizes multi-freedom posture control.As shown in Figure 7, the electronic hanger mechanism of rail mounted that this technical characterictic is not only applicable to the design to be narrated is applicable to that also mechanical hand (articulated type operating robot, multi-coordinate slide unit and turntable etc.), rotation-sliding formula suspension bracket etc. can clamping upper energy focusing ultrasonic-high emitter 2-1 finish other frame for movement of treatment registration and positioning requirements.As long as they satisfy its be positioned at 5 gaussian line scopes with part finish by nonmetal and weak magnetic material manufacturing and assembling that the present invention was realized, can both cooperate magnetic resonance system to finish the imaging guiding therapeutic process of high energy focusing ultrasonic system.Therefore, in fact the present invention holds and has contained other and can move by clamping upper energy focusing ultrasonic-high emitter, cooperate U type permanent-magnet to finish the motion of energy focusing ultrasonic-high therapeutic process, generally speaking, comprising: the electronic hanger mechanism of rail mounted, the manual hanger mechanism of rail mounted, mechanical hand (articulated type operating robot, multi-coordinate slide unit and turntable etc.), rotation-sliding formula suspension bracket etc.
Shown in Fig. 8 (a) and (b), can understand according to one embodiment of present invention the operation principle of top extracorporeal high energy focusing ultrasonic emitter.Adopt Water hermetic flexible water pocket 2-3 to be coupled between top extracorporeal high energy focusing ultrasonic emitter and the patient skin, this water pocket can adopt materials such as mylar, polyvinyl chloride (PVC), silicone rubber to make, its shape easily changes with the profile that lies in the patient body on the examinating couch first 3, this is present sophisticated coupling technique, repeats no more.It has the following advantages: on the one hand; the hermetic flexible water pocket that is full of de aerated water can cover energy focusing ultrasonic-high focus beam zone fully and satisfy seeing through of wave beam and require, and Water hermetic flexible water pocket can be protected extruding and the injury that motion that the patient avoids the energy focusing ultrasonic-high emitter may cause patient body after out of hand on the other hand.
With reference to shown in Figure 1, the range of movement of top energy focusing ultrasonic-high emitter 2-1 and working region are included in the space that magnetic resonance imaging reserved behind the installation in position of the patient body outside with the dual-purpose coil 6 of signal reception/emission, and the position of the dual-purpose coil 6 of signal reception/emission should not collided and influence to the position adjustment of top energy focusing ultrasonic-high emitter 2-1 in order to avoid influence the picture quality of magnetic resonance imaging.
With reference to shown in Figure 1, when top energy focusing ultrasonic-high emitter 2-1 worked alone, the scanning bed first 3 carrying healths outsides installed magnetic resonance imaging and enter magnet 1 and in place and fixing in suitable location with the patient of the dual-purpose coil 6 of signal reception/emission.When this examinating couch first 3 is in place, can use laser localized light comparing to determine its position accurately.Because examinating couch first 3 is more single and simple in the axial motion of y, need not move at x axle and z direction of principal axis, and can utilize laser localized light comparing accurately to locate at the y direction of principal axis, so be designed to simple support structure, the fixed manual operation bed of working depth.
With reference to Fig. 9 (a) with (b), can understand according to one embodiment of present invention, the system of bottom extracorporeal high energy focusing ultrasonic emitter 4-8 constitutes.Energy focusing ultrasonic-high emitter 4-8 design in bottom is below the glass steel bed panel of carrying patient's examinating couch second 4.Whole emitter integral body is included in and is full of in the airtight water tank of purifying waste water that outgases, and the water tank upper surface is concordant with bed panel.
In an exemplary example, the closed waterbox design is a hexahedron structure, comprise following table panel 4-1, by fixed belt frame 4-2 with occupy the upper surface that the flexible mantle 4-3 in the frame constitutes, four side 4-4,4-5,4-6,4-7 also are made of flexible membrane, are tightly connected together with two surface plate up and down.Upper surface panel is fixed on the bed panel of the examinating couch second 4 of carrying the patient, and is concordant with bed panel.Following table panel support the polynary battle array planar phased array row formula focus ultrasonic transmitter 4-8 that soaks during the degassing is purified waste water above it, the motion requirement of (the x axle of system), front and back (the y axle of system) and three kinematic axiss of upper-lower position adjustment campaign (the z axle of system) about can realizing.Four lateral flexible membrane 4-4,4-5,4-6,4-7 remain the air-tight state of closed water tank with the motion campaign of lower surface fixing head 4-1.The flexible mantle of upper surface panel is heaved behind water-filling, with the body surface close-coupled of needs of patients treatment.
The following table panel 4-1 of closed water tank adopts motor-driven rubber synchronous belt, the slide rail of synchronizing wheel traction, motion, adjustment, registration and the location that slide block mechanism is realized its locus, and whole motion is positioned at the support framework inside of examinating couch second.Each kinematic axis all is provided with pulse codr with accurate measurement displacement and corner, travel switch is set to control its range of movement, electromechanical stop is set to prevent the motion surpassed distance.The motor control of bottom energy focusing ultrasonic-high emitter motion adopts control mode step by step separate between each kinematic axis.Adopt two cover manual overvides, a cover is combined with each other with the manual control system that top energy focusing ultrasonic-high emitter is arranged on the magnet scanning room inner magnet outside.The another set of manual control system that is arranged on the outer operating console of magnet scanning room with top energy focusing ultrasonic-high emitter is combined with each other.
Because whole motion and motor control are prior art, therefore except its material is required to some extent, it is not done detailed description.In the present invention, 5 gaussian line scopes adopt satisfactory nonmetal and weak magnetic material manufacturing to avoid the influence that problem of materials causes magnetic resonance system with composition parts, the components and parts of the interior mechanism that uses.
With reference to shown in Figure 10, can know understanding according to one embodiment of present invention, the operation principle when bottom extracorporeal high energy focusing ultrasonic emitter 4-9 treats.
Hold between the closed water tank of bottom energy focusing ultrasonic-high emitter 4-9 and the patient skin and be coupled by the flexible mantle 4-3 that heaves behind the water tank upper surface water-filling, this flexibility mantle can adopt materials such as mylar, polyvinyl chloride (PVC), silicone rubber to make, its shape of heaving part easily changes with the profile that lies in the patient body on the examinating couch, this is present sophisticated coupling technique, repeats no more.Energy focusing ultrasonic-high focus beam zone is contained within the closed environment that is full of de aerated water fully, can cover and satisfy seeing through of energy focusing ultrasonic-high focus beam fully and require.
In actual use, be to improve or improve the acoustics coupling effect, the material 4-10 of the general water of medical personnel, ultrasonic conducting gel and similar performance is coated between the hermetic flexible water pocket heaved behind the water-filling and patient's the skin.When carrying out similar operations, should be noted that in the acoustics coupling material, not to be mingled with metal particle that contains the ferromagnetism composition etc., in order to avoid influence magnetic field homogeneity, produce pseudo-shadow.
The range of movement of bottom energy focusing ultrasonic-high emitter 4-9 and working region are included in the space that magnetic resonance imaging reserved behind the installation in position below patient body with the dual-purpose coil 7 of signal reception/emission, and the position that the dual-purpose coil 7 of signal reception/emission should not collided and influence to bottom energy focusing ultrasonic-high emitter 4-9 position adjustment is provided with in order to avoid influence the picture quality of magnetic resonance imaging.
With reference to shown in Figure 1, when needs bottom energy focusing ultrasonic-high emitter 4-9 works alone, connect relevant circuit and water route earlier, allow then it with this examinating couch second 4, in place on examinating couch the patient and the dual-purpose coil 7 of signal reception/emission that contains the patient scan position move along the y direction of principal axis, enter magnet 1 and in place and fixing in suitable location.When this examinating couch is in place, can use laser localized light comparing to determine its position accurately.Because this examinating couch is more single and simple in the axial motion of y, need not move at the x direction of principal axis, accurately the location is just passable at the y direction of principal axis to utilize laser localized light comparing.
With reference to shown in Figure 11, according to one embodiment of present invention, two energy focusing ultrasonic-high emitters adopt the same set of degassing to purify waste water to produce and delivery pipeline system production, filtration and the supply degassing are purified waste water up and down, are gone up water, draining and are stopped water supply by the control system decision according to instructions for use.Be used to supply the requirement that pipe-line system that the degassing purifies waste water should satisfy seal request and magnetic resonance imaging process, do not omit liquid corrosion magnet system, do not influence magnetic field homogeneity range and magnetic resonance imaging process.The degassing transfer pipeline of purifying waste water is communicated with and is positioned at the outer degassing of magnet scanning room and purifies waste water and handle two energy focusing ultrasonic-high emitters up and down of cabinet and magnet scanning room, passes the magnet scanning room and conducts panel and enter the magnet scanning room.Its pipeline in the magnet scanning room is divided into two parts, and a part of pipeline is attached in the hanger mechanism of top energy focusing ultrasonic-high emitter, and moves with hanger mechanism.The mechanical movement of hanger mechanism should not impact the normal operation of de aerated water pipe-line system. and another part pipeline is attached in the examinating couch second of holding bottom energy focusing ultrasonic-high emitter, and moves with examinating couch second.The mechanical movement of examinating couch second should not impact the normal operation of de aerated water pipe-line system.
Water circuit system keeps the cleaning of whole pipeline, and strictness prevents that those metal particles that contain ferromagnetism compositions such as ferrum, cobalt, nickel that produce enter Water hermetic flexible water pocket in the pipe-line system in manufacturing and work process.These microgranules not only can constitute influence, scanogram is produced pseudo-shadow interference magnetic field homogeneity, but also might puncture hermetic flexible water pocket (or fexible film), cause de aerated water leakage accident, injure the patient who carries out the energy focusing ultrasonic-high treatment and damage magnetic resonance system.
Launch, the present invention has emphasized requirement of water circuit system cleanliness factor and relevant technology implementation measure.In an exemplary specific embodiment, the multilamellar degassing that the high density filter element the constitutes filtering and purifying of purifying waste water has obtained successful application.In addition, the degassing that is arranged in water source outside the magnet scanning room and the water treatment cabinet magnetization filtering adsorpting device of purifying waste water also is proved to be effective water treatment measure.These 2 have constituted the basis that the degassing is purified waste water and stablized, uses safely in the design.
With reference to shown in Figure 12, this figure has showed the magnet scanning room that meets the electromagnetic shielding requirement based on of the present invention, increase equipment, enlarged-area are improved to the situation of the incorporate comprehensive consulting rooms of multiple diagnosis and treatment means such as comprising nuclear magnetic resonance image real-time inspection, extracorporeal high energy focusing ultrasonic treatment, surgical operation.
Except the composition of whole permanent magnet type magnetic resonance imaging guiding extracorporeal high energy focusing ultrasonic system of tumor treatment illustrated in fig. 1, the integrated comprehensive consulting room after expansion shown in Figure 12 improves also comprises table for operative materials 21, drip stand 22, anesthetic machine 23, respirator 24, monitor 25 etc.Condition is that they can not constitute influence, the magnetic resonance imaging image is produced pseudo-shadow interference magnetic field homogeneity.
Though below described design philosophy of the present invention and technical scheme according to a particular embodiment of the invention, it will be appreciated by those skilled in the art that, under the prerequisite that does not depart from thought of the present invention and scope, can carry out variations and modifications to the disclosed concrete technical scheme of description.

Claims (15)

1. level field permanent magnet type magnetic resonance imaging system that is used with the extracorporeal high energy focusing ultrasonic therapy system, it comprises:
Be used to build the permanent-magnet subsystem of a uniform magnetic field sample area;
Be used for producing the gradient subsystem of gradient fields at sample area;
Be used to launch the Radio Frequency Subsystem that radio-frequency field activates the purpose aspect of inspected object;
The top focus ultrasonic transmitter subsystem that comprises top energy focusing ultrasonic-high emitter;
The bottom focus ultrasonic transmitter subsystem that comprises bottom energy focusing ultrasonic-high emitter;
Inspected object carrying positioning subsystem with top energy focusing ultrasonic-high emitter adapted;
Inspected object carrying positioning subsystem with bottom energy focusing ultrasonic-high emitter adapted; With
Computer and image processing subsystem,
Wherein the permanent-magnet subsystem adopts the permanent-magnet of U type arrangement, and the architectural feature of the permanent-magnet of this U type arrangement is: magnetic gap space, a large-sized available magnetic gap spacing and the maximum usbale field strength that front and back connect, upper and lower is opened wide of building a larger-size elliposoidal uniform magnetic field sample area, a channel-type at himself center.
2. according to the system of claim 1, wherein, the structure of the permanent-magnet of the U type arrangement of permanent-magnet subsystem is: adopt the high open magnet structure of U type of arranging about magnetic pole, yoke is made of left side yoke, right side yoke, bottom yoke three parts, left side yoke and right side yoke symmetric arrangement, be fixed on the yoke of bottom, the bottom yoke is the basis of whole magnet; Right side Ci Duo is positioned at the left side of right side yoke, and magnetic buttress in left side is positioned at the right side of left side yoke, and two magnetic buttress is parallel relatively; Magnetic flux is sent by right side Ci Duo, crosses the magnetic gap space between two buttress, penetrates left side magnetic buttress, returns right side Ci Duo by the bottom yoke again, forms the closed-loop path;
Wherein gradient subsystem is included in first and second gradient coils that above-mentioned magnet right side magnetic is piled up neatly and magnetic buttress in left side is arranged towards a side of inspected object, and two gradient coils are parallel relatively.
3. according to the system of claim 2, wherein, magnet bulk temperature stable by being installed in the reaction type temperature control system of forming by a plurality of temperature measuring equipments and electric heater unit on the yoke and wrapping up yoke, prevent that the lost heat-insulation layer of heat from realizing.
4. according to the system of claim 2, wherein, the magnetic gap spacing between the magnetic pole is 600mm.
5. according to the system of claim 1 or 2, wherein, elliposoidal uniform magnetic field sample area, three radius values of ellipsoid are respectively 400mm, 400mm and 380mm; Can holding up and down, two energy focusing ultrasonic-high emitters move, work in its zone, holding the dual-purpose radio-frequency coil of magnetic resonance signal reception/emission is provided with in its zone, hold the motion in its zone of inspected object and inspected object carrying positioning subsystem, work, and the ecg-gating probe, respiration gate control pops one's head in, has the wound thermometric needle to work in its zone; Above-mentioned up and down two energy focusing ultrasonic-high emitters, magnetic resonance signals receive/launch dual-purpose radio-frequency coil, inspected object carrying positioning subsystem, ecg-gating with probe, respiration gate control probe, have the thermometric needle of wound all to use nonmetal and non-magnetic material manufacturing and assembling are finished.
6. according to the system of claim 1 or 2, wherein, two energy focusing ultrasonic-high emitters carry out work respectively independently up and down.
7. according to the system of claim 6, wherein, at least one adopts many array element phased array formula focus ultrasonic transmitter in two energy focusing ultrasonic-high emitters up and down, and described many array element phased array formula focus ultrasonic transmitter is selected from many array element sphere phase array row formula focus ultrasonic transmitter, many array element cambered surface phased array formula focus ultrasonic transmitter or many array element planar phased array row formula focus ultrasonic transmitter.
8. according to the system of claim 2, wherein, make the magnet shell body with glass fiber reinforced plastic material, adopt the method manufacturing of piecemeal design, piecemeal manufacturing to form, whole then chimeric, the splicing fit together, tightly wrap magnet system, machinery that it is all and electric component and inspected object separate; Bottom shell design has water collection system to leak and flow into magnet and cause the electrical safety accident to prevent to purify waste water as the degassing of couplings.
9. according to any system in the claim 1,2,7, wherein, with the inspected object of top energy focusing ultrasonic-high emitter adapted carrying positioning subsystem be the examinating couch first, with the inspected object of bottom energy focusing ultrasonic-high emitter adapted carrying positioning subsystem be examinating couch second, their parts in permanent-magnet 5 gaussian line scopes are made by non-conductive, nonmetal and non-magnetic material, and bed panel is made by the glass fiber reinforced plastic material of high strength, anti-distortion.
10. according to the system of claim 1 or 2, wherein, purify waste water coupling and device of the most of movement support device of two energy focusing ultrasonic-high emitters, described two energy focusing ultrasonic-high emitters up and down and the described degassing of two energy focusing ultrasonic-high emitters up and down up and down, used parts and components and parts are made by non-conductive, nonmetal and non-magnetic material, and all use in 5 gaussian line scopes of permanent-magnet.
11. system according to claim 1 or 2, also comprise the hydraulic pipeline system that purifies waste water that outgases, the cleaning that the de aerated water magnetization filtering adsorpting device of water source that the multilamellar de aerated water filtering and purifying that has used the high density filter element to constitute in the pipe-line system is outer with being arranged in the magnet scanning room and water treatment cabinet keeps whole pipeline.
12. system according to claim 9, wherein, examinating couch second contains bottom energy focusing ultrasonic-high emitter and movement support device thereof, the degassing purify waste water coupling and device, when not needing to use bottom energy focusing ultrasonic-high emitter, examinating couch second is released from the magnet working region, changed the examinating couch first and cooperate top energy focusing ultrasonic-high emitter work or only do independently nuclear magnetic resonance image inspection.
13. according to the system of claim 9, wherein, the examinating couch first is one pair of fixed stretcher of height dimension, the inspected object that it mainly carries the good radio-frequency transmissions/receiving coil of health arranged outside enters the even sample area of magnet and is fixed on the operating position.
14. according to the system of claim 2, wherein, described U type is arranged permanent-magnet, it is characterized in that described magnetic buttress is made of the permanent magnet material of single kind, permanent magnet material is selected sintered NdFeB, samarium-cobalt alloy for use.
15. system according to claim 3, wherein, heat-insulation layer comprises the flame-retardant sponge material, it is characterized in that forming by the flame-retardant sponge material block of multiple difformity and size, these material block integral body are chimeric, overlap, laminate, splice and fit together, tightly wrap yoke and the reaction type temperature control system of forming by a plurality of temperature measuring equipments and electric heater unit disposed thereon, constitute tight magnet heat-insulation layer thus.
CNB2006101113943A 2006-08-25 2006-08-25 Extracorporeal high energy focusing ultrasonic system guided by permanent magnet type magnetic resonance image and method thereof Expired - Fee Related CN100425199C (en)

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