CN103908751A - Focused-ultrasound treatment device and method - Google Patents
Focused-ultrasound treatment device and method Download PDFInfo
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- CN103908751A CN103908751A CN201210592185.0A CN201210592185A CN103908751A CN 103908751 A CN103908751 A CN 103908751A CN 201210592185 A CN201210592185 A CN 201210592185A CN 103908751 A CN103908751 A CN 103908751A
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Abstract
The invention provides a focused-ultrasound treatment device and method and belongs to the technical field of focused-ultrasound treatment. The device and method are capable of solving problems that it is difficult for the prior focused-ultrasound treatment technology to accurately control a focal point position of focused ultrasounds and that real-time evaluation of a treatment effect is impossible. The focused-ultrasound treatment device includes: an ultrasonic treatment head used for emitting focused ultrasounds for treatment; an anatomy image obtaining unit used for obtaining an anatomy image of an ultrasonic action area; a temperature distribution obtaining unit used for obtaining temperature distribution information of the ultrasonic action area; and a monitoring image generation unit used for generating a monitoring image according to the anatomy image and the temperature distribution information, wherein the monitoring image includes the anatomy image of the ultrasonic action area and temperature distribution information at least near the focal point of the focused ultrasounds. The focused-ultrasound treatment method includes using the focused ultrasounds for treatment and generating the monitoring image in a treatment process.
Description
Technical field
The invention belongs to focusing supersonic wave treatment technical field, be specifically related to a kind of focusing supersonic wave treatment device and method.
Background technology
Focusing supersonic wave treatment is a kind of non-invasive therapy technology, it utilizes ultrasonic therapeutic head (mainly comprising ultrasonic transducer) to send ultrasound wave, due to ultrasound wave have bio-tissue penetrance, can focusing etc. characteristic, therefore the ultrasound wave of the low energy densities that ultrasonic therapeutic head sends can be focused at lesions position place the ultrasound wave of high-energy-density, and the ultrasound wave of high-energy-density can produce heat effect, mechanical effect, cavitation effect etc. and make the tissue generation coagulation necrosis of lesions position, thus the diseases such as treatment tumor, prostatic hyperplasia, cervical erosion, cyclomastopathy.
Obviously, the position of concentration ultrasonic focus and the effect (the intensification situation that for example makes tissue produce) producing and safety, the effectiveness etc. for the treatment of are closely related; Therefore, how accurately to control the position of concentration ultrasonic focus and how Real-Time Evaluation therapeutic effect is significant to focusing supersonic wave treatment.
In order to control the position of concentration ultrasonic focus and to evaluate therapeutic effect, ultrasonic imaging (as B ultrasonic) unit can be set in focusing supersonic wave treatment device, ultrasonic imaging unit can form the real-time anatomic image (being the space two-dimension image of position to be treated tissue) at position to be treated, thereby therapist can be adjusted the position of concentration ultrasonic focus and evaluate therapeutic effect according to anatomic image.
But anatomic image only represents the spatial information of tissue, and can not directly demonstrate the position of concentration ultrasonic focus, thus the position that it can only auxiliary judgment concentration ultrasonic focus, and can not really effectively control the position of concentration ultrasonic focus.Simultaneously, in a lot of situations, only have for example, in the time that ultrasound wave has caused that tissue occurs to change (coagulation necrosis of higher degree) largely anatomic image just can change, that is to say, have certain hysteresis quality with anatomic image Estimating curative effect, this causes therapist not adjust therapeutic scheme according to curative effect in time; And the hysteresis quality of therapeutic evaluation also may cause safety problem, such as, if when concentration ultrasonic focus is offset to normal structure, can not find at once this problem by anatomic image, only have just reflection to some extent of anatomic image after normal structure is damaged largely, and at this moment tissue injury is irreversible.
Summary of the invention
Technical problem to be solved by this invention comprises, be difficult to accurately to control the position of concentration ultrasonic focus and problem that can not Real-Time Evaluation therapeutic effect for existing focusing supersonic wave treatment technology, a kind of position that can accurately control concentration ultrasonic focus and focusing supersonic wave treatment device that can Real-Time Evaluation therapeutic effect are provided.
The technical scheme that solution the technology of the present invention problem adopts is a kind of focusing supersonic wave treatment device, and it comprises:
For the ultrasonic therapeutic head of transmitting focusing ultrasound wave to treat;
Anatomic image acquiring unit, for obtaining the anatomic image in ul-trasonic irradiation region;
Temperature Distribution acquiring unit, for obtaining the temperature distribution information in ul-trasonic irradiation region;
Monitoring image generation unit, for generating monitoring image according to described anatomic image and temperature distribution information, described monitoring image comprises the anatomic image in ul-trasonic irradiation region and is at least positioned near the temperature distribution information of described concentration ultrasonic focus.
Focusing supersonic wave treatment device of the present invention has monitoring image generation unit, it can generate the monitoring image that comprises anatomic image and temperature distribution information, and monitoring image can embody the spatial information of position to be treated tissue simultaneously and organize the temperature information of each position; Because ultrasound wave can cause that tissue heats up and intensification degree is relevant with ultrasonic intensity (being focus level), therefore can accurately know the position (being the position that temperature is the highest) of concentration ultrasonic focus and it is controlled by analysis monitoring image (namely analyzing the Temperature Distribution of organizing diverse location place); Simultaneously, the temperature of tissue also can embody the intensity of variation (as coagulation necrosis degree) of tissue, therefore can real-time judge curative effect by analysis monitoring image, thereby adjust in time therapeutic scheme (as changed the position of concentration ultrasonic focus and adjusting ultrasound wave dosage etc.) according to curative effect, to reach best therapeutic effect.
Preferably, described focusing supersonic wave treatment device also comprises ultrasonic therapeutic head moving cell, and it is for driving described ultrasonic therapeutic head to move and obtaining the positional information of ultrasonic therapeutic head; And described monitoring image generation unit, in the time generating monitoring image, also utilizes the positional information of ultrasonic therapeutic head in monitoring image, to generate the ultrasonic passage of simulation and/or simulation ultrasound focus.
Preferably, described anatomic image acquiring unit and Temperature Distribution acquiring unit are nuclear magnetic resonance unit.
Preferably, described anatomic image acquiring unit is ultrasonic imaging unit or electronic computer x-ray tomography image-generating unit.
Preferably, described Temperature Distribution acquiring unit is infrared temperature measuring unit or ultrasound wave temperature measurement unit.
Technical problem to be solved by this invention also comprises, be difficult to accurately to control the position of concentration ultrasonic focus and problem that can not Real-Time Evaluation therapeutic effect for existing focusing supersonic wave treatment technology, a kind of position that can accurately control concentration ultrasonic focus and focusing supersonic wave treatment method that can Real-Time Evaluation therapeutic effect are provided.
Solving the technical scheme that the technology of the present invention problem adopts is a kind of focusing supersonic wave treatment method, and it comprises and send the process of concentration ultrasonic to treat with ultrasonic therapeutic head, and also comprises in therapeutic process:
Obtain anatomic image and the temperature distribution information in ul-trasonic irradiation region;
Generate monitoring image according to described anatomic image and temperature distribution information, described monitoring image comprises the anatomic image in ul-trasonic irradiation region and is at least positioned near the temperature distribution information of described concentration ultrasonic focus.
Because focusing supersonic wave treatment method of the present invention comprises the step that generates above-mentioned generation monitoring image, therefore it can accurately control by monitoring image position and the Real-Time Evaluation curative effect of concentration ultrasonic focus, thereby adjust in time therapeutic scheme, to reach best therapeutic effect.
Preferably, described ultrasonic therapeutic head is subject to the driving of ultrasonic therapeutic head moving cell and moves, and described ultrasonic therapeutic head moving cell can obtain the positional information of ultrasonic therapeutic head; And in the time generating monitoring image, also in monitoring image, generate the ultrasonic passage of simulation and/or simulation ultrasound focus according to the positional information of described ultrasonic therapeutic head.
Preferably, described concentration ultrasonic is pulse ultrasonic wave or continuous ultrasonic.
Further preferably, described concentration ultrasonic is pulse ultrasonic wave, and the persistent period of described pulse ultrasonic wave, interval time was between 2 ~ 8 seconds between 2 ~ 8 seconds.
Preferably, anatomic image and the temperature distribution information of described in, obtaining ul-trasonic irradiation region comprise: anatomic image and the temperature distribution information of obtaining ul-trasonic irradiation region by nuclear magnetic resonance.
Preferably, the anatomic image that obtains ul-trasonic irradiation region described in comprises: obtain the anatomic image in ul-trasonic irradiation region by ultrasonic imaging or the imaging of electronic computer x-ray tomography.
Preferably, the temperature distribution information of obtaining ul-trasonic irradiation region described in comprises: measure or the temperature distribution information in ul-trasonic irradiation region is obtained in ultrasound wave temperature survey by infrared temperature.
Accompanying drawing explanation
Fig. 1 is the component units schematic block diagram of the focusing supersonic wave treatment device of the embodiment of the present invention 3;
Fig. 2 is the process schematic diagram that generates monitoring image in the focusing supersonic wave treatment method of embodiments of the invention 3;
Fig. 3 is the monitoring image that the focusing supersonic wave treatment method of embodiments of the invention 3 obtains when bionical body mould is carried out to concentration ultrasonic irradiation;
Fig. 4 is the monitoring image that the focusing supersonic wave treatment method of embodiments of the invention 3 obtains when hysteromyoma is carried out to concentration ultrasonic irradiation;
Fig. 5 is the method schematic diagram that obtains OXYZ coordinate system and O ' X ' Y ' Z ' coordinate system position deviation in the focusing supersonic wave treatment method of embodiments of the invention 3.
The specific embodiment
For making those skilled in the art understand better technical scheme of the present invention, below in conjunction with the drawings and specific embodiments, the present invention is described in further detail.
Embodiment 1:
The present embodiment provides a kind of focusing supersonic wave treatment device, and it comprises:
For the ultrasonic therapeutic head of transmitting focusing ultrasound wave to treat.
Anatomic image acquiring unit, for obtaining the anatomic image in ul-trasonic irradiation region.
Temperature Distribution acquiring unit, for obtaining the temperature distribution information in ul-trasonic irradiation region.
Monitoring image generation unit, for generating monitoring image according to described anatomic image and temperature distribution information, described monitoring image comprises the anatomic image in ul-trasonic irradiation region and is at least positioned near the temperature distribution information of described concentration ultrasonic focus.
The focusing supersonic wave treatment device of the present embodiment has monitoring image generation unit, it can generate the monitoring image that comprises anatomic image and temperature distribution information, and monitoring image can embody the spatial information of position to be treated tissue simultaneously and organize the temperature information of each position; Because ultrasound wave can cause that tissue heats up and intensification degree is relevant with ultrasonic intensity (being focus level), therefore can accurately know the position (being the position that temperature is the highest) of concentration ultrasonic focus and it is controlled by analysis monitoring image (namely analyzing the Temperature Distribution of organizing diverse location place); Simultaneously, the temperature of tissue also can embody the intensity of variation (as coagulation necrosis degree) of tissue, therefore can real-time judge curative effect by analysis monitoring image, thereby adjust in time therapeutic scheme (as changed the position of concentration ultrasonic focus and adjusting ultrasound wave dosage etc.) according to curative effect, to reach best therapeutic effect.
Embodiment 2:
The present embodiment provides a kind of focusing supersonic wave treatment method, and it comprises and send the process of concentration ultrasonic to treat with ultrasonic therapeutic head, and also comprises the following steps: in therapeutic process
Obtain anatomic image and the temperature distribution information in ul-trasonic irradiation region.
Generate monitoring image according to described anatomic image and temperature distribution information, described monitoring image comprises the anatomic image in ul-trasonic irradiation region and is at least positioned near the temperature distribution information of described concentration ultrasonic focus.
Because the focusing supersonic wave treatment method of the present embodiment comprises the step that generates above-mentioned generation monitoring image, therefore it can accurately control by monitoring image position and the Real-Time Evaluation curative effect of concentration ultrasonic focus, thereby adjust in time therapeutic scheme, to reach best therapeutic effect.
Embodiment 3:
The present embodiment provides a kind of focusing supersonic wave treatment device and Therapeutic Method thereof.
As shown in Figure 1, the focusing supersonic wave treatment device of the present embodiment comprises ultrasonic therapeutic head, ultrasonic media units, anatomic image acquiring unit, Temperature Distribution acquiring unit, monitoring image generation unit.
Wherein, ultrasonic therapeutic head for sending concentration ultrasonic to treat under the driving of ultrasound-driven circuit.Ultrasonic therapeutic head can comprise the structures such as ultrasonic transducer, shell, support.Ultrasonic therapeutic head in focusing supersonic wave treatment device can be one or more, and in the time having multiple ultrasonic therapeutic head, the focus of the concentration ultrasonic that they send preferably overlaps.
Ultrasonic media units can comprise the ultrasonic media Containers for holding ultrasonic medium (as de aerated water etc.), and due to reasons such as safety, ultrasonic transducer can not directly contact with human body, and its ultrasound wave sending will import human body into through ultrasonic medium.The form of ultrasonic media Containers is various, and it can be " water tank " form, and ultrasonic therapeutic head can be soaked in the ultrasonic medium in water tank; Or ultrasonic media Containers also can be combined into one with ultrasonic therapeutic head, as ultrasonic medium being enclosed in the shell of ultrasonic therapeutic head (shell is ultrasonic media Containers).In addition, in ultrasonic media units, also can comprise ultrasonic media processes unit, the processing such as it is cooling for ultrasonic medium is carried out, purification, circulation.
Because above-mentioned ultrasonic therapeutic head, ultrasonic media units etc. all can be taked known structure, therefore be not described in detail at this.
Anatomic image acquiring unit is used for obtaining the anatomic image (being the space two-dimension image of position to be treated tissue) of ul-trasonic irradiation region (being position to be treated).Temperature Distribution acquiring unit is for obtaining the temperature distribution information (being the temperature of position, position to be treated) in ul-trasonic irradiation region.
Preferably, anatomic image acquiring unit and Temperature Distribution acquiring unit can be nuclear magnetic resonance (MRI, Magnetic Resonance Imaging) unit, above-mentioned ultrasonic media Containers (water tank) can be positioned at the imaging intracavity of nuclear magnetic resonance unit.
Nuclear magnetic resonance is the imaging technique of the signal acquisition object under test internal information that produces in nuclear magnetic resonance, NMR process according to atomic nucleus; By signal is carried out to different analyses, it both can obtain anatomic image, also can obtain temperature distribution information.
Nuclear magnetic resonance unit is known mature technology, the advantages such as it has, and spatial resolution is high, temperature resolving accuracy high (being less than 1 ℃), imaging time short (being less than 1 second), electromagnetic-radiation-free; And it can obtain anatomic image and temperature distribution information simultaneously, so both simplify equipment, can guarantee that again anatomic image and temperature distribution information, for same position, saved the process of adjusting the two position.
Preferably, anatomic image acquiring unit also can be ultrasonic imaging (B ultrasonic) unit or electronic computer x-ray tomography imaging (CT) unit; And Temperature Distribution acquiring unit also can be infrared temperature measuring unit or ultrasound wave temperature measurement unit.Certainly, anatomic image acquiring unit and Temperature Distribution acquiring unit also can be other form known, describe no longer one by one at this.
Monitoring image generation unit is for generating monitoring image according to above-mentioned anatomic image and temperature distribution information, and monitoring image comprises the anatomic image in ul-trasonic irradiation region and is at least positioned near the temperature distribution information of concentration ultrasonic focus.
That is to say, as shown in Figure 2, monitoring image generation unit can be monitoring image by anatomic image and temperature distribution information synthetic (" stack " in other words), this monitoring image both can represent the spatial image of position to be treated tissue, also can represent the temperature distribution state of its each position of therapentic part; Therefore, by observing monitoring image, therapist just can learn the temperature at diverse location place, position to be treated is how many, thereby according to position and the therapeutic effect of the real-time judgement concentration ultrasonic focus of this temperature, and adjust accordingly position and the therapeutic scheme of concentration ultrasonic focus, guarantee safety and the effectiveness for the treatment of.
Wherein, temperature distribution information is actual is the temperature data at different spatial place, and it can multiple different forms performance in monitoring image.
As a kind of mode that represents temperature distribution information, as shown in Figures 2 to 4, temperature distribution information can be the form of " temperature profile ", wherein represent that by different colors temperature range that everybody puts is (because of patent accompanying drawing netrual colour, therefore the different colours in accompanying drawing is presented as different gray scales), as blueness represents 45 ~ 50 ℃, cyan represents 50 ~ 55 ℃, yellow represents 55 ~ 60 ℃, and redness represents 60 ~ 110 ℃ etc.Obviously,, in monitoring image, temperature distribution information should not affect the demonstration of anatomic image.For reaching this purpose, can be as shown in Figure 3, Figure 4, in regulation " temperature profile ", the color corresponding with normal temperature range in human body (as 37 ℃) is " water white transparency "; Except the region of heating up because of ul-trasonic irradiation demonstrates different colours, the remainder of monitoring image only shows anatomic image like this.Or, also can preset the approximate range of focus area, and stipulate only to show the temperature distribution information within the scope of this, the temperature distribution information of other parts does not show, thereby exposes anatomic image.Again or, also can make " temperature profile " to there is higher transparency, like this in monitoring image can see through " temperature profile " see anatomic image.
As the another kind of mode that represents temperature distribution information, also available line marks off different Temperature Distribution regions, and indicates the temperature range value in each region by numeral.
In a word, the above-mentioned method that represents temperature distribution information in monitoring image is the part example of temperature distribution information method for expressing; Those skilled in the art also can adopt other diverse ways to represent temperature distribution information, as long as can embody anatomic image in monitoring image and at least be positioned near temperature distribution information focus simultaneously.
Preferably, focusing supersonic wave treatment device also comprises ultrasonic therapeutic head moving cell, and it is for driving ultrasonic therapeutic head to move and obtaining the positional information of ultrasonic therapeutic head, and the concrete structure of ultrasonic therapeutic head moving cell is known, is not described in detail at this.Like this, as shown in Figure 2, in the time generating monitoring image, also can utilize the positional information of ultrasonic therapeutic head in monitoring image, to generate the ultrasonic passage of simulation (sector region of light color in figure) and/or simulation ultrasound focus.
That is to say, ultrasonic therapeutic head can be can't help therapist hand-held, and by the driving of ultrasonic therapeutic head moving cell, thereby ultrasonic therapeutic head moving cell can record the positional information of ultrasonic therapeutic head, and extrapolate ultrasonic passage and the position of concentration ultrasonic focus in anatomic image by this positional information; Thereby as shown in Figure 3, Figure 4, also there is the ultrasonic passage of simulation (the fan-shaped frame of white in figure) and/or simulation ultrasound focus in monitoring image, thereby better guiding treatment.
Certainly, the focusing supersonic wave treatment device of the present embodiment also should comprise other known elements, for example: the power subsystem that is used to miscellaneous part power supply, for receiving the input block of the instruction that user assigns, for the display unit of display monitoring image, for control unit that each several part (ultrasound-driven circuit, ultrasonic therapeutic head moving cell, ultrasonic media processes unit etc.) is controlled etc.Wherein, middle control unit is the device with data-handling capacity, as central processing unit, programmable logic controller (PLC) etc.; For example, and monitoring image generation unit can be integrated with middle control unit (being a central processing unit), can be also two independently devices.
In the focusing supersonic wave treatment method of the present embodiment, use ultrasonic therapeutic head to send concentration ultrasonic to treat to patient's position to be treated.
Preferably, this concentration ultrasonic is continuous ultrasonic or pulse ultrasonic wave.
Further preferred, for pulse ultrasonic wave, its persistent period (launching hyperacoustic time), interval time, (stopping occurring hyperacoustic time) was at 2 ~ 8 seconds at 2 ~ 8 seconds.
Why preferably use the pulse ultrasonic wave with above-mentioned parameter, because conventionally judge that by monitoring image focal position and therapeutic effect need certain hour, and the renewal of monitoring image also needs certain hour, and the persistent period of above-mentioned pulse ultrasonic wave is not oversize, therefore need the long period could tissue be produced and be destroyed, so just can be therapist and reserve time enough, avoid, because reacting not as good as the damage that causes normal structure, guaranteeing the safety for the treatment of; Meanwhile, the persistent period of above-mentioned pulse ultrasonic wave is also not too short, therefore can produce variations in temperature within a short period of time, so that therapist can be observed in time therapeutic effect and adjust therapeutic scheme, guarantees therapeutic efficiency.
In the process for the treatment of with above-mentioned concentration ultrasonic, the ultrasonics therapy method of the present embodiment is further comprising the steps of:
S01, the anatomic image that obtains ul-trasonic irradiation region and temperature distribution information.
Preferably, in the time that anatomic image acquiring unit and Temperature Distribution acquiring unit are nuclear magnetic resonance unit, the anatomic image in ul-trasonic irradiation region and temperature distribution information all can be obtained by nuclear magnetic resonance mode; Its detailed process can comprise:
S011, starting to launch before ultrasound wave, obtain amplitude and the phase diagram of the gradin-echo (GRE sequence) of nuclear magnetic resonance unit, obtain anatomic image by analyzing the amplitude of gradin-echo.
After S012, certain hour (as 1 second), again obtain amplitude and the phase diagram of gradin-echo, obtain new anatomic image by the amplitude of gradin-echo, by proton resonance frequency deviation method (PRFS, Proton Resonance FrequencyShift) two phase diagrams and obtain phase contrast figure relatively, obtain again the temperature change value of each position, ul-trasonic irradiation region from phase contrast figure, and draw temperature distribution information according to this temperature change value.
S013, repeat S012 step, thereby constantly obtain anatomic image and temperature distribution information.
Wherein, whether there is displacement by the health that can judge patient in therapeutic process that whether changes of anatomic image relatively, thereby improved the safety for the treatment of.Meanwhile, in the time that anatomic image changes (patient body has displacement), also there is variation in the physical location of phase diagram, therefore also will be first by two amplitude phase diagrams " alignment " before calculating phase contrast figure.
Wherein, the method for obtaining temperature distribution information by phase contrast figure (being temperature change value scattergram) is various.For example, each phase diagram all can be compared with the phase diagram (phase diagram of obtaining in S011 step) of transmitting before ultrasound wave and obtain phase contrast figure, because each point temperature in the phase diagram before transmitting ultrasound wave is the normal temperature (as 37 ℃) in human body, therefore the temperature change value of phase contrast figure any point adds 37 ℃ of real time temperatures that are this point.Or, also can by each phase diagram all with its before phase diagram comparison and obtain phase contrast figure, the difference of this method and above method is that need to carry out " adding up " to the variations in temperature of each phase contrast figure obtains real time temperature.
Certainly, more than just obtain an example of anatomic image and temperature distribution information by nuclear magnetic resonance, its detailed process can have many differences: as used other the sequence such as spin-echo sequence (SE sequence) to calculate, also can use other algorithms outside proton free resonant frequency shift method etc.
Preferably, anatomic image also can obtain by the mode of ultrasonic imaging or the imaging of electronic computer x-ray tomography; And temperature distribution information also can be measured or the thermometric mode of ultrasound wave is obtained by infrared temperature.Certainly,, if adopt other mode to obtain anatomic image and temperature distribution information is also feasible, be not described in detail at this.
S02, generate monitoring image according to anatomic image and temperature distribution information, monitoring image comprises the anatomic image in ul-trasonic irradiation region and is at least positioned near the temperature distribution information of concentration ultrasonic focus.
That is to say, as shown in Figure 2, constantly by anatomic image together with temperature distribution information " stack " to generate in real time monitoring image; In monitoring image, temperature distribution information can be expressed by above-mentioned mode.
Obviously, the computing of obtaining monitoring image by anatomic image and temperature distribution information has multiple diverse ways, therefore no longer its concrete calculating process is described in detail at this.
It should be noted that, when anatomic image and temperature distribution information are obtained (as obtained anatomic image by ultrasonic imaging by different modes, and obtain temperature distribution information by infrared temperature measurement) time, they may be for patient body different parts; Should be for same position and generate the anatomic image used of monitoring image and temperature distribution information, otherwise can cause anatomic image and temperature distribution information " dislocation " or " not corresponding " in monitoring image.
For fear of above-mentioned " dislocation " problem, can adopt diverse ways.For example, the relative position between anatomic image acquiring unit and Temperature Distribution acquiring unit can be fixed (being that the two must be synchronized with the movement), thereby guarantees that the two always obtains the information of same area.Or, if anatomic image acquiring unit and Temperature Distribution acquiring unit when independent respectively can carry out " para-position " generating the anatomic image/temperature distribution information that obtain the two before monitoring image; The method of this para-position is also various, if anatomic image acquiring unit and Temperature Distribution acquiring unit are driven by motion separately respectively, can be by they are converted and know their relative position in the position in motion separately, then according to this relative position, anatomic image/temperature distribution information is carried out to para-position; Or, energy also can be set simultaneously by the marker of anatomic image and temperature distribution information embodiment, and by the marker alignment in anatomic image/temperature distribution information is realized to para-position.
Preferably, as shown in Figures 2 to 4, in the time that ultrasonic therapeutic head is driven by ultrasonic therapeutic head moving cell, in the process that generates monitoring image, also can in monitoring image, generate according to the positional information of ultrasonic therapeutic head the ultrasonic passage of simulation and/or simulation ultrasound focus.
Obviously, ultrasonic therapeutic head can, with respect to anatomic image acquiring unit (take nuclear magnetic resonance unit as example) motion, also change therefore simulate the position of ultrasonic passage (or simulation ultrasound focus) in monitoring image; Therefore, generating when monitoring image, the relative position relation of ultrasonic therapeutic head and nuclear magnetic resonance unit must be first known, thereby ultrasonic passage (or simulating ultrasound focus) will be simulated and be superimposed upon the proper position of anatomic image.
Wherein, the method for determining the relative position relation of ultrasonic therapeutic head and nuclear magnetic resonance unit is various.For example, can set up respectively the coordinate system OXYZ that represents nuclear magnetic resonance cell position and the coordinate system O ' X ' Y ' Z ' that represents ultrasonic therapeutic head position, like this in therapeutic process, nuclear magnetic resonance unit and the ultrasonic therapeutic head position in coordinate system is separately known; Therefore, as shown in Figure 5, as long as determine that position deviation Δ X, Δ Y, the Δ Z of two coordinate origins in X, Y, Z direction can convert to the position in two coordinate systems, also just can obtain the position of ultrasonic therapeutic head in the coordinate system OXYZ of nuclear magnetic resonance unit, thereby can draw the position of the ultrasonic passage of simulation (or simulation ultrasound focus) in anatomic image.
Certainly, an above-described example just determining ultrasonic therapeutic head and nuclear magnetic resonance unit relative position relation, its concrete methods of realizing also has a lot: for example, nuclear magnetic resonance unit and ultrasonic therapeutic head moving cell can by controlling in one, unit is unified controls (being that the two can adopt identical coordinate system), controls like this unit and can directly draw the position relationship of the two in this.
Obviously, as shown in Figure 3, Figure 4, in the monitoring image that the focusing supersonic wave treatment method of the present embodiment generates, also can comprise much other information, for example various parameters for corresponding relation, the image acquisition time (picture number in other words) of statistical data (area of maximum temperature, minimum temperature, mean temperature, each temperature province etc.), temperature and the color of Temperature Distribution, in treating etc.
Be understandable that, above embodiment is only used to principle of the present invention is described and the illustrative embodiments that adopts, but the present invention is not limited thereto.For those skilled in the art, without departing from the spirit and substance in the present invention, can make various modification and improvement, these modification and improvement are also considered as protection scope of the present invention.
Claims (12)
1. a focusing supersonic wave treatment device, comprises the ultrasonic therapeutic head to treat for transmitting focusing ultrasound wave, it is characterized in that, described focusing supersonic wave treatment device also comprises:
Anatomic image acquiring unit, for obtaining the anatomic image in ul-trasonic irradiation region;
Temperature Distribution acquiring unit, for obtaining the temperature distribution information in ul-trasonic irradiation region;
Monitoring image generation unit, for generating monitoring image according to described anatomic image and temperature distribution information, described monitoring image comprises the anatomic image in ul-trasonic irradiation region and is at least positioned near the temperature distribution information of described concentration ultrasonic focus.
2. ultrasonic treatment unit according to claim 1, is characterized in that, also comprises ultrasonic therapeutic head moving cell, and it is for driving described ultrasonic therapeutic head to move and obtaining the positional information of ultrasonic therapeutic head; And
Described monitoring image generation unit, in the time generating monitoring image, also utilizes the positional information of ultrasonic therapeutic head in monitoring image, to generate the ultrasonic passage of simulation and/or simulation ultrasound focus.
3. ultrasonic treatment unit according to claim 1 and 2, is characterized in that,
Described anatomic image acquiring unit and Temperature Distribution acquiring unit are nuclear magnetic resonance unit.
4. ultrasonic treatment unit according to claim 1 and 2, is characterized in that,
Described anatomic image acquiring unit is ultrasonic imaging unit or electronic computer x-ray tomography image-generating unit.
5. ultrasonic treatment unit according to claim 1 and 2, is characterized in that,
Described Temperature Distribution acquiring unit is infrared temperature measuring unit or ultrasound wave temperature measurement unit.
6. a focusing supersonic wave treatment method, it comprises and sends the process of concentration ultrasonic to treat with ultrasonic therapeutic head, it is characterized in that, in therapeutic process, also comprises:
Obtain anatomic image and the temperature distribution information in ul-trasonic irradiation region;
Generate monitoring image according to described anatomic image and temperature distribution information, described monitoring image comprises the anatomic image in ul-trasonic irradiation region and is at least positioned near the temperature distribution information of described concentration ultrasonic focus.
7. focusing supersonic wave treatment method according to claim 6, is characterized in that, described ultrasonic therapeutic head is subject to the driving of ultrasonic therapeutic head moving cell and moves, and described ultrasonic therapeutic head moving cell can obtain the positional information of ultrasonic therapeutic head; And
In the time generating monitoring image, also in monitoring image, generate the ultrasonic passage of simulation and/or simulation ultrasound focus according to the positional information of described ultrasonic therapeutic head.
8. focusing supersonic wave treatment method according to claim 6, is characterized in that,
Described concentration ultrasonic is pulse ultrasonic wave or continuous ultrasonic.
9. focusing supersonic wave treatment method according to claim 8, is characterized in that,
Described concentration ultrasonic is pulse ultrasonic wave, and the persistent period of described pulse ultrasonic wave, interval time was between 2 ~ 8 seconds between 2 ~ 8 seconds.
10. according to the focusing supersonic wave treatment method described in any one in claim 6 to 9, it is characterized in that, described in obtain ul-trasonic irradiation region anatomic image and temperature distribution information comprise:
Obtain anatomic image and the temperature distribution information in ul-trasonic irradiation region by nuclear magnetic resonance.
11. according to the focusing supersonic wave treatment method described in any one in claim 6 to 9, it is characterized in that, described in obtain ul-trasonic irradiation region anatomic image comprise:
Obtain the anatomic image in ul-trasonic irradiation region by ultrasonic imaging or the imaging of electronic computer x-ray tomography.
12. according to the focusing supersonic wave treatment method described in any one in claim 6 to 9, it is characterized in that, described in obtain ul-trasonic irradiation region temperature distribution information comprise:
Measure or the temperature distribution information in ul-trasonic irradiation region is obtained in ultrasound wave temperature survey by infrared temperature.
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| CN108904038A (en) * | 2018-08-29 | 2018-11-30 | 安徽声达愈医疗器械有限公司 | A kind of focusing ultrasonic therapeutic system and its control method |
| CN109999376A (en) * | 2019-03-19 | 2019-07-12 | 深圳市声科生物医学研究院 | A kind of HIFU apparatus control system and its noninvasive temperature estimation method |
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