CN205809045U - A kind of self-control detection drug dissolution auxiliary device - Google Patents
A kind of self-control detection drug dissolution auxiliary device Download PDFInfo
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- CN205809045U CN205809045U CN201620731742.6U CN201620731742U CN205809045U CN 205809045 U CN205809045 U CN 205809045U CN 201620731742 U CN201620731742 U CN 201620731742U CN 205809045 U CN205809045 U CN 205809045U
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- Prior art keywords
- basket
- perforated metal
- self
- auxiliary device
- metal tube
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Abstract
The utility model discloses a kind of self-control detection drug dissolution auxiliary device, including sedimentation basket, basket bar, perforated metal tube and stripping cup cap, basket bar is weldingly fixed on the centre of sedimentation basket, and basket bar is connected with perforated metal tube, and perforated metal tube welds together with stripping cup cap；Sedimentation basket includes acid metal card and acid metal support；Basket bar is passed by the hole in the middle of described perforated metal tube, and perforated metal inside pipe wall has screw thread；Basket bar is provided with screw thread；Stripping cup cap is provided with hole, perforated metal tube and described stripping cup cap and welds together.This utility model can make sedimentation basket be fixed on same position and same direction, different directions is had when settling under prior art at the bottom of basket is sunken to glass, and because hydrodynamics is complicated, settle basket position in cup and aspect effect drug-eluting, thus causing experimental error, this utility model improves accuracy and the repeatability of drug test；This utility model is with low cost, simple to operation, it is simple to promote.
Description
Technical field
This utility model belongs to medicine inspection field, specifically, relates to a kind of self-control detection drug dissolution auxiliary device.
Background technology
Most of oral solid formulations can must be played after reaching certain blood drug level through being absorbed into blood circulation
Effect.Therefore, drug release to be dissolved in body fluid be absorbed premise.This process is referred to as dissolution, tablet, capsule or
Speed and the degree of the dissolution under prescribed conditions of the solid preparations such as granule are referred to as dissolution.Owing to the dissolution of medicine directly affects
Medicine absorption in vivo and utilization, Dissolution Rate Testing has become one of important indicator evaluating the quality of the pharmaceutical preparations and production technology.
When preparation variety checks dissolution, paddle method is usually used in the detection of some tablet.During mensuration, sometimes because of sheet
The phenomenons such as agent floating, have a direct impact detection, and this is the most direct on the impact of release.Abroad when doing this series products sometimes
Adding the device of a silk screen sample, we are sedimentation basket, position and the dissolving acreage of tablet are relatively fixed, and improve due to preparation position
The impact that determination data is produced by the change put.Floating on liquid level for some tablet, Chinese Pharmacopoeia also requires that sample should be initially charged with
Detecting in sedimentation basket, the sedimentation basket that Chinese Pharmacopoeia specifies is made up of acid metal card and acid metal support.It passes through
Medicine is directly loadable into sedimentation basket, puts in stripping rotor.At the bottom of sinking to glass due to sedimentation basket, and the direction settling basket is also
Inconsistent, therefore medicine dissolving out experimental process is easily impacted by the motion of solution, makes dissolution investigate the accurate of result
Degree and poor repeatability mutation are big.
Utility model content
In view of this, technical problem to be solved in the utility model is that self-control detection drug dissolution auxiliary device is at medicine
How cannot not dip fixingly during the detection of thing dissolution the impact on drug test.
In order to solve above-mentioned technical problem, the utility model discloses a kind of self-control detection drug dissolution auxiliary device,
Including sedimentation basket, basket bar, perforated metal tube and stripping cup cap, described basket bar is weldingly fixed on the centre of described sedimentation basket, described
Basket bar is connected with described perforated metal tube, and described perforated metal tube welds together with described stripping cup cap.
Further, described sedimentation basket includes acid metal card and acid metal support, described acid metal card and acidproof
The hole internal diameter of metal rack is 3.5 ± 0.5mm, a length of 25mm ± 1mm of described acid metal support, a diameter of 12mm ±
0.2mm。
Further, described basket bar is passed by the hole in the middle of described perforated metal tube, and described perforated metal inside pipe wall has spiral shell
Stricture of vagina, hole internal diameter is 5mm ± 0.3mm.
Further, described basket bar is provided with screw thread, and a length of 180mm ± 2mm of described basket bar, a diameter of 5mm ±
0.2mm。
Further, described stripping cup cap is provided with hole, and described stripping cup cap uses acid metal material, described gold with holes
Belong to pipe and described stripping cup cap welds together.
Further, described basket bar uses acid metal material.
Further, described perforated metal tube uses acid metal material.
Compared with prior art, this utility model can obtain and include techniques below effect:
1) this utility model can make sedimentation basket be fixed on same position and same direction, settles basket and be sunken under prior art
Have different directions during the cup end, and because hydrodynamics is complicated, settle basket position in cup and aspect effect drug-eluting,
Thus causing experimental error, this utility model improves accuracy and the repeatability of drug test.
2) this utility model can pass through basket bar position described in threaded adjusting, and then regulation is put for reagent grade, makes experiment
More accurate.
3) this utility model is with low cost, simple to operation, it is simple to promote.
Certainly, implement arbitrary product of the present utility model must be not necessarily required to reach all the above technology effect simultaneously
Really.
Accompanying drawing explanation
Accompanying drawing described herein is used for providing being further appreciated by of the present utility model, constitutes one of the present utility model
Point, schematic description and description of the present utility model is used for explaining this utility model, is not intended that of the present utility model
Improper restriction.In the accompanying drawings:
Fig. 1 is a kind of schematic diagram making detection drug dissolution auxiliary device by oneself of this utility model embodiment.
Detailed description of the invention
Embodiment of the present utility model is described in detail below in conjunction with drawings and Examples, thereby please to utility model
How application technology means solve technical problem and reach the process that realizes of technology effect and can fully understand and implement according to this.
A kind of self-control detection drug dissolution auxiliary device that this utility model provides, it is adaptable to dissolution testing side
Paddle method in method, as it is shown in figure 1, include settling basket 100, basket bar 200, perforated metal tube 300 and stripping cup cap 400, described basket
Bar 200 is weldingly fixed on the centre of described sedimentation basket 100, and described basket bar 200 is connected with described perforated metal tube 300, described band
Mesoporous metal pipe 300 welds together with described stripping cup cap 400.
In the present embodiment, stripping rotor is the round bottom beaker of 1000ml, and internal diameter is 98～106mm high 160～175mm；Beaker
On have described stripping cup cap 400, cover porose, centre bore is the position of loom.
For making process container keep constant temperature, answering overcoat water-bath, the temperature of water-bath should be able to make the temperature of container internal solvent keep
At 37 ± 0.5 DEG C.
Stirring paddle is made of stainless steel, and described loom upper diameter is 9.4～10.1mm, and described loom lower diameter is
6.0 ± 0.2mm, during rotation, amplitude of fluctuation must not exceed ± 0.5mm.
Sample point should be in blade upper end in the middle of liquid level, and away from walls of beaker 6mm, bottom blade, the distance from beaker bottom is
15±1mm。
Motor is connected with loom, and rotating speed can arbitrarily regulate at 25～100 turns per minute, and speed stabilizing error is less than ± 1 turn,
Move package unit when turning and answer held stationary, must not rock or vibrate.
In the present embodiment, described sedimentation basket 100 includes acid metal card and acid metal support, described acid metal card and
The hole internal diameter of acid metal support is 3.5 ± 0.5mm, a length of 25mm ± 1mm of described acid metal support, a diameter of 12mm
± 0.2mm, described acid metal card can raise, and test sample puts in described sedimentation basket from there；Bottom described sedimentation basket 100
It is 10mm away from oar upper limb distance.
In the present embodiment, described basket bar 200 is passed by the hole in the middle of described perforated metal tube 300, described perforated metal tube
300 inwalls have screw thread, hole internal diameter to be 5mm ± 0.3mm.
In the present embodiment, described basket bar 200 is provided with screw thread, and a length of 180mm ± 2mm of described basket bar 200 is a diameter of
5mm ± 0.2mm, described basket bar can pass through screw thread up-down adjustment position.
In the present embodiment, described stripping cup cap 400 is provided with hole, and described stripping cup cap 400 uses acid metal material, institute
Stating perforated metal tube 300 and described stripping cup cap 400 welds together, described perforated metal tube 300 center is in loom
Heart distance is 30mm.
In the present embodiment, described basket bar 200 uses acid metal material, to prevent from experiment is produced impact, and also described
Basket bar 200 should have certain degree of hardness, described sedimentation basket 100 position can be made to fix, be difficult to rock；Use stainless resistance in the present embodiment
Acid steel (GB2100-80).
In the present embodiment, described perforated metal tube 300 uses acid metal material, because the dissolution fluid of this instrument is typically
Acidity or weakly alkaline solution, therefore use acidproof metal material.
In the present embodiment, measure the solvent 900ml of degassed process, inject in stripping rotor, heat and make solvent temperature protect
Hold at 37 ± 0.5 DEG C.
Take test sample 6 (individual), put into respectively in 6 described sedimentation baskets 100, start immediately and rotate and start timing,
Regulation sample point draw solution is appropriate, filters through 0.45 μm microporous filter membrane immediately, from sampling to filtering and should complete in 30 seconds.
Take filtrate, measure according to the method for regulation under each medicine item, calculate the stripping quantity of every (individual).
Also, it should be noted term " includes ", " comprising " or its any other variant are intended to nonexcludability
Comprise, so that include that the commodity of a series of key element or system not only include those key elements, but also include the most clearly
Other key elements listed, or also include the key element intrinsic for this commodity or system.In the feelings not having more restriction
Under condition, statement " including ... " key element limited, it is not excluded that in the commodity including described key element or system also
There is other identical element.
Described above illustrate and describes some preferred embodiments of the present utility model, but as previously mentioned, it should be understood that this
Utility model is not limited to form disclosed herein, is not to be taken as the eliminating to other embodiments, and can be used for various
Other combinations, amendment and environment, and can be in utility model contemplated scope described herein, by above-mentioned teaching or association area
Technology or knowledge be modified.And the change that those skilled in the art are carried out and change are without departing from spirit of the present utility model and model
Enclose, the most all should be in the protection domain of this utility model claims.
Claims (7)
1. one kind self-control detection drug dissolution auxiliary device, it is characterised in that include settle basket, basket bar, perforated metal tube and
Stripping cup cap, described basket bar is weldingly fixed on the centre of described sedimentation basket, and described basket bar is connected with described perforated metal tube, described
Perforated metal tube welds together with described stripping cup cap.
2. self-control detection drug dissolution auxiliary device as claimed in claim 1, it is characterised in that described sedimentation basket includes resistance to
Acid metal card and acid metal support, the hole internal diameter of described acid metal card and acid metal support is 3.5 ± 0.5mm, described
A length of 25mm ± the 1mm of acid metal support, a diameter of 12mm ± 0.2mm.
3. self-control detection drug dissolution auxiliary device as claimed in claim 2, it is characterised in that described basket bar is by described band
Hole in the middle of mesoporous metal pipe passes, and described perforated metal inside pipe wall has screw thread, hole internal diameter to be 5mm ± 0.3mm.
4. self-control detection drug dissolution auxiliary device as claimed in claim 3, it is characterised in that described basket bar is provided with spiral shell
Stricture of vagina, a length of 180mm ± 2mm of described basket bar, a diameter of 5mm ± 0.2mm.
5. self-control detection drug dissolution auxiliary device as claimed in claim 4, it is characterised in that set on described stripping cup cap
Porose, described stripping cup cap uses acid metal material, and described perforated metal tube and described stripping cup cap weld together.
6. self-control detection drug dissolution auxiliary device as claimed in claim 5, it is characterised in that described basket bar uses acidproof
Metal material.
7. self-control detection drug dissolution auxiliary device as claimed in claim 6, it is characterised in that described perforated metal tube is adopted
Use acid metal material.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201620731742.6U CN205809045U (en) | 2016-07-12 | 2016-07-12 | A kind of self-control detection drug dissolution auxiliary device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201620731742.6U CN205809045U (en) | 2016-07-12 | 2016-07-12 | A kind of self-control detection drug dissolution auxiliary device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN205809045U true CN205809045U (en) | 2016-12-14 |
Family
ID=57510144
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201620731742.6U Expired - Fee Related CN205809045U (en) | 2016-07-12 | 2016-07-12 | A kind of self-control detection drug dissolution auxiliary device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN205809045U (en) |
-
2016
- 2016-07-12 CN CN201620731742.6U patent/CN205809045U/en not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20161214 Termination date: 20180712 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |