CN205460520U - Beam shaper for neutron -capture therapy - Google Patents
Beam shaper for neutron -capture therapy Download PDFInfo
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- CN205460520U CN205460520U CN201620017409.9U CN201620017409U CN205460520U CN 205460520 U CN205460520 U CN 205460520U CN 201620017409 U CN201620017409 U CN 201620017409U CN 205460520 U CN205460520 U CN 205460520U
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Abstract
The utility model provides a beam shaper for neutron -capture therapy, neutron capture treatment is including being used for for the accelerated accelerating tube of proton beam, the target of the beam shaping body including the beam entry, in locating the accelerating tube, border on in the slow fast body of target, encirclement are in slowly fast external reflector, with it is in to delay the fast thermal neutron absorption body, the setting of bordering on of personally experiencing sth. Part of the body internal radiation shield and the beam outlet of beam shaping, the beam shaping body still have a cooling device, cooling device including the first cooling portion that is used for cooling off the target, respectively along be on a parallel with with higher speed that axial direction of the pipe extends and with the second cooling portion and the third cooling portion of first cooling portion intercommunication, first cooling portion and the contact of target plane, second cooling portion exports to the input coolant of first cooling portion, the coolant in the first cooling portion of third cooling inferior officer. Cool off the target through setting up cooling device through this application beam shaper for neutron -capture therapy, simple structure, the assembly is easy.
Description
Technical field
This utility model relates to a kind of beam-shaping body, particularly relates to a kind of beam-shaping body for neutron capture treatment.
Background technology
Along with the development of atomics, the radiation cure such as such as cobalt 60, linear accelerator, electron beam has become cancer and has controlled
One of Main Means treated.But conventional photonic or electronic therapy are limited by the physical condition of lonizing radiation own, are killing tumor
While cell, also normal structure substantial amounts of in beam approach can be damaged；Sensitive to lonizing radiation additionally, due to tumor cell
The difference of degree, traditional radiation therapy is for relatively having the malignant tumor of radiation resistance (such as: multirow glioblastoma multiforme
(glioblastoma multiforme), melanocytoma (melanoma)) treatment effect the best.
In order to reduce the radiation injury of tumor surrounding normal tissue, the target therapy concept in chemotherapy (chemotherapy) is just
It is applied in radiation cure；And for the tumor cell of radiation resistance, currently also actively development has high Relative biological effect
Answer the radiation source of (relative biological effectiveness, RBE), as proton therapeutic, heavy particle therapy, neutron capture are controlled
Treat.Wherein, neutron capture treatment is to combine above two concept, as boron neutron capture is treated, by boracic medicine swollen
The specificity of oncocyte gathers, and coordinates neutron beam regulation and control accurately, it is provided that treatment of cancer more more preferable than conventional radiation selects.
In accelerator boron neutron capture is treated, proton beam is accelerated by the treatment of accelerator boron neutron capture by accelerator, described matter
Son bundle accelerates to the energy that be enough to overcome target atom core coulomb repulsion, with described target generation nuclear reaction to produce neutron, therefore
During producing neutron, target can be subject to irradiating of the accelerating proton bundle of very same high-energy level, and the temperature of target can significantly go up
Rise, thus affect the service life of target.
Therefore, it is necessary to provide a kind of new technical scheme to solve the problems referred to above in fact.
Utility model content
In order to solve the problems referred to above, an aspect of the application provides the beam-shaping body for neutron capture treatment, described neutron
Capture treatment includes the accelerating tube for accelerating to proton beam, and described beam-shaping body includes beam entrance, is located in accelerating tube
Target, it is adjacent to the slow body of described target, is enclosed in adjacent the hankering of the most external described reflector and described slow body
Sub-absorber, the radiation shield being arranged in described beam-shaping body and beam outlet, described target enters with from described beam entrance
The proton beam generation nuclear reaction penetrated is to produce neutron, and described neutron forms neutron beam, and described slow body will produce from described target
Neutron degradation to epithermal neutron energy district, the neutron that described reflector will deviate from back to described slow body with improve epithermal neutron penetrate
Beam intensity, described thermal neutron absorber is used for when absorbing thermal neutron to avoid treating causing multiple dose with shallow-layer normal structure, institute
Stating radiation shield for shielding the neutron of seepage and photon to reduce the normal tissue dose in non-irradiated district, wherein, described beam is whole
Body also has chiller, and described chiller includes the first cooling end for cooling down target, respectively along being parallel to accelerating tube
Axis direction extends and the second cooling end of connecting with the first cooling end and the 3rd cooling end, described first cooling end and target plane
Contact, described second cooling end is to the first cooling end input cooling medium, and the 3rd cooling end is by the cooling medium in the first cooling end
Output.
So-called " extending along being parallel to accelerating tube axis direction " refers to cooling end (no matter the second cooling end or the 3rd cooling end)
Bearing of trend on the whole be one end from accelerating tube (as hereafter it is to be mentioned that accelerating tube embed the end of section) towards another
End (as hereafter it is to be mentioned that accelerating tube extension away from embed section end) have extension trend, if cooling end is with corrugated
Pipeline extends to the other end from one end of accelerating tube, or cooling end extends to another with spiral pipeline from one end of accelerating tube
End.
Further, described accelerating tube includes embedding section and extension, and described target is located at accelerating tube and is embedded the end of section, described
Embedding section to be embedded in slow body, described extension extends slow external side and is surrounded by reflector, described first cooling position
Between target and slow body, described second cooling end and the 3rd cooling end edge are parallel to accelerating tube axis direction and extend to accelerating tube
Embed the outside of section and be positioned in beam-shaping body.
Because accelerating tube is embedded in slow body, for the ease of to the cooling of target in embedded accelerating tube, chiller being arranged
For Contraband type structure.Specifically, described first cooling end is positioned at the end of accelerating tube and contacts with described target plane, described second
Cooling end and the 3rd cooling end lay respectively at the both sides up and down of accelerating tube and form Contraband type structure with the first cooling end.Art technology
Personnel know ground, and the both sides up and down that the second cooling end and the 3rd cooling end are arranged on accelerating tube are intended only as preferred embodiment.When
So, the second cooling end and the 3rd cooling end can also be not arranged in the both sides up and down of accelerating tube, such as can by the second cooling end also
Row is arranged on the side of accelerating tube.
Further, described second cooling end and the 3rd cooling end are all the tubular structures being made of copper, described second cooling end and
3rd cooling end is respectively perpendicular to target and the contact plane of the first cooling end.
Further, described first cooling end includes that the first contact site directly contacted with target contacts with slow body second connects
Contact portion and the cooling bath passed through for cooling medium between the first contact site and the second contact site, described cooling bath has and the
The input slot of two cooling ends connections and the output magazine that connects with the 3rd cooling end.
In order to make cooling medium input from cooling bath more swimmingly or export, can also drop to a certain extent simultaneously
Low cooling bath cools down the hydraulic pressure of water.The upper edge of described input slot is positioned at the top of the upper edge of the second cooling end, described output
The lower edge of groove is positioned at the lower section of the lower edge of the 3rd cooling end.
In order to relatively reasonably control the size of slow body, make the neutron beam of generation reach the most slow effect, make simultaneously
Beam-shaping body obtains preferable beam quality, further, described slow body is set to have at least one pyramidal knot
Structure.Described cone-shaped have first end, the second end and connect first end and the main part of the second end, described accelerating tube
Embedding section be positioned between pyramidal first end and the second end, described first cooling end is positioned at target and pyramidal second
Between end.
Described target includes lithium target layer, is positioned at the anti oxidation layer that lithium target layer side aoxidizes for preventing lithium target layer.
For the cooling of beneficially target, further, described first contact site by Heat Conduction Material or heat conduction can suppress again foaming
Material make, described second contact site by suppress foaming material make.It is to say, the first contact site and the second contact site
Can as an entirety by can heat conduction again can suppress foaming material make, or the first contact site by ratio suppression foaming
The more preferable Heat Conduction Material of heat conductivility of material is made, and the second contact site is made up of the material suppressing foaming.So arrange, favorably
Heat radiation and suppression foaming in target.
Described anti oxidation layer is made up of Al or rustless steel, when described first contact site by can heat conduction again can suppress foaming material
When making, described first contact site selected from any one of Fe, Ta or V, arbitrary by Fe, Ta or V of described second contact site
Planting and make, described cooling medium is water.
Compared with prior art, the application has the advantages that the beam-shaping body that the application treats for neutron capture leads to
Crossing and arrange chiller and cool down target, simple in construction, assembling easily, and is obtained in that the neutron beam of higher quality.
" cone " or " cone-shaped " described in the embodiment of the present application refers to along the side of direction as shown to its foreign steamer of opposite side
The structure that wide overall trend tapers into, a wherein contour line of outline can be line segment, corresponding such as cone shape
Contour line, it is also possible to be circular arc, such as the corresponding contour line of sphere body shape, the whole surface of outline can be rounding off,
Can also be non-rounding off, as done a lot of projection and groove on the surface of cone shape or sphere body shape.
Term described in the embodiment of the present application " contacts ", " connection " etc. refers to that the connection between two or more component all includes
Directly and indirectly, " directly contact " and " indirectly contacting " are i.e. included；" directly connection " and " indirectly connecting ".
Accompanying drawing explanation
Fig. 1 is the schematic diagram of the firing rate shaping body that the application treats for neutron capture；
Fig. 2 is the chiller schematic diagram of the application Contraband type structure；
Fig. 3 is the schematic diagram of the chiller of the application I type structure；
Fig. 4 is the target material structure schematic diagram of the application.
Detailed description of the invention
Neutron capture is treated the application in recent years of the means as a kind of effective treatment cancer and is gradually increased, and wherein catches with boron neutron
Obtaining treatment most commonly seen, the neutron of supply boron neutron capture treatment can be by nuclear reactor or accelerator supply.The enforcement of the application
Example is as a example by accelerator boron neutron capture is treated, and the basic module of accelerator boron neutron capture treatment generally includes for band electrochondria
Accelerator, neutron generating unit and hot removal system and the beam-shaping body that son (such as proton, deuteron etc.) is accelerated, wherein
Accelerate charged particle and produce neutron with metal neutron generating unit effect, according to required neutron yield rate and energy, available acceleration
Charged particle energy and size of current, the characteristic such as materialization of metal neutron generating unit select suitable nuclear reaction, often come into question
Nuclear reaction have7Li(p,n)7Be and9Be(p,n)9B, both reactions are all the endothermic reaction.The energy threshold of two kinds of nuclear reactions is divided
Not Wei 1.881MeV and 2.055MeV, due to boron neutron capture treatment the epithermal neutron that preferable neutron source is keV energy grade,
If using energy to be only slightly taller than the proton bombardment lithium metal neutron generating unit of threshold values in theory, the neutron of relative mental retardation can be produced, no
Too many slow process must just can be used for clinic, but lithium metal (Li) and two kinds of neutron generating units of beryllium metal (Be) and threshold values
The proton-effect cross section of energy is the highest, for producing sufficiently large neutron flux, generally selects the proton of higher-energy to carry out initiated core anti-
Should.
Preferably target should possess high neutron yield rate, the neutron energy distribution of generation (will in detail below close to epithermal neutron energy district
Describe), wear the most by force the characteristics such as radiation produces, safety is the most easily operated and high temperature resistant without too many, but actually and cannot find and meet
The nuclear reaction required, uses the target that lithium metal is made in embodiments herein.But it is well known to those skilled in the art,
The material of target can also be made up of other metal materials in addition to the above-mentioned metal material talked about.
Requirement for hot removal system is then different according to the nuclear reaction selected, as7Li(p,n)7Be is because of metal targets (lithium metal)
Fusing point and thermal conductivity coefficient poor, to the requirement of hot removal system the most relatively9Be(p,n)9B is high.Embodiments herein uses7Li(p,n)7The nuclear reaction of Be.It follows that the temperature of the target irradiated by the accelerating proton bundle of same high-energy level will necessarily be big
Width rises, thus affects the service life of target.
No matter the neutron source of boron neutron capture treatment is from the nuclear reaction of nuclear reactor or accelerator charged particle with target, generation
Be all mixed radiation field, i.e. beam contains mental retardation to the neutron of high energy, photon；Boron neutron capture for deep tumor is treated,
In addition to epithermal neutron, remaining radiation content is the most, and the ratio causing the non-selective dosage of normal structure to deposit is the biggest, because of
These these the radiation of unnecessary dosage can be caused to reduce as far as possible.Except air beam quality factor, for knowing more about neutron at human body
In the dose distribution that causes, embodiments herein uses human body head tissue prosthesis carry out Rapid Dose Calculation, and with prosthese beam
Quality factor is used as the design reference of neutron beam, will be described in more detail below.
International Atomic Energy Agency (IAEA) is for the neutron source of clinical boron neutron capture treatment, given five air beam product
Quality factor is advised, these five suggestions can be used for the quality of the different neutron source of comparison, and are provided with as selecting neutron the way of production, setting
Reference frame during meter beam-shaping body.These five suggestions are as follows:
Epithermal neutron beam flux Epithermal neutron flux > 1x 109n/cm2s
Fast neutron pollutes Fast neutron contamination < 2x 10-13Gy-cm2/n
Photon contamination Photon contamination < 2x 10-13Gy-cm2/n
Thermal and epithermal neutron flux ratio thermal to epithermal neutron flux ratio < 0.05
Epithermal neutron electric current and flux ratio epithermal neutron current to flux ratio > 0.7
Note: epithermal neutron energy district, between 0.5eV to 40keV, hankers subzone and is more than 40keV less than 0.5eV, fast-neutron range.
1, epithermal neutron beam flux:
In neutron beam flux and tumor, boracic drug level has together decided on the clinical treatment time.If tumor boracic medicine is dense
The enough height of degree, the requirement for neutron beam flux just can reduce；Otherwise, if boracic drug level is low in tumor, then need height
Flux epithermal neutron gives the dosage that tumor is enough.IAEA is every square per second for the requirement of epithermal neutron beam flux
Centimetre epithermal neutron number more than 109, the neutron beam under this flux can substantially control for current boracic medicine
Treatment time, short treatment time was in addition to having superiority to patient location and comfort level, it is possible to more effectively utilize in one hour
Boracic medicine is in intra-tumor limited holdup time.
2, fast neutron pollutes:
Owing to fast neutron can cause unnecessary normal tissue dose, therefore regard as pollute, this dosage size and neutron energy
Amount is proportionate, and therefore should reduce the content of fast neutron in neutron beam design as far as possible.Fast neutron pollutes and is defined as unit
The fast neutron dosage that epithermal neutron flux is adjoint, the suggestion that fast neutron is polluted by IAEA is less than 2x 10-13Gy-cm2/n。
3, photon contamination (gamma-ray contamination):
Gamma-rays belongs to wears by force radiation, can non-selectively cause institute's organized dosage deposition on course of the beam, therefore drop
Low gamma-rays content is also the exclusive requirement of neutron beam design, and gamma-ray contamination is defined as the γ that unit epithermal neutron flux is adjoint
Roentgendosis, IAEA is less than 2x 10 to the suggestion of gamma-ray contamination-13Gy-cm2/n。
4, thermal and epithermal neutron flux ratio:
Owing to thermal neutron decay speed is fast, penetration capacity is poor, after entering human body, major part energy deposition is at skin histology, removes
Outside the neutron source that the Several Epidermal Tumors such as melanocytoma need to be treated as boron neutron capture with thermal neutron, for deep layers such as cerebromas
Tumor should reduce thermal neutron content.IAEA is less than 0.05 to the suggestion of thermal and epithermal neutron flux ratio.
5, epithermal neutron electric current and flux ratio:
Epithermal neutron electric current and flux ratio represent the directivity of epithermal neutron beam, tropism before ratio the biggest expression neutron beam
Good, the neutron beam of high front tropism can reduce because neutron dissipates the normal surrounding tissue dosage caused, and additionally also improves and can treat deeply
Degree and pendulum pose gesture are elastic.IAEA centering electron current and flux ratio suggestion are for more than 0.7.
In order to make beam-shaping body that neutron capture treats while solving target cooling problem, it is possible to obtain preferable neutron and penetrate
Shu Pinzhi, the application provides a kind of beam-shaping body 10 for neutron capture treatment, is provided with use in described firing rate shaping body 10
In the chiller 20 that target is cooled down.
As it is shown in figure 1, described firing rate shaping body 10 includes beam entrance 11, the accelerating tube 12 that is positioned in beam-shaping body 10,
The target 13 being located in accelerating tube 12, the slow body 14 being adjacent to described target 13, be enclosed in outside described slow body 14 anti-
Beam 15 and the adjacent thermal neutron absorber 16 of described slow body 14, the radiation shield being arranged in described beam-shaping body 10
17 and beam outlet 18.Described target 13 and the proton beam generation nuclear reaction from the incidence of described beam entrance 11 to produce neutron,
Described neutron forms neutron beam, and described neutron beam limits a major axis X.Described slow body 14 will produce from described target 13
Raw neutron degradation is to epithermal neutron energy district, and described reflector 15 will deviate from the neutron of neutron beam major axis X back to described slow
Speed body 14 is to improve epithermal neutron intensity of beam.With shallow when described thermal neutron absorber 16 is used for absorbing thermal neutron to avoid treating
Layer normal structure caused multiple dose.Described radiation shield 17 is used for shielding the neutron of seepage and photon just to reduce non-irradiated district
Often tissue dose.
Proton beam is accelerated by the treatment of accelerator boron neutron capture by accelerator, and as a kind of preferred embodiment, target 13 is by lithium gold
Genus is made, and proton beam accelerates to the energy that be enough to overcome target atom core coulomb repulsion, occurs with target 137Li(p,n)7Be core is anti-
Should be to produce neutron, beam-shaping body 10 by neutron slowly to epithermal neutron energy district, and can reduce thermal neutron and fast neutron content.
Described slow body 14 is made by having the material that fast neutron action section is big, epithermal neutron action section is little, described reflector
15 are made up of the material having neutron reflection ability strong, and thermal neutron absorber 16 is made up of the material big with thermal neutron action section.
As a kind of preferred embodiment, slow body 14 is by D2O、AlF3、FluentalTM、CaF2、Li2CO3、MgF2And Al2O3
In at least one make, reflector 15 is made up of at least one in Pb or Ni, thermal neutron absorber 16 by6Li makes.
Radiation shield 17 includes photon shielding 171 and neutron shield 172, as a kind of preferred embodiment, radiation shield 17 include by
Photon that lead (Pb) is made shielding 171 and the neutron shield 172 being made up of polyethylene (PE).
Described accelerating tube 12 includes embedding section 121 and extension 122, and described target 13 is located at accelerating tube 12 section of embedding 121
End.Described embedding section 121 is embedded in slow body 14, and described extension 122 extends to be reflected outside slow body 14
Body 15 surrounds.In present embodiment, accelerating tube 12 is embedded in slow body 14, so that chiller 20 is to embedded
Accelerating tube 12 in target 13 cool down while ensure beam-shaping body 10 obtain preferable neutron beam quality, by cold
Radiator cooler 20 arranges as follows.
Described chiller 20 includes the first cooling end 21 for cooling down target 13, along the extension of accelerating tube 12 axis direction
Being positioned at the second cooling end 22 and the 3rd cooling end 23 of accelerating tube 12 both sides, described second cooling end 22 is to the first cooling end 21
Input cooling medium, the cooling medium in the first cooling end 21 is exported by the 3rd cooling end 23.Described first cooling end 21 is positioned at
Between target 13 and slow body 14, the side of described first cooling end 21 contacts opposite side and contacts with slow body 14 with target 13.
It is embedding that the outside of described second cooling end 22 and the 3rd cooling end 23 autoacceleration pipe 12 extension 122 respectively extends to accelerating tube 12
The outside of the section of entering 121 and connect with the first cooling end 21 respectively and be positioned in slow body 14.It is to say, the first cooling end 21
It is positioned at the end of the embedding section 121 of accelerating tube 12 and is positioned at target 13 side and directly contacts with target 13, described second cooling
Portion 22 lays respectively at the both sides up and down of accelerating tube 12 with the 3rd cooling end 23 and connects with the first cooling end 21 respectively, so that
Obtain whole chiller 20 to arrange in Contraband type structure.In present embodiment, described first cooling end 21 and target 13 plane contact,
Second cooling end 22 and the 3rd cooling end 23 are all the tubular structures being made of copper, and the second cooling end 22 and the 3rd cooling end
23 contact planes (in conjunction with Fig. 2) being respectively perpendicular to described first cooling end 21 and target 13.
Described first cooling end 21 includes first contact site the 211, second contact site 212 and is positioned at the first contact site 211 and second
The cooling bath 213 passed through for cooling medium between contact site 212.Described first contact site 211 directly contacts with target 13,
Described second contact site 212 can be directly to contact to pass through air mediate contact with slow body 14.Described cooling bath 213
There is the input slot 214 connected with the second cooling end 22 and the output magazine 215 connected with the 3rd cooling end 23.Described first connects
Contact portion 211 is made from a material that be thermally conductive.The upper edge of described input slot 214 is positioned at the top of the upper edge of the second cooling end 22, institute
State the lower section that the lower edge of output magazine 215 is positioned at the lower edge of the 3rd cooling end 23.The benefit so arranged is, chiller
Target 13 can in cooling water input cooling bath 213 and will be cooled down by 20 more swimmingly more in time, and after being heated
Cooling water also be able to the most smoothly from cooling bath 213 export, simultaneously, additionally it is possible to a certain extent reduce cooling bath 213
The hydraulic pressure of middle cooling water.
Certainly, it is possible to chiller is arranged to I type structure the target 13 in Embedded accelerating tube 12 is cooled down.Institute
The first cooling end 21 stating the first cooling end 21 ' in I type chiller 20 and Contraband type chiller 20 arranges identical, different
Part is, the second cooling end 22 ' of described I type chiller 20 and the 3rd cooling end 23 ' and the first cooling end 21 ' position
In same plane, and the second cooling end 22 ' wears out along the direction vertical with accelerating tube 12 axis respectively with the 3rd cooling end 23
Slow body 14, the most above-mentioned I type structure (as shown in Figure 3).Although the chiller 20 of described I type structure also is able to reality
The now cooling to target 13, however it is necessary that setting allows the second cooling end 22 ' and the 3rd cooling end 23 ' pass on slow body 14
Groove 24, assemble up more complicated.And chiller is set to the neutron flux of the beam-shaping body 10 after I type structure
Lead to compared to the neutron of the beam-shaping body 10 after chiller is arranged to Contraband type structure with beam quality factor performance in air
In amount and air, the performance of beam quality factor is poor.
Now use AlF----with slow body 143(2.78g/cm---), as a example by material is made, using MCNP software (is by the U.S.
Los Alamos National Laboratories (LosAlamos National Laboratory) develop based on DSMC by based on
Calculate the general of the neutron in 3 D complex geometry, photon, charged particle or coupling neutron/photon/charged particle transport problem
Software kit) it is simulated calculating to the beam-shaping body after arranging Contraband type and I type chiller respectively:
Wherein, beam quality factor performance in both embodiments in air is shown such as following table one:
Table one: beam quality factor in air
Note: the present embodiment is that conservatively assessment epithermal neutron flux and fast neutron pollute, and epithermal neutron energy district is set as 0.5eV
Between 10keV, hankering subzone and be set smaller than 0.5eV, fast-neutron range is set greater than 10keV.
Wherein, neutron flux performance in both embodiments is shown such as following table two:
Table two: neutron flux (n/cm2-mA)
Note: the present embodiment is that conservatively assessment epithermal neutron flux and fast neutron pollute, and epithermal neutron energy district is set as 0.5eV
Between 10keV, hankering subzone and be set smaller than 0.5eV, fast-neutron range is set greater than 10keV.
Described target 13 includes lithium target layer 131 and is positioned at the anti oxidation layer that lithium target layer 131 side aoxidizes for preventing lithium target layer 131
132.The anti oxidation layer 132 of described target 13 is made up of Al or rustless steel.First contact site 211 by Heat Conduction Material (as
The material of the good heat conductivity such as Cu, Fe, Al) or heat conduction the material of foaming can be suppressed again to make, the second contact site is by suppressing
The material of foaming is made, the material of suppression foaming the or heat conduction material of foaming can be suppressed again by any one of Fe, Ta or V
Make.Target 13 is raised by the accelerating proton bundle irradiation temperature of same high-energy level and generates heat, and described first contact site 211 is by heat
Derive, and by circulation cooling medium in cooling bath 213, heat is taken out of, thus target 13 is cooled down.In this reality
Executing in mode, described cooling medium is water.
As one preferred embodiment, described slow body 14 is configured with at least one structure of cone-shaped 140.Institute
Stating slow body 14 and have first end 141 and a second end 142, described cone-shaped 140 have and are positioned at first end 141 and
The 3rd end 143 between two ends 142 and connection first end 141 and the main part 144 of the 3rd end 143.Described add
Speed pipe 12 embedding section 121 between first end 141 and the 3rd end 143 of cone-shaped 140, described first cooling end
21 between target 13 and the 3rd end 143 of cone-shaped 140.The benefit so arranged it is possible to more reasonably control
Make the size of slow body 14, make the neutron beam of generation reach the most slow effect, make beam-shaping body obtain simultaneously and preferably penetrate
Shu Pinzhi.Specifically, because the first cooling end 21 is between target 13 and the 3rd end 143 of cone-shaped 140,
The neutron that front tropism is preferable and energy is higher can be carried out slowly, the most just by the slow body 14 of the rear section being positioned at the 3rd end 143
It is to say that the slow body that such setting still leaves longer dimension for the neutron that front tropism is preferable and energy is higher be enough to enter neutron
Row is the most slow；And for deviateing the neutron of neutron beam major axis X, when the neutron of deviation beam major axis X is through main part 144
Moving to reflector 15 after Huan Su, reflector 15 will deviate from beam master at an angle by the cone-shaped design of slow body 14
Neutron beam major axis X is returned in the neutron reflection of axle X, and the neutron that the most cone-shaped design can avoid energy relatively low is being reflected back beam master
On the path of axle X the most slowly, while the slow effect of the neutron that tropism is high before lifting, the intensity of neutron beam can be maintained,
Then ensure that beam-shaping body 10 obtains preferable neutron beam quality.
Described in the embodiment of the present application, " cone " or " cone-shaped " structure of slow body refers to that slow body is along the one of direction as shown
The structure that side tapers into the overall trend of its outline of opposite side, a wherein contour line of outline can be line segment, as
The corresponding contour line of cone shape, it is also possible to be circular arc, such as the corresponding contour line of sphere body shape, the whole surface of outline
Can be rounding off, it is also possible to be non-rounding off, as done a lot of projection on the surface of cone shape or sphere body shape
And groove.
The neutron capture treatment system that the application discloses is not limited to the content described in above example and the knot represented by accompanying drawing
Structure.The change apparently on the basis of the application, material, shape and the position of wherein component made, substitute or repair
Change, all within the scope of this application claims.
Claims (10)
- null1. the beam-shaping body for neutron capture treatment，The treatment of described neutron capture includes the accelerating tube for accelerating to proton beam，Described beam-shaping body includes beam entrance、The target being located in accelerating tube、It is adjacent to the slow body of described target、It is enclosed in the most external described reflector、The thermal neutron absorber adjacent with described slow body、It is arranged on the radiation shield in described beam-shaping body and beam outlet，Described target and the proton beam generation nuclear reaction incident from described beam entrance are to produce neutron，Described neutron forms neutron beam，Described slow body by the neutron degradation that produces from described target to epithermal neutron energy district，The neutron that described reflector will deviate from back to described slow body to improve epithermal neutron intensity of beam，Described thermal neutron absorber is used for when absorbing thermal neutron to avoid treating causing multiple dose with shallow-layer normal structure，Described radiation shield is used for shielding the neutron of seepage and photon to reduce the normal tissue dose in non-irradiated district，It is characterized in that，Described beam-shaping body also has chiller，Described chiller includes the first cooling end for cooling down target、Respectively along being parallel to the extension of accelerating tube axis direction the second cooling end connected with the first cooling end and the 3rd cooling end，Described first cooling end contacts with target plane，Described second cooling end is to the first cooling end input cooling medium，Cooling medium in first cooling end is exported by the 3rd cooling end.
- Beam-shaping body for neutron capture treatment the most according to claim 1, it is characterized in that: described accelerating tube includes embedding section and extension, described target is located at accelerating tube and is embedded the end of section, described embedding section is embedded in slow body, described extension extends slow external side and is surrounded by reflector, described first cooling end is between target and slow body, and described second cooling end and the 3rd cooling end edge are parallel to accelerating tube axis direction and extend to the outside of accelerating tube embedding section and be positioned in beam-shaping body.
- Beam-shaping body for neutron capture treatment the most according to claim 1, it is characterized in that: described first cooling end is positioned at the end of accelerating tube and contacts with described target plane, described second cooling end and the 3rd cooling end lay respectively at the both sides up and down of accelerating tube and form Contraband type structure with the first cooling end.
- Beam-shaping body for neutron capture treatment the most according to claim 1, it is characterized in that: described second cooling end and the 3rd cooling end are all the tubular structures being made of copper, described second cooling end and the 3rd cooling end are respectively perpendicular to target and the contact plane of the first cooling end.
- Beam-shaping body for neutron capture treatment the most according to claim 1, it is characterized in that: described first cooling end includes the first contact site directly contacted with target and the second contact site that body contacts slowly and the cooling bath passed through for cooling medium between the first contact site and the second contact site, and described cooling bath has the input slot connected with the second cooling end and the output magazine connected with the 3rd cooling end.
- Beam-shaping body for neutron capture treatment the most according to claim 5, it is characterised in that: the upper edge of described input slot is positioned at the top of the upper edge of the second cooling end, and the lower edge of described output magazine is positioned at the lower section of the lower edge of the 3rd cooling end.
- Beam-shaping body for neutron capture treatment the most according to claim 2, it is characterized in that: it is cone-shaped that described slow body has at least one, described slow body has first end and the second end, described cone-shaped the 3rd end having between first end and the second end and connect first end and the main part of the 3rd end, the embedding section of described accelerating tube is positioned between pyramidal first end and the 3rd end, and described first cooling end is between target and pyramidal 3rd end.
- Beam-shaping body for neutron capture treatment the most according to claim 5, it is characterised in that: described target includes lithium target layer and is positioned at the anti oxidation layer that lithium target layer side aoxidizes for preventing lithium target layer.
- Beam-shaping body for neutron capture treatment the most according to claim 5, it is characterised in that: described first contact site is by Heat Conduction Material or heat conduction the material of foaming can be suppressed again to make, and described second contact site is made up of the material suppressing foaming.
- Beam-shaping body for neutron capture treatment the most according to claim 8, it is characterized in that: described anti oxidation layer is made up of Al or rustless steel, when described first contact site by can heat conduction again can suppress foaming material make time, described first contact site is selected from any one of Fe, Ta or V, described second contact site is made up of any one of Fe, Ta or V, and described cooling medium is water.
Priority Applications (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201620017409.9U CN205460520U (en) | 2016-01-08 | 2016-01-08 | Beam shaper for neutron -capture therapy |
| PCT/CN2016/111346 WO2017118291A1 (en) | 2016-01-08 | 2016-12-21 | Beam shaper for neutron capture therapy |
| JP2018532142A JP2019502455A (en) | 2016-01-08 | 2016-12-21 | Beam shaped body for neutron capture therapy |
| EP16883417.4A EP3395404B1 (en) | 2016-01-08 | 2016-12-21 | Beam shaper for neutron capture therapy |
| RU2018127729A RU2720707C2 (en) | 2016-01-08 | 2016-12-21 | Beam forming element intended for use in neutron capture therapy |
| TW105219899U TWM541868U (en) | 2016-01-08 | 2016-12-29 | A beam shaping assembly for neutron capture therapy |
| US16/028,967 US10434333B2 (en) | 2016-01-08 | 2018-07-06 | Beam shaping assembly for neutron capture therapy |
| JP2022161810A JP7464672B2 (en) | 2016-01-08 | 2022-10-06 | Beam shapers for neutron capture therapy. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201620017409.9U CN205460520U (en) | 2016-01-08 | 2016-01-08 | Beam shaper for neutron -capture therapy |
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| CN205460520U true CN205460520U (en) | 2016-08-17 |
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