CN205210097U - Integrated device that magnetic particle was handled in full -automatic chemiluminescent immunoassay analysis - Google Patents
Integrated device that magnetic particle was handled in full -automatic chemiluminescent immunoassay analysis Download PDFInfo
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- CN205210097U CN205210097U CN201520700214.XU CN201520700214U CN205210097U CN 205210097 U CN205210097 U CN 205210097U CN 201520700214 U CN201520700214 U CN 201520700214U CN 205210097 U CN205210097 U CN 205210097U
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Abstract
The utility model discloses an integrated device that magnetic particle was handled in full -automatic chemiluminescent immunoassay analysis, motor vertical lift erects the periphery of arranging the washing dish in the device, it is connected with electrode vertical lift frame to wash the arm support frame, be provided with the cleaning head rotor on the washing arm support frame, lotion manage to find time needle and mixing motor, the mixing motor drives the rotation of cleaning head rotor, arbitrary lotion syringe needle or substrate syringe needle pass the setting of cleaning head rotor, be provided with rotatory position of reaction cup and magnet on the washing dish. In this way, the utility model discloses an integrated device that magnetic particle was handled in full -automatic chemiluminescent immunoassay analysis mainly is applicable to magnetic particle washing in the chemiluminescent immunoassay analytical equipment, stirring, separation and substrate and pours into into, has realized that the pipelined of magnetic particle washs, washs totallyer, and the magnetic particle loses still less, and the structure is more optimized, controls simplyr, possesses relatively independent function, suitable whole automatic system.
Description
Technical field
The utility model relates to a kind of inter-process device of extracorporeal diagnostic instrument, particularly relates to the cleaning of a kind of magnetic particle based on automatic chemiluminescence immunoassay system, stirs, is separated and substrate injection integrated apparatus.
Background technology
Immunoassay experienced by the different times such as radioimmunoassay, fluorescence immunoassay inspection, and Full-automatic chemiluminescence immunity inspection is a new stage of immunoassay development.Its environmental protection, fast and accurately feature have obtained the generally understanding of people.Therefore automatic chemiluminescence immunoassay leads to the perfect the only way which must be passed of immunity inspection.Full-automatic chemiluminescence apparatus device common in the market has three kinds, the first is the automatic immunity system adopting micro-pore plate type, the second adopts magnetic particle as the automatic immunity system of solid phase, and the third is galvanochemistry automatic immunity system.Wherein employing magnetic particle is as the automatic immunity system of solid phase relative to other two kinds of systems, and measuring accuracy and technical threshold can become following domestic main product system.
In the course of reaction adopting magnetic particle as the automatic immunity system of solid phase, traditional magnetic particle stirs detachment process and generally adopts stirrer, a washer and a separation vessel respectively.These three devices normally disperse, thus cause that the volume of instrument is comparatively large, the reaction time is long, Row control is lengthy and tedious, and stir and adopt stirring rod to carry out contact stirring to cause cross pollution.
Utility model content
The technical matters that the utility model mainly solves is to provide the cleaning of a kind of Full-automatic chemiluminescence system magnetic particle, stirs, is separated and substrate injection integrated apparatus, reduce the volume of instrument, reduce loss during magnetic particle cleaning, decrease the general reaction time, facilitate software to carry out pipeline system control simultaneously.
For solving the problems of the technologies described above, the technical scheme that the utility model adopts is: the integrated apparatus providing magnetic particle process in a kind of automatic chemiluminescence immunoassay, comprise cleaning disc, motor VTOL (vertical take off and landing) frame, cleaning arm bracing frame, cleaning head rotor, washing lotion entry needle, washing lotion is found time pin, substrate entry needle, magnet and mixing motor, described motor VTOL (vertical take off and landing) erection is placed in the periphery of described cleaning disc, described cleaning arm bracing frame is connected with described electrode vertical crane, described cleaning arm bracing frame is provided with cleaning head rotor, washing lotion find time pin and mixing motor, the rotation of cleaning head rotor described in described mixing driven by motor, described arbitrary washing lotion entry needle or substrate entry needle are arranged through described cleaning head rotor, described cleaning disc is provided with reaction cup and rotates position and magnet.
In the utility model preferred embodiment, described motor VTOL (vertical take off and landing) frame is two, is arranged at the both sides of described cleaning disc.
In the utility model preferred embodiment, described cleaning arm bracing frame comprises cleaning arm and supports side arm and cleaning arm support after-frame, described cleaning arm supports side arm and is connected with motor VTOL (vertical take off and landing) frame described in, and described cleaning arm supports after-frame and is connected with motor VTOL (vertical take off and landing) frame described in another.
In the utility model preferred embodiment, described cleaning arm supports and side arm is provided with a mixing motor, two cleaning head rotors and a washing lotion and finds time pin, and described two cleaning head rotors are respectively provided with a washing lotion entry needle.
In the utility model preferred embodiment, described cleaning arm supports and after-frame is provided with a mixing motor, two cleaning head rotors and two washing lotions and finds time pin, one of them cleaning head rotor is provided with a washing lotion entry needle, another cleaning head rotor is provided with a foundation thing entry needle.
In the utility model preferred embodiment, described arbitrary washing lotion entry needle or substrate entry needle are positioned at the cental axial position of described cleaning head rotor.
In the utility model preferred embodiment, be connected between described mixing motor with described cleaning head rotor by belt, described mixing driven by motor belt makes described cleaning head rotor turns.
In the utility model preferred embodiment, the reaction cup aperture arranged outside that described reaction cup rotates position has register pin, and the top of described cleaning head rotor is provided with projection, and described register pin and described projection docking are arranged.
In the utility model preferred embodiment, described device also comprises spring, and described spring is arranged on described cleaning head rotor
In the utility model preferred embodiment, the axle core that described reaction cup rotates position is connected with the base of described cleaning disc, makes reaction cup rotate position and rotates around axle core.
The beneficial effects of the utility model are: the integrated apparatus of magnetic particle process in automatic chemiluminescence immunoassay of the present utility model, mainly be applicable to the magnetic particle cleaning in chemiluminescence immune assay equipment, stir, be separated and substrate injection, achieve the pipeline system cleaning of magnetic particle, clean cleaner, magnetic particle loss is less, and more optimized structure, controls simpler, possess relatively independent function, be applicable to whole automated system.
Accompanying drawing explanation
In order to be illustrated more clearly in the technical scheme in the utility model embodiment, below the accompanying drawing used required in describing embodiment is briefly described, apparently, accompanying drawing in the following describes is only embodiments more of the present utility model, for those of ordinary skill in the art, under the prerequisite not paying creative work, other accompanying drawing can also be obtained according to these accompanying drawings, wherein:
Fig. 1 is the structural representation of integrated apparatus one preferred embodiment of magnetic particle process in automatic chemiluminescence immunoassay of the present utility model;
Fig. 2 is the structural representation that in Fig. 1, cleaning arm supports side arm;
Fig. 3 is the structural representation that in Fig. 1, cleaning arm supports after-frame;
Fig. 4 is the structural representation of cleaning disc in Fig. 1;
Fig. 5 is structural representation when cleaning disc uses in Fig. 1.
Embodiment
Be clearly and completely described to the technical scheme in the utility model embodiment below, obviously, described embodiment is only a part of embodiment of the present utility model, instead of whole embodiments.Based on the embodiment in the utility model, those of ordinary skill in the art are not making other embodiments all obtained under creative work prerequisite, all belong to the scope of the utility model protection.
Refer to Fig. 1, the utility model embodiment comprises:
Magnetic particle based on automatic chemiluminescence immunoassay system cleans, stir, be separated and substrate injects an integrated apparatus, comprises cleaning disc 1, motor VTOL (vertical take off and landing) frame 2, cleaning arm bracing frame 3, cleaning head rotor 4, washing lotion entry needle 5, washing lotion find time pin 6, substrate entry needle 7, magnet 8 and mixing motor 9.
Described motor VTOL (vertical take off and landing) frame 2 has two, is respectively arranged at the both sides of described cleaning disc 1.Each described electrode vertical crane 2 is equipped with cleaning arm bracing frame 3, is divided into the cleaning arm shown in Fig. 2 to support side arm and the support of the cleaning arm shown in Fig. 3 after-frame.Described cleaning arm bracing frame 3 is equipped with altogether two mixing motors, 9,3 washing lotion entry needles, 5,3 washing lotions to find time pin 6,1 foundation thing entry needle 7 and 4 cleaning head rotors 4, wherein 3 washing lotion entry needle 5 and 1 foundation thing entry needles 7 lay respectively at the cental axial position of 4 cleaning head rotors 4.The rotation of described mixing motor 9 drives belt 10 that cleaning head rotor 4 is rotated, and realizes agitating function.
Refer to Fig. 2, described cleaning arm supports and side arm is equipped with direct current mixing motor 9, two cleaning head rotors 4 and a washing lotion and finds time pin 6, and respectively there are a washing lotion entry needle 5 in the central authorities of described cleaning head rotor 4.Refer to Fig. 3, described cleaning arm supports and after-frame is equipped with equally direct current mixing motor 9, two cleaning head rotors 4 and two washing lotions and finds time pin 6, the central authorities of one of them cleaning head rotor 4 are 1 washing lotion entry needles 5, and the central authorities of another one cleaning head rotor 4 are 1 foundation thing entry needles 7.
Refer to Figure 4 and 5, cleaning disc 1 has been divided into 14 reaction cup and has rotated position 11.In cleaning disc 1, equally distributed 14 reaction cup rotate position 11, and inner space just holds the volume of a reaction cup.The axle core that reaction cup rotates position 11 is connected with cleaning disc 1 base, and making reaction cup rotate position 11 can rotate around axle core, makes inner reaction cup also produce rotation equally, and then produces mixing effect.
Cup aperture arranged outside is reacted in reaction cup rotation position 11 and has two register pins 12.The top of described cleaning head rotor 4 is provided with two bossings, can dock when stirring with two register pins 12 that reaction cup rotates on position 11, and formation cleaning head rotor 4 and reaction cup rotate the design that locked transmission is docked in position 11.Spring 13 is equipped with in the top of described cleaning head rotor 4, can avoid stirring when declining and reaction cup rotates position 11 and bumps against.
The inwall of described cleaning disc 1 is uniformly distributed the permanent magnet 8 that 9 pieces of magnetic is extremely strong, is divided into 3 groups, be distributed in 2,3,4 successively; 7,8,9; 12,13, No. 14 reaction cup rotate position 11 place.When washing lotion is found time, the magnetic particle in reaction cup is adsorbed on the wall of cup of reaction cup under the effect of magnetic force, when unconjugated antigen-antibody and cleaning buffer solution are siphoned away by washing lotion pin, eliminates or reduce the loss of magnetic particle.
Whole operating process is: the reaction cup of having added reagent and sample from hatching after dish catches cleaning disc 1, being injected through 3 washing lotions and finds time and stir, finally completing substrate and inject by mechanical gripper successively.Refer to Fig. 4, the reaction cup adding sample and reagent and magnetic particle, hatching dish after hatching 37 DEG C, is caught position, cleaning disc No. 1 hole by mechanical gripper, and namely No. 1 cleaning rotates in position, and then cleaning disc 1 can rotate counterclockwise successively according to hole bit number.When No. 1, the cleaning disc reaction cup rotated in position turns to No. 2 positions, hole, motor VTOL (vertical take off and landing) frame 2 on the cleaning assembly of both sides can according to the motor vertical motion step number uniform descent set, until washing lotion is found time, the needle point of pin 6 arrives and stops from about 1mm at the bottom of reaction cup.The register pin that now cleaning head rotor 4 just rotates position 11 with the reaction cup on cleaning disc 1 docks stuck.Washing lotion entry needle 5 first carries out the injection of washing lotion, then the mixing motor 9 on software control both sides cleaning arm bracing frame 3 rotates, mixing motor 9 drives cleaning head rotor 4 to rotate by belt 10 transmission, cleaning head rotor 4 drives again reaction cup rotation position 11 to rotate, thus mixing effect is produced to the reaction cup that reactant liquor is housed that reaction cup rotates in position 11, realization response cup can be carried out by the rotation direction controlling mixing motor 9 simultaneously and rotate position 11 clockwise and rotate counterclockwise, reach the effect of fully mixing.After stirring completes, motor VTOL (vertical take off and landing) frame 2 can rise to reset position automatically.Then when cleaning disc 1 is rotated further No. 3 positions, hole, the motor VTOL (vertical take off and landing) frame 2 of cleaning disc 1 both sides declines again, until washing lotion is found time, the needle point of pin 6 stops from about 1mm at the bottom of cup.Magnetic particle in reaction cup can be adsorbed onto the inwall of reaction cup by the permanent magnet that position place, No. 3 holes installs cleaning disc 1 inside, simultaneously unconjugated antigen-antibody and cleaning buffer solution are found time by washing lotion pin 6 of finding time, magnetic particle is adsorbed on the surface of reaction cup due to the effect of magnetic force, does not substantially lose.Through injecting and finding time after 3 times, to guarantee in reaction cup that only remaining take magnetic particle as the antigen-antibody concatenator of solid phase.After last stirring completes, substrate pin carries out the injection of substrate.Then reaction cup is grabbed the detection carrying out photon number into optical disc by mechanical gripper.This device achieves the pipeline system cleaning of magnetic particle, and cleaning is cleaner, and magnetic particle loss is less, more optimized structure, controls simpler, possesses relatively independent function, be applicable to whole automated system.
When this device can be implemented in syllogic cleaning, successively by 9 block permanent magnets, magnetic particle is adsorbed on the wall of cup of reaction cup, when unconjugated antigen-antibody and cleaning buffer solution are siphoned away by washing lotion pin, eliminates or reduce the loss of magnetic particle.Syllogic has been cleaned and automatically substrate has been injected reaction cup afterwards, and reaction cup is caught optical disc and carried out luminous value detection by mechanical gripper again.Cleaning, stirring and substrate injection are added in a mechanical module, reduce the volume of instrument, decrease the reaction time, facilitate software to carry out pipeline system control simultaneously.
The utility model device achieves the combination of functions of modules, reduces instrument volume, decreases the reaction time, has simplified the control in flow process.Novel all-in-one formula structure of the present utility model, can effectively amass by reduction printer body, reduces the loss produced when magnetic particle is separated, reduces lengthy and tedious Row control, simplify the operation of instrument, facilitate software to carry out the control of pipeline system.
The foregoing is only embodiment of the present utility model; not thereby the scope of the claims of the present utility model is limited; every utilize the utility model description to do equivalent structure or equivalent flow process conversion; or be directly or indirectly used in other relevant technical field, be all in like manner included in scope of patent protection of the present utility model.
Claims (10)
1. the integrated apparatus of magnetic particle process in an automatic chemiluminescence immunoassay, it is characterized in that, comprise cleaning disc, motor VTOL (vertical take off and landing) frame, cleaning arm bracing frame, cleaning head rotor, washing lotion entry needle, washing lotion is found time pin, substrate entry needle, magnet and mixing motor, described motor VTOL (vertical take off and landing) erection is placed in the periphery of described cleaning disc, described cleaning arm bracing frame is connected with described electrode vertical crane, described cleaning arm bracing frame is provided with cleaning head rotor, washing lotion find time pin and mixing motor, the rotation of cleaning head rotor described in described mixing driven by motor, described arbitrary washing lotion entry needle or substrate entry needle are arranged through described cleaning head rotor, described cleaning disc is provided with reaction cup and rotates position and magnet.
2. magnetic particle process integrated apparatus according to claim 1, is characterized in that, described motor VTOL (vertical take off and landing) frame is two, is arranged at the both sides of described cleaning disc.
3. magnetic particle process integrated apparatus according to claim 2, it is characterized in that, described cleaning arm bracing frame comprises cleaning arm and supports side arm and cleaning arm support after-frame, described cleaning arm supports side arm and is connected with motor VTOL (vertical take off and landing) frame described in, and described cleaning arm supports after-frame and is connected with motor VTOL (vertical take off and landing) frame described in another.
4. magnetic particle process integrated apparatus according to claim 3, it is characterized in that, described cleaning arm supports and side arm is provided with a mixing motor, two cleaning head rotors and a washing lotion and finds time pin, and described two cleaning head rotors are respectively provided with a washing lotion entry needle.
5. magnetic particle process integrated apparatus according to claim 3, it is characterized in that, described cleaning arm supports and after-frame is provided with a mixing motor, two cleaning head rotors and two washing lotions and finds time pin, one of them cleaning head rotor is provided with a washing lotion entry needle, another cleaning head rotor is provided with a foundation thing entry needle.
6. magnetic particle process integrated apparatus according to claim 1, is characterized in that, described arbitrary washing lotion entry needle or substrate entry needle are positioned at the cental axial position of described cleaning head rotor.
7. magnetic particle process integrated apparatus according to claim 1, is characterized in that, is connected between described mixing motor with described cleaning head rotor by belt, and described mixing driven by motor belt makes described cleaning head rotor turns.
8. magnetic particle process integrated apparatus according to claim 1, is characterized in that, the reaction cup aperture arranged outside that described reaction cup rotates position has register pin, and the top of described cleaning head rotor is provided with projection, and described register pin and described projection docking are arranged.
9. magnetic particle process integrated apparatus according to claim 1, it is characterized in that, described device also comprises spring, and described spring is arranged on described cleaning head rotor.
10. magnetic particle process integrated apparatus according to claim 1, is characterized in that, the axle core that described reaction cup rotates position is connected with the base of described cleaning disc, makes reaction cup rotate position and rotates around axle core.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520700214.XU CN205210097U (en) | 2015-09-11 | 2015-09-11 | Integrated device that magnetic particle was handled in full -automatic chemiluminescent immunoassay analysis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520700214.XU CN205210097U (en) | 2015-09-11 | 2015-09-11 | Integrated device that magnetic particle was handled in full -automatic chemiluminescent immunoassay analysis |
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| Publication Number | Publication Date |
|---|---|
| CN205210097U true CN205210097U (en) | 2016-05-04 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201520700214.XU Active CN205210097U (en) | 2015-09-11 | 2015-09-11 | Integrated device that magnetic particle was handled in full -automatic chemiluminescent immunoassay analysis |
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| CN (1) | CN205210097U (en) |
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Address after: Xinghu Street Industrial Park of Suzhou city in Jiangsu province 215000 No. 218 BioBAY C6 building 101 Patentee after: Jiangsu Hao Bo biomedical Limited by Share Ltd Address before: Xinghu Street Industrial Park of Suzhou city in Jiangsu province 215000 No. 218 BioBAY C6 building 101 Patentee before: Suzhou Haooubo Biopharmaceutical Co., Ltd. |