CN204740506U - Automatic join in marriage attitude mixing device that surges - Google Patents
Automatic join in marriage attitude mixing device that surges Download PDFInfo
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- CN204740506U CN204740506U CN201520397110.6U CN201520397110U CN204740506U CN 204740506 U CN204740506 U CN 204740506U CN 201520397110 U CN201520397110 U CN 201520397110U CN 204740506 U CN204740506 U CN 204740506U
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Abstract
The utility model provides a bio -pharmaceuticals technical field's automatic join in marriage attitude mixing device that surges, includes: developments blender and the on -line monitoring detector that links to each other with it, wherein: the input of developments blender links to each other with biological pump and mother liquor pump respectively, and the on -line monitoring detector includes: with the detection mechanism of dynamic blender series connection and the signal processor who links to each other with detection mechanism, signal processor's output links to each other with the controller, and the output of controller links to each other with biological pump and mother liquor pump respectively. This device can be used to the online solution delivery system of chromatography intelligence in biological medicine field, process analysis, quality control, and liquid dilution, the fast target of carrying of constant current are joined in marriage in the automation that makes its realization can preset the product quality standard. Simultaneously, it joins in marriage liquid, chromatography integrated system on line to provide one kind based on the process analysis technique. Satisfying the buffer solution practicality and joining in marriage at present, the buffer solution no longer needs to store, sparingly joins in marriage required area and liquid storage pot cost between liquid.
Description
Technical field
The utility model relates to a kind of device of biological pharmacy technical field, specifically a kind of dynamic evenly mixing device realized in the online process analysis procedure analysis control system of automatic liquid matching.
Background technology
The current whole world is in the medicine biological technique large-scale industrialized production stage, and progressively one of leading industry becoming world economy.The research and development of China's biotech drug is started late, especially in biological medicine automation equipment, and the larger gap of existence compared with the western countries of advanced person.But under the support energetically of national industrial policies (particularly the plan of National 863 high-tech), Bio-pharmaceutical Industry is becoming one of emerging strategic industry that China gives priority to, and the coming years will likely exceed many western countries and become world's second largest bio-pharmaceuticals market.
Recent years, just gradually process analysis technique (Process Analytical Technology, lower letter is PAT) is applied to pharmaceuticals industry in the world.PAT is a system, namely as the analysis and control of production run, be according to the quality testing data in production run for FEEDBACK CONTROL, realize the intelligent quality control of the production run of starting material or intermediate product, guarantee that final products reach stable accurate quality standard.In the application aspect of PAT, China's starting very late, and is researched and developed with the enterprise manufacturing this series products less, and the application particularly combined with drugs manufacture equipment is particularly rare.Therefore, the drugs manufacture equipment that exploitation manufactures containing process analysis technique has important economic worth and wide market outlook.
The industry of China's bio-pharmaceuticals has in recent years had and has developed fast, the scale comprising the industries such as monoclonal antibody, blood product, recombinant protein has had and has significantly promoted, the purifying of each batch may need to use several tons even damping fluid of tens tons, if still adopt traditional manual dosing technology, need a considerable amount of fluid reservoir and dosing personnel, and artificial dosing quality conformance is poor, qualification rate is low, opportunities for contamination is many, the problems such as rejection and waste rate is high, cost is high, inefficiency, artificial dosing has become one of current bio-pharmaceuticals popularization and has restricted greatly.
Existing bio-pharmaceuticals dosing technology great majority still adopt backward fluid reservoir manually to prepare, need to build between large-area dosing, and the preservation of a considerable amount of fluid reservoir for damping fluid need be purchased, fluid reservoir clean, safeguard, manpower and financial resources that checking needs at substantial.Part drugmaker also has and purchases external automatic liquid matching control system, but because of wherein without the structural design of dynamic evenly mixing device, finally cause dosing mix uneven, stabilization time is longer, quality control precision is lower, qualification rate is just low.
Utility model content
The utility model, for prior art above shortcomings, proposes the dynamic evenly mixing device of a kind of automatic liquid matching, can be used for chromatography intelligent online solution dispensed system, process analysis and the quality control of biomedicine field.Achieve the automatic liquid matching dilution of predeterminable target level of product quality, constant current speed conveying target.
The utility model is achieved through the following technical solutions:
The utility model comprises: dynamic mixer and the on-line monitoring detecting device be attached thereto, wherein: the input end of dynamic mixer is connected with mother liquor pump with bio-pump respectively, on-line monitoring detecting device comprises: the testing agency of connecting with dynamic mixer and the signal processor be connected with testing agency, the output terminal of signal processor is connected with controller, and the output terminal of controller is connected with mother liquor pump with bio-pump respectively.
Described dynamic mixer comprises: be composed in series the mixing pump of loop, pH detecting device and electric conductivity detector successively, wherein: the input end of mixing pump is the output terminal of dynamic mixer, mixing delivery side of pump is the input end of dynamic mixer, and pH detecting device and electric conductivity detector are connected with on-line monitoring detecting device respectively.
Technique effect
Compared with prior art, the utility model is introduced after dynamic mixer, improves that the mixing of original technology is uneven, mixing velocity slow, the problem such as cause the damping fluid fluctuation range that configures larger, unstable.Be integrated with chromatography module simultaneously, decrease the surge tank of original configuration damping fluid.While greatly reducing production cost, decrease the area of hold facility and shorten the production cycle, also reducing the pollution risk of intermediate steps.
Accompanying drawing explanation
Fig. 1 is the utility model structural representation;
Fig. 2 is with FEEDBACK CONTROL collection of illustrative plates report under online process analysis technique condition in embodiment;
Fig. 3 is not with FEEDBACK CONTROL collection of illustrative plates report under online process analysis technique condition in embodiment;
In figure: 1 be bio-pump, 2 be mother liquor pump, 3 be mixing pump, 4 be pressure detector, 5 be pH detecting device, 6 be electric conductivity detector, 7 be flow detector, 8 be outlet valve, 9 be network transmitter, 10 be controller, 11 for analog to digital converter.
Embodiment
Below embodiment of the present utility model is elaborated; the present embodiment is implemented under premised on technical solutions of the utility model; give detailed embodiment and concrete operating process, but protection domain of the present utility model is not limited to following embodiment.
Embodiment 1
As shown in Figure 1, the present embodiment comprises: dynamic mixer and the on-line monitoring detecting device be attached thereto, wherein: the input end of dynamic mixer is connected with mother liquor pump 2 with bio-pump 1 respectively, on-line monitoring detecting device comprises: the testing agency 4,7 of connecting with dynamic mixer and the signal processor 11 be connected with testing agency, the output terminal of signal processor 11 is connected with controller 10, and the output terminal of controller is connected with mother liquor pump 2 with bio-pump 1 respectively.
The quantity of described mother liquor pump 2 is at least one, the built-in damping fluid of this mother liquor pump 2 and be in parallel between bio-pump 1.
Described testing agency includes but not limited to pressure detector 4, flow detector 7 etc., wherein: pressure detector 4 and flow detector 7 are all connected with dynamic mixer and be connected with on-line monitoring detecting device respectively.
Described dynamic mixer comprises: be composed in series the mixing pump 3 of loop, pH detecting device 5 and electric conductivity detector 6 successively, wherein: the input end of mixing pump 3 is the output terminal of dynamic mixer, the output terminal of mixing pump 3 is the input end of dynamic mixer, and pH detecting device 5 is connected with on-line monitoring detecting device respectively with electric conductivity detector 6.
The output terminal of described dynamic mixer is provided with outlet valve 8.
Described signal processor comprises: analog to digital converter 11, controller 10 and network transmitter 9, wherein: the input end of analog to digital converter 11 is connected with testing agency, output terminal is connected with network transmitter 9 with controller 10 respectively, and the output terminal of controller 10 is connected with bio-pump 1 respectively at network transmitter 9.
Pipeline solvent conductivity, pH or flow velocity signal are transformed into electric signal by described on-line monitoring detecting device, be sent in central processing unit, have volume little by data acquisition unit, the feature that precision is high.
As shown in Figure 2, the detection collection of illustrative plates after practical dynamically evenly mixing device.
As shown in Figure 3, the detection collection of illustrative plates before dynamic evenly mixing device is not used.
This device adopts modular design configuration, and user can determine configuration entrance mother liquor pump size and quantity according to need of production.Wherein on-line checkingi device is standard configuration.Solvent strength, pH value conductivity realize Automatic Control operation by on-line checkingi device FEEDBACK CONTROL, controller carries out communication by Socket mode and computer system, reach operating process dynamic monitoring, ensure that high precision controls, and operation result data can be preserved.This system has the structure of Highgrade integration, and volume is little, convenient mobile.
Claims (6)
1. the dynamic evenly mixing device of automatic liquid matching, it is characterized in that, comprise: dynamic mixer and the on-line monitoring detecting device be attached thereto, wherein: the input end of dynamic mixer is connected with mother liquor pump with bio-pump respectively, on-line monitoring detecting device comprises: the testing agency of connecting with dynamic mixer and the signal processor be connected with testing agency, the output terminal of signal processor is connected with controller, and the output terminal of controller is connected with mother liquor pump with bio-pump respectively.
2. the dynamic evenly mixing device of automatic liquid matching according to claim 1, it is characterized in that, described dynamic mixer comprises: be composed in series the mixing pump of loop, pH detecting device and electric conductivity detector successively, wherein: the input end of mixing pump is the output terminal of dynamic mixer, mixing delivery side of pump is the input end of dynamic mixer, and pH detecting device and electric conductivity detector are connected with on-line monitoring detecting device respectively.
3. the dynamic evenly mixing device of automatic liquid matching according to claim 1, it is characterized in that, described testing agency comprises: pressure detector, flow detector, wherein: pressure detector and flow detector are all connected with dynamic mixer and be connected with on-line monitoring detecting device respectively.
4. the dynamic evenly mixing device of automatic liquid matching according to claim 1, is characterized in that, the quantity of described mother liquor pump is at least one, the built-in damping fluid of this mother liquor pump and be in parallel between bio-pump.
5. the dynamic evenly mixing device of automatic liquid matching according to claim 2, is characterized in that, the output terminal of described dynamic mixer is provided with outlet valve.
6. the dynamic evenly mixing device of automatic liquid matching according to claim 1, it is characterized in that, described signal processor comprises: analog to digital converter, controller and network transmitter, wherein: the input end of analog to digital converter is connected with testing agency, output terminal is connected with network transmitter with controller respectively, and the output terminal of controller is connected with bio-pump respectively at network transmitter.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520397110.6U CN204740506U (en) | 2015-06-10 | 2015-06-10 | Automatic join in marriage attitude mixing device that surges |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520397110.6U CN204740506U (en) | 2015-06-10 | 2015-06-10 | Automatic join in marriage attitude mixing device that surges |
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| CN204740506U true CN204740506U (en) | 2015-11-04 |
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| CN201520397110.6U Active CN204740506U (en) | 2015-06-10 | 2015-06-10 | Automatic join in marriage attitude mixing device that surges |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107096407A (en) * | 2017-06-08 | 2017-08-29 | 利穗科技(苏州)有限公司 | buffer solution configuration system based on binary pump system |
| CN111467989A (en) * | 2019-12-30 | 2020-07-31 | 江苏汉邦科技有限公司 | Novel circulating dynamic online mixer |
| CN111551423A (en) * | 2020-05-14 | 2020-08-18 | 杭州奕安济世生物药业有限公司 | Sample conditioning apparatus and sample conditioning method |
-
2015
- 2015-06-10 CN CN201520397110.6U patent/CN204740506U/en active Active
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107096407A (en) * | 2017-06-08 | 2017-08-29 | 利穗科技(苏州)有限公司 | buffer solution configuration system based on binary pump system |
| CN111467989A (en) * | 2019-12-30 | 2020-07-31 | 江苏汉邦科技有限公司 | Novel circulating dynamic online mixer |
| CN111551423A (en) * | 2020-05-14 | 2020-08-18 | 杭州奕安济世生物药业有限公司 | Sample conditioning apparatus and sample conditioning method |
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