CN111551423A - Sample conditioning apparatus and sample conditioning method - Google Patents
Sample conditioning apparatus and sample conditioning method Download PDFInfo
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- CN111551423A CN111551423A CN202010411033.0A CN202010411033A CN111551423A CN 111551423 A CN111551423 A CN 111551423A CN 202010411033 A CN202010411033 A CN 202010411033A CN 111551423 A CN111551423 A CN 111551423A
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- 238000000034 method Methods 0.000 title claims abstract description 12
- 230000003750 conditioning effect Effects 0.000 title claims description 27
- 239000007788 liquid Substances 0.000 claims abstract description 99
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 41
- 239000012530 fluid Substances 0.000 claims abstract description 31
- 238000004891 communication Methods 0.000 claims abstract description 25
- 238000001514 detection method Methods 0.000 claims description 17
- 239000003002 pH adjusting agent Substances 0.000 claims description 15
- 239000003607 modifier Substances 0.000 claims description 14
- 230000001105 regulatory effect Effects 0.000 claims description 12
- 238000012840 feeding operation Methods 0.000 claims description 3
- 238000010992 reflux Methods 0.000 abstract description 2
- 239000000523 sample Substances 0.000 description 54
- 238000005516 engineering process Methods 0.000 description 3
- 229960000074 biopharmaceutical Drugs 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 230000001276 controlling effect Effects 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 230000002779 inactivation Effects 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 241000700605 Viruses Species 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 238000011143 downstream manufacturing Methods 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/38—Diluting, dispersing or mixing samples
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/02—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance
- G01N27/04—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance
- G01N27/06—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance of a liquid
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- Chemical & Material Sciences (AREA)
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- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Electrochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
Abstract
The invention provides a sample adjusting device and a sample adjusting method, relating to the technical field of sample adjustment, wherein the sample adjusting device provided by the invention comprises: the device comprises a mixing container, a collecting container, a first liquid pump and a flow guide valve group; a liquid inlet pipe of the first liquid pump is in fluid communication with the mixing container, and a return port of the mixing container and the collecting container are respectively connected with the flow guide valve group; the flow guide valve group is used for selecting one of the reflux port of the mixing container and the collecting container to be communicated with the liquid outlet pipe of the first liquid pump. The sample adjusting device provided by the invention can uniformly mix the sample reagent in the mixing container and convey the sample reagent to the collecting container.
Description
Technical Field
The invention relates to the technical field of sample adjustment, in particular to sample adjusting equipment and a sample adjusting method.
Background
With the innovation of the process technology, the biopharmaceutical industry has rapidly developed. Frequent pH and conductance adjustments are required in downstream purification steps of biopharmaceuticals. In conventional purification processes, the adjustment of the pH and conductivity of the sample requires a lot of manpower and it is difficult to ensure that the adjusted pH and conductivity are accurate. When the reagent is to be adjusted, a pH probe is usually inserted into the adjustment tank to detect the pH of the reagent in the adjustment tank. Because it is difficult to ensure reagent evenly distributed in the adjusting tank, influence the accuracy of testing result. Furthermore, in a continuous low pH inactivation process, a pH probe is typically inserted into the conditioning tank, and the dead volume in the process is large.
Disclosure of Invention
The invention aims to provide a sample adjusting device and a sample adjusting method, which can uniformly mix sample reagents in a mixing container and convey the sample reagents to a collecting container.
In a first aspect, the present invention provides a sample conditioning device comprising: the device comprises a mixing container, a collecting container, a first liquid pump and a flow guide valve group;
a liquid inlet pipe of the first liquid pump is in fluid communication with the mixing container, and a return port of the mixing container and the collecting container are respectively connected with the flow guide valve group;
the flow guide valve group is used for selecting one of the reflux port of the mixing container and the collecting container to be in fluid communication with the liquid outlet pipe of the first liquid pump.
With reference to the first aspect, the present invention provides a first possible implementation manner of the first aspect, wherein the flow guide valve group includes: a first control valve provided between the return port of the mixing container and the first liquid pump, and a second control valve provided between the collection container and the first liquid pump.
With reference to the first aspect, the present disclosure provides a second possible implementation manner of the first aspect, wherein the sample conditioning device further comprises a reagent detection component for detecting a physicochemical property of a reagent.
In combination with the second possible implementation manner of the first aspect, the present disclosure provides a third possible implementation manner of the first aspect, wherein the sample conditioning apparatus further comprises a liquid supply assembly in fluid communication with the mixing container.
With reference to the third possible implementation manner of the first aspect, the present invention provides a fourth possible implementation manner of the first aspect, wherein the reagent detection assembly includes a pH detector, and the pH detector is disposed between the backflow port of the mixing container and the flow guide valve group.
With reference to the fourth possible implementation manner of the first aspect, the present invention provides a fifth possible implementation manner of the first aspect, wherein the liquid supply assembly comprises: a first pH regulator container, a second pH regulator container, a third control valve and a fourth control valve;
the first and second pH adjuster containers are each in fluid communication with the mixing container;
the third control valve is arranged between the first pH regulator container and the mixing container, and the fourth control valve is arranged between the second pH regulator container and the mixing container.
In combination with the third possible implementation manner of the first aspect, the present invention provides a sixth possible implementation manner of the first aspect, wherein the reagent detection assembly includes a conductivity detector, and the conductivity detector is disposed between the backflow port of the mixing container and the flow guide valve group.
With reference to the sixth possible implementation manner of the first aspect, the present invention provides a seventh possible implementation manner of the first aspect, wherein the liquid supply assembly comprises: a first conductivity modifier container, a second conductivity modifier container, a fifth control valve, and a sixth control valve;
the fifth control valve is provided between the first conductivity adjuster container and the mixing container, and the sixth control valve is provided between the second conductivity adjuster container and the mixing container.
With reference to the third possible implementation manner of the first aspect, the present invention provides an eighth possible implementation manner of the first aspect, wherein the liquid supply assembly comprises: the mixing device comprises a liquid supply pipeline, a seventh control valve and a second liquid pump, wherein one end of the liquid supply pipeline is in fluid communication with the mixing container, and the other end of the liquid supply pipeline is used for communicating with a sample source to be regulated;
the second liquid pump is arranged between the liquid supply pipeline and the mixing container, and the seventh control valve is used for regulating the on-off state of the liquid supply pipeline.
In a second aspect, the sample conditioning method provided by the present invention employs the sample conditioning apparatus provided in the first aspect, and includes a mixing operating state and a sample feeding operating state;
in the mixing working state, regulating and controlling the flow guide valve group to fluidly communicate the liquid outlet pipe of the first liquid pump with the return port of the mixing container;
and under the sample feeding working state, regulating and controlling the flow guide valve group to fluidly communicate the liquid outlet pipe of the first liquid pump with the collection container.
The embodiment of the invention has the following beneficial effects: feed liquor pipe and mixing vessel fluid intercommunication through first liquid pump, mixing vessel's backward flow mouth and collection container connect the valve unit respectively, make mixing vessel's backward flow mouth and collection container alternative and the drain pipe fluid intercommunication of first liquid pump through the valve unit to make sample adjusting device can switch between mixing operation state and the working state of sending a kind, and then ensure the sample reagent misce bene in the mixing vessel.
In order to make the aforementioned and other objects, features and advantages of the present invention comprehensible, preferred embodiments accompanied with figures are described in detail below.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present invention or related technologies, the drawings used in the description of the embodiments or related technologies will be briefly introduced below, and it is obvious that the drawings in the following description are some embodiments of the present invention, and other drawings can be obtained by those skilled in the art without creative efforts.
Fig. 1 is a schematic diagram of a sample conditioning apparatus according to an embodiment of the present invention.
Icon: 100-a mixing vessel; 200-a collection vessel; 300-a first liquid pump; 400-a flow guide valve group; 410-a first control valve; 420-a second control valve; 500-a reagent detection assembly; 510-a pH detector; 520-a conductivity detector; 600-a liquid supply assembly; 601-a first pH adjuster container; 602-a second pH adjuster container; 603-a third control valve; 604-a fourth control valve; 605-a first conductivity modifier vessel; 606-a second conductivity modifier container; 607-fifth control valve; 608-a sixth control valve; 609-a liquid supply pipeline; 610-a seventh control valve; 611-second liquid pump.
Detailed Description
The technical solutions of the present invention will be described clearly and completely with reference to the accompanying drawings, and it should be understood that the described embodiments are some, but not all embodiments of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
In the description of the present invention, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc., indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are only for convenience of description and simplicity of description, but do not indicate or imply that the device or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus, should not be construed as limiting the present invention. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance. The term "physical quantity" in the formula, unless otherwise noted, is understood to mean a basic quantity of a basic unit of international system of units, or a derived quantity derived from a basic quantity by a mathematical operation such as multiplication, division, differentiation, or integration.
In the description of the present invention, it should be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "connected," and "connected" are to be construed broadly, e.g., as meaning either a fixed connection, a removable connection, or an integral connection; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meanings of the above terms in the present invention can be understood in specific cases to those skilled in the art.
Example one
As shown in fig. 1, a sample conditioning apparatus provided in an embodiment of the present invention includes: a mixing vessel 100, a collection vessel 200, a first liquid pump 300, and a valve block 400; a liquid inlet pipe of the first liquid pump 300 is in fluid communication with the mixing container 100, and a return port of the mixing container 100 and the collecting container 200 are respectively connected with the valve block 400; the valve manifold 400 is used to place the return port of the mixing container 100 and the collection container 200 in selective fluid communication with the outlet of the first liquid pump 300.
Specifically, the outlet of the first liquid pump 300 is fluidly connected to the return port of the mixing container 100 via the valve assembly 400, and the sample reagent flows from the mixing container 100 back to the mixing container 100 via the first liquid pump 300 and the return port, so that the sample reagent can be uniformly mixed in the mixing container 100. When the valve block 400 is adjusted to place the outlet of the first liquid pump 300 in fluid communication with the collection container 200, the first liquid pump 300 delivers the sample from the mixing container 100 into the collection container 200.
In an embodiment of the present invention, the valve block 400 includes: a first control valve 410 and a second control valve 420, the first control valve 410 being provided between the return port of the mixing container 100 and the first liquid pump 300, and the second control valve 420 being provided between the collection container 200 and the first liquid pump 300.
Specifically, the second control valve 420 is closed, the first control valve 410 is opened, and the sample in the mixing container 100 is delivered to the return port via the first liquid pump 300 and flows back into the mixing container 100; the first control valve 410 is closed and the second control valve 420 is opened and the sample in the mixing container 100 is transferred to the collection container 200 via the first liquid pump 300.
Further, the sample conditioning device further comprises a reagent detection assembly 500, wherein the reagent detection assembly 500 is used for detecting the physicochemical property of the reagent.
Specifically, the reagent detection assembly 500 is used to detect the pH or conductivity of the reagent, or the reagent detection assembly 500 can detect both the pH and conductivity of the reagent. The second control valve 420 is closed and the first control valve 410 is opened to ensure that the sample is adequately mixed within the mixing container 100 by the first liquid pump 300 driving the reagent in the mixing container 100 through the first liquid pump 300 and the return port and back into the mixing container 100. In this process, the measured parameter of the reagent detecting assembly 500 gradually approaches the target value, the opening degree of the first control valve 410 gradually decreases, and the first liquid pump 300 gradually decreases the infusion speed. When the measured parameter of the reagent detection assembly 500 reaches a target value, the first control valve 410 is closed and the first liquid pump 300 is stopped. Thereafter, the second control valve 420 is opened, the first liquid pump 300 is activated, and the sample in the mixing container 100 is drained into the collection container 200 by the first liquid pump 300.
Further, the sample conditioning apparatus also includes a liquid supply assembly 600, the liquid supply assembly 600 being in fluid communication with the mixing container 100. Specifically, the liquid supply assembly 600 may deliver the physicochemical conditioning agent and the sample material to the mixing container 100, where the physicochemical conditioning agent and the sample material are thoroughly mixed in the mixing container 100, such that the pH and the conductivity of the sample both reach target values.
Further, the reagent detecting assembly 500 includes a pH detector 510, and the pH detector 510 is disposed between the backflow port of the mixing container 100 and the valve assembly 400.
Specifically, the pH detector 510 may detect the sample flowing back to the mixing container 100 through the backflow port, and when the detection value of the pH detector 510 is equal to the target pH value, the valve set 400 is adjusted to fluidly connect the drain pipe of the first liquid pump 300 with the collection container 200, so as to deliver the sample with the pH up to the standard to the collection container 200.
Further, the liquid supply assembly 600 includes: a first pH adjuster container 601, a second pH adjuster container 602, a third control valve 603, and a fourth control valve 604; the first pH adjuster container 601 and the second pH adjuster container 602 are respectively in fluid communication with the mixing container 100; a third control valve 603 is provided between the first pH adjuster container 601 and the mixing container 100, and a fourth control valve 604 is provided between the second pH adjuster container 602 and the mixing container 100.
Specifically, the first pH adjuster container 601 is used to contain a reagent for adjusting the pH to a lower value, and the second pH adjuster container 602 is used to contain a reagent for adjusting the pH to a higher value. When the detection value of the pH detector 510 is higher than the target value, the third control valve 603 is opened, the fourth control valve 604 is closed, and the first pH adjustor container 601 is brought into fluid communication with the mixing container 100, so that the pH of the sample in the mixing container 100 is adjusted by the reagent in the first pH adjustor container 601. When the detection value of the pH detector 510 is lower than the target value, the fourth control valve 604 is opened, the third control valve 603 is closed, and the second pH adjustor container 602 is brought into fluid communication with the mixing container 100, so that the pH of the sample in the mixing container 100 is adjusted to be high by the reagent in the second pH adjustor container 602.
Further, the reagent detection assembly 500 includes a conductivity detector 520, the conductivity detector 520 being disposed between the return port of the mixing vessel 100 and the valve block 400.
Specifically, the conductivity detector 520 detects the sample flowing into the mixing container 100 through the return port, and when the detected value of the conductivity detector 520 is equal to the target value of the conductivity, the valve set 400 is adjusted to connect the outlet pipe of the first liquid pump 300 with the collection container 200, so as to deliver the sample with the conductivity up to the standard to the collection container 200.
Further, the liquid supply assembly 600 includes: a first conductivity modifier container 605, a second conductivity modifier container 606, a fifth control valve 607, and a sixth control valve 608; a fifth control valve 607 is provided between the first conductivity adjuster container 605 and the mixing container 100, and a sixth control valve 608 is provided between the second conductivity adjuster container 606 and the mixing container 100.
Specifically, the first conductivity modifier container 605 is used to contain a conductivity-reduced reagent, and the second conductivity modifier container 606 is used to contain a conductivity-increased reagent. When the value detected by the conductivity detector 520 is higher than the target value of the conductivity, the fifth control valve 607 is opened, the sixth control valve 608 is closed, the first conductivity modifier container 605 is brought into fluid communication with the mixing container 100, and the conductivity of the sample in the mixing container 100 is reduced by the reagent in the first conductivity modifier container 605. When the detected value of the conductivity detector 520 is lower than the target value of the conductivity, the sixth control valve 608 is opened, the fifth control valve 607 is closed, the second conductivity adjustor container 606 is brought into fluid communication with the mixing container 100, and the conductivity of the sample in the mixing container 100 is adjusted to be high by the reagent in the second conductivity adjustor container 606.
Further, the liquid supply assembly 600 includes: a liquid supply line 609, a seventh control valve 610 and a second liquid pump 611, wherein one end of the liquid supply line 609 is in fluid communication with the mixing container 100, and the other end of the liquid supply line 609 is used for communicating with a sample source to be regulated; the second liquid pump 611 is provided between the liquid supply line 609 and the mixing container 100, and the seventh control valve 610 is used to regulate the on-off state of the liquid supply line 609. Wherein, the sample to be adjusted can be driven by the second liquid pump 611 to flow through the seventh control valve 610 and the second liquid pump 611 in sequence along the liquid supply line 609 and flow into the mixing container 100. Further, the third control valve 603, the fourth control valve 604, the fifth control valve 607, and the sixth control valve 608 are respectively in fluid communication with a second liquid pump 611, and the second liquid pump 611 can respectively transfer the reagents in the first pH adjustor container 601, the second pH adjustor container 602, the first conductivity adjustor container 605, and the second conductivity adjustor container 606 into the mixing container 100.
Example two
As shown in fig. 1, the sample adjustment method provided by the embodiment of the present invention adopts the sample adjustment apparatus provided by the first embodiment, and includes a mixing operation state and a sample feeding operation state; in a mixing operation state, the valve block 400 is regulated and controlled to fluidly communicate the liquid outlet pipe of the first liquid pump 300 with the return port of the mixing container 100; in the sample feeding operation, the valve block 400 is adjusted and controlled to fluidly connect the outlet of the first liquid pump 300 with the collection container 200.
Specifically, valve manifold 400 is manipulated and placed such that the outlet of first fluid pump 300 is in fluid communication with the return of mixing container 100, thereby allowing mixing container 100 to flow back to mixing container 100 via first fluid pump 300. When the pH and conductivity of the sample reach target values, the valve block 400 is manipulated and the effluent line of the first fluid pump 300 is placed in fluid communication with the collection container 200, thereby storing the sample in the collection container 200. When the sample to be adjusted is introduced into the mixing container 100, the valve block 400 is adjusted again to connect the liquid outlet of the first liquid pump 300 with the return port of the mixing container 100, so as to start the next round of virus inactivation under the low pH state. The pH and conductivity can be continuously regulated and controlled by adopting the sample regulating equipment, so that the technical problem of large dead volume is solved, and the continuity of a downstream process is maintained.
Finally, it should be noted that: the above embodiments are only used to illustrate the technical solution of the present invention, and not to limit the same; while the invention has been described in detail and with reference to the foregoing embodiments, it will be understood by those skilled in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some or all of the technical features may be equivalently replaced; and the modifications or the substitutions do not make the essence of the corresponding technical solutions depart from the scope of the technical solutions of the embodiments of the present invention.
Claims (10)
1. A sample conditioning apparatus, comprising: a mixing container (100), a collection container (200), a first liquid pump (300) and a valve block (400);
a liquid inlet pipe of the first liquid pump (300) is in fluid communication with the mixing container (100), and a return port of the mixing container (100) and the collecting container (200) are respectively connected with the flow guide valve group (400);
the valve block (400) is used for enabling the backflow port of the mixing container (100) and the collection container (200) to be in fluid communication with the liquid outlet pipe of the first liquid pump (300) alternatively.
2. The sample conditioning apparatus of claim 1, wherein the set of fluidic valves (400) comprises: a first control valve (410) and a second control valve (420), the first control valve (410) being provided between the return opening of the mixing container (100) and the first liquid pump (300), the second control valve (420) being provided between the collection container (200) and the first liquid pump (300).
3. The sample conditioning device of claim 1, further comprising a reagent detection assembly (500), the reagent detection assembly (500) for detecting a physicochemical property of a reagent.
4. The sample conditioning device of claim 3, further comprising a liquid supply assembly (600), the liquid supply assembly (600) in fluid communication with the mixing container (100).
5. The sample conditioning device of claim 4, wherein the reagent detection assembly (500) comprises a pH detector (510), the pH detector (510) being disposed between a return port of the mixing container (100) and the set of fluidic valves (400).
6. The sample conditioning apparatus of claim 5, wherein the liquid supply assembly (600) comprises: a first pH adjuster container (601), a second pH adjuster container (602), a third control valve (603), and a fourth control valve (604);
the first pH adjuster container (601) and the second pH adjuster container (602) are respectively in fluid communication with the mixing container (100);
the third control valve (603) is provided between the first pH adjustor container (601) and the mixing container (100), and the fourth control valve (604) is provided between the second pH adjustor container (602) and the mixing container (100).
7. The sample conditioning apparatus of claim 4, wherein the reagent detection assembly (500) comprises a conductivity detector (520), the conductivity detector (520) being disposed between a return port of the mixing vessel (100) and the set of fluidic valves (400).
8. The sample conditioning apparatus of claim 7, wherein the liquid supply assembly (600) comprises: a first conductivity modifier container (605), a second conductivity modifier container (606), a fifth control valve (607), and a sixth control valve (608);
the fifth control valve (607) is provided between the first conductivity modifier container (605) and the mixing container (100), and the sixth control valve (608) is provided between the second conductivity modifier container (606) and the mixing container (100).
9. The sample conditioning apparatus of claim 4, wherein the liquid supply assembly (600) comprises: a liquid supply pipeline (609), a seventh control valve (610) and a second liquid pump (611), wherein one end of the liquid supply pipeline (609) is communicated with the fluid of the mixing container (100), and the other end of the liquid supply pipeline (609) is used for being communicated with a sample source to be regulated;
the second liquid pump (611) is arranged between the liquid supply pipeline (609) and the mixing container (100), and the seventh control valve (610) is used for regulating the on-off state of the liquid supply pipeline (609).
10. A sample conditioning method, characterized in that it employs the sample conditioning apparatus of any one of claims 1 to 9 and comprises a mixing operation state and a sample-feeding operation state;
in the mixing working state, the flow guide valve group (400) is regulated to enable a liquid outlet pipe of the first liquid pump (300) to be in fluid communication with a backflow port of the mixing container (100);
and under the sample sending working state, the flow guide valve group (400) is regulated and controlled to enable the liquid outlet pipe of the first liquid pump (300) to be in fluid communication with the collection container (200).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010411033.0A CN111551423A (en) | 2020-05-14 | 2020-05-14 | Sample conditioning apparatus and sample conditioning method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010411033.0A CN111551423A (en) | 2020-05-14 | 2020-05-14 | Sample conditioning apparatus and sample conditioning method |
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| CN111551423A true CN111551423A (en) | 2020-08-18 |
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| CN202010411033.0A Pending CN111551423A (en) | 2020-05-14 | 2020-05-14 | Sample conditioning apparatus and sample conditioning method |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN204740506U (en) * | 2015-06-10 | 2015-11-04 | 荣捷生物工程（苏州）有限公司 | Automatic join in marriage attitude mixing device that surges |
| CN206121605U (en) * | 2016-09-07 | 2017-04-26 | 荣捷生物工程（苏州）有限公司 | Mixer |
| CN109453727A (en) * | 2018-11-30 | 2019-03-12 | 唐林 | A kind of PH regulating device |
| CN209974790U (en) * | 2019-03-23 | 2020-01-21 | 上海傲中生物工程设备有限公司 | Stainless steel fermentation cylinder with pH value adjusting device |
| CN111111484A (en) * | 2020-01-02 | 2020-05-08 | 利穗科技(苏州)有限公司 | Synergistic continuous pH inactivation liquid mixing system and application thereof |
-
2020
- 2020-05-14 CN CN202010411033.0A patent/CN111551423A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN204740506U (en) * | 2015-06-10 | 2015-11-04 | 荣捷生物工程（苏州）有限公司 | Automatic join in marriage attitude mixing device that surges |
| CN206121605U (en) * | 2016-09-07 | 2017-04-26 | 荣捷生物工程（苏州）有限公司 | Mixer |
| CN109453727A (en) * | 2018-11-30 | 2019-03-12 | 唐林 | A kind of PH regulating device |
| CN209974790U (en) * | 2019-03-23 | 2020-01-21 | 上海傲中生物工程设备有限公司 | Stainless steel fermentation cylinder with pH value adjusting device |
| CN111111484A (en) * | 2020-01-02 | 2020-05-08 | 利穗科技(苏州)有限公司 | Synergistic continuous pH inactivation liquid mixing system and application thereof |
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Application publication date: 20200818 |