CN211677234U - Novel circulating dynamic online mixer - Google Patents
Novel circulating dynamic online mixer Download PDFInfo
- Publication number
- CN211677234U CN211677234U CN201922417586.2U CN201922417586U CN211677234U CN 211677234 U CN211677234 U CN 211677234U CN 201922417586 U CN201922417586 U CN 201922417586U CN 211677234 U CN211677234 U CN 211677234U
- Authority
- CN
- China
- Prior art keywords
- liquid
- mixer
- control unit
- circulating
- novel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Landscapes
- Accessories For Mixers (AREA)
Abstract
A novel circulating dynamic on-line mixer comprises a static mixer, a liquid circulating device, a detection device, a control unit and the like; the invention can realize the functions of mixing liquid uniformly and detecting the process parameters of the liquid such as conductivity, pH and the like on line in real time, and has the advantages of more uniform mixing effect, short balancing time of mixed solution and the like.
Description
Technical Field
The invention relates to a liquid mixing device, in particular to a dynamic mixing device for realizing the functions of online automatic mixing and online automatic detection of liquid, and belongs to the technical field of biological pharmacy.
Background
At present, the biopharmaceutical industry in China is in a rapid development stage, the scale of industries such as monoclonal antibodies, blood products, recombinant proteins and the like is greatly improved, and a large amount of buffer solution is needed for purifying products in each batch; the buffer solution is prepared mainly by the following methods: the first method is manual preparation, which is currently used more, needs a large amount of liquid preparation personnel, a liquid storage tank and a large-area liquid preparation room, and has low liquid preparation qualification rate, poor consistency, easy pollution, high cost and low efficiency; secondly, a static mixer is adopted for liquid preparation, pH and conductivity detection and the like are simultaneously adopted for realizing on-line liquid preparation, but the static mixer utilizes the natural properties of liquid for mixing, the balance time is long, and the liquid is not uniformly mixed; thirdly, liquid is mixed by mechanical stirring or magnetic stirring, a liquid raw material mixing device (patent application No. 201711099174.8) and an energy-saving stirring device (patent application No. 201811345058.4) for mixing liquid are all provided with a motor to drive a stirring paddle to mix liquid, and a dynamic mixer (patent application No. 201822130327.7) is provided with magnetic stirring liquid, so that the problems that the mechanical stirring and the magnetic stirring cannot detect in real time and mix the liquid are solved.
SUMMERY OF THE UTILITY MODEL
In order to solve the problems, the invention provides a novel circulating dynamic online mixer which can effectively improve the quality and efficiency of liquid preparation, reduce the balance time, reduce the cost of liquid preparation and reduce the area between liquid preparation rooms.
The technical scheme adopted by the invention is as follows:
the utility model provides a novel online blender of circulating developments, includes flowmeter, static mixer, detection device, the control unit, 2 go out the liquid valve, be equipped with the blender entry on the online mixer, its characterized in that the online mixer of developments still includes liquid circulation device, static mixer and liquid circulation device establish ties into the closed loop through circulation pipeline, detection device one end is passed through the tube coupling and is between static mixer and liquid circulation device, and the other end passes through the circuit and links to each other with the control unit, detection device's back parallel connection 2 goes out the liquid valve, and 2 go out the liquid valve and respectively are equipped with 1 liquid outlet at the back, and the control unit passes through the circuit and links to each other with liquid circulation device, flowmeter, 2 play liquid valve, liquid circulation device's velocity of flow is greater than the velocity of flow of blender entrance.
A further development of the invention is that the liquid circulation device is a circulation pump which may be a centrifugal pump, a diaphragm pump, a plunger pump, preferably a magnetically levitated centrifugal pump.
The invention is further improved in that the static mixer further comprises a pressure detector, and the pressure detector is connected between the flowmeter and the static mixer through a pipeline and is connected to the control unit through a line.
A further improvement of the invention is that the detection means is a conductivity detector and/or a pH detector.
The invention is further improved in that the control unit is an independent control unit or is integrated in the liquid preparation system and the chromatography system, and the control unit can adjust the flow rate of the circulating pump according to the flow rate of the flow meter at the inlet.
The invention has the further improvement that 1 of the 2 liquid outlet valves is a waste liquid valve, and 1 is an outlet valve; 2 liquid outlet 1 is the waste liquid mouth, 1 is the blender export.
The invention has the beneficial effects that:
the invention adopts a method of combining the static mixer and the liquid circulating device to mix the liquid to be mixed, and can monitor whether the process parameters such as the conductance and the pH of the mixed liquid meet the requirements in real time, thereby adjusting the mixing times according to the situation, so that the solution is mixed more uniformly, improving the mixing efficiency, shortening the balance time of the mixed solution, and greatly reducing the number of buffer tanks for preparing the solution and the area between the prepared solutions.
Description of the drawings:
FIG. 1 is a schematic view of the present invention.
The specific code numbers in the figure are as follows:
1. the mixer comprises a mixer inlet 2, a flowmeter 3, a static mixer 4, an electrical conductivity detector 5, a pH detector 6, a waste liquid valve 7, an outlet valve 8, a mixer outlet 9, a waste liquid port 10, a circulating pump 11, a circulating pipeline 12, a control unit 13 and a pressure detector.
The specific implementation mode is as follows:
the above-described scheme is further illustrated below with reference to specific examples.
The scheme of the invention is further described in detail with reference to fig. 1, and the novel circulating dynamic online mixer shown in fig. 1 is composed of a mixer inlet (1), a flowmeter (2), a static mixer (3), a conductivity detector (4), a pH detector (5), a waste liquid valve (6), an outlet valve (7), a mixer outlet (8), a waste liquid port (9), a circulating pump (10) (which can be a centrifugal pump, a diaphragm pump, a plunger pump, a magnetic suspension centrifugal pump), a circulating pipeline (11), a control unit (12) and a pressure detector (13).
The mixer inlet (1) is connected with a flowmeter (2), a pressure detector (13) and a static mixer (3) in sequence through pipelines, a circulating pump (10) is connected with the static mixer (3) in series through a circulating pipeline (11) to form a closed loop, one ends of a conductivity detector (4) and a pH detector (5) are connected between the static mixer (3) and the circulating pump (10) in series through pipelines, the other ends are connected with a control unit (12) through a circuit, the conductivity detector (4), the rear part of the pH detector (5) is connected with a waste liquid valve (6) and an outlet valve (7) in series, the waste liquid valve (6) is connected with a waste liquid port (9), the outlet valve (7) is connected with a mixer outlet (8), a control unit (12) is connected with a flowmeter (2), the waste liquid valve (6), the outlet valve (7) and a pressure detector (13) through lines, and the control unit (12) is used for monitoring and controlling each component in a flow path.
When the device is used specifically, two or more solutions enter from the mixer inlet (1), the flow meter (2) detects the flow of the solutions, the solutions are preliminarily mixed through the static mixer (3) after flow detection, the solutions after preliminary mixing are subjected to online detection through the conductivity detector (4) and the pH detector (5), the detected conductivity value and pH value are fed back to the control unit (12) in real time, and the control unit (12) processes, judges and records and displays real-time data on the feedback value. When the pH and conductivity detection values of the mixed solution can not be stabilized within the required range, the control unit (12) increases the rotating speed of the circulating pump (10) to increase the flow rate so as to increase the mixing times of the solution to be mixed through the static mixer (3) until the detection values are stabilized within the required range. When the pH and conductivity detection values of the mixed solution meet the requirements, opening a waste liquid valve (6) to discharge waste liquid at the front end of the pipeline through a waste liquid port (9), and then opening an outlet valve (7) to supply qualified mixed solution required by the chromatography system through a mixer outlet (8); the control unit (12) controls the rotating speed of the circulating pump (10) in real time according to the detection values of the flowmeter (2), the conductivity detector (4) and the pH detector (5) during work, so that the mixed solution flowing out of the outlet (8) of the mixer always meets the set requirement, and the pressure monitor (13) detects the pressure in real time.
The above embodiments are only for illustrating the technical idea of the present invention, and the protection scope of the present invention is not limited thereby, and any modifications made on the basis of the technical scheme according to the technical idea of the present invention fall within the protection scope of the present invention.
Claims (6)
1. The utility model provides a novel online blender of circulating developments, includes flowmeter, static mixer, detection device, the control unit, 2 go out the liquid valve, be equipped with the blender entry on the online mixer, its characterized in that the online mixer of developments still includes liquid circulation device, static mixer and liquid circulation device establish ties into the closed loop through circulation pipeline, detection device one end is passed through the tube coupling and is between static mixer and liquid circulation device, and the other end passes through the circuit and links to each other with the control unit, detection device's back parallel connection 2 goes out the liquid valve, and 2 go out the liquid valve and respectively are equipped with 1 liquid outlet at the back, and the control unit passes through the circuit and links to each other with liquid circulation device, flowmeter, 2 play liquid valve, liquid circulation device's velocity of flow is greater than the velocity of flow of blender entrance.
2. The novel circulating dynamic online mixer of claim 1, wherein: the liquid circulating device is a circulating pump, and the circulating pump is a centrifugal pump, a diaphragm pump, a plunger pump or a magnetic suspension centrifugal pump.
3. The novel circulating dynamic online mixer of claim 1, wherein: the static mixer also comprises a pressure detector, wherein the pressure detector is connected between the flowmeter and the static mixer through a pipeline and is connected to the control unit through a line.
4. The novel circulating dynamic online mixer of claim 1, wherein: the detection device is a conductivity detector and/or a pH detector.
5. The novel circulating dynamic online mixer of claim 1, wherein: the control unit is an independent control unit or is integrated in a liquid preparation system and a chromatography system.
6. The novel circulating dynamic online mixer of claim 1, wherein: 1 of the 2 liquid outlet valves is a waste liquid valve, and 1 is an outlet valve; 2 liquid outlet 1 is the waste liquid mouth, 1 is the blender export.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201922417586.2U CN211677234U (en) | 2019-12-30 | 2019-12-30 | Novel circulating dynamic online mixer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201922417586.2U CN211677234U (en) | 2019-12-30 | 2019-12-30 | Novel circulating dynamic online mixer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN211677234U true CN211677234U (en) | 2020-10-16 |
Family
ID=72795982
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201922417586.2U Active CN211677234U (en) | 2019-12-30 | 2019-12-30 | Novel circulating dynamic online mixer |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN211677234U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111467989A (en) * | 2019-12-30 | 2020-07-31 | 江苏汉邦科技有限公司 | Novel circulating dynamic online mixer |
-
2019
- 2019-12-30 CN CN201922417586.2U patent/CN211677234U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111467989A (en) * | 2019-12-30 | 2020-07-31 | 江苏汉邦科技有限公司 | Novel circulating dynamic online mixer |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN111467989A (en) | Novel circulating dynamic online mixer | |
| CN205659678U (en) | Reation kettle of intelligence batching | |
| CN211677234U (en) | Novel circulating dynamic online mixer | |
| CN214570954U (en) | Intelligent coagulant adding system | |
| CN212663252U (en) | Intelligent ethanol blending system | |
| CN105174402B (en) | A kind of automatic adding flocculant system settled for black water and its method | |
| CN208911888U (en) | Agitating device and urea machine with it | |
| CN207913700U (en) | A kind of trace element water-soluble fertilizer dilution device | |
| CN206378411U (en) | A kind of calibration system in online analytical instrument | |
| CN205576065U (en) | Beer wheat juice aerating device | |
| CN107410052A (en) | A kind of hydrogeneous water mixing drawing-in device of animal husbandry | |
| CN217663145U (en) | Online dilution system | |
| CN209491981U (en) | A kind of magnetizing assembly of magnetized concrete mixing water | |
| CN206713988U (en) | A kind of online enzyme preparation add-on system of rice protein feed liquid multistage timesharing | |
| CN206014493U (en) | A kind of novel reducer chemicals dosing plant | |
| CN206214490U (en) | A kind of dialysis concentrate of recycle heat prepares dialysis system | |
| CN211159588U (en) | Efficient and intelligent additive compounding device | |
| CN205386431U (en) | Supplementary material hybrid system in full price feed production technology | |
| CN211051415U (en) | Intelligent additive masterbatch batching system | |
| CN207100479U (en) | A kind of fast activating of additive for microbe feedstuff expands numerous equipment | |
| CN212142185U (en) | Automatic solution diluting system | |
| CN209974924U (en) | Electrolytic copper foil silane adding device | |
| CN106699835A (en) | Full-automatic plasma processing equipment and method | |
| CN209155564U (en) | A kind of intelligence liquid compounding system | |
| CN215877683U (en) | Intelligent laboratory buffer solution configuration system |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CP01 | Change in the name or title of a patent holder |
Address after: 223005 no.1-9 Jixian Road, Huai'an Economic and Technological Development Zone, Huai'an City, Jiangsu Province Patentee after: Jiangsu Hanbang Technology Co.,Ltd. Address before: 223005 no.1-9 Jixian Road, Huai'an Economic and Technological Development Zone, Huai'an City, Jiangsu Province Patentee before: JIANGSU HANBON SCIENCE & TECHNOLOGY Co.,Ltd. |
|
| CP01 | Change in the name or title of a patent holder |