CN217663145U - Online dilution system - Google Patents

Online dilution system Download PDF

Info

Publication number
CN217663145U
CN217663145U CN202221025057.3U CN202221025057U CN217663145U CN 217663145 U CN217663145 U CN 217663145U CN 202221025057 U CN202221025057 U CN 202221025057U CN 217663145 U CN217663145 U CN 217663145U
Authority
CN
China
Prior art keywords
pipeline
valve
jar
mother liquor
controller
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN202221025057.3U
Other languages
Chinese (zh)
Inventor
张尧
刘勇
邓靖
李丹
肖春桥
杨龙
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Guizhou Taibang Biological Products Co ltd
Original Assignee
Guizhou Taibang Biological Products Co ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Guizhou Taibang Biological Products Co ltd filed Critical Guizhou Taibang Biological Products Co ltd
Priority to CN202221025057.3U priority Critical patent/CN217663145U/en
Application granted granted Critical
Publication of CN217663145U publication Critical patent/CN217663145U/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Landscapes

  • Control Of Non-Electrical Variables (AREA)
  • Accessories For Mixers (AREA)

Abstract

The utility model discloses an online dilution system belongs to solution dilution technical field. This system includes mother liquor jar, solvent jar, blender and controller, the mother liquor jar with the top of solvent jar all is equipped with the constant voltage subassembly, the blender is connected through pipeline A and mother liquor jar, solvent jar's bottom respectively, and is equipped with valve B on the pipeline A, be equipped with pipeline C on the blender, and be equipped with the concentration detection subassembly on the pipeline C, controller and constant voltage subassembly, valve B and concentration detection subassembly electric connection. The mother solution dilution can be automatically completed on line, the solution preparation efficiency is high, and the consistency of the concentration of the obtained diluted solution is good. Pipeline B is parallelly connected with pipeline A, and valve A is parallelly connected with valve B, and the system can be widened to the dilution proportion range of mother liquor to this structure.

Description

Online dilution system
Technical Field
The utility model relates to an online dilution system belongs to solution dilution technical field.
Background
Currently, in the field of biopharmaceutical, the traditional solution dilution method is: the concentration of the mother liquor is detected firstly, the concentration can be mass ratio concentration, volume ratio concentration or mass volume ratio concentration, and the like, then the mother liquor is mixed into a buffer tank according to different proportions according to the concentration, and then offline sampling analysis is carried out to detect whether the diluted concentration is qualified or not.
However, this dilution method is basically a method in which a worker manually dilutes the solution, the solution preparation efficiency is low, and various errors are generated artificially, so that the concentration of the diluted solution prepared in each batch is not always consistent.
SUMMERY OF THE UTILITY MODEL
In order to solve the technical problem, the utility model provides an online dilution system.
The utility model discloses a following technical scheme can realize:
the utility model provides an online dilution system, includes mother liquor jar, solvent jar, blender and controller, the mother liquor jar with the top of solvent jar all is equipped with the constant voltage subassembly, the blender is connected through the bottom of pipeline A with mother liquor jar, solvent jar respectively, and is equipped with valve B on the pipeline A, be equipped with pipeline C on the blender, and be equipped with the concentration detection subassembly on the pipeline C, controller and constant voltage subassembly, valve B and concentration detection subassembly electric connection.
The constant voltage component comprises an inflator pump and a digital barometer, and the inflator pump and the digital barometer are both electrically connected with the controller.
The middle part of pipeline A is equipped with pipeline B, is equipped with valve A on the pipeline B, and valve A and valve B are parallelly connected.
And the valve A and the valve B are both electric proportional regulating valves and are electrically connected with the controller.
The inner diameter of the pipeline B is smaller than that of the pipeline A.
The mixer is a static mixer.
The concentration detection component is a conductivity meter.
The system still includes the jar of keeping in, and the jar of keeping in is connected through pipeline D and pipeline C's middle part, and is equipped with valve D on the pipeline D, is equipped with valve C on the pipeline C, and concentration detection subassembly is located between valve C and the blender, and pipeline D and pipeline C's tie point is located between concentration detection subassembly and the valve C.
And the valve C and the valve D are both pneumatic diaphragm valves, and the pneumatic diaphragm valves are electrically connected with the controller.
The beneficial effects of the utility model reside in that: the mother solution dilution can be automatically completed on line, the solution preparation efficiency is high, and the consistency of the concentration of the obtained diluted solution is good. Pipeline B is parallelly connected with pipeline A, and valve A is parallelly connected with valve B, and the system can be widened to the dilution proportion range of mother liquor to this structure. Make the atmospheric pressure in mother liquor jar, the solvent jar keep invariable through the constant voltage subassembly, for mother liquor and solvent transport provide pressure, atmospheric pressure is invariable to be helped making the liquid flow velocity stable, helps improving the concentration accuracy of the dilute solution who prepares simultaneously.
Drawings
Fig. 1 is a schematic structural diagram of the present invention.
In the figure: 1-mother liquor tank, 2-solvent tank, 3-pipeline A, 4-pipeline B, 5-valve A, 6-valve B, 7-mixer, 8-concentration detection component, 9-valve C, 10-pipeline C, 11-valve D, 12-pipeline D, 13-temporary storage tank.
Detailed Description
The technical solution of the present invention is further described below, but the scope of the claimed invention is not limited to the described.
As shown in figure 1, an online dilution system, including mother liquor jar 1, solvent jar 2, blender 7 and controller, mother liquor jar 1 with the constant voltage subassembly is all installed at the top of solvent jar 2, blender 7 is connected with mother liquor jar 1, solvent jar 2's bottom through pipeline A3 respectively, and installs valve B6 on the pipeline A3, be connected with pipeline C10 on the blender 7, and install concentration detection subassembly 8 on the pipeline C10, controller and constant voltage subassembly, valve B6 and concentration detection subassembly 8 electric connection. When the device is used, the air pressure in the mother liquor tank 1 and the air pressure in the solvent tank 2 are kept constant through the constant pressure assembly, pressure is provided for conveying mother liquor and solvent, meanwhile, the constant air pressure is also beneficial to stabilizing the flow rate of the liquid, the controller adjusts the amount of the mother liquor and the solvent entering the mixer 7 in unit time through controlling the opening degree of the valve B6 so as to obtain diluted solution with required concentration, finally, the concentration of the diluted solution is detected or verified through the concentration detection assembly 8, relevant information is transmitted to the controller, and the opening degree of the valve B6 is corrected by the controller according to the actual concentration of the diluted solution so as to form closed-loop control.
The constant voltage component comprises an inflator pump and a digital barometer, and the inflator pump and the digital barometer are both electrically connected with the controller. When in use, the gas pressure in the mother liquor tank 1 and the solvent tank 2 may be detected by a gas pressure sensor or the like.
The middle part of pipeline A3 is connected with pipeline B4, installs valve A5 on the pipeline B4, and valve A5 and valve B6 are parallelly connected. In use, a flow meter may be installed on the conduit A3 near the mixer 7 to detect the flow of mother liquor and solvent.
And the valve A5 and the valve B6 are both electric proportional control valves and are electrically connected with the controller. The electric proportional control valve is a prior art and will not be described herein.
The inner diameter of the pipeline B4 is smaller than that of the pipeline A3. Pipeline B4 is parallelly connected with pipeline A4, and valve A5 is parallelly connected with valve B6, and the dilution proportion range of system to the mother liquor can be widened to this structure.
The mixer 7 is a static mixer. The static mixer is a high-efficiency mixing device without moving parts, and the basic working mechanism of the static mixer is to change the flowing state of fluid in a pipe by using a mixing unit body fixed in the pipe so as to achieve the purposes of good dispersion and full mixing of different fluids. The main types include SV type static mixer, SK type static mixer, SX type static mixer, SH type static mixer, and SL type static mixer, which are not described herein for the prior art.
The concentration detection component 8 is a conductivity meter. And detecting the conductivity of the diluted solution by a conductivity meter to further judge whether the diluted solution meets the dilution requirement. When the device is used, the concentration of the solution is taken as an abscissa, the conductivity of the solution is taken as an ordinate, a solution concentration and conductivity relation curve is drawn, and the controller can determine the concentration of the solution according to the conductivity through the relation curve.
The system still includes the jar 13 of keeping in, and jar 13 of keeping in is connected through pipeline D12 and pipeline C10's middle part, and installs valve D11 on the pipeline D12, installs valve C9 on the pipeline C10, and concentration detection subassembly 8 is located between valve C9 and the blender 7, and pipeline D12 is located between concentration detection subassembly 8 and the valve C9 with the tie point of pipeline C10. The temporary storage tank 13 is used for storing the diluted solution with the concentration meeting the requirement.
And the valve C9 and the valve D11 are both pneumatic diaphragm valves, and the pneumatic diaphragm valves are electrically connected with the controller.
On-line dilution system, its theory of operation as follows:
the air pressure in the mother liquor tank 1 and the air pressure in the solvent tank 2 are respectively detected through a digital air pressure gauge, and the gas is respectively filled into the mother liquor tank 1 and the solvent tank 2 through a gas filling pump, so that the gas pressure in the mother liquor tank 1 and the gas pressure in the solvent tank 2 are kept in a required range. According to the concentration of the diluted solution to be prepared, the volume ratio of the mother liquor to the solvent is input into a controller, the controller correspondingly controls the opening degrees of a valve A5 and a valve B6, and the amount of the mother liquor and the solvent entering a mixer 7 in unit time is further controlled. The diluted solution obtained by mixing in the mixer 7 is detected by the conductivity meter, and the data is transmitted to the controller, and the controller judges whether the concentration of the diluted solution meets the requirement. If the concentration of the diluted solution meets the requirement, the controller closes the valve C9, opens the valve D11, and guides the diluted solution into the temporary storage tank 13; if the concentration of the dilute solution is not satisfactory, the controller opens valve C9 and closes valve D11 to discharge the dilute solution to the waste liquid collection container.
The utility model provides an online dilution system can accomplish the mother liquor and dilute the work online, automatically, and it is efficient to join in marriage liquid, and the concentration uniformity of gained dilute solution is good. Pipeline B4 is parallelly connected with pipeline A4, and valve A5 is parallelly connected with valve B6, and the dilution proportion range of system to the mother liquor can be widened to this structure. Make the atmospheric pressure in mother liquor jar 1, the solvent jar 2 keep invariable through the constant voltage subassembly, for mother liquor and solvent transport provide pressure, the atmospheric pressure is invariable to help making the liquid velocity of flow stable, helps improving the concentration accuracy of the dilute solution who prepares simultaneously.

Claims (9)

1. An on-line dilution system, comprising: including mother liquor jar (1), solvent jar (2), blender (7) and controller, mother liquor jar (1) with the top of solvent jar (2) all is equipped with the constant voltage subassembly, blender (7) are connected with the bottom of mother liquor jar (1), solvent jar (2) through pipeline A (3) respectively, and are equipped with valve B (6) on pipeline A (3), be equipped with pipeline C (10) on blender (7), and be equipped with concentration detection subassembly (8) on pipeline C (10), controller and constant voltage subassembly, valve B (6) and concentration detection subassembly (8) electric connection.
2. The in-line dilution system of claim 1, wherein: the constant voltage component comprises an inflator pump and a digital barometer, and the inflator pump and the digital barometer are both electrically connected with the controller.
3. The in-line dilution system of claim 1, wherein: the middle part of pipeline A (3) is equipped with pipeline B (4), is equipped with valve A (5) on pipeline B (4), and valve A (5) and valve B (6) are parallelly connected.
4. The in-line dilution system of claim 3, wherein: and the valve A (5) and the valve B (6) are both electric proportional regulating valves and are electrically connected with the controller.
5. The in-line dilution system of claim 3, wherein: the inner diameter of the pipeline B (4) is smaller than that of the pipeline A (3).
6. The in-line dilution system of claim 1, wherein: the mixer (7) is a static mixer.
7. The in-line dilution system of claim 1, wherein: the concentration detection component (8) is a conductivity meter.
8. The in-line dilution system of claim 1, wherein: the system also comprises a temporary storage tank (13), the temporary storage tank (13) is connected with the middle part of the pipeline C (10) through a pipeline D (12), and a valve D (11) is arranged on the pipeline D (12); and a valve C (9) is arranged on the pipeline C (10), the concentration detection component (8) is positioned between the valve C (9) and the mixer (7), and the connection point of the pipeline D (12) and the pipeline C (10) is positioned between the concentration detection component (8) and the valve C (9).
9. The in-line dilution system of claim 8, wherein: and the valve C (9) and the valve D (11) are both pneumatic diaphragm valves, and the pneumatic diaphragm valves are electrically connected with the controller.
CN202221025057.3U 2022-04-29 2022-04-29 Online dilution system Active CN217663145U (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202221025057.3U CN217663145U (en) 2022-04-29 2022-04-29 Online dilution system

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202221025057.3U CN217663145U (en) 2022-04-29 2022-04-29 Online dilution system

Publications (1)

Publication Number Publication Date
CN217663145U true CN217663145U (en) 2022-10-28

Family

ID=83737350

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202221025057.3U Active CN217663145U (en) 2022-04-29 2022-04-29 Online dilution system

Country Status (1)

Country Link
CN (1) CN217663145U (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116785775A (en) * 2023-08-23 2023-09-22 哈尔滨瀚邦医疗科技有限公司 Multidimensional high performance liquid chromatography separation system

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116785775A (en) * 2023-08-23 2023-09-22 哈尔滨瀚邦医疗科技有限公司 Multidimensional high performance liquid chromatography separation system
CN116785775B (en) * 2023-08-23 2023-11-21 哈尔滨瀚邦医疗科技有限公司 Multidimensional high performance liquid chromatography separation system

Similar Documents

Publication Publication Date Title
CN217663145U (en) Online dilution system
CN204214881U (en) A kind of automatic quantitative liquid feeder
CN108607462B (en) Liquid mixing device and liquid flow control method
CN101659087A (en) Additive metering system and metering method of cement concrete stirring device
CN108593522B (en) Automatic online labeling water purification filter element test line and labeling method
CN2702918Y (en) Automatic gas distribution apparatus
CN201413478Y (en) Liquid flow control device
CN204883403U (en) Online ratio detecting system of solution strength
CN204469662U (en) A kind of high viscosity glue air mix facilities
CN212031455U (en) Standard liquid proportioning quality control instrument
CN203971552U (en) A kind of water filter element life Online Transaction Processing
CN210356891U (en) System and device for high-precision dilution of high-concentration chemicals
CN2593168Y (en) Equi-liquid-level liquid quantitative metering apparatus
CN205210712U (en) Chemical combination bucket acidification system
CN213590410U (en) Solution positive pressure metering and conveying system
CN103933781A (en) On-line testing system for life of water filtering element
CN201046385Y (en) Apparatus for diluting chemical stock solution
CN106442408A (en) Chemical-mechanical polishing liquid automatic preparation control system
CN218860367U (en) MVR medicine adding device
CN212215408U (en) Liquid material batching device capable of improving batching precision
CN220909968U (en) Peristaltic pump correcting unit
CN216654949U (en) Coal slime flotation charge device
CN217855660U (en) Corrosion-resistant agitating unit of adjustable speed
CN114426149A (en) Accurate liquid feeding device and method in PI resin production process
CN216208027U (en) High-precision dilution instrument

Legal Events

Date Code Title Description
GR01 Patent grant
GR01 Patent grant