CN204522994U - A kind of centrifugal microfluidic control chip for Capillary Electrophoresis and gel electrophoresis apparatus - Google Patents
A kind of centrifugal microfluidic control chip for Capillary Electrophoresis and gel electrophoresis apparatus Download PDFInfo
- Publication number
- CN204522994U CN204522994U CN201520113919.1U CN201520113919U CN204522994U CN 204522994 U CN204522994 U CN 204522994U CN 201520113919 U CN201520113919 U CN 201520113919U CN 204522994 U CN204522994 U CN 204522994U
- Authority
- CN
- China
- Prior art keywords
- capillary electrophoresis
- passage
- capillary
- chip
- electrophoresis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Abstract
The utility model belongs to medicine analysis and detection field, is specifically related to a kind of centrifugal microfluidic control chip for Capillary Electrophoresis and gel electrophoresis apparatus.Higher in order to solve existing silicon capillary micro-fluidic chip cost, the problem that sensitivity is lower, the utility model provides a kind of centrifugal microfluidic control chip for Capillary Electrophoresis.Described chip comprises slide glass and chip lid; Described slide glass is provided with Capillary Electrophoresis passage, Capillary Electrophoresis passage is along chip radial distribution; The side of Capillary Electrophoresis passage is provided with cooling passage; The initiating terminal of Capillary Electrophoresis passage is communicated with sample cell and buffer pool, and the terminal of Capillary Electrophoresis passage is communicated with waste liquid pool; The initiating terminal of Capillary Electrophoresis passage is provided with negative electrode jack, and terminal is provided with anode jack; The terminal of Capillary Electrophoresis passage is provided with GRAVITY CONTROL valve; The two ends of described cooling passage are provided with cooling fluid connector.This centrifugal microfluidic control chip cost is low, highly sensitive, processing flux is high.
Description
Technical field
The utility model belongs to medicine analysis and detection field, is specifically related to a kind of centrifugal microfluidic control chip for Capillary Electrophoresis and gel electrophoresis apparatus.
Background technology
The micro-fluidic chip for Capillary Electrophoresis conventional is at present silicon capillary micro-fluidic chip, and the cross section of silicon capillary is normally circular.The cost of this silicon capillary micro-fluidic chip is higher, and sensitivity is lower.
Summary of the invention
Higher in order to solve existing silicon capillary micro-fluidic chip cost, the problem that sensitivity is lower, the invention provides a kind of centrifugal microfluidic control chip for Capillary Electrophoresis and gel electrophoresis apparatus.This centrifugal microfluidic control chip cost is low, highly sensitive, processing flux is high.
In order to achieve the above object, the present invention adopts following technical proposals:
The invention provides a kind of centrifugal microfluidic control chip for Capillary Electrophoresis, described chip comprises slide glass and chip lid; Described slide glass is provided with Capillary Electrophoresis passage, Capillary Electrophoresis passage is along chip radial distribution; The side of Capillary Electrophoresis passage is provided with cooling passage; The initiating terminal of Capillary Electrophoresis passage is communicated with sample cell and buffer pool, and the terminal of Capillary Electrophoresis passage is communicated with waste liquid pool; The initiating terminal of Capillary Electrophoresis passage is provided with negative electrode jack, and terminal is provided with anode jack; The terminal of Capillary Electrophoresis passage is provided with GRAVITY CONTROL valve; The two ends of described cooling passage are provided with cooling fluid connector.
Further, described in the centrifugal microfluidic control chip of Capillary Electrophoresis, be provided with GRAVITY CONTROL valve between described sample cell and Capillary Electrophoresis passage; GRAVITY CONTROL valve is provided with between described buffer pool and Capillary Electrophoresis passage.
Further, described in the centrifugal microfluidic control chip of Capillary Electrophoresis, described capillary channel is the gel capillary electrophoresis path with rectangular cross section.
Further, described in the centrifugal microfluidic control chip of Capillary Electrophoresis, described capillary channel is bending capillary channel.
Further, described in the centrifugal microfluidic control chip of Capillary Electrophoresis, described Capillary Electrophoresis passage is sine wave shape, the adjacent comers of described sine wave is called flex point C, flex point D, from the center of circle to circumferencial direction, described sinusoidal wave period is constant, and the distance between flex point C and flex point D increases gradually.
Further, described in the centrifugal microfluidic control chip of Capillary Electrophoresis, described cooling passage comprises the first cooling passage and the second cooling passage, and the first cooling passage and the second cooling passage lay respectively at the both sides of Capillary Electrophoresis passage.
Further, described in the centrifugal microfluidic control chip of Capillary Electrophoresis, the rectangular cross section of capillary channel is narrow rectangle, and width is 10 to 50 microns, and the degree of depth is 200 to 500 microns.
Further, described in the centrifugal microfluidic control chip of Capillary Electrophoresis, described capillary channel inwall is coated with the coating being beneficial to protein movement in electrophoresis.
The present invention also provides a kind of gel electrophoresis apparatus, and described gel electrophoresis apparatus is capillary gel electrophoresis device, and described device comprises the described centrifugal microfluidic control chip for Capillary Electrophoresis.
Further, in described capillary gel electrophoresis device, described device also comprises signals collecting and processing module, the first convex lens, the second convex lens and light source; Light source is arranged the first convex lens, the first convex lens arrange chip, chip is arranged the second convex lens, signalization collection and outer reason module on the second convex lens.
The initiating terminal of described Capillary Electrophoresis passage also claims liquid feeding end, and be the one end near the chip center of circle, the terminal of Capillary Electrophoresis passage also claims outlet end, is the one end near chip circumference.
Further, described chip is circular.Further, described chip is annular.
Further, GRAVITY CONTROL valve is provided with between the terminal of Capillary Electrophoresis passage and waste liquid pool.
Above-mentioned centrifugal microfluidic control chip also can be described as centrifugal CD micro-fluidic chip.
The operating process of above-mentioned centrifugal CD micro-fluidic chip is as follows: sample is added sample cell, buffer solution is added buffer pool, cooling fluid is passed into cooling passage by cooling fluid connector, negative electrode is inserted negative electrode jack, anode is inserted anode jack; Start CD micro-fluidic chip, under the influence of centrifugal force, buffer solution enters Capillary Electrophoresis passage by buffer pool, sample enters Capillary Electrophoresis passage by sample cell, sample electrophoresis in passage under the effect of electrode, after completing electrophoresis, sample and buffer solution enter waste liquid pool by Capillary Electrophoresis passage.In electrophoresis process, cooling fluid flows through cooling passage, the liquid in Capillary Electrophoresis passage is played to the effect of cooling.
Different from present conventional silicon capillary, it can the polymer of penetrating ultraviolet light be raw material that chip provided by the invention adopts, and with mold injection molding, cost is below the one thousandth of silicon capillary.
Compared with prior art, the centrifugal microfluidic control chip for Capillary Electrophoresis provided by the invention improves sensitivity, reduces cost, improves processing flux, have wide market prospects.
Accompanying drawing explanation
Fig. 1 is the slide structure schematic diagram of micro-fluidic chip provided by the invention;
Fig. 2 is the structural representation of the chip lid of micro-fluidic chip provided by the invention;
Fig. 3 is the side structure schematic diagram of the part A of micro-fluidic chip shown in Fig. 1 and chip lid;
Fig. 4 is the structural representation of capillary gel electrophoresis device provided by the invention.
Detailed description of the invention
Below in conjunction with specific embodiment and Figure of description, the technical scheme that the application provides is described in detail.
As shown in Figure 1, Figure 2 and Figure 3, the invention provides a kind of centrifugal microfluidic control chip for Capillary Electrophoresis, described chip comprises slide glass 10 and chip lid 20; Described slide glass 10 is provided with Capillary Electrophoresis path 10 1, and Capillary Electrophoresis passage is along chip radial distribution; The side of Capillary Electrophoresis path 10 1 is provided with cooling passage 102; The initiating terminal of Capillary Electrophoresis passage (or claim liquid feeding end, one end near the chip center of circle) be communicated with sample cell 108 and buffer pool 107, the terminal (or claiming outlet end, the one end near chip circumference) of Capillary Electrophoresis passage is communicated with waste liquid pool 109; The initiating terminal of Capillary Electrophoresis passage is provided with negative electrode jack 105, and terminal is provided with anode jack 106; The terminal of Capillary Electrophoresis passage is provided with GRAVITY CONTROL valve 104; The two ends of described cooling passage are provided with cooling fluid connector 103.
Further, GRAVITY CONTROL valve 104 is provided with between the terminal of Capillary Electrophoresis passage and waste liquid pool 109.
The operating process of above-mentioned centrifugal microfluidic control chip is as follows: sample is added sample cell 108, buffer solution is added buffer pool 107, cooling fluid is passed into cooling passage 102 by cooling fluid connector 103, negative electrode is inserted negative electrode jack 105, anode is inserted anode jack 106; Start CD micro-fluidic chip, under the influence of centrifugal force, buffer solution enters Capillary Electrophoresis passage by buffer pool, sample enters Capillary Electrophoresis passage by sample cell, sample electrophoresis in passage under the effect of electrode, after completing electrophoresis, sample and buffer solution enter waste liquid pool 109 by Capillary Electrophoresis passage.In electrophoresis process, cooling fluid flows through cooling passage, the liquid in Capillary Electrophoresis passage is played to the effect of cooling.
Centrifugal microfluidic control chip is also referred to as centrifugal CD micro-fluidic chip.
Said chip is the centrifugal microfluidic control chip for capillary gel electrophoresis.
Said chip is the centrifugal microfluidic control chip for image Capillary Electrophoresis.
Further, multiple Capillary Electrophoresis passage be integrated in one piece 3 × 4 inches ultraviolet light can through chip on.Said chip can carry out multiple Capillary Electrophoresis test simultaneously.Described Capillary Electrophoresis passage can be 2-12, such as, and 4,5,6,8.
Described sample cell is circular or other shapes.Sample cell is used for sample introduction.Further, the distance between neighboring samples pond (also referred to as sample inlet pool) is 9 millimeters, so that the use of existing multichannel injector or self-reacting device.
The sample introduction end of Capillary Electrophoresis passage is provided with negative electrode jack 105, negative electrode jack for connecting female jack, for electrophoresis.
Described chip lid 20 comprises cooling liquid inlet 203, cooling liquid outlet 204, negative electrode through hole 205, anode through hole 206, and buffer solution adds mouth 208, and sample adds mouth 209.Described cooling liquid inlet 203 and cooling liquid outlet 204 are connected with the cooling fluid connector 103 at cooling passage two ends respectively.Described negative electrode through hole 205 is connected with negative electrode jack 105.Described anode through hole 206 is connected with anode jack 106.Described buffer solution adds mouth 208 and is connected with buffer pool 107.Described sample adds mouth 209 and is connected with sample cell 108.
Image Capillary Electrophoresis, comprise image capillary isoelectric focusing (Imaging Capillary Isoeletric Focusing Electrophoresis (icIEF) and image sds gel Capillary Electrophoresis (Imaging Capillary SDS Gel Electrophoresis) (iCE-SDS), being the image of the whole electrophoresis path of Real-Time Monitoring, is the technology for detecting the molecule in electrophoresis in real time.
Centrifugal microfluidic control chip (centrifugal microfluidic chip) is a kind of technology utilizing liquid flow in centrifugal force controlled micro-fluidic chip.Its key problem in technology is to utilize the switch of centrifugal force sensitivity to control the perfusion of liquid and emptying etc.
Further, GRAVITY CONTROL valve is provided with between described sample cell 108 and Capillary Electrophoresis path 10 1; GRAVITY CONTROL valve is provided with between described buffer pool 107 and Capillary Electrophoresis path 10 1.
The present invention is integrated with all samples of Capillary Electrophoresis on centrifugal microfluidic control chip, and open different GRAVITY CONTROL valves by different centrifugal force, under the influence of centrifugal force simultaneously, liquid is injected different Capillary Electrophoresis passages (also referred to as electrophoresis path, microfluidic channel, or capillary channel) or the emptying passage having completed reaction, thus complete automatic filling capillary or automatically prepare capillary.Above-mentioned centrifugal microfluidic control chip energy automatic Loading electrophoresis Sample, carries out a series of operations such as Capillary Electrophoresis automatically.
Above-mentioned GRAVITY CONTROL valve is opened by centrifugal force controlled or closes.Such as, when centrifugal force is 100XG, open the valve between buffer pool and Capillary Electrophoresis passage, buffer solution enters Capillary Electrophoresis passage due to centrifugal force, time centrifugal force brings up to 200XG, valve (or claiming the valve in sample path) between sample cell and Capillary Electrophoresis passage is opened, and sample enters Capillary Electrophoresis passage under the influence of centrifugal force, completes sample load.After having reacted, centrifugal force brings up to 300XG, the valve open of Capillary Electrophoresis passage outlet end, reactant liquor is drained into waste liquid pool 109.
The advantage of centrifugal microfluidic control is: do not have alveolate interference in (a), system; B (), sample inject and adopt centrifugal switch accurately to control; C (), sample inject and adopt sample solution entirety to inject, instead of adopt electrodynamic method to inject sample, are conducive to sample accurate quantification.
Further, described capillary channel is the gel capillary electrophoresis path with rectangular cross section.
The gel capillary electrophoresis path of rectangular cross section is conducive to increasing the length detecting light light path, but do not increase the area of cross section, like this when not increasing resistance (namely the current strength) of electrophoresis path, add the sensitivity of detection.
Further, described capillary channel is bending capillary channel.
Bending electrophoresis path makes the detection light of limited areal can cover whole electrophoresis capillary road to greatest extent, thus under the condition not having moving device, can obtain the image of whole electrophoresis path.
Further, electrophoresis path is continuous print S shape.
Further, electrophoresis path is sine wave shape.
Further, as shown in Figure 2, chip includes multiple bending roundabout capillary channel.Usually, above-mentioned micro-fluidic chip comprises six capillary channels, and compared with rectilinear passage, in the space of the micro-fluidic chip of 3 × 4 inches, the length of electrophoresis path can increase by 3 to 10 times, and this greatly increases the resolution ratio of electrophoresis.
Further, electrophoresis path is sine wave shape, and from the center of circle to circumferencial direction, described sinusoidal wave period is constant, increases highly gradually.
Further, electrophoresis path is sine wave shape, and as shown in Figure 1, the adjacent comers of described sine wave is called flex point C, flex point D, and from the center of circle to circumferencial direction, described sinusoidal wave period is constant, and the distance between flex point C and flex point D increases gradually.
Further, described slide glass and chip lid are made up of the polymeric material of ultraviolet light transmissive.
Employing can be prepared chip through the polymeric material of ultraviolet light and have the following advantages: chip manufacturing cost reduces greatly, good repetitiveness, chip piece can make at least 12 Capillary Electrophoresis passages, cooling passage can be set directly at electrophoresis path both sides, and cooling passage does not cover the surface of capillary, be conducive to the detection carrying out all woolen tubule image like this, eliminate and allow final products successively by the program of detector.
The polymer resins such as described polymeric material is selected from polymethylpentene (Polymethylpentene, PMP), polymethyl methacrylate (PMMA), such as, TOPAS Advanced Polymersshengchande produces
cOC.
Further, described cooling passage 102 comprises the both sides that the first cooling passage 1021 and the second cooling passage 1022, first cooling passage 1021 and the second cooling passage 1022 lay respectively at Capillary Electrophoresis passage.
Further, the rectangular cross section of capillary channel is narrow rectangle, and width is 10 to 50 microns, and the degree of depth is 200 to 500 microns.
Like this, capillary channel is when cross-sectional area is constant, and width can only have 25 microns, but the degree of depth can reach 300 to 500 microns.Like this, the passage detecting light will will grow more than 10 times than the light path of common circular channel (the circular capillaries passage as in traditional instrument).Like this, the sensitivity of detection just can improve 10 times.
Further, the rectangular cross section of described capillary channel is narrow rectangle, and width is 10 to 25 microns, and the degree of depth is 300 to 500 microns.
Further, described capillary channel is about 300 millimeters, wide 50 microns, dark 500 microns.
Further, described capillary channel inwall is coated with the coating being beneficial to protein movement in electrophoresis.
Described coating is material well known in the art, and such as, hydroxyethylcellulose, polyvinyl alcohol, polyoxyethylene etc., so that the motion of protein or nucleic acid.
The using method of above-mentioned micro-fluidic chip comprises the steps:
(1) in each sample cell, appropriate sample (albumen) is added with Multi-channel liquid transfer device;
(2) by centrifugation, sample is added in capillary channel, and get rid of bubble;
(3) chip that step (2) obtains is put into electrophoresis apparatus, at the two ends electrode insertion of each capillary channel; Cooling fluid is communicated with at the two ends of each cooling passage.
(4) electrophoresis and gather data is started.
The present invention also provides a kind of capillary gel electrophoresis device, and described device comprises described centrifugal microfluidic control chip.
Further, as shown in Figure 4, described device also comprises signals collecting and processing module, the first convex lens, the second convex lens and light source; Light source 501 is arranged on the first convex lens 502, first convex lens 502 and chip 503 is set, chip 503 is arranged signalization collection and outer reason module 505 on the second convex lens 504, second convex lens 504.
Further, described Signal acquiring and processing module comprises charge-coupled image sensor (Charge Coupled Device is called for short CCD).
Compared with the circular cross section of existing silicon capillary, the cross section of the electrophoresis path of centrifugal microfluidic control chip provided by the invention is rectangle.Like this, when using the solution of same volume, the light path of above-mentioned centrifugal microfluidic control chip will grow to few 5 times than silicon capillary; Like this, under identical condition, compared with silicon capillary micro-fluidic chip, the sensitivity of above-mentioned centrifugal microfluidic control chip can improve more than 5 times.Simultaneously, electrophoresis path due to centrifugal microfluidic control chip can be made into bending roundabout shape, inner at the micro-fluidic chip (such as, 3 × 4 inches) of similar size, the length of the electrophoresis path of centrifugal microfluidic control chip provided by the invention reaches 20 centimetres, is 2 times of silicon capillary.Like this when applied sample amount improves twice, still can reach same resolution.Therefore, the theoretical sensitivity of centrifugal microfluidic control chip provided by the invention is higher than silicon capillary chip about 10 times.Meanwhile, centrifugal microfluidic control chip provided by the invention also add processing flux, is integrated with 6 electrophoresis paths on one chip.When single treatment 2 chip block, can parallel processing 12 samples.The profile of this micro-fluidic chip adopts the design of half 96 hole microwell plate.The size of sample cell is consistent with Distance geometry 96 hole microwell plate.When use 96 hole microwell plate, can with existing full-automatic laboratory apparatus process.
Embodiment 1
Centrifugal microfluidic control chip for Capillary Electrophoresis provided by the invention (or claiming the capillary gel electrophoresis chip of CD disc form), wherein, slide glass is circular, thick 1.5 millimeters, external diameter 120 millimeters, internal diameter 15 millimeters.Capillary channel is about 300 millimeters, wide 50 microns, dark 500 microns.
Chip lid adopts the material same with slide glass, thick 1.0 millimeters, diameter 120 millimeters, internal diameter 15 millimeters.Chip lid and slide glass sticky with together with.
The above, be only preferred embodiment of the present invention, be not intended to limit protection scope of the present invention.Every equalization done according to content of the present invention changes and modifies, and is all encompassed in the scope of the claims of the present invention.
Claims (10)
1. for a centrifugal microfluidic control chip for Capillary Electrophoresis, it is characterized in that, described chip comprises slide glass and chip lid; Described slide glass is provided with Capillary Electrophoresis passage, Capillary Electrophoresis passage is along chip radial distribution; The side of Capillary Electrophoresis passage is provided with cooling passage; The initiating terminal of Capillary Electrophoresis passage is communicated with sample cell and buffer pool, and the terminal of Capillary Electrophoresis passage is communicated with waste liquid pool; The initiating terminal of Capillary Electrophoresis passage is provided with negative electrode jack, and terminal is provided with anode jack; The terminal of Capillary Electrophoresis passage is provided with GRAVITY CONTROL valve; The two ends of described cooling passage are provided with cooling fluid connector.
2. the centrifugal microfluidic control chip for Capillary Electrophoresis according to claim 1, is characterized in that, be provided with GRAVITY CONTROL valve between described sample cell and Capillary Electrophoresis passage; GRAVITY CONTROL valve is provided with between described buffer pool and Capillary Electrophoresis passage.
3. the centrifugal microfluidic control chip for Capillary Electrophoresis according to claim 1, is characterized in that, described capillary channel is the gel capillary electrophoresis path with rectangular cross section.
4. the centrifugal microfluidic control chip for Capillary Electrophoresis according to claim 1, it is characterized in that, described capillary channel is bending capillary channel.
5. the centrifugal microfluidic control chip for Capillary Electrophoresis according to claim 1, it is characterized in that, described Capillary Electrophoresis passage is sine wave shape, the adjacent comers of described sine wave is called flex point C, flex point D, from the center of circle to circumferencial direction, described sinusoidal wave period is constant, and the distance between flex point C and flex point D increases gradually.
6. the centrifugal microfluidic control chip for Capillary Electrophoresis according to claim 1, it is characterized in that, described cooling passage comprises the first cooling passage and the second cooling passage, and the first cooling passage and the second cooling passage lay respectively at the both sides of Capillary Electrophoresis passage.
7. the centrifugal microfluidic control chip for Capillary Electrophoresis according to claim 3, is characterized in that, the rectangular cross section of capillary channel is narrow rectangle, and width is 10 to 50 microns, and the degree of depth is 200 to 500 microns.
8. the centrifugal microfluidic control chip for Capillary Electrophoresis according to claim 1, it is characterized in that, described capillary channel inwall is coated with the coating being beneficial to protein movement in electrophoresis.
9. a gel electrophoresis apparatus, is characterized in that, described gel electrophoresis apparatus is capillary gel electrophoresis device, and described device comprises the described centrifugal microfluidic control chip for Capillary Electrophoresis of one of claim 1-8.
10. gel electrophoresis apparatus according to claim 9, it is characterized in that, described device also comprises signals collecting and processing module, the first convex lens, the second convex lens and light source; Light source is arranged the first convex lens, the first convex lens arrange chip, chip is arranged the second convex lens, signalization collection and outer reason module on the second convex lens.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520113919.1U CN204522994U (en) | 2015-02-17 | 2015-02-17 | A kind of centrifugal microfluidic control chip for Capillary Electrophoresis and gel electrophoresis apparatus |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520113919.1U CN204522994U (en) | 2015-02-17 | 2015-02-17 | A kind of centrifugal microfluidic control chip for Capillary Electrophoresis and gel electrophoresis apparatus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN204522994U true CN204522994U (en) | 2015-08-05 |
Family
ID=53737049
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201520113919.1U Expired - Fee Related CN204522994U (en) | 2015-02-17 | 2015-02-17 | A kind of centrifugal microfluidic control chip for Capillary Electrophoresis and gel electrophoresis apparatus |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN204522994U (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104646079A (en) * | 2015-02-17 | 2015-05-27 | 方雪萍 | Centrifugal CD micro-fluidic chip for capillary electrophoresis and capillary gel electrophoresis device |
| CN105717186A (en) * | 2016-02-01 | 2016-06-29 | 常熟理工学院 | Rotary type dielectrophoresis microfluidic analysis device |
| WO2017113902A1 (en) * | 2015-12-31 | 2017-07-06 | 深圳市贝沃德克生物技术研究院有限公司 | Blood serum marker testing system |
| CN117907408A (en) * | 2024-03-18 | 2024-04-19 | 深圳市真迈生物科技有限公司 | Chip, chip transfer device and analysis system |
-
2015
- 2015-02-17 CN CN201520113919.1U patent/CN204522994U/en not_active Expired - Fee Related
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104646079A (en) * | 2015-02-17 | 2015-05-27 | 方雪萍 | Centrifugal CD micro-fluidic chip for capillary electrophoresis and capillary gel electrophoresis device |
| WO2017113902A1 (en) * | 2015-12-31 | 2017-07-06 | 深圳市贝沃德克生物技术研究院有限公司 | Blood serum marker testing system |
| CN105717186A (en) * | 2016-02-01 | 2016-06-29 | 常熟理工学院 | Rotary type dielectrophoresis microfluidic analysis device |
| CN105717186B (en) * | 2016-02-01 | 2018-06-29 | 常熟理工学院 | Swinging dielectrophoresis microfluidic analysis device |
| CN117907408A (en) * | 2024-03-18 | 2024-04-19 | 深圳市真迈生物科技有限公司 | Chip, chip transfer device and analysis system |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104646079B (en) | A kind of centrifugal microfluidic control chip for capillary electrophoresis and capillary gel electrophoresis device | |
| CN204522994U (en) | A kind of centrifugal microfluidic control chip for Capillary Electrophoresis and gel electrophoresis apparatus | |
| CN105062866B (en) | For disposable separating chips module and the using method thereof of Peripheral Circulation tumour cell | |
| CN103439241A (en) | Micro-fluidic chip detection system based on single-cell multi-parameter representation | |
| CN203220910U (en) | Integrated chip for high-throughput sorting and count detection of biological particles | |
| CN108148744A (en) | A kind of drop number pcr chip and corresponding method of detection and detecting system | |
| CN101581724A (en) | Special multichannel syphilis diagnosis device combined with quasi-one-dimensional specific antigen modified electrodes | |
| JP2000146910A (en) | Electrophoresis system | |
| CN207933458U (en) | A kind of visualization detects the micro-fluidic chip of pathogen nucleic acid immediately | |
| CN111157734A (en) | Grating waveguide microfluid detection system based on CMOS image sensing | |
| CN208399514U (en) | A kind of micro-fluidic immunoassay device | |
| CN207596861U (en) | Micro-fluidic tumour cell detection chip based on immunomagnetic isolation | |
| CN211785573U (en) | Grating waveguide microfluid detection system based on CMOS image sensing | |
| CN106959332B (en) | The automatic fine sampling device and its control method of electrophoresis detection instrument | |
| CN212134710U (en) | Grating waveguide multi-micro-channel detection system based on CMOS image sensing | |
| CN211603213U (en) | Optical waveguide multi-micro-channel detection system | |
| CN211826083U (en) | Optical waveguide multi-micro-channel detection system based on CMOS image sensing | |
| CN211826084U (en) | Grating waveguide microfluid detection system | |
| CN211936963U (en) | Micro-fluidic chip for detection | |
| CN211603214U (en) | Grating waveguide microfluid detection system | |
| CN110639628B (en) | Micro-fluidic chip and method for cell sorting and positioning | |
| CN103424556A (en) | Portable detection system for allergic diseases | |
| CN103760361A (en) | Biological chip for detecting person Hsp90a (heat shock protein 90) and detection method thereof | |
| CN211847950U (en) | Cell capturing and screening device | |
| CN105126940B (en) | Complex structure body and the microchip for analyzing particulate |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20160621 Address after: 101-106 room 388, No. 312400, South Main Road, Pukou Economic Development Zone, Shengzhou, Zhejiang Patentee after: SHENGZHOU BAOKANG MEDICAL TECHNOLOGY Co.,Ltd. Address before: 130011 Jilin province Changchun Luyuan District Four 450 Avenue 3 door 6 floor No. 35 Patentee before: Fang Xueping Patentee before: Chen Songming |
|
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20150805 Termination date: 20220217 |