CN2044255U - Purrifying device for bilirubin - Google Patents
Purrifying device for bilirubin Download PDFInfo
- Publication number
- CN2044255U CN2044255U CN 88219353 CN88219353U CN2044255U CN 2044255 U CN2044255 U CN 2044255U CN 88219353 CN88219353 CN 88219353 CN 88219353 U CN88219353 U CN 88219353U CN 2044255 U CN2044255 U CN 2044255U
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- bilirubin
- extraction
- chloroform
- filter bag
- utility
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Abstract
The utility model discloses a purifying device for bilirubin, which is used for chloroform pumping and refining stages of in bilirubin preparation in a calcium salt method. The instrument integrates the back flow or mixing extraction adopted in the existing production, and also integrates the extraction, filtering and condensation. The utility model is mainly composed of a poker, a seal rubber strip sleeve, a tee coupling, a hollow glass floater, a steam passage tube, a condenser socket, a filter bag and an extraction flask. Because the extraction is contiguously and automatically carried out under the hermetic condition, the chloroform loss reaches the minimal level, the environment pollution caused by chloroform is avoided, and the labor intensity of operators is lightened. Adopting the utility model can exhaust more than 99% of bilirubin from the crude product, and the yield rate is raised.
Description
This instrument is a kind of chemical separation purification instrument.Be used for calcium salt method and produce the FF of bilirubin technology.Design philosophy comes from apparatus,Soxhlet's.
Calcium salt method is produced bilirubin technology and be please refer to " animal biochemical pharmacy " P.278 (People's Health Publisher 1983).Apparatus,Soxhlet's is referring to " Chemistry for Chinese Traditional Medicine experimental technique and experiment " P.21 (Henan Science Press 1986).
Calcium salt method is the most stable technology of generally acknowledging during bilirubin is produced.This method is all used in all biochemical pharmaceutical factories at present.Primary process is
The bilirubin elaboration can be used to prepare artificial Calculus Bovis.Just possesses pharmaceutical use.Treating process generally refluxes with chloroform or stirring at normal temperature is extracted, filters then, concentrates, filtration owing to will incline.The chloroform increase cost that volatilizees in a large number on the one hand.Polluted air again on the other hand.Especially in summer.Workpeople's strong reaction.This process for purification not only chloroform consumption is big, time-consuming, in general the production because bothersome and extracting secondary only.Therefore extract not exclusively.Bilirubin purifying instrument collection refluxes and stirs and is extracted from one, integrates extraction, filtration, concentration process.Automatically finish in closed system and meet the leaching process solvent and need a small amount of principle repeatedly, extract fully, the satisfactory the problems referred to above that solved have improved economic benefit.
Because the crude product fine size adopts general method that crude product is wrapped, and puts into apparatus,Soxhlet's and extracts, the effect extreme difference.Because the static process of oozing out of chloroform is too slow, bilirubin can not propose easy oxidation discoloration as early as possible in the bag.I improve on Soxhlet formula extractor basis, add whipping appts and filter bag, am designed to bilirubin purifying instrument.The test-results proof can solve above-mentioned all problems, works very well.Extraction for other material has also improved efficient greatly.
Instrument please the glassware workman process by design effect, the filter bag self-control.Embed the filter bag pickup groove with sewing up the plastelast circle that filters sack, it is suitable for reading to make steam hole aim at the vapour passage pipe.Packing in the bag, (loading amount is lower than steam hole 1～2cm) to the bilirubin crude product.Reductive agent is an amount of, chloroform is an amount of, covers the extraction bottle cap, and top connects each parts by accompanying drawing, adorns a prolong in the condenser spigot.Adorn the round-bottomed flask of chloroform, a small amount of reductive agent, zeolite in bottom round-bottomed flask interface connects one, the chloroform amount should be slightly less than round-bottomed flask loading amount (greater than the amount that siphon takes place in the extraction flask) in the system.Water-bath (70 °) heating round-bottomed flask, agitator arm upper end connect an electric mixer and stir to make and extract fully, and the hollow glass float can float around axle, stirs fully, is difficult for being obstructed, and a whole set of instrument is fixed on the brandreth.Purification process is: chloroform through heating in water bath gasification through steam hole until prolong, splash into filter bag after the condensation.Dissolving is extracted bilirubin and is filtered extraction flask gradually, and chloroform reaches certain altitude after siphon pipe sucks back round-bottomed flask automatically in the extraction flask.The effective cotton of vapour passage parcel is beneficial to gas and rises, reach certain hour after, separate out crystallization in the round-bottomed flask owing to bilirubin constantly accumulates on, filtration promptly gets the bilirubin elaboration.
The bilirubinic advantage of bilirubin purifying instrument purifying is automatic for (1): small number of operations in the time of only need beginning and finish saves time, laborsaving; (2) airtight: polluted air, saving chloroform do not reduce cost; (3) efficient height: solvent is few, and it is big to handle the crude product amount, extracts fully, increases yield (4) less investment, instant effect.
Description of drawings: this figure is the front full sectional view.Because glass wall and filter bag cloth are very thin, are difficult to the section that draws in proportion, so represent with heavy line.Each component names is 1, agitator arm (glass), 2, the sealed rubber cover, 3, top cover, 4, Y-junction, 5, extract bottle cap, 6, the filter bag pickup groove, 7, hollow glass float, 8, the vapour passage pipe, 9, the condenser socket, 10, plastelast circle, 11, steam hole, 12, siphon pipe, 13, filter bag (white silk), 14, round-bottomed flask interface, 15, extraction flask.
Realize mode of the present utility model: after obtaining patent right as early as possible, sell to glass apparatus factory and biochemical-pharmaceutical factory. Require also can increase the extraction flask diameter, increase steam channel pipe quantity according to manufacturer. Can scaled instrument size for individuality production, in order to make this instrument be able to extensive use, give full play to its practical value.
Claims (4)
1, bilirubin purifying instrument.It is characterized in that agitator arm 1, top cover 3, Y-junction 4, extraction bottle cap 5, vapour passage pipe 8 by the electro-motor drive.Extraction flask 15, filter bag 13 7 parts are formed.Y-junction 4 can be connected with the glass prolong.The extraction flask bottom can connect the steaming flask.
2, according to the described device of claim 1.It is characterized in that with slit between sealed rubber cover 2 sealing agitator arms 1 and the top cover 3.Other parts are tightly connected by glass ground joint.
3, according to claim 1,2 described devices.It is characterized in that filter bag pickup groove 6 is arranged at extraction flask 15 tops.
4, according to claim 1,2,3 described devices.It is characterized in that filter bag 13 being fixed in the filter bag pickup groove 6 with plastelast circle 10.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 88219353 CN2044255U (en) | 1988-10-19 | 1988-10-19 | Purrifying device for bilirubin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 88219353 CN2044255U (en) | 1988-10-19 | 1988-10-19 | Purrifying device for bilirubin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN2044255U true CN2044255U (en) | 1989-09-13 |
Family
ID=4851707
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 88219353 Withdrawn CN2044255U (en) | 1988-10-19 | 1988-10-19 | Purrifying device for bilirubin |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN2044255U (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103823023A (en) * | 2014-02-27 | 2014-05-28 | 北京英斯派克科技有限公司 | Apparatus for determining insoluble substance |
| CN103837423A (en) * | 2014-03-24 | 2014-06-04 | 北京英斯派克科技有限公司 | Device for simultaneously measuring plurality of types of insoluble substances |
| CN103792342B (en) * | 2014-02-27 | 2015-12-09 | 北京英斯派克科技有限公司 | A kind of toluene insoluble object measuring device |
| CN108031145A (en) * | 2018-01-04 | 2018-05-15 | 安徽华智生物制药有限公司 | A kind of gall bladder mesobilirubin rapid extraction device |
-
1988
- 1988-10-19 CN CN 88219353 patent/CN2044255U/en not_active Withdrawn
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103823023A (en) * | 2014-02-27 | 2014-05-28 | 北京英斯派克科技有限公司 | Apparatus for determining insoluble substance |
| CN103792342B (en) * | 2014-02-27 | 2015-12-09 | 北京英斯派克科技有限公司 | A kind of toluene insoluble object measuring device |
| CN103837423A (en) * | 2014-03-24 | 2014-06-04 | 北京英斯派克科技有限公司 | Device for simultaneously measuring plurality of types of insoluble substances |
| CN103837423B (en) * | 2014-03-24 | 2016-06-15 | 北京英斯派克科技有限公司 | A kind of device simultaneously measuring polymorphic type insoluble matter |
| CN108031145A (en) * | 2018-01-04 | 2018-05-15 | 安徽华智生物制药有限公司 | A kind of gall bladder mesobilirubin rapid extraction device |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |