CN204347030U - The kit of quick detection syphilis helicoid antibody - Google Patents
The kit of quick detection syphilis helicoid antibody Download PDFInfo
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- CN204347030U CN204347030U CN201420611580.3U CN201420611580U CN204347030U CN 204347030 U CN204347030 U CN 204347030U CN 201420611580 U CN201420611580 U CN 201420611580U CN 204347030 U CN204347030 U CN 204347030U
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Abstract
The kit of quick detection syphilis helicoid antibody, the lid comprising box body and be hinged and connected with box body, box body is provided with spring locking device lid and box body sealed, the sponge holder measure-alike with box body is provided with in box body, groove in sponge holder is placed with the solid phase carrier of microspironema pallidum specific recombinant proteins Hangzhoupro primordial covering respectively, the negative antibody reagent bottle of microspironema pallidum, microspironema pallidum positive antibody reagent bottle, the microspironema pallidum specific recombinant proteins antigenic agents bottle of acridinium ester label, the alkaline luminous substrate reagent bottle that above-mentioned acridinium ester acts on, be fixed on the magnet plate on lid.The utility model adds magnet plate structure, substitutes electromagnetic equipment, is applicable to field environment and research work, enhances the range of application of this kit.There is high specificity, and sensitivity advantages of higher.
Description
Technical field
The utility model relates to immunoassay medical diagnostic techniqu field, is specially a kind of kit of quick detection syphilis helicoid antibody.
Background technology
Syphilis (syphilis) is the Common STD caused by microspironema pallidum (also known as spirochaeta pallida), clinical manifestation is very complicated, almost can invade tissue and the organ of whole body, and produce clinical symptoms and the Signs of varied complexity, early stage main invade mucocutaneous, late period invades internal organs, and severe patient can cause serious cardiovascular system to unify nervous system damage, cause maimed person's even threat to life, very harmful.Syphilis is transmitted to other people mainly through sexual behaviour, also passes to fetus by placenta, and congenital syphilis occurs; Only a few patient can by kiss, lactation, blood transfusion, contact be infectious infringement patient articles for daily use and infect.Early syphilis is infectious, and late period is then without infectiousness.Early syphilis result for the treatment of is good, and late period, then result for the treatment of was poor.The global syphilis incidence of disease is in ascendant trend year by year in recent years, it is reported that the whole world about has 12,000,000 routine new infeetioa cases every year.Therefore, syphilis has been classified as the global public health problem of serious harm human health by WHO.In China, syphilis report of infectious disease is after continuous 6 years of the nineties in 20th century continued to rise, and within nearest 3 years, present year after year rising tendency-2006 years national Report of Syphilis numbers fast and exceed gonorrhoea first, general report number reaches 174506 examples.In order to effectively contain the popular of syphilis, instruction is assigned by the hygiene department of China, each medical institutions must to marrying, donating blood, transfuse blood or preoperative personnel carry out serological syphilis examination, join the army for those, participate in the personnel of recruitment, and be engaged in tourism industry, the personnel and gutter man etc. of food, beverage trade also must carry out serological syphilis examination.
At present, common serological syphilis examination comprises Rapid plasma reagintest (RPR), tolulized red unheated serum test (TRUST), treponema pallidum haemagglutination assay (TPHA), Treponema pallidum particle assay (TPPA), enzyme linked immunosorbent assay (ELISA) etc.Wherein, RPR and TRUST method for detecting the non-specific antibody of microspironema pallidum, its sensitivity and specificity poor (there is false positive and the false negative rate of more than 30%).The specificity of TPHA is higher, but sensitivity is not as ELISA method, and reagent cost is high, needs manual operation, can not realize robotization.TPPA method is the upgrading products of TPHA, although its specificity and sensitivity are all higher, the natural helix isoantigen that uses, expensive, the reaction time is long, and test findings is comparatively large by interference from human factor, is unsuitable for large batch of detection.The detection of microspironema pallidum uses immunoassay now mostly, and along with going deep into of understanding (antibody specificity and the Changing Pattern) to Treponema pallidum specific antibody, new detection target spot also there will be, people are making great efforts the antigenic specificity studying microspironema pallidum specific proteins fragment, and the antibody caused is in the feature in syphilis progress each period.
Chemiluminescence immune assay (CLIA) came out in 1977, and within 1985, first generation chemical luminescence immune analysis reagent box is succeeded in developing and puts on market.Enter the nineties, the development of chemical luminescence immune analysis reagent box and the production of automatic measurement instrument achieve breakthrough, thus enter the high speed development stage.Chemiluminescence immune assay is the new immuno analytical method of of growing up after fluorescence, radioactive isotope and EIA enzyme immunoassay, according to a large amount of experimental results and clinical practice data, from practicality, stability, accuracy and development prospect, in nonradioactive labeling's analytical technology, chemiluminescence immune assay maintains the leading position, represent direction and the trend of world today's development, it not only has immunoreactive specificity, and has the high sensitivity of chemiluminescence reaction.Chemiluminescence immunoassay technology has the advantages such as highly sensitive, quick, accurate, reproducible, effect phase long also safety non-toxic is pollution-free, becomes the first-selection replacing radiommunoassay and Enzyme Immunoassay.
Chemical luminescence immune analysis reagent box of the prior art is closed full automatic chemiluminescence measuring system, thus limits and promote the use of, and cannot be widely used in field diagnosis and research work.Wherein have fixing electromagnetic field to run stabilization of kit in closed system to play a crucial role.And electromagnetic equipment not Portable belt, transport, limit the range of application of this kit.
Utility model content
The technical matters that the utility model solves is the kit providing a kind of quick detection syphilis helicoid antibody, to solve the problem proposed in above-mentioned background technology.
The technical matters that the utility model solves realizes by the following technical solutions:
The kit of quick detection syphilis helicoid antibody, the lid comprising box body and be hinged and connected with box body, box body is provided with spring locking device lid and box body sealed, the sponge holder measure-alike with box body is provided with in box body, groove in sponge holder is placed with the magnetic carrier of microspironema pallidum specific recombinant proteins Hangzhoupro primordial covering respectively, the negative antibody reagent bottle of microspironema pallidum, microspironema pallidum positive antibody reagent bottle, the microspironema pallidum specific recombinant proteins antigenic agents bottle of acridinium ester label, the alkaline luminous substrate reagent bottle that above-mentioned acridinium ester acts on, be fixed on the magnet plate on lid.
Beneficial effect:
The utility model adds magnet plate structure, substitutes electromagnetic equipment, is applicable to field environment and research work, enhances the range of application of this kit.There is high specificity, and sensitivity advantages of higher.
Accompanying drawing explanation
Fig. 1 is structural representation of the present utility model.
Fig. 2 is magnet plate of the present utility model
Embodiment
In order to make actualizing technology means of the present utility model, creation characteristic, reach object and effect is easy to understand, below in conjunction with concrete diagram, set forth the utility model further.
As shown in Figure 1, the kit of quick detection syphilis helicoid antibody, the lid 2 comprising box body 1 and be hinged and connected with box body 1, box body 1 is provided with the spring locking device 4 lid 2 and box body 1 sealed, the sponge holder 5 measure-alike with box body is provided with in box body 1, groove in sponge holder 5 is placed with the magnetic carrier 6 of microspironema pallidum specific recombinant proteins Hangzhoupro primordial covering respectively, the negative antibody reagent bottle 7 of microspironema pallidum, microspironema pallidum positive antibody reagent bottle 8, the microspironema pallidum specific recombinant proteins antigenic agents bottle 9 of acridinium ester label, the alkaline luminous substrate reagent bottle 10 that above-mentioned acridinium ester acts on, be fixed on the magnet plate 11 on lid.
The utility model adopts the microspironema pallidum specific recombinant proteins antigen of multiple combination to prepare solid phase and acridinium ester label, adds key component magnet plate, has both efficiently utilized chemiluminescence principle, and in turn ensure that the sensitivity of detection.It has the advantages such as easy, quick, sensitive, stable.The utility model open-sky technique, fast easy, do not need expensive Full-automatic chemiluminescence measuring instrument, be applicable to field operation, for diagnosis and research work provide one very valuable detection means.
More than show and describe ultimate principle of the present utility model and principal character and advantage of the present utility model.The technician of the industry should understand; the utility model is not restricted to the described embodiments; what describe in above-described embodiment and instructions just illustrates principle of the present utility model; under the prerequisite not departing from the utility model spirit and scope; the utility model also has various changes and modifications, and these changes and improvements all fall within the scope of claimed the utility model.Claimed scope of the present utility model is defined by appending claims and equivalent thereof.
Claims (1)
1. detect the kit of syphilis helicoid antibody fast, the lid comprising box body and be hinged and connected with box body, it is characterized in that: box body is provided with spring locking device lid and box body sealed, the sponge holder measure-alike with box body is provided with in box body, groove in sponge holder is placed with the solid phase carrier of microspironema pallidum specific recombinant proteins Hangzhoupro primordial covering respectively, the negative antibody reagent bottle of microspironema pallidum, microspironema pallidum positive antibody reagent bottle, the microspironema pallidum specific recombinant proteins antigenic agents bottle of acridinium ester label, the alkaline luminous substrate reagent bottle that above-mentioned acridinium ester acts on, be fixed on the magnet plate on lid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420611580.3U CN204347030U (en) | 2014-10-22 | 2014-10-22 | The kit of quick detection syphilis helicoid antibody |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420611580.3U CN204347030U (en) | 2014-10-22 | 2014-10-22 | The kit of quick detection syphilis helicoid antibody |
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| Publication Number | Publication Date |
|---|---|
| CN204347030U true CN204347030U (en) | 2015-05-20 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201420611580.3U Active CN204347030U (en) | 2014-10-22 | 2014-10-22 | The kit of quick detection syphilis helicoid antibody |
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| CN (1) | CN204347030U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106771214A (en) * | 2016-11-30 | 2017-05-31 | 百奥森（江苏）食品安全科技有限公司 | Metopycide detection method and kit in a kind of poultry |
-
2014
- 2014-10-22 CN CN201420611580.3U patent/CN204347030U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106771214A (en) * | 2016-11-30 | 2017-05-31 | 百奥森（江苏）食品安全科技有限公司 | Metopycide detection method and kit in a kind of poultry |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20160406 Address after: 215163 building, No. 8, Jinfeng Road, hi tech Zone, Suzhou, Jiangsu, China Patentee after: Suzhou Changguang Huayi Biomedical Engineering Co., Ltd. Address before: 215163 building, No. 8, Jinfeng Road, hi tech Zone, Suzhou, Jiangsu, China Patentee before: Suzhou Changguang Huayi Biological Reagent Co., Ltd. |