CN204193045U - A kind of powder-liquid double-chamber transfusion bag of spicing forming type - Google Patents

A kind of powder-liquid double-chamber transfusion bag of spicing forming type Download PDF

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Publication number
CN204193045U
CN204193045U CN201420514246.6U CN201420514246U CN204193045U CN 204193045 U CN204193045 U CN 204193045U CN 201420514246 U CN201420514246 U CN 201420514246U CN 204193045 U CN204193045 U CN 204193045U
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China
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bag
liquid
powder
flour
chamber
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CN201420514246.6U
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Inventor
赵栋
田洪伍
佘佑廷
朱朝清
胡志凤
胡思玉
王利春
王晶翼
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Sichuan Kelun Pharmaceutical Research Institute Co Ltd
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Sichuan Kelun Pharmaceutical Research Institute Co Ltd
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Abstract

The utility model discloses a kind of powder-liquid double-chamber transfusion bag of spicing forming type, comprise flour bag and liquid bag, flour bag is separated by least one weak welding rod mutually with liquid bag, the bag wall of this transfusion bag is by being at least provided with, PP TYPE material two-layer is outward made, wherein, the internal layer of liquid bag is made up of polypropylene/modified polypropylene, the internal layer of flour bag is made up of polyethylene/modified poly ethylene, the place of joining of the bag wall of liquid bag and the bag wall of flour bag is provided with splicing bar, this utility model solves and is used alone polyethylene or the polypropylene dilemma as chamber internal layer, using polyethylene/modified polyethylene film material as the internal layer of flour bag, film material and medicated powder have the good compatibility, using polypropylene/modified polypropylene screen material as the liquid bag internal layer needing terminal sterilization, the requirement of terminal sterilization can be born, during use, extruding makes weak welding rod collapse and convinces logical flour bag and liquid bag by patient analysis, the aseptic mixing of powder liquid, the invention also discloses a kind of preparation method of powder-liquid double-chamber transfusion bag of spicing forming type.

Description

A kind of powder-liquid double-chamber transfusion bag of spicing forming type
Technical field
This utility model relates to a kind of powder-liquid double-chamber transfusion bag of spicing forming type.
Background technology
Powder-liquid double-chamber transfusion bag product is a kind of immediate dispensing infusion product, packaging material powder-liquid the double-chamber transfusion bag of this series products means and is combined into bag surrounding by multilayer co-squeeze film for transfusion by real welding heat, is separated with weak welding heat conjunction (can exert pressure and open) transfusion bag made inner space, and two chambers of this transfusion bag can be respectively used to liquid drug and aseptic powder.Before transfusion, operator only need apply certain pressure to sap cavity bag, is opened at weak weldering position and makes two chambers through and shake up, thus make sterile liquid medicine and aseptic powder fully mix and dissolve, and can carry out clinical transfusion subsequently by after the suspension of this transfusion bag.Compared with traditional infusion bag, powder-liquid double-chamber transfusion bag has following advantage on Clinical practice: (1) clinical treatment is without error of making up a prescription, and prevents nosocomial infection, without the need to special sterile dispense chamber when making up a prescription, uses very convenient, safety; (2) significantly can shorten incorporation time of making up a prescription, improve medical personnel's work efficiency; (3) can reduce the storage area of medicine in intermediate links and medical institutions, reduce Biohazard Waste; (4) be specially adapted to speedily carry out rescue work, the disaster relief, emergent, field relief, the occasion such as war.
The manufacture of powder-liquid double-chamber transfusion bag need adopt dedicated film material, common multilayer co-squeeze film for transfusion cannot use owing to can not realize weak weldering, at present, on medical packaging market, the film material that can be used for manufacturing powder-liquid double-chamber transfusion bag mainly contains two kinds: one is internal layer material is poly multilayer co-squeeze film for transfusion; Another kind is internal layer material is polyacrylic multilayer co-squeeze film for transfusion.Above-mentioned two kinds of film materials all can realize weakly being welded the powder-liquid double-chamber transfusion bag produced and meet Clinical practice requirement.
Although above-mentioned two kinds of dedicated film materials can realize weak being welded and produce powder-liquid double-chamber bag, but limit the scope of application because of the defect of respective material own, wherein, internal layer material is that poly film material and most of powder injection formulation compatibility are better, go on the market for many years in Japan, but due to the terminal sterilization (as: 121 DEG C, 12 minutes) that it can not tolerate injection requirement, cannot promote the use of at home; Internal layer material be polyacrylic film material then because polypropylene material itself is containing large weight oligomers, not good with most of powder injection formulation compatibility, and use limited.
Utility model content
For prior art Problems existing, primary and foremost purpose of the present utility model is the powder-liquid double-chamber transfusion bag providing a kind of spicing forming type, and quasi-solution certainly existing powder-liquid double-chamber bag product causes because of the defect of film material material own using limited problem.Secondary objective of the present utility model is the preparation method of the powder-liquid double-chamber transfusion bag providing a kind of spicing forming type.
For achieving the above object, technical solution of the present utility model is:
A kind of powder-liquid double-chamber transfusion bag of spicing forming type, this transfusion bag comprises flour bag and liquid bag, described flour bag is separated by least one weak welding rod mutually with described liquid bag, the bag wall of this transfusion bag is made by being at least provided with inside and outside two-layer PP TYPE material, wherein, the internal layer of liquid bag is made up of polypropylene/modified polypropylene, and the internal layer of flour bag is made up of polyethylene/modified poly ethylene, and the place of joining of the bag wall of liquid bag and the bag wall of flour bag is provided with splicing bar.
Further, described splicing bar is arranged on the side being close to described weak welding rod in described flour bag chamber.
Further, described liquid bag is provided with plastic interface, described plastic interface is welded with plastic closure.
Further, be welded with its coated aluminum-plastic composite membrane outside described flour bag, described aluminum-plastic composite membrane offers suppending hole.
A preparation method for the powder-liquid double-chamber transfusion bag of above-mentioned spicing forming type, described preparation method comprises the steps:
1) to get internal layer material be polypropylene/modified polyacrylic PP TYPE material A and internal layer material is the PP TYPE material B of polyethylene/modified poly ethylene, in the two intersection, the side of two kinds of film materials is stacked with, splicing bar is formed by heat seal welding, make splicing film material, wherein, PP TYPE material A and PP TYPE material B has at least inside and outside two-layer;
2) get the splicing film material prepared and make bag blank by heat seal welding, weak welding rod bag inner chamber being separated into flour bag and liquid bag is welded with in the side heat seal being close to described splicing bar, wherein, described liquid bag is surrounded by PP TYPE material A, and described flour bag is surrounded by PP TYPE material B;
3) in liquid bag chamber, pour into medicinal liquid, sterilizing after fill, drying, then inject medicated powder in flour bag chamber, seal after fill.
Further, also comprise step 4) and be welded with its coated aluminum-plastic composite membrane outside flour bag, described aluminum-plastic composite membrane offers suppending hole.
Powder-liquid the double-chamber transfusion bag of spicing forming type of the present utility model solves and is used alone polyethylene or the polypropylene dilemma as chamber internal layer, using polyethylene/modified polyethylene film material as the internal layer of flour bag, film material and medicated powder have the good compatibility, using polypropylene/modified polypropylene screen material as the liquid bag internal layer needing terminal sterilization, the requirement of terminal sterilization can be born, during use, extrude weak welding rod place, weak welding rod is collapsed and convinces logical flour bag and liquid bag by patient analysis, make the aseptic mixing of powder liquid; Arranging the weak welding rod of multiple tracks can avoid at pilot processs such as storage, transports, because missing the problem that pressure infuser bag causes weak welding rod to collapse out; Multilayer bag wall makes transfusion bag more solid, and barrier is better, and can not affect the terminal sterilization of liquid bag; Aluminum-plastic composite membrane meets the requirement that flour bag Chinese medicine powder lucifuge stores, and convenient hanging.
Accompanying drawing explanation
Fig. 1 is the first structural representation of the powder-liquid double-chamber transfusion bag of spicing forming type of the present utility model;
Fig. 2 is the view profile at B-B place in Fig. 1;
Fig. 3 is the top view of splicing film material;
Fig. 4 is the forward and backward view profile of the splicing at A-A place in Fig. 3;
Fig. 5 is the second structural representation of the powder-liquid double-chamber transfusion bag of spicing forming type of the present utility model;
Fig. 6 is the view profile at C-C place in Fig. 5;
Fig. 7 is the third structural representation of the powder-liquid double-chamber transfusion bag of spicing forming type of the present utility model;
In figure: 1 liquid bag, 2 flour bags, 3 splicing bar, 4 weak welding rods, 5 transition regions, 6 plastic interfaces, 7 plastic closures, 8 aluminum-plastic composite membranes, 9 suppending holes.
Detailed description of the invention
Below, with reference to accompanying drawing, this utility model is more fully illustrated, shown in the drawings of exemplary embodiment of the present utility model.But this utility model can be presented as multiple multi-form, and should not be construed as the exemplary embodiment being confined to describe here.But, these embodiments are provided, thus make this utility model comprehensively with complete, and scope of the present utility model is fully conveyed to those of ordinary skill in the art.
For ease of illustrating, here can use such as " on ", the space relative terms such as D score " left side " " right side ", for illustration of the element of shown in figure or the feature relation relative to another element or feature.It should be understood that except the orientation shown in figure, spatial terminology is intended to comprise device different azimuth in use or operation.Such as, if the device in figure is squeezed, be stated as the element being positioned at other elements or feature D score will be positioned at other elements or feature " on ".Therefore, exemplary term D score can comprise upper and lower both orientation.Device can otherwise be located (90-degree rotation or be positioned at other orientation), and space used here illustrates relatively can correspondingly explain.
Be the first specific constructive form of the powder-liquid double-chamber transfusion bag of a kind of spicing forming type of this utility model as depicted in figs. 1 and 2, this powder-liquid double-chamber transfusion bag comprises the flour bag 2 on top and the liquid bag 1 of bottom.Flour bag 2 and liquid bag 1 are made up of PP TYPE material, PP TYPE material at least comprises internal layer and outer field double-decker, certainly, it can also be the co-extrusion film material of more multi-layered number, as three layers or five layers, the film material of flour bag 2 can with the film sheet material layers number disunity of liquid bag 1, specialize according to requiring the difference of bag wall thickness, wherein the internal layer of liquid bag 1 is made up of polypropylene/modified polypropylene, and the internal layer of flour bag 2 is made up of polyethylene/modified poly ethylene.The junction of the bag wall of liquid bag 1 and the bag wall of flour bag 2 is provided with splicing bar 3.A weak welding rod 4 is set between flour bag 2 and liquid bag 1, by weak welding rod 4, flour bag 2 chamber is separated mutually with liquid bag 1 chamber.Splicing bar 3 is arranged in flour bag 2 chamber is close to weak welding rod 4 place.Weak welding rod 4 conjunction of bag wall pressure is formed by heat seal welding, and the bonding strength at weak welding rod 4 place will far below the bonding strength of transfusion bag periphery.Liquid bag 1 lower end is provided with plastic interface 6, plastic interface 6 is welded with plastic closure 7.
Be the splicing schematic diagram of co-extrusion film material as shown in Figure 3 and Figure 4, in figure 3, for making the co-extrusion film material of liquid bag 1 bag of wall on the left of splicing bar 3, for making the co-extrusion film material of flour bag 2 bags of walls on the right side of splicing bar 3, before splicing, two kinds of film edge edge are stacked with mutually, then make splicing bar 3 by heat seal welding.
Be the second specific constructive form of the powder-liquid double-chamber transfusion bag of a kind of spicing forming type of this utility model as shown in Figure 5 and Figure 6, substantially identical with the first specific constructive form shown in Fig. 1 with Fig. 2, difference is pointed out to be, the weak welding rod 4 of twice is provided with in the second specific constructive form, transition region 5 is provided with between the weak welding rod 4 of twice, than the version arranging weak welding rod 4 together, the weak welding rod 4 of twice can be avoided in storage, the pilot processs such as transport, because missing the problem that pressure infuser bag causes wherein weak welding rod 4 together to collapse out, the isolated effect of liquid bag 1 and flour bag 2 can be ensured further.
Be illustrated in figure 7 the third specific constructive form of the powder-liquid double-chamber transfusion bag of a kind of spicing forming type of this utility model, on the first basis with the second concrete structure, be welded with its coated aluminum-plastic composite membrane 8 outside flour bag 2, aluminum-plastic composite membrane 8 offers suppending hole 9.Aluminum-plastic composite membrane 8 meets the requirement that flour bag 2 Chinese medicine powder lucifuge stores, and suppending hole 9 facilitates transfusion bag hanging in use.
embodiment 1
One of preparation method of the powder-liquid double-chamber transfusion bag of spicing forming type:
It be polyacrylic three-layer extrusion film material A and internal layer material is poly five-layer co-squeezing film material B that step 1) gets internal layer material, three-layer extrusion film material A is followed successively by inner layer of polypropylene from the inside to the outside, modified polypropene middle level and modified polypropene skin, five-layer co-squeezing film material B is followed successively by polyethylene inner layer from the inside to the outside, adhesive phase, polypropylene middle level, adhesive phase and outer layer of polypropylene, at the two A, the side of two kinds of film materials is stacked with by B intersection, splicing bar is formed by heat seal welding (welding temperature is 185 DEG C), by splicing bar by two kinds of film material A, B splicing becomes overall splicing film material,
Step 2) get the splicing film material surrounding for preparing and make bag blank by heat seal welding (welding temperature is 180 DEG C), be welded with weak welding rod together being close to splicing bar heat seal, bag is separated into flour bag and liquid bag two chambers, splicing bar is arranged in flour bag chamber at liquid bag, and the heat sealing strength of weak welding rod is 8.6N/15mm; Wherein, liquid bag is surrounded by co-extrusion film material A, and flour bag is surrounded by co-extrusion film material B;
Step 3) is at liquid bag top welding plastic interface, for liquid drug, a certain amount of sterile nitrogen is injected by injection device flour bag one jiao, then heat seal sealing decanting point, in liquid bag, 0.9% sodium chloride injection is poured into by the plastic interface welded in advance, after fill completes, at plastic interface top welding plastic seal cover, then semi-finished product are delivered to bactericidal unit, sterilizing 12 minutes under 121 DEG C of high temperature, after sterilizing completes, semi-finished product are placed in air dry oven and carry out dried, baking temperature is 80 DEG C, 1.5 hours drying times, after drying completes, move to medicated powder fill operation, the flour bag base cuts first will closed, drain nitrogen, fill cefazolin sodium for injection, again by bottom heat seal welded closure,
Then step 4) welds aluminum-plastic composite membrane in flour bag front with the back side respectively, a die-cut suppending hole on aluminum-plastic composite membrane top.
To prepare under powder-liquid double-chamber bag dress cefazolin sodium for injection/sodium chloride injection sample is placed in 60 DEG C of environment and accelerate to investigate, carry out key index detection by Chinese Pharmacopoeia standard to flour bag content medicine respectively at sampling in 5 days, 10 days, result is as following table:
Table 1 cefazolin sodium for injection accelerates to investigate result
Result shows, adopt the cefazolin sodium for injection/sodium chloride injection of a kind of Novel powder of this utility model-liquid double-chamber bag packaging, accelerate investigation 10 days through 60 DEG C, clarity of solution, medicament contg, related substance all meet Chinese Pharmacopoeia standard-required.
embodiment 2
The preparation method two of the powder-liquid double-chamber transfusion bag of spicing forming type:
Two of method is with the difference of one of method, co-extrusion film material A and co-extrusion film material B all adopts three layers, it is outer that co-extrusion film material A is followed successively by modified polypropene internal layer, modified polypropene middle level and modified polypropene from the inside to the outside, it is outer that co-extrusion film material B is followed successively by modified poly ethylene internal layer, modified polypropene middle level and modified polypropene from the inside to the outside, liquid bag is surrounded by co-extrusion film material A, and flour bag is surrounded by co-extrusion film material B.The weak welding rod that liquid bag is parallel with arranging two between flour bag, is provided with transition region between two weak welding rods; The medicine of liquid bag and flour bag fill is 5% glucose injection and cefuroxime sodium for injection.
To prepare under powder-liquid double-chamber bag dress cefuroxime sodium for injection/glucose injection sample is placed in 60 DEG C of environment and accelerate to investigate, carry out key index detection by Chinese Pharmacopoeia standard to flour bag content medicine respectively at sampling in 5 days, 10 days, result is as following table:
Table 2 cefuroxime sodium for injection accelerates to investigate result
Result shows, adopt the cefuroxime sodium for injection/glucose injection of a kind of Novel powder of this utility model-liquid double-chamber bag packaging, accelerate investigation 10 days through 60 DEG C, clarity of solution, medicament contg, related substance all meet Chinese Pharmacopoeia standard-required.
embodiment 3
The preparation method three of the powder-liquid double-chamber transfusion bag of spicing forming type:
Three of method are with the difference of method two, and liquid bag 1 is 5% glucose injection and fosfomycin sodium for injection with the medicine of flour bag 2 fill.
To prepare under powder-liquid double-chamber bag dress injection head fosfomycin sodium/glucose injection sample is placed in 60 DEG C of environment and accelerate to investigate, carry out key index detection by Chinese Pharmacopoeia standard to flour bag content medicine respectively at sampling in 5 days, 10 days, result is as following table:
Table 3 fosfomycin sodium for injection accelerates to investigate result
Result shows, adopt the fosfomycin sodium for injection/glucose injection of a kind of Novel powder of this utility model-liquid double-chamber bag packaging, accelerate investigation 10 days through 60 DEG C, clarity of solution, medicament contg all meet Chinese Pharmacopoeia standard-required.
embodiment 4
The preparation method four of the powder-liquid double-chamber transfusion bag of spicing forming type:
Four of method are with the difference of method two, and the medicine of liquid bag and flour bag fill is 0.9% sodium chloride injection and cefoperazone sodium and sulbactam sodium for injection.
To prepare under powder-liquid double-chamber bag dress cefoperazone sodium and sulbactam sodium for injection/sodium chloride injection sample is placed in 60 DEG C of environment and accelerate to investigate, carry out key index detection by Chinese Pharmacopoeia standard to flour bag content medicine respectively at sampling in 5 days, 10 days, result is as following table:
Table 4 cefoperazone sodium and sulbactam sodium for injection accelerates to investigate result
Result shows, adopt the cefoperazone sodium and sulbactam sodium for injection/sodium chloride injection of a kind of Novel powder of this utility model-liquid double-chamber bag packaging, accelerate investigation 10 days through 60 DEG C, clarity of solution, medicament contg all meet Chinese Pharmacopoeia standard-required.

Claims (5)

1. powder-liquid the double-chamber transfusion bag of a spicing forming type, this transfusion bag comprises flour bag and liquid bag, it is characterized in that, described flour bag is separated by least one weak welding rod mutually with described liquid bag, the bag wall of this transfusion bag is made by being at least provided with inside and outside two-layer PP TYPE material, and wherein, the internal layer of liquid bag is made up of polypropylene/modified polypropylene, the internal layer of flour bag is made up of polyethylene/modified poly ethylene, and the place of joining of the bag wall of liquid bag and the bag wall of flour bag is provided with splicing bar.
2. powder-liquid the double-chamber transfusion bag of spicing forming type as claimed in claim 1, it is characterized in that, described splicing bar is arranged on the side being close to described weak welding rod in described flour bag chamber.
3. powder-liquid the double-chamber transfusion bag of spicing forming type as claimed in claim 1 or 2, is characterized in that, described liquid bag is provided with plastic interface, described plastic interface is welded with plastic closure.
4. powder-liquid the double-chamber transfusion bag of spicing forming type as claimed in claim 1 or 2, is characterized in that, be welded with its coated aluminum-plastic composite membrane, described aluminum-plastic composite membrane offers suppending hole outside described flour bag.
5. powder-liquid the double-chamber transfusion bag of spicing forming type as claimed in claim 3, is characterized in that, be welded with its coated aluminum-plastic composite membrane, described aluminum-plastic composite membrane offers suppending hole outside described flour bag.
CN201420514246.6U 2014-09-09 2014-09-09 A kind of powder-liquid double-chamber transfusion bag of spicing forming type Expired - Lifetime CN204193045U (en)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104188800A (en) * 2014-09-09 2014-12-10 四川科伦药物研究院有限公司 Spliced powder-liquid dual-chamber infusion bag and preparation method thereof
CN115384160A (en) * 2022-09-23 2022-11-25 湖南怡永丰新材料科技有限公司 Covering film for powder-liquid double-chamber bag and preparation method and application thereof
CN117141053A (en) * 2023-10-27 2023-12-01 湖南大道新材料有限公司 Double-sub-bag production equipment

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104188800A (en) * 2014-09-09 2014-12-10 四川科伦药物研究院有限公司 Spliced powder-liquid dual-chamber infusion bag and preparation method thereof
CN115384160A (en) * 2022-09-23 2022-11-25 湖南怡永丰新材料科技有限公司 Covering film for powder-liquid double-chamber bag and preparation method and application thereof
CN115384160B (en) * 2022-09-23 2024-02-06 湖南怡永丰新材料科技有限公司 Cover film for powder-liquid double-chamber bag and preparation method and application thereof
CN117141053A (en) * 2023-10-27 2023-12-01 湖南大道新材料有限公司 Double-sub-bag production equipment
CN117141053B (en) * 2023-10-27 2024-01-05 湖南大道新材料有限公司 Double-sub-bag production equipment

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