CN115384160A - Covering film for powder-liquid double-chamber bag and preparation method and application thereof - Google Patents

Covering film for powder-liquid double-chamber bag and preparation method and application thereof Download PDF

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CN115384160A
CN115384160A CN202211166812.4A CN202211166812A CN115384160A CN 115384160 A CN115384160 A CN 115384160A CN 202211166812 A CN202211166812 A CN 202211166812A CN 115384160 A CN115384160 A CN 115384160A
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powder
chamber bag
film
density polyethylene
layer
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CN115384160B (en
Inventor
王剑
袁志庆
黄永发
阳康丽
滕敏
陈建
谭湘其
湛红日
曾焰
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Hunan Yiyongfeng New Material Technology Co ltd
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Hunan Yiyongfeng New Material Technology Co ltd
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B27/00—Layered products comprising a layer of synthetic resin
    • B32B27/36—Layered products comprising a layer of synthetic resin comprising polyesters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/10—Bag-type containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2093—Containers having several compartments for products to be mixed
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29D—PRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE
    • B29D7/00—Producing flat articles, e.g. films or sheets
    • B29D7/01—Films or sheets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B15/00—Layered products comprising a layer of metal
    • B32B15/04—Layered products comprising a layer of metal comprising metal as the main or only constituent of a layer, which is next to another layer of the same or of a different material
    • B32B15/08—Layered products comprising a layer of metal comprising metal as the main or only constituent of a layer, which is next to another layer of the same or of a different material of synthetic resin
    • B32B15/085—Layered products comprising a layer of metal comprising metal as the main or only constituent of a layer, which is next to another layer of the same or of a different material of synthetic resin comprising polyolefins
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B15/00—Layered products comprising a layer of metal
    • B32B15/04—Layered products comprising a layer of metal comprising metal as the main or only constituent of a layer, which is next to another layer of the same or of a different material
    • B32B15/08—Layered products comprising a layer of metal comprising metal as the main or only constituent of a layer, which is next to another layer of the same or of a different material of synthetic resin
    • B32B15/09—Layered products comprising a layer of metal comprising metal as the main or only constituent of a layer, which is next to another layer of the same or of a different material of synthetic resin comprising polyesters
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B15/00—Layered products comprising a layer of metal
    • B32B15/20—Layered products comprising a layer of metal comprising aluminium or copper
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B27/00—Layered products comprising a layer of synthetic resin
    • B32B27/18—Layered products comprising a layer of synthetic resin characterised by the use of special additives
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B27/00—Layered products comprising a layer of synthetic resin
    • B32B27/32—Layered products comprising a layer of synthetic resin comprising polyolefins
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B33/00—Layered products characterised by particular properties or particular surface features, e.g. particular surface coatings; Layered products designed for particular purposes not covered by another single class
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2307/00—Properties of the layers or laminate
    • B32B2307/30—Properties of the layers or laminate having particular thermal properties
    • B32B2307/31—Heat sealable
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2439/00—Containers; Receptacles
    • B32B2439/80—Medical packaging

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Wrappers (AREA)
  • Laminated Bodies (AREA)

Abstract

The invention discloses a covering film for a powder-liquid double-chamber bag, a preparation method and application thereof, wherein the covering film for the powder-liquid double-chamber bag consists of a polyester film layer, an aluminum foil layer and a modified low-density polyethylene film layer from outside to inside, and the modified low-density polyethylene film layer is prepared from the following raw materials: 35-65% of low-density polyethylene, 15-25% of nano calcium carbonate, 10-15% of nano silicon dioxide, 5-10% of nano titanium dioxide, 3-5% of solid paraffin, 1-5% of silane coupling agent and 1-5% of maleic anhydride. The preparation method comprises compounding polyester film, aluminum foil, and modified low density polyethylene film with adhesive. The covering film for the powder-liquid double-chamber bag can simultaneously meet the requirements that the heat sealing strength of the covering film and the surface of the powder-liquid double-chamber bag reaches 4-12N/15mm and the welding rod welding fastness between the two chambers of the double-chamber bag is in the range of 5-9N/15mm, and the preparation method has low cost and simple and controllable process and is suitable for large-scale production.

Description

Covering film for powder-liquid double-chamber bag and preparation method and application thereof
Technical Field
The invention relates to the technical field of medicine packaging materials, in particular to a covering film for a powder-liquid double-chamber bag, and a preparation method and application thereof.
Background
The special name of the powder-liquid double-chamber bag is an instant powder-liquid double-chamber transfusion soft bag, which is a special powder-liquid double-chamber transfusion soft bag based on a common plastic transfusion bag, the bag is divided into two independent closed chambers by adopting a special technology, different medicines are respectively packaged in the two chambers, and a weak sealing tape (10-30 mm) between the two chambers is opened by extrusion before use, so that the mixing of an injection solvent and medicine powder is realized, and the medicine dispensing is finished. The powder-liquid double-chamber bag is a novel medicine packaging bag, and has the main advantages that: (1) the medicine proportion is set according to clinical needs before leaving factory, and the whole medicine dispensing process is carried out in a closed packaging container, so that medicine loss can be effectively avoided, and accurate medicine dispensing is realized; (2) the medicine mixing process is completely closed, so that the risk of pollution is avoided, and the medicine safety is ensured; (3) the infusion bag saves packaging materials and storage space, is convenient and quick to operate, is suitable for emergency treatment, emergency rescue and relief, field and exploration rescue and the like, and is one of important directions for the development of infusion products.
In order to ensure that the medicines have good visibility in the mixing and using processes, the bag body material of the powder-liquid double-chamber bag usually adopts a transparent co-extrusion packaging material, and in the practical application process, because many medicines such as powder need to be moisture-proof, oxygen permeation-proof and light-proof, the outer surface of the powder chamber bag is usually covered with a layer of lightproof aluminum-plastic composite cover film through heat sealing so as to ensure the stability and safety of the medicines in the storage and transportation processes. Before dispensing, the aluminum-plastic composite cover film is uncovered from the surface of the powder-liquid double-chamber bag, so that visual dispensing and use can be realized.
However, in the manufacturing process of the powder-liquid dual-chamber bag injection product which is sealed and welded in the same body (same mold), at the same temperature and at the same time, the aluminum-plastic composite cover film in the market at present has the main problems that: (1) when the heat sealing strength of the aluminum-plastic composite covering film and the surface of the powder-liquid double-chamber bag reaches 4-12N/15mm, if the heat sealing temperature of the aluminum-plastic composite covering film and the surface of the powder-liquid double-chamber bag is too high, the welding rod between the two chambers is welded too firmly and cannot be opened during extrusion; if the heat sealing temperature of the aluminum-plastic composite covering film and the surface of the powder-liquid double-chamber bag is too low, the welding rod between the two chambers is not firmly welded, so that the powder-liquid double-chamber bag can be automatically opened in storage and transportation, and the product is scrapped; (2) when the welding rod welding fastness between two cavities of the powder-liquid double-chamber bag is in an optimal range, if the heat sealing strength of the aluminum-plastic composite covering film and the surface of the powder-liquid double-chamber bag exceeds 12N/15mm, the aluminum-plastic composite covering film cannot be uncovered from the surface of the powder-liquid double-chamber bag, and the quality condition of the medicinal powder cannot be seen when the powder-liquid double-chamber bag is used; if the heat sealing strength of the aluminum-plastic composite cover film and the surface of the powder-liquid double-chamber bag is less than 4N/15mm, the aluminum-plastic composite cover film is easily uncovered from the surface of the powder-liquid double-chamber bag and even automatically falls off, so that the medicine powder loses protection and deteriorates. The aluminum-plastic composite covering film in the current market cannot be manufactured according to practice, and the requirements that the heat sealing strength of the aluminum-plastic composite covering film and the surface of the powder-liquid double-chamber bag reaches the range of 4-12N/15mm and the welding rod welding fastness between two chambers of the powder-liquid double-chamber bag is in the optimal range (5-9N/15 mm) are met.
Therefore, the research and development of the aluminum-plastic composite cover film which simultaneously meets the requirements have important significance.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provide a covering film for a powder-liquid double-chamber bag, which can simultaneously meet the two conditions that the heat sealing strength of the covering film with the surface of the powder-liquid double-chamber bag reaches 4-12N/15mm and the welding rod welding fastness between two chambers of the powder-liquid double-chamber bag is in the optimal range of 5-9N/15mm within the heat sealing range of 140-170 ℃, and a preparation method and application thereof.
In order to solve the technical problems, the invention adopts the following technical scheme.
A covering film for a powder-liquid double-chamber bag is composed of an outer surface layer, a middle layer and an inner surface layer, wherein the outer surface layer is a polyester film layer, the middle layer is an aluminum foil layer, and the inner surface layer is a modified low-density polyethylene film layer;
the modified low-density polyethylene film layer is prepared from the following raw materials in percentage by mass:
35 to 65 percent of low-density polyethylene,
15 to 25 percent of nano calcium carbonate,
10 to 15 percent of nano silicon dioxide,
5 to 10 percent of nano titanium dioxide,
3 to 5 percent of solid paraffin,
1 to 5 percent of silane coupling agent, and
1 to 5 percent of maleic anhydride.
Preferably, the modified low-density polyethylene film layer is prepared from the following raw materials in percentage by mass:
40 to 60 percent of low-density polyethylene,
15 to 20 percent of nano calcium carbonate,
10 to 12 percent of nano silicon dioxide,
6 to 9 percent of nano titanium dioxide,
4 to 5 percent of solid paraffin,
2 to 3 percent of silane coupling agent, and
2 to 3 percent of maleic anhydride;
the sum of the mass fractions of the raw materials is 100 percent.
Preferably, the cover film for the powder-liquid dual-chamber bag has a thickness of 5-20 μm for the polyester film layer, a thickness of 5-20 μm for the aluminum foil layer, and a thickness of 10-90 μm for the modified low-density polyethylene film layer.
The cover film for the powder-liquid dual-chamber bag is preferably made of low-density polyethylene with the density of 0.91g/cm 3 ～0.93g/cm 3 。
Preferably, the polyester of the polyester film layer comprises one or more of PET7, PET8, PET10, PET12 and PET15, and the silane coupling agent comprises one or more of KH550, KH560 and KH570.
As a general technical concept, the invention also provides a preparation method of the cover film for the powder-liquid dual-chamber bag, which comprises the following steps:
(1) Preparing a modified low-density polyethylene film according to the raw materials and the proportion;
(2) And compounding the polyester film and the aluminum foil by adopting an adhesive to obtain a polyester film/aluminum foil composite film, compounding the aluminum foil surface of the composite film and the modified low-density polyethylene film by adopting the adhesive, and curing to obtain the covering film for the powder-liquid double-chamber bag.
In the above method for producing a lidding film for powder-liquid dual-compartment pouches, preferably, in step (1), the production method includes an extrusion-blow-stretching method, an extrusion-calendering-stretching method or a casting method.
In the above method for preparing the cover film for the powder-liquid dual-chamber bag, preferably, in the step (2), the curing time is 20 to 48 hours.
In the above method for preparing the cover film for the powder-liquid dual-chamber bag, preferably, in the step (2), the adhesive is a polyurethane adhesive.
As a general technical concept, the invention also provides an application of the covering film for the powder-liquid dual-chamber bag or the covering film for the powder-liquid dual-chamber bag prepared by the preparation method in the field of medicine packaging.
In the invention, the inner surface layer modified low-density polyethylene film layer is used as a heat sealing layer in application.
In the present invention, the polyester film and the aluminum foil are those for packaging commercially available foods and medicines.
In the present invention, the low density polyethylene is a cast grade low density polyethylene or a blown grade low density polyethylene.
The main innovation points of the invention are as follows:
in the manufacturing process of a powder-liquid double-chamber bag injection product which is in the same body (same mould), at the same temperature and is packaged by rapid sealing welding at the same time, the balance between the heat sealing strength of the surface of a covering film for a powder-liquid double-chamber bag and the powder-liquid double-chamber bag in the heat sealing range of 140-170 ℃ and the welding fastness of a welding rod between two chambers of the powder-liquid double-chamber bag is regulated and controlled by screening and combination design of raw materials; the balance degree of the heat sealing strength and the welding fastness can be accurately controlled within the range of the raw material proportion, the heat sealing strength of the surfaces of the covering film and the powder-liquid double-chamber bag can reach 4-12N/15mm within the heat sealing range of 140-170 ℃, and the welding fastness of the welding rod between two chambers of the powder-liquid double-chamber bag is in the optimal range of 5-9N/15mm.
Compared with the prior art, the invention has the advantages that:
(1) The covering film for the powder-liquid double-chamber bag is composed of a polyester film, an aluminum foil and a modified low-density polyethylene film, wherein the modified low-density polyethylene film is prepared from specific components and proportions, namely, the components of nano calcium carbonate, nano silicon dioxide, nano titanium dioxide and the like are added into a low-density polyethylene material, so that the film layer is slightly vacant, and uneven heat sealing is formed, and the balance between the heat sealing strength and the welding fastness is facilitated, therefore, the covering film for the powder-liquid double-chamber bag can simultaneously meet the two conditions that the heat sealing strength of the covering film and the surface of the powder-liquid double-chamber bag reaches 4-12N/15mm, the welding rod welding fastness between the two chambers of the powder-liquid double-chamber bag is in the optimal range of 5-9N/15mm, and the covering film is easy to heat seal and easy to uncover from the surface of the powder-liquid double-chamber bag.
(2) The preparation method has the advantages of low cost, simple and controllable process and the like, and is suitable for large-scale production.
Drawings
Fig. 1 is a schematic structural view of a cover film for a powder-liquid dual-chamber bag prepared in example 1 of the present invention.
Illustration of the drawings:
1. a polyester film layer; 2. an aluminum foil layer; 3. a modified low density polyethylene film layer.
Detailed Description
The invention is further described below with reference to the drawings and the specific preferred embodiments, without thereby limiting the scope of protection of the invention. The materials and instruments used in the following examples are commercially available.
Example 1
The invention relates to a covering film for a powder-liquid double-chamber bag, which is composed of an outer surface layer, a middle layer and an inner surface layer as shown in figure 1, wherein the outer surface layer is a polyester film layer 1, the middle layer is an aluminum foil layer 2, the inner surface layer is a modified low-density polyethylene film layer 3, and the modified low-density polyethylene film layer 3 is prepared from the following raw materials in percentage by mass: 65% of low-density polyethylene, 15% of nano calcium carbonate, 10% of nano silicon dioxide, 5% of nano titanium dioxide, 3% of solid paraffin, 1% of silane coupling agent and 1% of maleic anhydride.
In this example, the thickness of the polyester film layer 1 was 12 μm, the thickness of the aluminum foil layer 2 was 16 μm, and the thickness of the low density polyethylene film layer was 70 μm.
In this example, the polyester is PET12 (parylene)Ethylene glycol acid ester), the silane coupling agent is KH550. The density of the low density polyethylene is 0.91g/cm 3 。
The preparation method of the cover film for the powder-liquid dual-chamber bag comprises the following steps:
(1) The modified low-density polyethylene film is prepared from the following raw materials: 65% of low-density polyethylene, 15% of nano calcium carbonate, 10% of nano silicon dioxide, 5% of nano titanium dioxide, 3% of solid paraffin, 1% of silane coupling agent and 1% of maleic anhydride; weighing the raw materials according to the raw material formula, uniformly mixing in a mixer, and preparing the modified low-density polyethylene film with the thickness of 70 mu m by a conventional extrusion-blow molding-stretching process. Wherein, the extrusion process can adopt methods of single-layer extrusion blow molding, 2-10-layer co-extrusion blow molding, casting extrusion and the like.
(2) Coating polyurethane adhesive on a polyester film with the thickness of 12 microns, compounding the polyester film with an aluminum foil with the thickness of 16 microns on a compounding machine to obtain a polyester film/aluminum foil composite film, coating the polyurethane adhesive on the surface of the aluminum foil of the polyester film/aluminum foil composite film, compounding the polyester film/aluminum foil composite film with the modified low-density polyethylene film with the thickness of 70 microns obtained in the step (1), and curing for 20 hours to obtain the covering film for the powder-liquid double-chamber bag.
Example 2
The invention relates to a covering film for a powder-liquid double-chamber bag, which consists of an outer surface layer, a middle layer and an inner surface layer, wherein the outer surface layer is a polyester film layer 1, the middle layer is an aluminum foil layer 2, the inner surface layer is a modified low-density polyethylene film layer 3, and the modified low-density polyethylene film layer 3 is prepared from the following raw materials in percentage by mass: 35% of low-density polyethylene, 25% of nano calcium carbonate, 15% of nano silicon dioxide, 10% of nano titanium dioxide, 5% of solid paraffin, 5% of silane coupling agent and 5% of maleic anhydride.
In this example, the thickness of the polyester film layer 1 was 7 μm, the thickness of the aluminum foil layer 2 was 12 μm, and the thickness of the modified low-density polyethylene film layer 3 was 30 μm.
In this example, the polyester was PET7, and the silane coupling agent was KH560. The low density polyethylene has a density of 0.91g/cm 3 。
The preparation method of the cover film for the powder-liquid dual-chamber bag comprises the following steps:
(1) The modified low-density polyethylene film is prepared from the following raw materials: 35% of low-density polyethylene, 25% of nano calcium carbonate, 15% of nano silicon dioxide, 10% of nano titanium dioxide, 5% of solid paraffin, 5% of silane coupling agent and 5% of maleic anhydride; weighing the raw materials according to the formula of the raw materials, uniformly mixing the raw materials in a mixer, and preparing the modified low-density polyethylene film with the thickness of 30 mu m by an extrusion-calendering-stretching process. Wherein, the extrusion process can adopt methods of single-layer extrusion blow molding, 2-10-layer co-extrusion blow molding, casting extrusion and the like.
(2) Coating a polyester film with the thickness of 7 mu m with a polyurethane adhesive, compounding the polyester film with an aluminum foil with the thickness of 12 mu m on a compounding machine, coating the polyurethane adhesive on the surface of the aluminum foil, compounding the aluminum foil with a modified low-density polyethylene film with the thickness of 30 mu m, curing for 20 hours, and obtaining the covering film for the powder-liquid dual-chamber bag.
Example 3
The covering film for the powder-liquid double-chamber bag comprises an outer surface layer, a middle layer and an inner surface layer, wherein the outer surface layer is a polyester film layer 1, the middle layer is an aluminum foil layer 2, the inner surface layer is a modified low-density polyethylene film layer 3, and the modified low-density polyethylene film layer 3 is prepared from the following raw materials in percentage by mass: 50% of low-density polyethylene, 20% of nano calcium carbonate, 12% of nano silicon dioxide, 8% of nano titanium dioxide, 4% of solid paraffin, 4% of silane coupling agent and 2% of maleic anhydride.
In this example, the thickness of the polyester film layer 1 was 10 μm, the thickness of the aluminum foil layer 2 was 9 μm, and the thickness of the modified low-density polyethylene film layer 3 was 50 μm.
In this example, the polyester was PET10, and the silane coupling agent was KH550. The low density polyethylene has a density of 0.91g/cm 3 。
The preparation method of the cover film for the powder-liquid dual-chamber bag comprises the following steps:
(1) The modified low-density polyethylene film is prepared from the following raw materials in formula: 50% of low-density polyethylene, 20% of nano calcium carbonate, 12% of nano silicon dioxide, 8% of nano titanium dioxide, 4% of solid paraffin, 4% of silane coupling agent and 2% of maleic anhydride; weighing raw materials according to the formula of the raw materials, uniformly mixing the raw materials in a mixer, and preparing the modified low-density polyethylene film with the thickness of 50 mu m by an extrusion-blow molding-stretching process.
(2) Coating polyurethane adhesive on a polyester film with the thickness of 10 mu m, compounding the polyester film with an aluminum foil with the thickness of 9 mu m on a compounding machine, coating the polyurethane adhesive on the surface of the aluminum foil, compounding the aluminum foil with the low-density polyethylene film with the thickness of 50 mu m prepared in the step (1), and curing for 20 hours to obtain the covering film for the powder-liquid double-chamber bag.
Example 4
The invention relates to a covering film for a powder-liquid double-chamber bag, which consists of an outer surface layer, a middle layer and an inner surface layer, wherein the outer surface layer is a polyester film layer 1, the middle layer is an aluminum foil layer 2, the inner surface layer is a modified low-density polyethylene film layer 3, and the modified low-density polyethylene film layer 3 is prepared from the following raw materials in percentage by mass: 45% of low-density polyethylene, 20% of nano calcium carbonate, 13% of nano silicon dioxide, 8% of nano titanium dioxide, 4% of solid paraffin, 5% of silane coupling agent and 5% of maleic anhydride.
In this example, the thickness of the polyester film layer 1 was 15 μm, the thickness of the aluminum foil layer 2 was 10 μm, and the thickness of the modified low-density polyethylene film layer 3 was 80 μm.
In this example, the polyester was PET15 and the silane coupling agent was KH550. The density of the low density polyethylene is 0.91g/cm 3 。
The preparation method of the cover film for the powder-liquid dual-chamber bag comprises the following steps:
(1) The modified low-density polyethylene film is prepared from the following raw materials: 45% of low-density polyethylene, 20% of nano calcium carbonate, 13% of nano silicon dioxide, 8% of nano titanium dioxide, 4% of solid paraffin, 5% of silane coupling agent and 5% of maleic anhydride; weighing the raw materials according to the formula of the raw materials, uniformly mixing the raw materials in a mixer, and preparing the modified low-density polyethylene film with the thickness of 80 mu m by an extrusion-calendering-stretching process.
(2) Coating polyurethane adhesive on a polyester film with the thickness of 15 μm, compounding with an aluminum foil with the thickness of 10 μm on a compounding machine, coating polyurethane adhesive on the surface of the aluminum foil, compounding with the low-density polyethylene film with the thickness of 80 μm, curing for 20h, and obtaining the covering film for the powder-liquid dual-chamber bag.
Example 5
The covering film for the powder-liquid double-chamber bag comprises an outer surface layer, a middle layer and an inner surface layer, wherein the outer surface layer is a polyester film layer 1, the middle layer is an aluminum foil layer 2, the inner surface layer is a modified low-density polyethylene film layer 3, and the modified low-density polyethylene film layer 3 is prepared from the following raw materials in percentage by mass: 43% of low-density polyethylene, 22% of nano calcium carbonate, 11% of nano silicon dioxide, 9% of nano titanium dioxide, 5% of solid paraffin, 5% of a silane coupling agent and 5% of maleic anhydride.
In this example, the thickness of the polyester film layer 1 was 8 μm, the thickness of the aluminum foil layer 2 was 7 μm, and the thickness of the modified low-density polyethylene film layer 3 was 60 μm.
In this example, the polyester was PET8, and the silane coupling agent was KH570. The low density polyethylene has a density of 0.91g/cm 3 。
The preparation method of the cover film for the powder-liquid dual-chamber bag comprises the following steps:
(1) The modified low-density polyethylene film is prepared from the following raw materials in formula: 43% of low-density polyethylene, 22% of nano calcium carbonate, 11% of nano silicon dioxide, 9% of nano titanium dioxide, 5% of solid paraffin, 5% of silane coupling agent and 5% of maleic anhydride; weighing the raw materials according to the formula of the raw materials, uniformly mixing the raw materials in a mixer, and preparing the modified low-density polyethylene film with the thickness of 60 mu m by an extrusion-calendering-stretching process.
(2) Coating polyurethane adhesive on polyester film with thickness of 8 μm, compounding with aluminum foil with thickness of 7 μm on a compounding machine, coating polyurethane adhesive on the surface of the aluminum foil, compounding with the low density polyethylene film with thickness of 60 μm, aging for 20h, and obtaining the covering film for the powder-liquid dual-chamber bag.
Examples 1-5 the cover film for the powder-liquid dual-chamber bag (aluminum-plastic composite cover film) and the heat-seal strength range of the surface of the powder-liquid dual-chamber bag at a temperature of 142-165 ℃ are as follows: 8.05-11.37N/15mm, 4.27-7.09N/15mm, 6.93-10.35N/15mm, 6.52-9.77N/15mm and 6.04-8.99N/15mm, the welding rod welding fastness range between two chambers of the powder-liquid double-chamber bag is 5.96-8.16N/15mm, the values of the five embodiments meet the requirements, and the requirements of customers are met. The heat sealing strength range of the cover film compounded by adopting the common low-density polyethylene film and the surface of the powder-liquid double-chamber bag at the temperature of 142-165 ℃ is 18.53-27.66N/15mm, and the cover film cannot be peeled off from the surface of the powder-liquid double-chamber bag and does not meet the requirement; the surface heat-sealing strength range of the covering film compounded with the common low-density polyethylene film and the powder-liquid double-chamber bag at the temperature of 110-130 ℃ is 7.07-13.21N/15mm, and the surface heat-sealing strength range can partially meet the heat-sealing strength requirement, but the welding rod welding sealing fastness range between two chambers of the powder-liquid double-chamber bag is 3.17-4.47N/15mm and is lower than 5N/15mm, and the welding rod welding sealing fastness is too low, so the covering film and the powder-liquid double-chamber bag are easy to extrude and pass, and the requirement is not met.
The foregoing is merely a preferred embodiment of the invention and is not intended to limit the invention in any manner. Although the present invention has been described with reference to the preferred embodiments, it is not intended to be limited thereto. Those skilled in the art can make many possible variations and modifications to the disclosed embodiments, or equivalent modifications, without departing from the spirit and scope of the invention, using the methods and techniques disclosed above. Therefore, any simple modifications, equivalent substitutions, equivalent changes and modifications made to the above embodiments according to the technical essence of the present invention are within the scope of the technical scheme of the present invention.

Claims (10)

1. The cover film for the powder-liquid double-chamber bag is characterized by comprising an outer surface layer, a middle layer and an inner surface layer, wherein the outer surface layer is a polyester film layer, the middle layer is an aluminum foil layer, and the inner surface layer is a modified low-density polyethylene film layer;
the modified low-density polyethylene film layer is prepared from the following raw materials in percentage by mass:
35 to 65 percent of low-density polyethylene,
15 to 25 percent of nano calcium carbonate,
10 to 15 percent of nano silicon dioxide,
5 to 10 percent of nano titanium dioxide,
3 to 5 percent of solid paraffin,
1% to 5% of a silane coupling agent, and
1 to 5 percent of maleic anhydride.
2. The cover film for the powder-liquid double-chamber bag according to claim 1, wherein the modified low-density polyethylene film layer is prepared from the following raw materials in percentage by mass:
40 to 60 percent of low-density polyethylene,
15 to 20 percent of nano calcium carbonate,
10 to 12 percent of nano silicon dioxide,
6 to 9 percent of nano titanium dioxide,
4 to 5 percent of solid paraffin,
2 to 3 percent of silane coupling agent, and
2 to 3 percent of maleic anhydride;
the sum of the mass fractions of the raw materials is 100 percent.
3. The cover film for the powder-liquid dual-chamber bag according to claim 1 or 2, wherein the thickness of the polyester film layer is 5 to 20 μm, the thickness of the aluminum foil layer is 5 to 20 μm, and the thickness of the modified low-density polyethylene film layer is 10 to 90 μm.
4. The cover film for the powder-liquid dual-chamber bag according to claim 1 or 2, wherein the density of the low density polyethylene is 0.91g/cm 3 ～0.93g/cm 3 。
5. The cover film for the powder-liquid dual-chamber bag according to claim 1 or 2, wherein the polyester of the polyester film layer comprises one or more of PET7, PET8, PET10, PET12 and PET15, and the silane coupling agent comprises one or more of KH550, KH560 and KH570.
6. A method for preparing the cover film for the powder-liquid dual-chamber bag according to any one of claims 1 to 5, which comprises the following steps:
(1) Preparing a modified low-density polyethylene film according to the raw materials and the proportion;
(2) And compounding the polyester film and the aluminum foil by adopting an adhesive to obtain a polyester film/aluminum foil composite film, compounding the aluminum foil surface of the composite film and the modified low-density polyethylene film by adopting the adhesive, and curing to obtain the covering film for the powder-liquid double-chamber bag.
7. The method for preparing the cover film for the powder-liquid dual-chamber bag according to claim 6, wherein in the step (1), the preparation method comprises an extrusion-blow molding-stretching method, an extrusion-calendering-stretching method or a casting method.
8. The preparation method of the cover film for the powder-liquid dual-chamber bag according to claim 6 or 7, wherein in the step (2), the curing time is 20-48 h.
9. The method for preparing the cover film for the powder-liquid dual-chamber bag according to claim 6 or 7, wherein in the step (2), the adhesive is polyurethane adhesive.
10. Use of the cover film for the powder-liquid dual-chamber bag according to any one of claims 1 to 5 or the cover film for the powder-liquid dual-chamber bag prepared by the preparation method according to any one of claims 6 to 9 in the field of medicine packaging.
CN202211166812.4A 2022-09-23 2022-09-23 Cover film for powder-liquid double-chamber bag and preparation method and application thereof Active CN115384160B (en)

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