CN115384160B - Cover film for powder-liquid double-chamber bag and preparation method and application thereof - Google Patents

Cover film for powder-liquid double-chamber bag and preparation method and application thereof Download PDF

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Publication number
CN115384160B
CN115384160B CN202211166812.4A CN202211166812A CN115384160B CN 115384160 B CN115384160 B CN 115384160B CN 202211166812 A CN202211166812 A CN 202211166812A CN 115384160 B CN115384160 B CN 115384160B
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powder
density polyethylene
chamber bag
film
layer
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CN115384160A (en
Inventor
王剑
袁志庆
黄永发
阳康丽
滕敏
陈建
谭湘其
湛红日
曾焰
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Hunan Yiyongfeng New Material Technology Co ltd
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Hunan Yiyongfeng New Material Technology Co ltd
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B27/00—Layered products comprising a layer of synthetic resin
    • B32B27/36—Layered products comprising a layer of synthetic resin comprising polyesters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/10—Bag-type containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2093—Containers having several compartments for products to be mixed
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29D—PRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE
    • B29D7/00—Producing flat articles, e.g. films or sheets
    • B29D7/01—Films or sheets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B15/00—Layered products comprising a layer of metal
    • B32B15/04—Layered products comprising a layer of metal comprising metal as the main or only constituent of a layer, which is next to another layer of the same or of a different material
    • B32B15/08—Layered products comprising a layer of metal comprising metal as the main or only constituent of a layer, which is next to another layer of the same or of a different material of synthetic resin
    • B32B15/085—Layered products comprising a layer of metal comprising metal as the main or only constituent of a layer, which is next to another layer of the same or of a different material of synthetic resin comprising polyolefins
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B15/00—Layered products comprising a layer of metal
    • B32B15/04—Layered products comprising a layer of metal comprising metal as the main or only constituent of a layer, which is next to another layer of the same or of a different material
    • B32B15/08—Layered products comprising a layer of metal comprising metal as the main or only constituent of a layer, which is next to another layer of the same or of a different material of synthetic resin
    • B32B15/09—Layered products comprising a layer of metal comprising metal as the main or only constituent of a layer, which is next to another layer of the same or of a different material of synthetic resin comprising polyesters
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B15/00—Layered products comprising a layer of metal
    • B32B15/20—Layered products comprising a layer of metal comprising aluminium or copper
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B27/00—Layered products comprising a layer of synthetic resin
    • B32B27/18—Layered products comprising a layer of synthetic resin characterised by the use of special additives
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B27/00—Layered products comprising a layer of synthetic resin
    • B32B27/32—Layered products comprising a layer of synthetic resin comprising polyolefins
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B33/00—Layered products characterised by particular properties or particular surface features, e.g. particular surface coatings; Layered products designed for particular purposes not covered by another single class
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2307/00—Properties of the layers or laminate
    • B32B2307/30—Properties of the layers or laminate having particular thermal properties
    • B32B2307/31—Heat sealable
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2439/00—Containers; Receptacles
    • B32B2439/80—Medical packaging

Abstract

The invention discloses a cover film for a powder-liquid double-chamber bag, and a preparation method and application thereof, wherein the cover film for the powder-liquid double-chamber bag consists of a polyester film layer, an aluminum foil layer and a modified low-density polyethylene film layer from outside to inside, and the modified low-density polyethylene film layer is prepared from the following raw materials: 35-65% of low-density polyethylene, 15-25% of nano calcium carbonate, 10-15% of nano silicon dioxide, 5-10% of nano titanium dioxide, 3-5% of solid paraffin, 1-5% of silane coupling agent and 1-5% of maleic anhydride. The preparation method comprises compounding polyester film, aluminum foil and modified low density polyethylene film with adhesive. The cover film for the powder-liquid double-chamber bag can simultaneously meet the requirement that the heat sealing strength between the cover film and the surface of the powder-liquid double-chamber bag reaches 4-12N/15mm, and ensures that the welding rod sealing firmness between two chambers of the double-chamber bag is in the range of 5-9N/15mm, and the preparation method has low cost, simple and controllable process and is suitable for large-scale production.

Description

Cover film for powder-liquid double-chamber bag and preparation method and application thereof
Technical Field
The invention relates to the technical field of medicine packaging materials, in particular to a cover film for a powder-liquid double-chamber bag, and a preparation method and application thereof.
Background
The special name of the powder-liquid double-chamber bag is an instant powder-liquid double-chamber transfusion soft bag, which is based on a common plastic transfusion bag, and is divided into two independent closed chambers by adopting a special technology, different medicines are respectively packaged in the two chambers, and a weak sealing belt (10-30 mm) between the two chambers is opened by extrusion before use, so that the mixing of injection solvent and medicine powder is realized, and the medicine dispensing is completed. The powder-liquid double-chamber bag is a novel medical packaging bag, and has the main advantages that: (1) the medicine proportion is set according to clinical requirements before delivery, and the whole medicine dispensing process is carried out in a sealed packaging container, so that medicine loss can be effectively avoided, and accurate medicine dispensing is realized; (2) the medicine mixing process is completely closed, so that the pollution risk is avoided, and the medicine safety is ensured; (3) the packaging material and the storage space are saved, the operation is convenient and quick, the infusion device is suitable for emergency treatment, rescue and relief work, field and exploration rescue and the like, and is one of important directions of the development of infusion products.
In order to ensure good visibility in the process of mixing and using the medicines, the powder-liquid double-chamber bag body material is usually made of transparent co-extrusion packaging materials, and in the practical application process, as a plurality of powder medicines need to be dampproof, oxygen permeation-proof and shading, a layer of opaque aluminum-plastic composite cover film is covered outside the powder chamber bag through heat sealing so as to ensure the stability and safety of the medicines in the storage and transportation processes. Before dispensing, the aluminum-plastic composite cover film is uncovered from the surface of the powder-liquid double-chamber bag, so that visual dispensing and use can be realized.
However, in the process for manufacturing the powder-liquid double-chamber bag injection product which is packaged by the same body (same mold) and the same temperature and simultaneously and fast sealing and welding, the main problems of the aluminum-plastic composite cover film in the current market are as follows: (1) when the heat sealing strength of the aluminum-plastic composite cover film and the surface of the powder-liquid double-chamber bag reaches 4-12N/15mm, if the heat sealing temperature of the aluminum-plastic composite cover film and the surface of the powder-liquid double-chamber bag is too high, the welding rod between the two chambers is too firm to seal, and the aluminum-plastic composite cover film and the surface of the powder-liquid double-chamber bag cannot be opened during extrusion; if the heat sealing temperature of the aluminum-plastic composite cover film and the surface of the powder-liquid double-chamber bag is too low, the welding rod between the two chambers is not firmly sealed, so that the powder-liquid double-chamber bag can be automatically opened in storage and transportation, and the product is scrapped; (2) when the welding rod sealing fastness between two cavities of the powder-liquid double-chamber bag is in an optimal range, if the heat sealing strength of the aluminum-plastic composite cover film and the surface of the powder-liquid double-chamber bag exceeds 12N/15mm, the aluminum-plastic composite cover film cannot be uncovered from the surface of the powder-liquid double-chamber bag, and the quality condition of the powder cannot be seen when the powder-liquid double-chamber bag is used; if the heat sealing strength of the aluminum-plastic composite cover film and the surface of the powder-liquid double-chamber bag is smaller than 4N/15mm, the aluminum-plastic composite cover film is easily uncovered from the surface of the powder-liquid double-chamber bag, even automatically falls off, and the powder is damaged due to the loss of protection. The heat sealing strength of the surface of the aluminum-plastic composite cover film and the surface of the powder-liquid double-chamber bag reach the range of 4-12N/15mm, and the welding rod sealing fastness between the two chambers of the powder-liquid double-chamber bag is in the optimal range (5-9N/15 mm), so that the existing aluminum-plastic composite cover film in the market can not be achieved according to practice.
Therefore, research and development of the aluminum-plastic composite cover film meeting the requirements simultaneously have important significance.
Disclosure of Invention
The invention aims to solve the technical problem of overcoming the defects in the prior art, and provides a cover film for a powder-liquid double-chamber bag, which can simultaneously meet the two conditions that the heat sealing strength with the surface of the powder-liquid double-chamber bag reaches 4-12N/15mm and the welding rod sealing fastness between two chambers of the powder-liquid double-chamber bag is in the optimal range of 5-9N/15mm within the heat sealing range of 140-170 ℃, and a preparation method and application thereof.
In order to solve the technical problems, the invention adopts the following technical scheme.
The cover film for the powder-liquid double-chamber bag consists of an outer surface layer, an intermediate layer and an inner surface layer, wherein the outer surface layer is a polyester film layer, the intermediate layer is an aluminum foil layer, and the inner surface layer is a modified low-density polyethylene film layer;
the modified low-density polyethylene film layer is prepared from the following raw materials in percentage by mass:
35 to 65 percent of low density polyethylene,
15 to 25 percent of nano calcium carbonate,
10 to 15 percent of nano silicon dioxide,
5 to 10 percent of nano titanium dioxide,
3 to 5 percent of solid paraffin,
1% -5% of silane coupling agent, and
1 to 5 percent of maleic anhydride.
In the cover film for powder-liquid double-chamber bag, preferably, the modified low-density polyethylene film layer is prepared from the following raw materials in percentage by mass:
40 to 60 percent of low-density polyethylene,
15 to 20 percent of nano calcium carbonate,
10 to 12 percent of nano silicon dioxide,
nano titanium dioxide 6-9%,
4 to 5 percent of solid paraffin,
2% -3% of silane coupling agent, and
2% -3% of maleic anhydride;
the sum of the mass fractions of the raw materials is 100 percent.
In the above-mentioned cover film for powder-liquid double-chamber bag, the thickness of the polyester film layer is preferably 5 μm to 20 μm, the thickness of the aluminum foil layer is preferably 5 μm to 20 μm, and the thickness of the modified low-density polyethylene film layer is preferably 10 μm to 90 μm.
The film for powder-liquid double-chamber bag preferably has a density of 0.91g/cm 3 ～0.93g/cm 3 。
Preferably, the polyester of the polyester film layer comprises one or more of PET7, PET8, PET10, PET12 and PET15, and the silane coupling agent comprises one or more of KH550, KH560 and KH570.
The invention also provides a preparation method of the cover film for the powder-liquid double-chamber bag, which comprises the following steps of:
(1) Preparing a modified low-density polyethylene film according to the raw materials and the proportions;
(2) And (3) compositing the polyester film and the aluminum foil by adopting an adhesive to obtain a polyester film/aluminum foil composite film, compositing the aluminum foil surface of the composite film and the modified low-density polyethylene film by adopting the adhesive, and curing to obtain the powder-liquid double-chamber cover film for the bag.
In the above method for producing a cover film for a powder-liquid two-compartment bag, preferably, in the step (1), the production method comprises an extrusion-blow molding-stretching method, an extrusion-calendaring-stretching method or a casting method.
In the above preparation method of the cover film for powder-liquid double-chamber bag, preferably, in the step (2), the curing time is 20-48 hours.
In the above preparation method of the cover film for powder-liquid dual-chamber bag, preferably, in the step (2), the adhesive is a polyurethane adhesive.
The invention also provides an application of the cover film for the powder-liquid double-chamber bag or the cover film for the powder-liquid double-chamber bag prepared by the preparation method in the field of medicine packaging.
In the invention, when in application, the inner surface modified low-density polyethylene film layer is used as a heat sealing layer.
In the present invention, the polyester film and aluminum foil are commercially available polyester film and aluminum foil for packaging food and medicine.
In the present invention, the low density polyethylene is a cast grade low density polyethylene or a blow molded grade low density polyethylene.
The main innovation point of the invention is that:
in the process for manufacturing the powder-liquid double-chamber bag injection product, which is packaged by the same body (same mould) and the same temperature and simultaneously and rapidly sealed and welded, the invention regulates and controls the balance between the heat sealing strength of the surface of the powder-liquid double-chamber bag and the welding sealing fastness of a welding rod between two chambers of the powder-liquid double-chamber bag through the screening and the combination design of raw materials, and the invention adopts nano calcium carbonate, nano silicon dioxide and nano titanium dioxide as the raw materials of an inner surface layer (heat sealing layer) to ensure that the film layer generates micro-gaps, and the film layer can form uneven heat sealing due to the existence of the micro-gaps, thereby ensuring that the sealing fastness reaches the optimal range while controlling the heat sealing strength to reach the preset target; the invention can accurately control the balance degree of heat sealing strength and welding sealing fastness in the range of 140-170 ℃ so that the heat sealing strength of the surface of the cover film and powder liquid double-chamber bag reaches 4-12N/15mm, and the welding rod welding sealing fastness between the two chambers of the powder liquid double-chamber bag is in the optimal range of 5-9N/15mm.
Compared with the prior art, the invention has the advantages that:
(1) The cover film for the powder-liquid double-chamber bag consists of a polyester film, an aluminum foil and a modified low-density polyethylene film, wherein the modified low-density polyethylene film layer is prepared by specific components and proportions, namely, the components such as nano calcium carbonate, nano silicon dioxide, nano titanium dioxide and the like are added into a low-density polyethylene material to enable the film layer to generate micro-gaps and form uneven heat sealing, so that the heat sealing strength and the welding fastness are balanced, and therefore, the cover film for the powder-liquid double-chamber bag can simultaneously meet the conditions that the heat sealing strength with the surface of the powder-liquid double-chamber bag reaches 4-12N/15mm and the welding rod welding fastness between two chambers of the powder-liquid double-chamber bag is in an optimal range of 5-9N/15mm, and is easy to heat seal and uncover from the surface of the powder-liquid double-chamber bag.
(2) The preparation method has the advantages of low cost, simple and controllable process and the like, and is suitable for large-scale production.
Drawings
Fig. 1 is a schematic structural view of a cover film for a powder-liquid dual-chamber bag prepared in example 1 of the present invention.
Legend description:
1. a polyester film layer; 2. an aluminum foil layer; 3. a modified low density polyethylene film layer.
Detailed Description
The invention is further described below in connection with the drawings and the specific preferred embodiments, but the scope of protection of the invention is not limited thereby. The materials and instruments used in the examples below are all commercially available.
Example 1
The invention relates to a cover film for a powder-liquid double-chamber bag, which is shown in figure 1, and consists of an outer surface layer, an intermediate layer and an inner surface layer, wherein the outer surface layer is a polyester film layer 1, the intermediate layer is an aluminum foil layer 2, the inner surface layer is a modified low-density polyethylene film layer 3, and the modified low-density polyethylene film layer 3 is prepared from the following raw materials in percentage by mass: 65% of low-density polyethylene, 15% of nano calcium carbonate, 10% of nano silicon dioxide, 5% of nano titanium dioxide, 3% of solid paraffin, 1% of silane coupling agent and 1% of maleic anhydride.
In this example, the thickness of the mylar layer 1 was 12 μm, the thickness of the aluminum foil layer 2 was 16 μm, and the thickness of the low density polyethylene film layer was 70 μm.
In this example, the polyester was PET12 (polyethylene terephthalate) and the silane coupling agent was KH550. The density of the low density polyethylene is 0.91g/cm 3 。
The preparation method of the cover film for the powder-liquid double-chamber bag comprises the following steps:
(1) The preparation method of the modified low-density polyethylene film comprises the following raw material formulas: 65% of low-density polyethylene, 15% of nano calcium carbonate, 10% of nano silicon dioxide, 5% of nano titanium dioxide, 3% of solid paraffin, 1% of silane coupling agent and 1% of maleic anhydride; the raw materials are weighed according to the raw material formula, uniformly mixed in a mixer, and then the modified low-density polyethylene film with the thickness of 70 mu m is prepared through a conventional extrusion-blow molding-stretching process. Wherein, the extrusion process can adopt a single-layer extrusion blow molding method, a 2-10-layer coextrusion blow molding method, a tape casting extrusion method and the like.
(2) Coating polyurethane adhesive on a polyester film with the thickness of 12 mu m, compounding the polyester film with an aluminum foil with the thickness of 16 mu m on a compounding machine to obtain a polyester film/aluminum foil composite film, coating polyurethane adhesive on the surface of the aluminum foil of the polyester film/aluminum foil composite film, compounding the polyester film/aluminum foil composite film with the modified low-density polyethylene film with the thickness of 70 mu m obtained in the step (1), and curing the polyester film/aluminum foil composite film for 20 hours to obtain the powder-liquid double-chamber bag cover film.
Example 2
The invention relates to a cover film for a powder-liquid double-chamber bag, which consists of an outer surface layer, an intermediate layer and an inner surface layer, wherein the outer surface layer is a polyester film layer 1, the intermediate layer is an aluminum foil layer 2, the inner surface layer is a modified low-density polyethylene film layer 3, and the modified low-density polyethylene film layer 3 is prepared from the following raw materials in percentage by mass: 35% of low-density polyethylene, 25% of nano calcium carbonate, 15% of nano silicon dioxide, 10% of nano titanium dioxide, 5% of solid paraffin, 5% of silane coupling agent and 5% of maleic anhydride.
In this example, the thickness of the polyester film layer 1 was 7. Mu.m, the thickness of the aluminum foil layer 2 was 12. Mu.m, and the thickness of the modified low-density polyethylene film layer 3 was 30. Mu.m.
In this example, the polyester was PET7 and the silane coupling agent was KH560. The density of the low density polyethylene is 0.91g/cm 3 。
The preparation method of the cover film for the powder-liquid double-chamber bag comprises the following steps:
(1) The preparation method of the modified low-density polyethylene film comprises the following raw material formulas: 35% of low-density polyethylene, 25% of nano calcium carbonate, 15% of nano silicon dioxide, 10% of nano titanium dioxide, 5% of solid paraffin, 5% of silane coupling agent and 5% of maleic anhydride; the raw materials are weighed according to the raw material formula, uniformly mixed in a mixer, and then the modified low-density polyethylene film with the thickness of 30 mu m is prepared through an extrusion-calendaring-stretching process. Wherein, the extrusion process can adopt a single-layer extrusion blow molding method, a 2-10-layer coextrusion blow molding method, a tape casting extrusion method and the like.
(2) Coating polyurethane adhesive on a polyester film with the thickness of 7 mu m, compounding with an aluminum foil with the thickness of 12 mu m on a compounding machine, coating polyurethane adhesive on the surface of the aluminum foil, compounding with the modified low-density polyethylene film with the thickness of 30 mu m, and curing for 20 hours to obtain the cover film for the powder-liquid double-chamber bag.
Example 3
The invention relates to a cover film for a powder-liquid double-chamber bag, which consists of an outer surface layer, an intermediate layer and an inner surface layer, wherein the outer surface layer is a polyester film layer 1, the intermediate layer is an aluminum foil layer 2, the inner surface layer is a modified low-density polyethylene film layer 3, and the modified low-density polyethylene film layer 3 is prepared from the following raw materials in percentage by mass: 50% of low-density polyethylene, 20% of nano calcium carbonate, 12% of nano silicon dioxide, 8% of nano titanium dioxide, 4% of solid paraffin, 4% of silane coupling agent and 2% of maleic anhydride.
In this example, the thickness of the polyester film layer 1 was 10. Mu.m, the thickness of the aluminum foil layer 2 was 9. Mu.m, and the thickness of the modified low-density polyethylene film layer 3 was 50. Mu.m.
In this example, the polyester was PET10 and the silane coupling agent was KH550. The density of the low density polyethylene is 0.91g/cm 3 。
The preparation method of the cover film for the powder-liquid double-chamber bag comprises the following steps:
(1) The preparation method of the modified low-density polyethylene film comprises the following raw material formulas: 50% of low-density polyethylene, 20% of nano calcium carbonate, 12% of nano silicon dioxide, 8% of nano titanium dioxide, 4% of solid paraffin, 4% of silane coupling agent and 2% of maleic anhydride; the raw materials are weighed according to the raw material formula, uniformly mixed in a mixer, and then the modified low-density polyethylene film with the thickness of 50 mu m is prepared through an extrusion-blow molding-stretching process.
(2) Coating polyurethane adhesive on a polyester film with the thickness of 10 mu m, compounding with an aluminum foil with the thickness of 9 mu m on a compounding machine, coating polyurethane adhesive on the surface of the aluminum foil, compounding with the low-density polyethylene film with the thickness of 50 mu m prepared in the step (1), curing for 20 hours, and obtaining the cover film for the powder-liquid double-chamber bag.
Example 4
The invention relates to a cover film for a powder-liquid double-chamber bag, which consists of an outer surface layer, an intermediate layer and an inner surface layer, wherein the outer surface layer is a polyester film layer 1, the intermediate layer is an aluminum foil layer 2, the inner surface layer is a modified low-density polyethylene film layer 3, and the modified low-density polyethylene film layer 3 is prepared from the following raw materials in percentage by mass: 45% of low-density polyethylene, 20% of nano calcium carbonate, 13% of nano silicon dioxide, 8% of nano titanium dioxide, 4% of solid paraffin, 5% of silane coupling agent and 5% of maleic anhydride.
In this example, the thickness of the polyester film layer 1 was 15. Mu.m, the thickness of the aluminum foil layer 2 was 10. Mu.m, and the thickness of the modified low-density polyethylene film layer 3 was 80. Mu.m.
In this example, the polyester was PET15 and the silane coupling agent was KH550. The density of the low density polyethylene is 0.91g/cm 3 。
The preparation method of the cover film for the powder-liquid double-chamber bag comprises the following steps:
(1) The preparation method of the modified low-density polyethylene film comprises the following raw material formulas: 45% of low-density polyethylene, 20% of nano calcium carbonate, 13% of nano silicon dioxide, 8% of nano titanium dioxide, 4% of solid paraffin, 5% of silane coupling agent and 5% of maleic anhydride; the raw materials are weighed according to the raw material formula, uniformly mixed in a mixer, and then the modified low-density polyethylene film with the thickness of 80 mu m is prepared through an extrusion-calendaring-stretching process.
(2) Coating polyurethane adhesive on a polyester film with the thickness of 15 mu m, compounding with an aluminum foil with the thickness of 10 mu m on a compounding machine, coating polyurethane adhesive on the surface of the aluminum foil, compounding with the low-density polyethylene film with the thickness of 80 mu m, and curing for 20 hours to obtain the cover film for the powder-liquid double-chamber bag.
Example 5
The invention relates to a cover film for a powder-liquid double-chamber bag, which consists of an outer surface layer, an intermediate layer and an inner surface layer, wherein the outer surface layer is a polyester film layer 1, the intermediate layer is an aluminum foil layer 2, the inner surface layer is a modified low-density polyethylene film layer 3, and the modified low-density polyethylene film layer 3 is prepared from the following raw materials in percentage by mass: 43% of low-density polyethylene, 22% of nano calcium carbonate, 11% of nano silicon dioxide, 9% of nano titanium dioxide, 5% of solid paraffin, 5% of silane coupling agent and 5% of maleic anhydride.
In this example, the thickness of the polyester film layer 1 was 8. Mu.m, the thickness of the aluminum foil layer 2 was 7. Mu.m, and the thickness of the modified low-density polyethylene film layer 3 was 60. Mu.m.
In this example, the polyester was PET8 and the silane coupling agent was KH570. The density of the low density polyethylene is 0.91g/cm 3 。
The preparation method of the cover film for the powder-liquid double-chamber bag comprises the following steps:
(1) The preparation method of the modified low-density polyethylene film comprises the following raw material formulas: 43% of low-density polyethylene, 22% of nano calcium carbonate, 11% of nano silicon dioxide, 9% of nano titanium dioxide, 5% of solid paraffin, 5% of silane coupling agent and 5% of maleic anhydride; the raw materials are weighed according to the raw material formula, uniformly mixed in a mixer, and then the modified low-density polyethylene film with the thickness of 60 mu m is prepared through an extrusion-calendaring-stretching process.
(2) Coating polyurethane adhesive on a polyester film with the thickness of 8 mu m, compounding with an aluminum foil with the thickness of 7 mu m on a compounding machine, coating polyurethane adhesive on the surface of the aluminum foil, compounding with the low-density polyethylene film with the thickness of 60 mu m, and curing for 20 hours to obtain the cover film for the powder-liquid double-chamber bag.
Examples 1-5 the heat seal strength ranges of the cover film (aluminum plastic composite cover film) for the powder-liquid double-chamber bag and the surface of the powder-liquid double-chamber bag are as follows: 8.05-11.37N/15mm, 4.27-7.09N/15mm, 6.93-10.35N/15mm, 6.52-9.77N/15mm, 6.04-8.99N/15mm, and the welding rod sealing fastness between two chambers of the powder-liquid double-chamber bag ranges from 5.96N/15 mm, the values of the five embodiments meet the requirements, and the requirements of customers are met. The heat sealing strength of the cover film compounded by the common low-density polyethylene film and the surface of the powder-liquid double-chamber bag is 18.53-27.66N/15mm at the temperature of 142-165 ℃, and the cover film cannot be peeled off from the surface of the powder-liquid double-chamber bag and does not meet the requirements; the heat sealing strength of the surface of the common low-density polyethylene film composite film and powder-liquid double-chamber bag is 7.07-13.21N/15mm at the temperature of 110-130 ℃, and part of the surface can meet the heat sealing strength requirement, but the welding rod sealing fastness between two chambers of the powder-liquid double-chamber bag is 3.17-4.47N/15mm and is lower than 5N/15mm, and the welding rod sealing fastness is too low and is easy to squeeze through, so that the surface is not in accordance with the requirement.
The above description is only of the preferred embodiment of the present invention, and is not intended to limit the present invention in any way. While the invention has been described in terms of preferred embodiments, it is not intended to be limiting. Any person skilled in the art can make many possible variations and modifications to the technical solution of the present invention or equivalent embodiments using the method and technical solution disclosed above without departing from the spirit and technical solution of the present invention. Therefore, any simple modification, equivalent substitution, equivalent variation and modification of the above embodiments according to the technical substance of the present invention, which do not depart from the technical solution of the present invention, still fall within the scope of the technical solution of the present invention.

Claims (10)

1. The cover film for the powder-liquid double-chamber bag is characterized by comprising an outer surface layer, an intermediate layer and an inner surface layer, wherein the outer surface layer is a polyester film layer, the intermediate layer is an aluminum foil layer, and the inner surface layer is a modified low-density polyethylene film layer;
the modified low-density polyethylene film layer is prepared from the following raw materials in percentage by mass:
35 to 65 percent of low density polyethylene,
15 to 25 percent of nano calcium carbonate,
10 to 15 percent of nano silicon dioxide,
5 to 10 percent of nano titanium dioxide,
3 to 5 percent of solid paraffin,
1% -5% of silane coupling agent, and
1 to 5 percent of maleic anhydride.
2. The cover film for a powder-liquid double-chamber bag according to claim 1, wherein the modified low-density polyethylene film layer is prepared from the following raw materials in percentage by mass:
40 to 60 percent of low-density polyethylene,
15 to 20 percent of nano calcium carbonate,
10 to 12 percent of nano silicon dioxide,
nano titanium dioxide 6-9%,
4 to 5 percent of solid paraffin,
2% -3% of silane coupling agent, and
2% -3% of maleic anhydride;
the sum of the mass fractions of the raw materials is 100 percent.
3. The cover film for a powder-liquid dual chamber bag according to claim 1 or 2, wherein the thickness of the polyester film layer is 5 μm to 20 μm, the thickness of the aluminum foil layer is 5 μm to 20 μm, and the thickness of the modified low-density polyethylene film layer is 10 μm to 90 μm.
4. The cover film for a powder-liquid dual-chamber bag according to claim 1 or 2, wherein the density of the low-density polyethylene is 0.91g/cm 3 ～0.93g/cm 3 。
5. The cover film for a powder-liquid dual-compartment pouch according to claim 1 or 2, wherein the polyester of the polyester film layer comprises one or more of PET7, PET8, PET10, PET12 and PET15, and the silane coupling agent comprises one or more of KH550, KH560 and KH570.
6. A method for producing the cover film for a powder-liquid double-chamber bag according to any one of claims 1 to 5, comprising the steps of:
(1) Preparing a modified low-density polyethylene film according to the raw materials and the proportions;
(2) And (3) compositing the polyester film and the aluminum foil by adopting an adhesive to obtain a polyester film/aluminum foil composite film, compositing the aluminum foil surface of the composite film and the modified low-density polyethylene film by adopting the adhesive, and curing to obtain the powder-liquid double-chamber cover film for the bag.
7. The method for producing a cover film for a powder-liquid two-compartment bag according to claim 6, wherein in the step (1), the production method comprises an extrusion-blow-stretching method, an extrusion-calendaring-stretching method or a casting method.
8. The method for producing a cover film for a powder-liquid dual-chamber bag according to claim 6 or 7, wherein in the step (2), the curing time is 20 to 48 hours.
9. The method of producing a cover film for a powder-liquid dual-chamber bag according to claim 6 or 7, wherein in the step (2), the adhesive is a polyurethane adhesive.
10. Use of the cover film for a powder-liquid dual-chamber bag according to any one of claims 1 to 5 or the cover film for a powder-liquid dual-chamber bag produced by the production method according to any one of claims 6 to 9 in the field of medicine packaging.
CN202211166812.4A 2022-09-23 2022-09-23 Cover film for powder-liquid double-chamber bag and preparation method and application thereof Active CN115384160B (en)

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GB8332127D0 (en) * 1980-06-23 1984-01-11 Grace W R & Co Aluminium-based laminated and packaging bag
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