CN204169950U - A kind of brain solid positioner - Google Patents
A kind of brain solid positioner Download PDFInfo
- Publication number
- CN204169950U CN204169950U CN201420516073.1U CN201420516073U CN204169950U CN 204169950 U CN204169950 U CN 204169950U CN 201420516073 U CN201420516073 U CN 201420516073U CN 204169950 U CN204169950 U CN 204169950U
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- fixing frame
- movement platform
- probe fixing
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- lead screw
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Abstract
This utility model provides a kind of brain solid positioner, comprise base plate, ear bar, U-shaped seat, triaxial movement platform, the tri-axial motion controller of triaxial movement platform standard configuration, front tooth holder, probe fixing frame and positioning attachment, described positioning attachment is made up of laser sight, probe and biomarker pen, described brain solid positioner controls triaxial movement platform by tri-axial motion controller, the three-dimensional realizing probe fixing frame moves, precision is 0.01mm, identical with the precision of internationally recognized brain map, greatly can improve the accuracy of location; Laser sight carries out the fast speed non-contact location of horizontal X, Y-axis coordinate; Use green laser as sight, because the collimation of laser is good, light path is straight, luminous point is very little, can not need to carry out moving up and down contact skull just to realize successfully locating, re-use a biomarker labelling record laser aiming point, operator's posture is comfortable, labelling accuracy is high, effectively increases work efficiency.
Description
Technical field
This utility model relates to a kind of positioner, especially a kind of brain solid positioner.
Background technology
At present, scientific experiments animal brain stereotaxic instrument is mechanical connection, manual operations.This kind of brain solid positioner is by base plate, the three-dimensional manipulating arm (X that is arranged on the animal head holder (comprising U-shaped seat, ear bar and front tooth holder) on base plate and is arranged on U-shaped seat, Y, Z-direction) the three-dimensional probe carriage navigation system that forms, the three-dimensional manipulating arm of described three-dimensional probe carriage navigation system is made up of the motion bar of guide rail and band regulating handle usually, this three-dimensional manipulating arm is respectively equipped with and along the vernier seat of guide rail movement, the motion bar of band regulating handle all can indicates scale; X motion arm is arranged on Z motion arm vernier seat, can handle the guide rail movement of X motion arm along Z motion arm by band regulating handle motion bar; The vernier seat of described X motion arm is fixed on the back side of Z motion arm vernier seat; Probe fixed bar is arranged on the guide rail end of X motion arm, the guide rail of X motion arm can be impelled to move axially by the adjusting rod crossing band handle; Described Z motion arm is arranged on the vernier seat of Y motion arm by feathering axis and vertical rotating shaft, can handle Z motion arm along moving at the guide rail of Y motion arm by being with the adjusting rod of handle.Visible, by means of said structure, be arranged on the X on U-shaped seat, Y, Z motion arm can divide X, and Y, Z tri-direction horizontal movements and level 360 ° rotate and vertical 180 ° of rotations, by being with the scale on the motion bar of regulating handle and the scale on vernier seat surface plate to read corresponding coordinate figure, then or brain locator data can be obtained as calculated.
Existing brain solid positioner carries out in animal brain positioning action process actual, postanesthetic animal is placed on this stereotaxic instrument, adjustment front tooth bar is until bregma is equal with lambda, after divesting animal scalp, by the probe carriage manual adjustments of stereotaxic instrument to bregma place, read the X-axis of position finder level and the reading of Y-axis at this place by slide gauge, calculate required X-axis and the reading of Y-axis for zero point according to above-mentioned internationally recognized brain map with this.The motion arm of manual running fix instrument is to corresponding point, and Z axis take skull surface as zero point, moves down make probe reach skull surface by brain map, bores get out locating hole from side at probe indication point with cranium, then on move probe after, use cranium to creep into row boring.If need to carry out drug injection in the corresponding degree of depth, then after having needed boring, then move down probe to respective depth by brain map, thus complete location.This traditional stereotaxic instrument, its probe must drop to contact skull could determine coordinate and position, and then realize location, at this moment only can from limit, cranium be utilized to drill through locating hole sideling, not only process is very loaded down with trivial details, waste time and energy, also may due to the oblique inserting needle of operator, posture is uncomfortable and cause bore position just not locate unsuccessfully, and overall process needs operator's manual operations, not only inefficiency, operating time is increased greatly, thus have animal clear-headed and cause the risk of the failure of an experiment from anesthesia, simultaneously, repeatedly coordinates computed is easily made mistakes, and the precision of slide gauge is 0.1mm (part slide gauge precision only has 1mm), and the precision of real EEG collection of illustrative plates is 0.01mm, the precision of testing is caused to have restriction in various degree like this.
Describe a kind of digital display brain stereotaxic instrument in the patent application of application number 200620016851.6, be characterized in using coral film digital display induction apparatus to instead of traditional slide gauge display.Because coral film digital display induction apparatus can measure rear zero setting in first time, then only need single reading, can stereoscopic localized be realized, and its precision reaches precision (0.01mm) requirement of Naoliqing capsule collection of illustrative plates.But this digital display brain stereotaxic instrument still adopts full Non-follow control to locate, the very loaded down with trivial details problem of whole operating process is not resolved yet.
Utility model content
Technical problem to be solved in the utility model is to provide a kind of brain solid positioner that arbitrarily can regulate height.
For solving the problems of the technologies described above, the technical solution of the utility model is:
A kind of brain solid positioner, comprise base plate, ear bar, U-shaped seat, triaxial movement platform, the tri-axial motion controller of triaxial movement platform standard configuration, front tooth holder, probe fixing frame and positioning attachment, described positioning attachment is by laser sight, probe and biomarker pen composition, described front tooth holder and ear bar are fixed on above base plate by U-shaped seat, described triaxial movement platform is fixed on above base plate, this triaxial movement platform is made up of drive lead screw and the screw mandrel slide unit being provided with motor, first drive lead screw of the Z-direction of described triaxial movement platform is fixedly connected with base plate by the first screw mandrel slide unit, second drive lead screw of Y direction is slidably connected by the second screw mandrel slide unit and the first drive lead screw, 3rd drive lead screw of X-direction is slidably connected by the 3rd screw mandrel slide unit and the second drive lead screw, described probe fixing frame is arranged on described 3rd screw mandrel slide unit, the probe of described positioning attachment is fixed in probe fixing frame, the laser sight of described positioning attachment is vertical with described probe fixing frame to be fixed, and be positioned at directly over described front tooth holder, biomarker pen and the described probe fixing frame of described positioning attachment are independently arranged, the motor of described each screw mandrel slide unit and the tri-axial motion controller of described positioning attachment are by control line connection.
Preferably, above-mentioned brain solid positioner, described drive lead screw is ball screw.
Preferably, above-mentioned brain solid positioner, described laser sight is green laser sight.
Preferably, above-mentioned brain solid positioner, described probe fixing frame is for detachably to change parts.
Preferably, above-mentioned brain solid positioner, described probe fixing frame is fixedly installed syringe and/or electronic cranium bores.
The beneficial effects of the utility model are:
Above-mentioned brain solid positioner, controls triaxial movement platform by tri-axial motion controller, and the three-dimensional realizing probe fixing frame moves, instead of operator's manual adjustment scale, precision is 0.01mm, identical with the precision of internationally recognized brain map, greatly can improve the accuracy of location; Laser sight carries out the fast speed non-contact location of horizontal X, Y-axis coordinate; Use green laser as sight, because the collimation of laser is good, light path is straight, luminous point is very little, can not need to carry out moving up and down contact skull just to realize successfully locating, re-use a biomarker labelling record laser aiming point, operator's posture is comfortable, labelling accuracy is high, effectively increases work efficiency.
Accompanying drawing explanation
Fig. 1 is the structural representation of a kind of brain solid positioner that this utility model provides.
In figure: 1-base plate 2-ear bar 3-U type seat 4-motor 5-drive lead screw 6-screw mandrel slide unit 7-front tooth holder 8-probe fixing frame 9-laser sight
Detailed description of the invention
In order to make those skilled in the art better understand the technical solution of the utility model, below in conjunction with the drawings and the specific embodiments, technical scheme described in the utility model is described in further detail.
As shown in Figure 1, described brain solid positioner, comprise base plate 1, ear bar 2, U-shaped seat 3, triaxial movement platform, the tri-axial motion controller of triaxial movement platform standard configuration, front tooth holder 7, probe fixing frame 8 and positioning attachment, described positioning attachment is by laser sight 9, probe and biomarker pen composition, described front tooth holder and ear bar are fixed on above base plate by U-shaped seat, described triaxial movement platform is fixed on above base plate, this triaxial movement platform is made up of drive lead screw 5 and the screw mandrel slide unit 6 being provided with motor 4, this drive lead screw is ball screw, first drive lead screw of the Z-direction of described triaxial movement platform is fixedly connected with base plate by the first screw mandrel slide unit, second drive lead screw of Y direction is slidably connected by the second screw mandrel slide unit and the first drive lead screw, 3rd drive lead screw of X-direction is slidably connected by the 3rd screw mandrel slide unit and the second drive lead screw, described probe fixing frame is arranged on described 3rd screw mandrel slide unit, the probe of described positioning attachment is fixed in probe fixing frame, the laser sight of described positioning attachment is green laser sight, this laser sight is vertical with described probe fixing frame to be fixed, and be positioned at directly over described front tooth holder, biomarker pen and the described probe fixing frame of described positioning attachment are independently arranged, in use procedure, the position of luminous point on Rat calvarial of laser sight reaches in advance after calibration value, labelling is carried out at Rat calvarial by light spot position with marker pen, use to facilitate experiment operator, described probe fixing frame is for detachably to change parts, there is multiple specific shape system optional, syringe and/or electronic cranium brill can be set as required in described probe fixing frame, the motor of described each screw mandrel slide unit and the tri-axial motion controller of described positioning attachment are by control line connection, this tri-axial motion controller is arranged at described triaxial movement platform side.
In use procedure, by tri-axial motion controller from tape program can realize triaxial movement platform manual high speed, crawl operation, backhaul sequence zero-sum return machinery 04 kinds of operating functions.Utilize and manually at a high speed probe or laser aiming point are moved to after near bregma fast, use crawl operation accurate adjustment probe or laser aiming point to bregma point; Again by this point being set to program zero point, can regression routine zero point fast in position fixing process, convenient and swift, registration; Due to the existence that manual crawl operates, this pattern can be utilized to realize accurate inserting needle when using syringe to carry out drug injection to corresponding brain territory.In addition, traveling probe or laser aiming point are to specified coordinate point automatically, fast by realizing motion platform from tape program in tri-axial motion controller for described brain solid positioner, and quick, full-automatic realization is located; And implementation patternization operation, the zoopery more to anchor point needed for the animal brain positioning experiment carried out in a large number, skull, locate by program realization flowization, only need an initial setting up or importing program just can carry out stereoscopic localized to all animals in experiment, improve work efficiency, reduce working strength.
Above-mentioned detailed description of this kind of brain solid positioner being carried out with reference to detailed description of the invention; illustrative instead of determinate; several embodiments can be listed according to institute's limited range; therefore in the change do not departed under this utility model general plotting and amendment, should belong within protection domain of the present utility model.
Claims (5)
1. a brain solid positioner, it is characterized in that: comprise base plate, ear bar, U-shaped seat, triaxial movement platform, the tri-axial motion controller of triaxial movement platform standard configuration, front tooth holder, probe fixing frame and positioning attachment, described positioning attachment is by laser sight, probe and biomarker pen composition, described front tooth holder and ear bar are fixed on above base plate by U-shaped seat, described triaxial movement platform is fixed on above base plate, this triaxial movement platform is made up of drive lead screw and the screw mandrel slide unit being provided with motor, first drive lead screw of the Z-direction of described triaxial movement platform is fixedly connected with base plate by the first screw mandrel slide unit, second drive lead screw of Y direction is slidably connected by the second screw mandrel slide unit and the first drive lead screw, 3rd drive lead screw of X-direction is slidably connected by the 3rd screw mandrel slide unit and the second drive lead screw, described probe fixing frame is arranged on described 3rd screw mandrel slide unit, the probe of described positioning attachment is fixed in probe fixing frame, the laser sight of described positioning attachment is vertical with described probe fixing frame to be fixed, and be positioned at directly over described front tooth holder, biomarker pen and the described probe fixing frame of described positioning attachment are independently arranged, the motor of described each screw mandrel slide unit and the tri-axial motion controller of described positioning attachment are by control line connection.
2. brain solid positioner according to claim 1, is characterized in that: described drive lead screw is ball screw.
3. brain solid positioner according to claim 1, is characterized in that: described laser sight is green laser sight.
4. brain solid positioner according to claim 1, is characterized in that: described probe fixing frame is for detachably to change parts.
5. the brain solid positioner according to claim 1 or 4, is characterized in that: described probe fixing frame is fixedly installed syringe and/or electronic cranium brill.
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CN201420516073.1U CN204169950U (en) | 2014-09-09 | 2014-09-09 | A kind of brain solid positioner |
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CN201420516073.1U CN204169950U (en) | 2014-09-09 | 2014-09-09 | A kind of brain solid positioner |
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Cited By (15)
Publication number | Priority date | Publication date | Assignee | Title |
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CN104921836A (en) * | 2015-05-22 | 2015-09-23 | 郑州大学 | Stereotaxic four-point pigeon brain localization device and operation method thereof |
CN105128542A (en) * | 2015-08-28 | 2015-12-09 | 武汉九武光电技术有限公司 | Multi-dimensional adjustable laser marking machine |
CN105686865A (en) * | 2016-01-14 | 2016-06-22 | 深圳安科高技术股份有限公司 | Automatic mammary gland stereotaxis device, system and control method thereof |
CN109009544A (en) * | 2018-07-26 | 2018-12-18 | 山东中医药大学 | A kind of Naoliqing capsule device and localization method |
CN109172025A (en) * | 2018-10-09 | 2019-01-11 | 中国科学技术大学 | Animal brain surgical apparatus and its control device, control system |
CN109498177A (en) * | 2018-11-16 | 2019-03-22 | 邹先军 | A kind of orthopaedics therapy leg perforating device |
CN109730800A (en) * | 2019-03-15 | 2019-05-10 | 河南医学高等专科学校 | Micro slow positioning injection device is used in a kind of experiment of rat brain |
CN110478079A (en) * | 2019-09-05 | 2019-11-22 | 南通大学 | A kind of mouse brain injection auxiliary locator |
CN110711044A (en) * | 2019-11-05 | 2020-01-21 | 广州医科大学 | Five-axis zebra fish brain stereotaxic instrument based on precise sliding table |
CN110794126A (en) * | 2019-11-04 | 2020-02-14 | 苏州煜水生物科技有限公司 | Biological sample detecting instrument convenient to adjust |
CN111012524A (en) * | 2019-12-27 | 2020-04-17 | 苏州溢博伦光电仪器有限公司 | Separated optical vibration reduction platform |
CN112345320A (en) * | 2020-10-20 | 2021-02-09 | 江南大学 | Method for micro-controlling two-dimensional material based on semi-automatic probe station |
CN112603582A (en) * | 2020-12-11 | 2021-04-06 | 南京农业大学 | Poultry brain injection experimental apparatus |
CN112807122A (en) * | 2019-11-18 | 2021-05-18 | 中国科学院深圳先进技术研究院 | Positioning arm with cranial drill |
CN113142088A (en) * | 2021-05-14 | 2021-07-23 | 广西盛思蓝生物医药技术有限公司 | Brain stereotaxic device and method for non-human primate experimental animals |
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2014
- 2014-09-09 CN CN201420516073.1U patent/CN204169950U/en not_active Expired - Fee Related
Cited By (21)
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CN104921836B (en) * | 2015-05-22 | 2016-09-21 | 郑州大学 | Family's Columba livia brain solid four point positioning device |
CN104921836A (en) * | 2015-05-22 | 2015-09-23 | 郑州大学 | Stereotaxic four-point pigeon brain localization device and operation method thereof |
CN105128542A (en) * | 2015-08-28 | 2015-12-09 | 武汉九武光电技术有限公司 | Multi-dimensional adjustable laser marking machine |
CN105686865A (en) * | 2016-01-14 | 2016-06-22 | 深圳安科高技术股份有限公司 | Automatic mammary gland stereotaxis device, system and control method thereof |
CN109009544B (en) * | 2018-07-26 | 2021-02-23 | 山东中医药大学 | Brain stereotaxic apparatus |
CN109009544A (en) * | 2018-07-26 | 2018-12-18 | 山东中医药大学 | A kind of Naoliqing capsule device and localization method |
CN109172025A (en) * | 2018-10-09 | 2019-01-11 | 中国科学技术大学 | Animal brain surgical apparatus and its control device, control system |
CN109498177A (en) * | 2018-11-16 | 2019-03-22 | 邹先军 | A kind of orthopaedics therapy leg perforating device |
CN109730800A (en) * | 2019-03-15 | 2019-05-10 | 河南医学高等专科学校 | Micro slow positioning injection device is used in a kind of experiment of rat brain |
CN109730800B (en) * | 2019-03-15 | 2021-02-23 | 河南医学高等专科学校 | Slow injection device that fixes a position of trace for rat brain experiments |
CN110478079A (en) * | 2019-09-05 | 2019-11-22 | 南通大学 | A kind of mouse brain injection auxiliary locator |
CN110794126A (en) * | 2019-11-04 | 2020-02-14 | 苏州煜水生物科技有限公司 | Biological sample detecting instrument convenient to adjust |
CN110794126B (en) * | 2019-11-04 | 2021-05-04 | 杭州凯曼健康科技有限公司 | Biological sample detecting instrument convenient to adjust |
CN110711044A (en) * | 2019-11-05 | 2020-01-21 | 广州医科大学 | Five-axis zebra fish brain stereotaxic instrument based on precise sliding table |
CN110711044B (en) * | 2019-11-05 | 2021-07-27 | 广州医科大学 | Five-axis zebra fish brain stereotaxic instrument based on precise sliding table |
CN112807122A (en) * | 2019-11-18 | 2021-05-18 | 中国科学院深圳先进技术研究院 | Positioning arm with cranial drill |
WO2021098658A1 (en) * | 2019-11-18 | 2021-05-27 | 中国科学院深圳先进技术研究院 | Positioning arm with cranial drill |
CN111012524A (en) * | 2019-12-27 | 2020-04-17 | 苏州溢博伦光电仪器有限公司 | Separated optical vibration reduction platform |
CN112345320A (en) * | 2020-10-20 | 2021-02-09 | 江南大学 | Method for micro-controlling two-dimensional material based on semi-automatic probe station |
CN112603582A (en) * | 2020-12-11 | 2021-04-06 | 南京农业大学 | Poultry brain injection experimental apparatus |
CN113142088A (en) * | 2021-05-14 | 2021-07-23 | 广西盛思蓝生物医药技术有限公司 | Brain stereotaxic device and method for non-human primate experimental animals |
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C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
CF01 | Termination of patent right due to non-payment of annual fee | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20150225 Termination date: 20190909 |