CN110478079A - A kind of mouse brain injection auxiliary locator - Google Patents
A kind of mouse brain injection auxiliary locator Download PDFInfo
- Publication number
- CN110478079A CN110478079A CN201910834907.0A CN201910834907A CN110478079A CN 110478079 A CN110478079 A CN 110478079A CN 201910834907 A CN201910834907 A CN 201910834907A CN 110478079 A CN110478079 A CN 110478079A
- Authority
- CN
- China
- Prior art keywords
- constant temperature
- mobile
- plate
- scale
- fixed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D3/00—Appliances for supporting or fettering animals for operative purposes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/42—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for desensitising skin, for protruding skin to facilitate piercing, or for locating point where body is to be pierced
- A61M5/427—Locating point where body is to be pierced, e.g. vein location means using ultrasonic waves, injection site templates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D3/00—Appliances for supporting or fettering animals for operative purposes
- A61D2003/003—Appliances for supporting or fettering animals for operative purposes with head or neck restraining means
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Vascular Medicine (AREA)
- Dermatology (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Animal Husbandry (AREA)
- Laser Surgery Devices (AREA)
Abstract
The invention discloses a kind of mouse brain injection auxiliary locators, including constant temperature bottom plate, the mobile scale of the longitudinal axis and clamp assemblies, the lower surface quadrangle of the constant temperature bottom plate is threaded with support foot, and the inside of constant temperature bottom plate is equipped with heated at constant temperature component, fixation kit is fixed on rear side of the upper surface of the constant temperature bottom plate, the mobile scale of the longitudinal axis is installed on the left surface of constant temperature bottom plate, and the upper end of the mobile scale of the longitudinal axis is fixed with vertical plate, the bosom position of the vertical plate is equipped with screw rod, and the top of screw rod is welded with regulation handle, the outer wall thread of the screw rod is connected with ball slide unit, and horizontal axis mobile scale is installed on the right side of ball slide unit, the clamp assemblies are installed on the lower section of the mobile scale of horizontal axis.The present invention reaches the mobile scale of 0.01mm by using positioning accuracy, substantially increases the precision of entire positioning device, thus solve in the prior art, due to hippocampus of mice portion it is smaller and can not precise positioning the problem of.
Description
Technical field
The present invention relates to Animal Medicine technical field, specially a kind of mouse brain injection auxiliary locator.
Background technique
Memory is exactly the connection form between nerve cell in fact, however, storage or the certain information of jettisoning, do not come from but
Conscious judgement, but handled by the hippocampus in human brain, hippocampus serves as the function of switching station during memory
Can, when the neuron in cerebral cortex receives various sense organs or consciousness message, they can pass to message hippocampus, false
If hippocampus is reacted, neuron will initially form lasting network, but if not over the mode of this approval, that
Just automatic disappear shows that hippocampus is learning and memory without track, a large amount of experimental study and clinical observation to the experience that brain receives
Key position, the especially crucial brain area of association's type learning and memory, in the research inquired into hippocampus and participate in learning and memory mechanism,
Usually intracerebral is needed to be directly administered, intracerebroventricular is currently used method, but its maximum defect is that drug effect range is wide,
Each brain area is almost spread over, to discovery mechanism or explains that experimental phenomena brings difficulty, therefore, brain area site-specific delivery of drugs is ideal
Approach.
Report currently on the market in relation to rat hippocampus microinjection is commonplace, mostly casing heeling-in method, due to current
Common laboratory is very universal using mouse, and mouse is because its hippocampus very little is not easy to carry out microinjection, in the difference for being directed to hippocampus
Subregion when selecting different coordinate to be injected, still has many deviations, it is difficult to the problem of carrying out precise positioning,
For this purpose, it is proposed that a kind of higher mouse brain injection auxiliary locator of practicability.
Summary of the invention
The purpose of the present invention is to provide a kind of mouse brain injection auxiliary locators, solve existing current city
Report in relation to rat hippocampus microinjection on field is commonplace, mostly casing heeling-in method, since current common laboratory uses
Mouse is very universal, and mouse, in the different subregions for being directed to hippocampus, selects different because its hippocampus very little is not easy to carry out microinjection
Coordinate when injected, still have many deviations, it is difficult to the problem of carrying out precise positioning.
To achieve the above object, the invention provides the following technical scheme: a kind of mouse brain injection auxiliary locator,
Anti-skid support is threaded with including constant temperature bottom plate, the mobile scale of the longitudinal axis and clamp assemblies, the lower surface quadrangle of the constant temperature bottom plate
Foot, and the inside of constant temperature bottom plate is equipped with heated at constant temperature component, is fixed with fixation kit on rear side of the upper surface of the constant temperature bottom plate,
The mobile scale of the longitudinal axis is installed on the left surface of constant temperature bottom plate, and the upper end of the mobile scale of the longitudinal axis is fixed with vertical plate, described vertical
The bosom position of plate is equipped with screw rod, and the top of screw rod is welded with regulation handle, the outer wall thread connection of the screw rod
There is ball slide unit, and horizontal axis mobile scale is installed on the right side of ball slide unit, the clamp assemblies are installed on the mobile scale of horizontal axis
Lower section.
Preferably, the heated at constant temperature component includes heat-conducting plate, heating wire, temperature sensor and controller, and constant temperature bottom
The upper surface middle position of plate is inlaid with heat-conducting plate, heating wire is connected with below the heat-conducting plate, and set on the right side of heat-conducting plate
It is equipped with temperature sensor, and is connected with temperature sensor below temperature sensor.
Preferably, the lower surface of the heat-conducting plate is fitted closely with heating wire, and heating wire passes through conducting wire and controller electricity
Property connection, and controller is electrically connected by conducting wire and temperature sensor.
Preferably, the fixation kit includes fixed block, spring, sliding block, fixed pole, connecting rod, earplug, elastic band and cunning
Rail, and spring is respectively and fixedly provided at left and right sides of fixed block, sliding block is installed, and be connected on the outside of the spring below sliding block
Sliding rail, the sliding block outside is fixed with fixed pole, and one end of connecting rod is socketed on the outside of fixed pole, and the other end of connecting rod
Earplug is installed, while being socketed with elastic band on the outside of earplug.
Preferably, it cooperates between the sliding block and sliding rail and constitutes slide construction, and between sliding rail and constant temperature bottom plate
Connection type is to be fixedly connected, and cooperates between the fixed pole and connecting rod and constitutes rotational structure, and connecting rod and earplug it
Between connection type be threadedly coupled.
Preferably, the mobile scale of the longitudinal axis includes scale main body, display screen, mobile block, fastening bolt and first laser
Sighting device, and mobile block is socketed on the outside of scale main body, display screen is fixed on the left of the mobile block, and mobile block is upper
Square thread is connected with fastening bolt, and the inner wall of mobile block is inlaid with first laser sighting device.
Preferably, the structure of the mobile scale of the longitudinal axis is identical as the mobile structure of scale of horizontal axis, and the mobile scale of the longitudinal axis
It is mutually perpendicular to the mobile scale of horizontal axis, the lower end outside of the screw rod is socketed with bearing, and screw rod is through the inside of vertical plate.
Preferably, the clamp assemblies include center-pole, first clamping plate, torque spring, second clamping plate, second laser aiming
Device and Skidproof soft cushion, and first clamping plate is socketed on the left of center-pole, are socketed with torque spring on the outside of the center-pole, and in
The bottom of core bar is fixed with second laser sighting device, and second clamping plate, and second clamping plate and are socketed on the right side of the center-pole
The rear side inner wall of one clamping plate is respectively connected with Skidproof soft cushion.
Preferably, the vertical centerline bilateral symmetry of the first clamping plate and second clamping plate about center-pole, and the first folder
Plate is by constituting elastic construction between torque spring and second clamping plate, and the material of Skidproof soft cushion is elastic rubber.
Compared with prior art, beneficial effects of the present invention are as follows:
1. the present invention reaches the mobile scale of 0.01mm by using positioning accuracy, entire positioning device is substantially increased
Precision, thus solve in the prior art, due to hippocampus of mice portion it is smaller and can not precise positioning the problem of, while it is entire
Device not only can easily fix mouse, be also convenient for fixed injection device, so that being directed to the injection operation in hippocampus of mice portion more
It is convenient to add；
2. the heat-conducting plate in present invention setting heated at constant temperature component being total in heating wire, temperature sensor and controller
It is in heated at constant temperature state under same-action, mouse is avoided to suffer from cold in brain injection medical procedure, and causes brain injury,
It is unfavorable for later period comparison observation；
3. the spring in present invention setting fixation kit is connected between fixed block and sliding block, while connecting rod can be around
Fixed pole rotation, in order to carry out size fine tuning according to the size of mouse head, allow two earplugs in most cases all
The head of mouse can be clamped, while earplug is made of silica gel material, there is certain elasticity, be conducive to reduce to mouse
Injury, while elastic band can assist earplug that further mouse head is fixed, and guarantee that mouse head is in the shape ajusted
State；
4. the mobile scale of the present invention setting longitudinal axis and the mobile scale of horizontal axis are the identical scales of two structures, and the two
The accuracy of scale is higher, while itself has range data display function, can be when carrying out positioning operation, and real-time display is vertical
The mobile distance of mobile block, conveniently directly reads data, carries out data record on the mobile scale of axis and the mobile scale of horizontal axis；
5. a clip shape is formed between the first clamping plate and second clamping plate in present invention setting clamp assemblies, and the
One clamping circular hole of the rear end of one clamping plate and second clamping plate formation closed together, in order to utilize the clamping action of clamp assemblies
The injection devices such as syringe are gripped, carry out puncture procedure, asking for position error can be generated by solving man-hour manually hand-held
Topic substantially increases the accuracy of injection position positioning.
Detailed description of the invention
Fig. 1 is positive structure diagram of the present invention；
Fig. 2 is the left side structure schematic view of the present invention；
Fig. 3 is fixation kit overlooking structure diagram of the present invention；
Fig. 4 is that constant temperature bottom plate of the present invention and fixation kit overlook mounting structure schematic diagram；
Fig. 5 is clamp assemblies structural schematic diagram of the present invention；
Fig. 6 is clamp assemblies overlooking structure diagram of the present invention.
In figure: 1, constant temperature bottom plate；2, support foot；3, heated at constant temperature component；301, heat-conducting plate；302, heating wire；303,
Temperature sensor；304, controller；4, fixation kit；401, fixed block；402, spring；403, sliding block；404, fixed pole；405, even
Extension bar；406, earplug；407, elastic band；408, sliding rail；5, the mobile scale of the longitudinal axis；501, scale main body；502, display screen；503,
Mobile block；504, fastening bolt；505, first laser sighting device；6, vertical plate；7, screw rod；8, ball slide unit；9, regulation handle；
10, the mobile scale of horizontal axis；11, clamp assemblies；1101, center-pole；1102, first clamping plate；1103, torque spring；1104, second
Clamping plate；1105, second laser sighting device；1106, Skidproof soft cushion.
Specific embodiment
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete
Site preparation description, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.It is based on
Embodiment in the present invention, it is obtained by those of ordinary skill in the art without making creative efforts every other
Embodiment shall fall within the protection scope of the present invention.
Please refer to Fig. 1-6, a kind of mouse brain injection auxiliary locator, including constant temperature bottom plate 1, support foot 2, perseverance
Warm heating component 3, heat-conducting plate 301, heating wire 302, temperature sensor 303, controller 304, fixation kit 4, fixed block 401,
The mobile scale 5 of spring 402, sliding block 403, fixed pole 404, connecting rod 405, earplug 406, elastic band 407, sliding rail 408, the longitudinal axis, mark
Ruler main body 501, display screen 502, mobile block 503, fastening bolt 504, first laser sighting device 505, vertical plate 6, screw rod 7, ball
Slide unit 8, regulation handle 9, horizontal axis mobile scale 10, clamp assemblies 11, center-pole 1101, first clamping plate 1102, torque spring
1103, second clamping plate 1104, second laser sighting device 1105 and Skidproof soft cushion 1106, the lower surface quadrangle screw thread of constant temperature bottom plate 1
It is connected with support foot 2, and the inside of constant temperature bottom plate 1 is equipped with heated at constant temperature component 3, the upper surface rear side of constant temperature bottom plate 1 is solid
Surely there is fixation kit 4, the mobile scale 5 of the longitudinal axis is installed on the left surface of constant temperature bottom plate 1, and the upper end of the mobile scale 5 of the longitudinal axis is fixed
Have a vertical plate 6, the bosom position of vertical plate 6 is equipped with screw rod 7, and the top of screw rod 7 is welded with regulation handle 9, screw rod 7 it is outer
Wall is threaded with ball slide unit 8, and the right side of ball slide unit 8 is equipped with the mobile scale 10 of horizontal axis, and clamp assemblies 11 are installed on
The lower section of the mobile scale 10 of horizontal axis, the present invention reach the mobile scale of 0.01mm by using positioning accuracy, substantially increase
The precision of entire positioning device, thus solve in the prior art, due to hippocampus of mice portion it is smaller and can not precise positioning
Problem, while whole device not only can easily fix mouse, be also convenient for fixed injection device, so that being directed to hippocampus of mice portion
Injection operation it is more convenient；
Heated at constant temperature component 3 includes heat-conducting plate 301, heating wire 302, temperature sensor 303 and controller 304, and constant temperature
The upper surface middle position of bottom plate 1 is inlaid with heat-conducting plate 301, and the lower section of heat-conducting plate 301 is connected with heating wire 302, and heat-conducting plate
301 right side is provided with temperature sensor 303, and the lower section of temperature sensor 303 is connected with temperature sensor 303, thermally conductive
The lower surface of plate 301 is fitted closely with heating wire 302, and heating wire 302 is electrically connected by conducting wire and controller 304, and
Controller 304 is electrically connected by conducting wire and temperature sensor 303, and heat-conducting plate 301 in heated at constant temperature component 3 is arranged can be
It is in heated at constant temperature state under the collective effect of heating wire 302, temperature sensor 303 and controller 304, avoids mouse in brain
It suffers from cold in injection medical procedure, and causes brain injury, be unfavorable for later period comparison observation；
Fixation kit 4 includes fixed block 401, spring 402, sliding block 403, fixed pole 404, connecting rod 405, earplug 406, elastic force
Band 407 and sliding rail 408, and the left and right sides of fixed block 401 is respectively and fixedly provided with spring 402, the outside of spring 402 is equipped with sliding block
403, and the lower section of sliding block 403 is connected with sliding rail 408, and fixed pole 404, and the outside socket of fixed pole 404 are fixed on the outside of sliding block 403
There is one end of connecting rod 405, and the other end of connecting rod 405 is equipped with earplug 406, while the outside of earplug 406 is socketed with
Elastic band 407 cooperates between sliding block 403 and sliding rail 408 and constitutes slide construction, and between sliding rail 408 and constant temperature bottom plate 1
Connection type is to be fixedly connected, and cooperates between fixed pole 404 and connecting rod 405 and constitutes rotational structure, and connecting rod 405 and ear
Connection type between plug 406 is to be threadedly coupled, and the spring 402 being arranged in fixation kit 4 is connected to fixed block 401 and sliding block
Between 403, while connecting rod 405 can be rotated around fixed pole 404, in order to which it is micro- to carry out size according to the size of mouse head
It adjusts, allows two earplugs 406 that can clamp the head of mouse in most cases, while earplug 406 is by silica gel material
It constitutes, there is certain elasticity, be conducive to reduce the injury to mouse, while elastic band 407 can assist earplug 406 into one
Mouse head is fixed in step, guarantees that mouse head is in the state ajusted；
The mobile scale 5 of the longitudinal axis includes that scale main body 501, display screen 502, mobile block 503, fastening bolt 504 and first are sharp
Light sighting device 505, and the outside of scale main body 501 is socketed with mobile block 503, the left side of mobile block 503 is fixed with display screen
502, and the top of mobile block 503 is threaded with fastening bolt 504, and the inner wall of mobile block 503 is inlaid with first laser
The structure of sighting device 505, the mobile scale 5 of the longitudinal axis is identical as the mobile structure of scale 10 of horizontal axis, and the mobile scale 5 of the longitudinal axis and horizontal axis
Mobile scale 10 is mutually perpendicular to, and the lower end outside of screw rod 7 is socketed with bearing, and screw rod 7, through the inside of vertical plate 6, setting is vertical
The mobile scale 5 of axis and the mobile scale 10 of horizontal axis are the identical scales of two structures, and the accuracy of the two scales is higher, together
Shi Zishen has range data display function, can be when carrying out positioning operation, and the mobile scale 5 of the real-time display longitudinal axis and horizontal axis move
The mobile distance of mobile block 503, conveniently directly reads data on dynamic scale 10, carries out data record；
Clamp assemblies 11 include center-pole 1101, first clamping plate 1102, torque spring 1103, second clamping plate 1104, second
Laser sight 1105 and Skidproof soft cushion 1106, and the left side of center-pole 1101 is socketed with first clamping plate 1102, center-pole 1101
Outside be socketed with torque spring 1103, and the bottom of center-pole 1101 is fixed with second laser sighting device 1105, center-pole
1101 right side is socketed with second clamping plate 1104, and the rear side inner wall of second clamping plate 1104 and first clamping plate 1102 be respectively connected with it is anti-
The vertical centerline bilateral symmetry of sliding cushion 1106, first clamping plate 1102 and second clamping plate 1104 about center-pole 1101, and the
One clamping plate 1102 is by constituting elastic construction, and the material of Skidproof soft cushion 1106 between torque spring 1103 and second clamping plate 1104
Matter is elastic rubber, is arranged between the first clamping plate 1102 and second clamping plate 1104 in clamp assemblies 11 and forms a clip shape
Shape, and one clamping circular hole of rear end formation closed together of first clamping plate 1102 and second clamping plate 1104, in order to utilize
The clamping action of clamp assemblies 11 grips the injection devices such as syringe, carries out puncture procedure, solves artificial hand
Position error can be led to the problem of by holding, and substantially increase the accuracy of injection position positioning.
Working principle: for this kind of mouse brain injection auxiliary locator, whole device is placed on first flat
On whole desktop, support foot 2 contacts desktop, is supported to constant temperature bottom plate 1, postanesthetic mouse is then placed on constant temperature
Then 1 upper surface of bottom plate starts the heating wire 302 in heated at constant temperature component 3, heating wire so that mouse lies on heat-conducting plate 301
302 work distribute heat, and heat transfer is to heat-conducting plate 301, while the temperature sensor 303 of model PT100 can detecte
Temperature information on heat-conducting plate 301, and temperature information is passed to the controller 304 of model AT89S51, controller 304
Temperature information is analyzed and processed, when temperature information exceeds normal range (NR), controller 304 then controls the closing of heating wire 302；
Then pull the sliding block 403 in fixation kit 4 while outward, sliding block 403 along the outside Slideslip of sliding rail 408,
It drives spring 402 to extend between sliding block 403 and fixed block 401, while the distance between two earplugs 406 become larger, then will
Mouse is placed between two earplugs 406, can be with thing since earplug 406 is threadedly secured in connecting rod 405
The earplug 406 that suitable size is first replaced according to the selection of the ear size of mouse, is rotatablely connected bar 405, connecting rod 405 then up
Certain angle is rotated around fixed pole 404, so that the position of two earplugs 406 is concordant with mouse ear, then by two earplugs 406
Be inserted into mouse ear inside, at this time unclamp earplug 406, earplug 406 with spring 402 elastic reaction rebound it is a bit of away from
From so that two earplugs 406 clamp mouse heads, then two elastic bands 407 being pushed aside, so that 407 sets of elastic band exists
Mouse forehead, 407 sets of another elastic band is in the decimal back side of head, to fix mouse head；
Then first of the model HO-S635PX-22110 on the mobile scale 5 of the longitudinal axis of model MNT-150T is opened
Laser sight 505, first laser sighting device 505 issue ray, are radiated at mouse head, and user is according to the position of ray
Mobile mobile block 503 is set, mobile block 503 is slided along scale main body 501, until hippocampus of the radiation exposure in mouse head,
Mobile distance can be shown on display screen 502 at this time, is then screwed down fastening bolt 504, this position is fixed, is then led to
It crosses clamp assemblies 11 and fixes syringe, first inwardly clutch one end that first clamping plate 1102 and second clamping plate 1104 are opened, first
While clamping plate 1102 and second clamping plate 1104 are rotated around center-pole 1101, torque spring 1103 can be compressed, and first clamping plate
1102 open with the other end of second clamping plate 1104, and syringe is placed on to the other end of first clamping plate 1102 Yu second clamping plate 1104
Between, one end of then the come up first clamping plate 1102 and second clamping plate 1104 that pinch, first clamping plate 1102 and second is pressed from both sides
Plate 1104 re-closes under the elastic reaction of torque spring 1103, clamps syringe；
Skidproof soft cushion 1106 is interposed between syringe and first clamping plate 1102 and second clamping plate 1104 at this time, not only can be to prevent
It is sliding, moreover it is possible to reduce first clamping plate 1102 and damage of the second clamping plate 1104 to syringe, the syringe fixed and horizontal axis are mobile
Scale 10 is mutually perpendicular to, and then opens second laser sighting device 1105, and second laser sighting device 1105 issues ray, irradiation
In mouse head, can similarly obtain, user operates the mobile scale 10 of horizontal axis, so that hippocampus of the radiation exposure in mouse head,
To carrying out injection positioning, rotate regulation handle 9 at this time, regulation handle 9 drives screw rod 7 in 6 central rotational of vertical plate, screw rod 7 with
Threaded function occurs between ball slide unit 8, ball slide unit 8 is moved down along screw rod 7, drives the mobile scale 10 of horizontal axis, clamping
Component 11 and syringe move down, until syringe needle point lunges mouse head, complete localised puncture, then injected i.e.
Can, the use process of entire mouse brain injection auxiliary locator is completed like this.
It although an embodiment of the present invention has been shown and described, for the ordinary skill in the art, can be with
A variety of variations, modification, replacement can be carried out to these embodiments without departing from the principles and spirit of the present invention by understanding
And modification, the scope of the present invention is defined by the appended.
Claims (9)
1. a kind of mouse brain injection auxiliary locator, including constant temperature bottom plate (1), the longitudinal axis mobile scale (5) and clamping group
Part (11), it is characterised in that: the lower surface quadrangle of the constant temperature bottom plate (1) is threaded with support foot (2), and constant temperature bottom plate
(1) inside is equipped with heated at constant temperature component (3), is fixed with fixation kit (4) on rear side of the upper surface of the constant temperature bottom plate (1),
The longitudinal axis mobile scale (5) is installed on the left surface of constant temperature bottom plate (1), and the upper end of the longitudinal axis mobile scale (5) be fixed with it is vertical
The bosom position of plate (6), the vertical plate (6) is equipped with screw rod (7), and the top of screw rod (7) is welded with regulation handle
(9), the outer wall thread of the screw rod (7) is connected with ball slide unit (8), and it is mobile that horizontal axis is equipped on the right side of ball slide unit (8)
Scale (10), the clamp assemblies (11) are installed on the lower section of horizontal axis mobile scale (10).
2. a kind of mouse brain injection auxiliary locator according to claim 1, it is characterised in that: the constant temperature adds
Hot component (3) includes heat-conducting plate (301), heating wire (302), temperature sensor (303) and controller (304), and constant temperature bottom plate
(1) upper surface middle position is inlaid with heat-conducting plate (301), is connected with heating wire (302) below the heat-conducting plate (301),
And temperature sensor (303) are provided on the right side of heat-conducting plate (301), and be connected with temperature below temperature sensor (303)
Sensor (303).
3. a kind of mouse brain injection auxiliary locator according to claim 2, it is characterised in that: the heat-conducting plate
(301) lower surface is fitted closely with heating wire (302), and heating wire (302) is electrically connected by conducting wire with controller (304)
It connects, and controller (304) is electrically connected by conducting wire and temperature sensor (303).
4. a kind of mouse brain injection auxiliary locator according to claim 1, it is characterised in that: described fixed group
Part (4) includes fixed block (401), spring (402), sliding block (403), fixed pole (404), connecting rod (405), earplug (406), elastic force
Band (407) and sliding rail (408), and spring (402) are respectively and fixedly provided at left and right sides of fixed block (401), outside the spring (402)
Side is equipped with sliding block (403), and sliding rail (408) are connected with below sliding block (403), and it is fixed to be fixed on the outside of the sliding block (403)
Bar (404), and one end of connecting rod (405) is socketed on the outside of fixed pole (404), and the other end installation of connecting rod (405)
Have earplug (406), while being socketed with elastic band (407) on the outside of earplug (406).
5. a kind of mouse brain injection auxiliary locator according to claim 4, it is characterised in that: the sliding block
(403) it cooperates between sliding rail (408) and constitutes slide construction, and the connection side between sliding rail (408) and constant temperature bottom plate (1)
Formula is to be fixedly connected, and cooperates between the fixed pole (404) and connecting rod (405) and constitutes rotational structure, and connecting rod (405)
Connection type between earplug (406) is to be threadedly coupled.
6. a kind of mouse brain injection auxiliary locator according to claim 1, it is characterised in that: the longitudinal axis moves
Dynamic scale (5) include that scale main body (501), display screen (502), mobile block (503), fastening bolt (504) and first laser are taken aim at
Quasi- device (505), and mobile block (503) are socketed on the outside of scale main body (501), it is fixed on the left of the mobile block (503)
Display screen (502), and fastening bolt (504) are threaded with above mobile block (503), and the inner wall of mobile block (503)
It is inlaid with first laser sighting device (505).
7. a kind of mouse brain injection auxiliary locator according to claim 1, it is characterised in that: the longitudinal axis moves
The structure of dynamic scale (5) is identical as the mobile structure of scale (10) of horizontal axis, and the longitudinal axis mobile scale (5) and the mobile scale of horizontal axis
(10) it is mutually perpendicular to, the lower end outside of the screw rod (7) is socketed with bearing, and screw rod (7) is through the inside of vertical plate (6).
8. a kind of mouse brain injection auxiliary locator according to claim 1, it is characterised in that: the clamping group
Part (11) includes center-pole (1101), first clamping plate (1102), torque spring (1103), second clamping plate (1104), second laser
Sighting device (1105) and Skidproof soft cushion (1106), and first clamping plate (1102) are socketed on the left of center-pole (1101), it is described in
It is socketed on the outside of core bar (1101) torque spring (1103), and the bottom of center-pole (1101) is fixed with second laser sighting device
(1105), it is socketed with second clamping plate (1104) on the right side of the center-pole (1101), and second clamping plate (1104) and first clamping plate
(1102) rear side inner wall is respectively connected with Skidproof soft cushion (1106).
9. a kind of mouse brain injection auxiliary locator according to claim 8, it is characterised in that: first folder
The vertical centerline bilateral symmetry of plate (1102) and second clamping plate (1104) about center-pole (1101), and first clamping plate (1102)
By constituting elastic construction between torque spring (1103) and second clamping plate (1104), and the material of Skidproof soft cushion (1106) is
Elastic rubber.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910834907.0A CN110478079B (en) | 2019-09-05 | 2019-09-05 | Mouse brain is auxiliary positioning device for injection |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910834907.0A CN110478079B (en) | 2019-09-05 | 2019-09-05 | Mouse brain is auxiliary positioning device for injection |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN110478079A true CN110478079A (en) | 2019-11-22 |
| CN110478079B CN110478079B (en) | 2021-09-10 |
Family
ID=68556549
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910834907.0A Active CN110478079B (en) | 2019-09-05 | 2019-09-05 | Mouse brain is auxiliary positioning device for injection |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110478079B (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111281595A (en) * | 2020-03-06 | 2020-06-16 | 武汉联影生命科学仪器有限公司 | Animal fixing bin and imaging scanning system |
| CN112168414A (en) * | 2020-10-20 | 2021-01-05 | 河南省中医院（河南中医药大学第二附属医院） | Injection device for rat brain experiments |
| CN114869534A (en) * | 2022-04-25 | 2022-08-09 | 四川大学华西医院 | Temperature control type head three-dimensional fixing instrument |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH09253104A (en) * | 1996-03-22 | 1997-09-30 | Tokyo Met Gov Shinkei Kagaku Sogo Kenkyusho | Slight movement positioning device of brain stereotaxic apparatus |
| CN201283004Y (en) * | 2008-10-20 | 2009-08-05 | 淮北正华生物仪器设备有限公司 | Constant-temperature digital display type stereotaxic apparatus |
| CN204169950U (en) * | 2014-09-09 | 2015-02-25 | 中国医学科学院生物医学工程研究所 | A kind of brain solid positioner |
| CN204814275U (en) * | 2015-07-31 | 2015-12-02 | 昆明洛宇生物科技有限公司 | Rodent heat preservation operation platen |
| CN204909479U (en) * | 2015-09-15 | 2015-12-30 | 朱佳本 | CT puncture location bed |
| CN205163302U (en) * | 2015-11-10 | 2016-04-20 | 西安东澳生物科技有限公司 | Three -dimensional directional injection device of child mouse |
| TW201626964A (en) * | 2015-01-23 | 2016-08-01 | Univ Kun Shan | Skull surgical device |
| CN108451664A (en) * | 2017-02-17 | 2018-08-28 | 陈昭先 | Stereotactic device |
| CN110013280A (en) * | 2019-04-19 | 2019-07-16 | 徐增强 | A kind of animal and veterinary marrow puncture device |
-
2019
- 2019-09-05 CN CN201910834907.0A patent/CN110478079B/en active Active
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH09253104A (en) * | 1996-03-22 | 1997-09-30 | Tokyo Met Gov Shinkei Kagaku Sogo Kenkyusho | Slight movement positioning device of brain stereotaxic apparatus |
| CN201283004Y (en) * | 2008-10-20 | 2009-08-05 | 淮北正华生物仪器设备有限公司 | Constant-temperature digital display type stereotaxic apparatus |
| CN204169950U (en) * | 2014-09-09 | 2015-02-25 | 中国医学科学院生物医学工程研究所 | A kind of brain solid positioner |
| TW201626964A (en) * | 2015-01-23 | 2016-08-01 | Univ Kun Shan | Skull surgical device |
| CN204814275U (en) * | 2015-07-31 | 2015-12-02 | 昆明洛宇生物科技有限公司 | Rodent heat preservation operation platen |
| CN204909479U (en) * | 2015-09-15 | 2015-12-30 | 朱佳本 | CT puncture location bed |
| CN205163302U (en) * | 2015-11-10 | 2016-04-20 | 西安东澳生物科技有限公司 | Three -dimensional directional injection device of child mouse |
| CN108451664A (en) * | 2017-02-17 | 2018-08-28 | 陈昭先 | Stereotactic device |
| CN110013280A (en) * | 2019-04-19 | 2019-07-16 | 徐增强 | A kind of animal and veterinary marrow puncture device |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111281595A (en) * | 2020-03-06 | 2020-06-16 | 武汉联影生命科学仪器有限公司 | Animal fixing bin and imaging scanning system |
| CN112168414A (en) * | 2020-10-20 | 2021-01-05 | 河南省中医院（河南中医药大学第二附属医院） | Injection device for rat brain experiments |
| CN114869534A (en) * | 2022-04-25 | 2022-08-09 | 四川大学华西医院 | Temperature control type head three-dimensional fixing instrument |
Also Published As
| Publication number | Publication date |
|---|---|
| CN110478079B (en) | 2021-09-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN110478079A (en) | A kind of mouse brain injection auxiliary locator | |
| CN204910065U (en) | Novel acupuncture and moxibustion therapy appearance | |
| CN206473428U (en) | A kind of integrated lighting temperature control micro- stereotaxic instrument of improvement | |
| CN109107054B (en) | Head fixing device for sitting posture radiotherapy | |
| CN207745316U (en) | A kind of Medical hand rehabilitation nursing instrument | |
| CN211409964U (en) | Oral cavity and head neck maxillofacial surgery headstock | |
| CN211067257U (en) | Intelligent cervical vertebra rehabilitation therapeutic apparatus | |
| CN211326533U (en) | Head fixing clamp for neurosurgery | |
| CN206198237U (en) | A kind of Head supporting rack | |
| CN213787865U (en) | Head fixing device for neurosurgery | |
| CN209827781U (en) | Infusion nursing device for neurology | |
| CN211723838U (en) | Auxiliary device for neurosurgical clinical operation | |
| CN211634921U (en) | Multifunctional rheumatism immunity infrared warm pain relieving device | |
| CN205006857U (en) | Laryngoscope device suitable for animal | |
| CN204033361U (en) | Nuclear medicine radiation inspection treatment all-in-one | |
| CN215653020U (en) | Infusion support with adjustable surgical nursing is used | |
| CN111744115A (en) | Physiotherapy lamp with quick temperature control response | |
| CN213465872U (en) | Head fixing device for craniotomy | |
| CN214913158U (en) | Physique trainer is used to broadcaster's specialty | |
| CN110811694A (en) | Percussion diagnosis hammer for nerve examination | |
| CN221229577U (en) | Head operation positioning device for neurosurgery | |
| CN221013238U (en) | Traditional Chinese medicine eye diagnosis instrument | |
| CN110652333A (en) | Improved skull drilling device for neurosurgery | |
| CN2557072Y (en) | Head and neck fixator for radiation therapy | |
| CN213488741U (en) | Computer perimeter for ophthalmology |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |