CN204074254U - A kind of magnetic separator - Google Patents
A kind of magnetic separator Download PDFInfo
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- CN204074254U CN204074254U CN201420423965.7U CN201420423965U CN204074254U CN 204074254 U CN204074254 U CN 204074254U CN 201420423965 U CN201420423965 U CN 201420423965U CN 204074254 U CN204074254 U CN 204074254U
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Abstract
The utility model discloses a kind of magnetic separator, belong to biological technical field.Described magnetic separator, be applicable to isolated or purified biomolecule, described magnetic separator comprises: magnet, with housing and two support plates of cavity, the cross sectional shape of cavity is cross, cavity comprises vertically arranged first cavity and the second cavity mutually, two support plates are arranged in parallel in the relative both sides of housing and two support plates are parallel with the first cavity, two support plates are respectively arranged with multiple through hole, magnets free is arranged in the first cavity or the second cavity, make when magnet is positioned at the first cavity, the magnetic direction that magnet provides is vertical with two support plates, when magnet is positioned at the second cavity, the magnetic direction that magnet provides is parallel with two described support plates.The magnetic separator that the utility model provides can provide the magnetic field of both direction, and the tube wall making magnetic bead can either be adsorbed on centrifuge tube can be adsorbed on again at the bottom of the pipe of centrifuge tube, and then improves the utilization rate of magnetic separator.
Description
Technical field
The present invention relates to biological technical field, particularly a kind of magnetic separator.
Background technology
Magnetic separation technique a kind ofly utilizes in the adsorptive liquid of magnetic field the suspended particulate having magnetic or be magnetized, to reach the object of separatin non-soluble particulate and decentralized medium.Current magnetic separation technique obtains application in medical science and biology field.
Magnetic separation technique mainly realizes the object of extraction or purification of target molecule in field of biology by magnetic separator, particularly, magnetic separator comprises the support being provided with through hole and the magnet that can provide magnetic field, magnetic bead and preextraction liquid are added in centrifuge tube, this centrifuge tube is put into the through hole on support, magnetic bead can adsorb the target molecule in preextraction liquid, experimental different situations simultaneously, the magnetic direction that design magnet provides, magnetic bead is optionally adsorbed at the bottom of the tube wall of centrifuge tube or pipe, then the liquid in centrifuge tube is removed by methods such as pipettor absorptions, thus reach the object of Separation of Solid and Liquid, because process magnetic bead premenstruum (premenstrua) of solid phase can effective adsorbed target molecule, non-targeted molecule is not because being stayed by adsorbing in the liquid phase, so just achieve the object of extraction or purification of target molecule.
Realizing in process of the present invention, inventor finds that prior art at least exists following problem:
The position of the magnet in magnetic field is provided to be fixing in existing magnetic separator, the magnetic direction that magnetic separator is provided is single, namely same magnetic separator can only make magnetic bead be adsorbed in the tube wall of centrifuge tube or be adsorbed at the bottom of pipe, if need different magnetic directions to adsorb in experiment simultaneously, then need to purchase two kinds of different magnetic separators simultaneously, cause waste to a certain extent.
Summary of the invention
Single in order to solve the magnetic direction that magnetic separator of the prior art provides, the problem of user demand can not be met, embodiments provide a kind of magnetic separator.Described technical scheme is as follows:
Embodiments provide a kind of magnetic separator, be applicable to isolated or purified biomolecule, described magnetic separator comprises: magnet, with housing and two support plates of cavity, the cross sectional shape of described cavity is cross, described cavity comprises vertically arranged first cavity and the second cavity mutually, two described support plates are arranged in parallel in the relative both sides of described housing and two described support plates are parallel with described first cavity, two described support plates are respectively arranged with multiple through hole, described magnets free is arranged in described first cavity or described second cavity, make when described magnet is positioned at described first cavity, the magnetic direction that described magnet provides is vertical with two described support plates, when described magnet is positioned at described second cavity, the magnetic direction that described magnet provides is parallel with two described support plates.
Particularly, described housing is cross-shaped configuration and closes with the matching form of described first cavity and described second cavity.
Particularly, described housing is provided with the baffle plate of the one end for cavity described in shutoff.
Particularly, the described baffle plate of the infall of described first cavity and described second cavity is provided with iron plate, two the described support plates being positioned at described second cavity are respectively arranged with iron plate.
Particularly, each described support plate is provided with the described through hole of two rows, and the described through hole of two rows on each described support plate lays respectively at described second cavity both sides, and is oppositely arranged with described first cavity.
Particularly, described magnet is cuboid, and the South Pole of described magnet and the arctic lay respectively at two the maximum faces on described magnet.
Further, described magnet is neodymium iron boron magnetic body.
Further, the outer wall of described magnet is coated with protective layer.
Further, one end of described protective layer is provided with handle.
Particularly, the diameter of the described through hole of each row on two described support plates is different.
The beneficial effect that the technical scheme that the embodiment of the present invention provides is brought is: the magnetic separator that the embodiment of the present invention provides, when magnetic bead needs to be adsorbed at the bottom of the pipe of centrifuge tube, magnet is placed in the first cavity, now magnet can provide the magnetic field force perpendicular to support plate, the centrifuge tube that magnetic bead and preextraction liquid are housed is put on the through hole of support, magnetic bead can be adsorbed at the bottom of the pipe of centrifuge tube by the attraction of magnet; When magnetic bead needs the tube wall being adsorbed in centrifuge tube, magnet is placed in the second cavity, magnet can provide the magnetic field force being parallel to support plate, make magnetic bead can be adsorbed on the tube wall of centrifuge tube by the attraction of magnet, magnetic separator provided by the invention can provide the magnetic field of both direction, the tube wall making magnetic bead can either be adsorbed on centrifuge tube can be adsorbed on again at the bottom of the pipe of centrifuge tube, and then improves the utilization rate of magnetic separator, reduces experimental cost.
Accompanying drawing explanation
In order to be illustrated more clearly in the technical scheme in the embodiment of the present invention, below the accompanying drawing used required in describing embodiment is briefly described, apparently, accompanying drawing in the following describes is only some embodiments of the present invention, for those of ordinary skill in the art, under the prerequisite not paying creative work, other accompanying drawing can also be obtained according to these accompanying drawings.
Fig. 1 is the perspective view of the magnetic separator that the embodiment of the present invention provides;
Fig. 2 is the inverted perspective view of magnetic separator in Fig. 1 of providing of the embodiment of the present invention;
Fig. 3 is the perspective view of the magnet that the embodiment of the present invention provides;
Fig. 4 is the plan structure schematic diagram of the magnet that the embodiment of the present invention provides;
Fig. 5 is the side-looking structural representation of the magnet that the embodiment of the present invention provides;
Fig. 6 is the main TV structure schematic diagram of the magnet that the embodiment of the present invention provides;
Fig. 7 is the structural representation of the support plate that the embodiment of the present invention provides;
Fig. 8 is the structural representation of another support plate that the embodiment of the present invention provides;
Fig. 9 is the backsight structural representation being fixed with the magnetic separator of baffle plate that the embodiment of the present invention provides.
Detailed description of the invention
For making the object, technical solutions and advantages of the present invention clearly, below in conjunction with accompanying drawing, embodiment of the present invention is described further in detail.
Embodiment
Embodiments provide a kind of magnetic separator, be applicable to isolated or purified biomolecule, wherein biomolecule can comprise nucleic acid, protein, polypeptide and cell etc., as Fig. 1, shown in Fig. 2 and Fig. 3, this magnetic separator comprises: magnet 1, with housing 2 and two support plates 3 of cavity, the cross sectional shape of cavity is cross, cavity comprises vertically arranged first cavity 4 and the second cavity 5 mutually, two support plates 3 are arranged in parallel in the relative both sides of housing 2 and two support plates 3 are parallel with the first cavity 4, two support plates 3 are respectively arranged with through hole 6, magnet 1 is movably set in the first cavity 4 or the second cavity 5, make when magnet 1 is positioned at the first cavity 4, the magnetic direction that magnet 1 provides is vertical with two support plates 3, when magnet 1 is positioned at the second cavity 5, the magnetic direction that magnet 1 provides is parallel with two support plates 3.
Particularly, housing 2 is cross-shaped configuration and closes with the matching form of the first cavity 4 and the second cavity 5.The profile of housing 2 is arranged to the form fit that cross build is used for the first cavity 4 and the second cavity 5, housing 2 material used can be reduced further, thus reduce the cost producing magnetic separator.
Particularly, as shown in Figure 9, housing 2 is provided with the baffle plate 7 for one end of shutoff cavity.The shape of this baffle plate 7 can match with the cross section profile of cavity, when installing this baffle plate 7, can directly baffle plate 7 be fixed on the inwall of cavity, when magnet 1 stretches in the first cavity 4 or the second cavity 5, this baffle plate 7 can play spacing effect, prevents magnet 1 from skidding off in the first cavity 4 or the second cavity 5.
Particularly, as shown in Figure 7, Figure 8 and Figure 9, the baffle plate 7 of the infall of the first cavity 4 and the second cavity 5 is provided with iron plate 8, two support plates 3 being positioned at the second cavity 5 are respectively arranged with iron plate 8.When magnet 1 is positioned at the first cavity 4 or the second cavity 5, this iron plate 8 all can attract with magnet 1, prevent magnet 1 be in use moved or come off, make this magnetic separator can not move because of magnet 1 or come off in use and interrupt operation or make test failure.
Particularly, each support plate 3 is provided with two exhausting holes 6, and two exhausting holes 6 on each support plate 3 lay respectively at the second cavity 5 both sides, and are oppositely arranged with the first cavity 4.This stronger magnetic field range making through hole 6 can be positioned at magnet 1 to provide.
Particularly, as shown in Fig. 3, Fig. 4, Fig. 5 and Fig. 6, this magnet 1 can be cuboid, and the South Pole of magnet 1 and the arctic lay respectively at the maximum face of on magnet 1 two, the i.e. face at length and wide place, when magnet 1 stretches in the first cavity 4 and the second cavity 5, the face at the wide and high place of magnet 1 is against on baffle plate 7, the magnetic field area that such layout can make the first cavity 4 can provide larger, make two support plates 3 can arrange more through hole 6, and multiple through hole 6 all can be subject to stronger magnetic fields.
Particularly, magnet 1 is permanent magnet.Permanent magnet is hard magnetic body, and hard magnetic body can be positioned in cavity compared to soft magnetic bodies more easily, and in addition, permanent magnet can keep the magnet of its magnetic for a long time, and not easily loss of excitation, is also not easily magnetized.
Further, magnet 1 can be neodymium iron boron magnetic body.Neodymium iron boron magnetic body has very strong magnetocrystalline anisotropy and very high saturation magnetization, is more preferably selecting as magnet 1 material.
Further, the outer wall of magnet 1 is coated with protective layer 9.Because neodymium-iron-boron volume property is fragile, easily fracture, and the wedge angle of section is more, so adopt protective layer 9 by coated for magnet 1, prevents magnet 1 from rupturing for the protection of magnet 1.This protective layer 9 can be made of plastics, and thickness can be 1mm.
Further, protective layer 9 can be provided with handle 10.This handle 10 can, so that pull protective layer 9, make the magnet 1 in protective layer 9 to realize easily putting into or extracting action out in cavity.
Particularly, as shown in Figure 7 and Figure 8, the diameter of each exhausting hole 6 on two support plates 3 is different, make multiple through hole 6 can with the centrifuge tube of plurality of specifications with the use of, particularly, the specification of conventional centrifuge tube mostly is 0.2ml, 0.5ml, 1.5ml and 2.0ml, corresponding centrifuge tube capacity is the through hole 6 of 0.2ml, its diameter can be set to 6.5 ± 0.05mm, the spacing of through hole 6 is 2.45 ± 0.05mm, diameter is the through hole 6 that the through hole 6 of 6.5 ± 0.05mm can be arranged side by side eight same diameter, for laying eight unions of 0.2ml × 8; Corresponding centrifuge tube capacity is the through hole 6 of 0.5ml, the diameter of its through hole 6 can be set to 8 ± 0.05mm, the spacing of through hole 6 is 2.45 ± 0.05mm, and this diameter is that the through hole 6 of 8 ± 0.05mm also can be arranged side by side eight (corresponding centrifuge tube capacity is that the through hole 6 of 0.5ml also can place the centrifuge tube that capacity is 0.2ml); Corresponding centrifuge tube capacity is the through hole 6 of 1.5ml and 2.0ml, the diameter of its through hole 6 all can be set to 11.5 ± 0.05mm, the spacing of through hole 6 is 2.45 ± 0.05mm, diameter is that the through hole 6 of 11.5 ± 0.05mm can be arranged side by side six, in addition, support plate 3 also can arrange the through hole 6 of the centrifuge tube can placing 5ml and more than 5ml specification, and the number that through hole 6 specifically sets can adjust according to the size of two support plates 3; Wherein, corresponding centrifuge tube capacity is that the through hole 6 of 1.5ml and 2.0ml can be arranged on same support plate 3, and corresponding centrifuge tube capacity is that the through hole 6 of 0.5ml and 0.2ml can be arranged on another support plate 3.When the through hole 6 on use support plate 3 is tested, another support plate 3 can as base use, thus magnetic separator is placed more firm.
The magnetic separator that the embodiment of the present invention provides, when magnetic bead needs to be adsorbed at the bottom of the pipe of centrifuge tube, magnet is placed in the first cavity, now magnet can provide the magnetic field force perpendicular to support plate, the centrifuge tube that magnetic bead and preextraction liquid are housed is put on the through hole of support plate, magnetic bead can be adsorbed at the bottom of the pipe of centrifuge tube by the attraction of magnet; When magnetic bead needs the tube wall being adsorbed in centrifuge tube, magnet is placed in the second cavity, magnet can provide the magnetic field force being parallel to support plate, make magnetic bead can be adsorbed on the tube wall of centrifuge tube by the attraction of magnet, magnetic separator provided by the invention can provide the magnetic field of both direction, the tube wall making magnetic bead can either be adsorbed on centrifuge tube can be adsorbed on again at the bottom of the pipe of centrifuge tube, and then improves the utilization rate of magnetic separator.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (10)
1. a magnetic separator, be applicable to isolated or purified biomolecule, it is characterized in that, described magnetic separator comprises: magnet (1), with housing (2) and two support plates (3) of cavity, the cross sectional shape of described cavity is cross, described cavity comprises vertically arranged first cavity (4) and the second cavity (5) mutually, two described support plates (3) are arranged in parallel in the relative both sides of described housing (2) and two described support plates (3) are parallel with described first cavity (4), two described support plates (3) are respectively arranged with multiple through hole (6), described magnet (1) is movably set in described first cavity (4) or described second cavity (5), make when described magnet (1) is positioned at described first cavity (4), the magnetic direction that described magnet (1) provides is vertical with two described support plates (3), when described magnet (1) is positioned at described second cavity (5), the magnetic direction that described magnet (1) provides is parallel with two described support plates (3).
2. magnetic separator according to claim 1, is characterized in that, described housing (2) is for cross-shaped configuration and close with the matching form of described first cavity (4) and described second cavity (5).
3. magnetic separator according to claim 1 and 2, is characterized in that, described housing (2) is provided with the baffle plate (7) of the one end for cavity described in shutoff.
4. magnetic separator according to claim 3, it is characterized in that, the described baffle plate (7) of the infall of described first cavity (4) and described second cavity (5) is provided with iron plate (8), two the described support plates (3) being positioned at described second cavity (5) are respectively arranged with iron plate (8).
5. magnetic separator according to claim 1, it is characterized in that, each described support plate (3) is provided with the described through hole of two row (6), the two described through hole of rows (6) on each described support plate (3) lay respectively at described second cavity (5) both sides, and are oppositely arranged with described first cavity (4).
6. magnetic separator according to claim 5, is characterized in that, described magnet (1) is cuboid, and the South Pole of described magnet (1) and the arctic lay respectively at two the maximum faces on described magnet (1).
7. magnetic separator according to claim 6, is characterized in that, described magnet (1) is neodymium iron boron magnetic body.
8. magnetic separator according to claim 7, is characterized in that, the outer wall of described magnet (1) is coated with protective layer (9).
9. magnetic separator according to claim 8, is characterized in that, one end of described protective layer (9) is provided with handle (10).
10. magnetic separator according to claim 5, is characterized in that, the diameter of the described through hole of each row (6) on two described support plates (3) is different.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420423965.7U CN204074254U (en) | 2014-07-29 | 2014-07-29 | A kind of magnetic separator |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420423965.7U CN204074254U (en) | 2014-07-29 | 2014-07-29 | A kind of magnetic separator |
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| CN204074254U true CN204074254U (en) | 2015-01-07 |
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| CN201420423965.7U Active CN204074254U (en) | 2014-07-29 | 2014-07-29 | A kind of magnetic separator |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109311023A (en) * | 2016-04-22 | 2019-02-05 | 普渡研究基金会 | High-throughput particle capture and analysis |
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2014
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109311023A (en) * | 2016-04-22 | 2019-02-05 | 普渡研究基金会 | High-throughput particle capture and analysis |
| CN109311023B (en) * | 2016-04-22 | 2021-11-26 | 普渡研究基金会 | High throughput particle capture and analysis |
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