CN204039542U - Multi-functional volatilization crystallizer - Google Patents
Multi-functional volatilization crystallizer Download PDFInfo
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- CN204039542U CN204039542U CN201420444653.4U CN201420444653U CN204039542U CN 204039542 U CN204039542 U CN 204039542U CN 201420444653 U CN201420444653 U CN 201420444653U CN 204039542 U CN204039542 U CN 204039542U
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Abstract
The utility model relates to a kind of multi-functional volatilization crystallizer, belongs to crystallising apparatus field, and this device can carry out control speed control temperature volatilization crystallization, the temperature diffusion crystallization of control speed control and crystallisation by cooling.Described multi-functional volatilization crystallizer comprises two sample hoses and the outside container that can connect temperature control water pump that are connected by tubule.Wherein, two sample hoses all have screw-cap, and the screw-cap of the higher sample hose in position has the valve of controllable bore diameter.Two sample hoses are connected by tubule, tubule have the valve of controllable bore diameter.The utility model is applicable to volatilization and diffusion way carries out single crystal cultivation, is especially applicable to the volatilization crystallization of highly volatile solvent, has simple to operate, crystal and is easily separated, and is easy to clean and reusable advantage.
Description
Technical field
The utility model relates to the crystallization apparatus of a kind of volatilization, diffusion and cooling three, especially a kind of crystallizer carrying out single crystal cultivation by controlling solvent evaporates speed, solvent diffusion speed and Tc.
Background technology
At present, single crystal cultivation realizes mainly through volatilization crystallization, diffusion crystallization and crystallisation by cooling three kinds of modes.
In the single crystal cultivation process of routine, volatilization crystallization, diffusion crystallization and crystallisation by cooling all have respective experiment porch, when carrying out high-throughout culture experiment, need a large amount of spaces, and instrument is placed and arranged these devices.
Use conventional equipment to be mostly disposable test bottle during single crystal cultivation, tested rear little recovery and cleaning, caused waste.
Conventional volatilization crystallization and diffusion crystallization have very large randomness on crystallization velocity controls, and are easy to cause the crystal grown to have irregular, incomplete profile.
Therefore, need to develop a kind of new crystallization apparatus that can change above-mentioned defect.
Utility model content
In order to overcome the deficiency of existing conventional crystallization device, the utility model provides the crystallization apparatus of a kind of volatilization, diffusion and cooling three, the different parts that this device passes through to control can realize three kinds of different crystallization modes, and whole crystallisation process can be monitored in real time and regulate.Carrying out multiple culture experiment for needing, high-throughput cultivation can be carried out very easily.
The utility model solves the technical scheme that its technical problem adopts: a kind of controllable type volatilization, diffusion and cooling three crystallizers, it comprises the container D that sample hose A and B that connected by tubule C and outside can connect temperature control water pump, sample hose A and B has difference of height, all have screw-cap, the screw-cap of sample hose B has the valve of controllable bore diameter.Sample hose A with B is connected by tubule C, and tubule C has the valve of controllable bore diameter.Container D to be connected with outside temperature control water pump by two interfaces and to circulate.
According to the difference of crystallization mode, there is following several method:
1, volatilization crystallization, appropriate amount of sample solution is added in pipe A, sample solution height can not exceed tubule C, sealed tube A, opens pipe B screw-cap valve, is connected by container D with temperature control water pump, it is down water-in, upper is water outlet, controls volatilization Tc by water pump, regulates tubule C valve apertures size to control volatilization crystallization velocity and carries out control speed control temperature volatilization crystallization.
2, crystallization is spread, add in pipe A and spread solvent in right amount, appropriate amount of sample solution is added in pipe B, solvent and solution height can not exceed tubule C, and sealed tube A and pipe B, is connected container D with temperature control water pump, it is down water-in, upper is water outlet, controls diffusion Tc by water pump, regulates tubule C valve apertures size to carry out control speed control temperature diffusion crystallization.
3, crystallisation by cooling, adds appropriate amount of sample solution in pipe A, and sample solution height can not exceed tubule C, and sealed tube A and pipe B, is connected container D with temperature control water pump, and lower is water-in, is above water outlet, carries out crystallisation by cooling by water pump crystallization control temperature.
In culturing process, when strength of solution is higher than supersaturation district higher limit, has crystal and occur, after there is crystal, by by-pass valve control aperture or the further crystallization control speed of temperature, make crystal continue growth and reach suitable size.
Compared with the crystallization apparatus of routine, the beneficial effects of the utility model are:
1, the utility model crystallization apparatus integrates volatilization, diffusion and cooling three kinds of functions, has better practicality.
2, adopt band valve tubule to connect, possess the real-time monitoring of volatilization and diffusion crystallization experiments and the function of adjustment.
3, by changing the volume of temperature controlled container, high-throughout temperature control control speed single crystal cultivation can be realized.
Accompanying drawing explanation
Fig. 1 is device schematic diagram of the present utility model.
Fig. 2 is the compound L YP007 crystal using apparatus of the present invention volatilization crystallization to obtain in embodiment 1.
Fig. 3 is the compound L YP007 crystal using conventional containers to obtain.
Fig. 4 is the compound L YP007 crystal using apparatus of the present invention diffusion crystallization to obtain in embodiment 2.
Fig. 5 is the compound L YP506 crystal using apparatus of the present invention crystallisation by cooling to obtain in embodiment 3.
Fig. 6 is the compound L YP506 crystal using conventional containers to obtain.
The long sample hose of the threaded lid of A. in figure, B. is containing the short sample hose (lid is equipped with valve) of thread cap, and C. connects the tubule (valve is housed) of A pipe and B pipe, and D. fills circulating water container (there is recirculated water interface on side).
Embodiment
embodiment 1
Volatilization crystallization: open A gas thread lid, add the compound L YP007 acetonitrile solution that 1mL concentration is 7mg/mL, cover A gas thread lid, open valve on tubule C and B pipe, container D external tapping connects recirculated water, bottom in and top out, water temperature controls at 40 DEG C, volatilize, obtain compound L YP007 crystal after the dry solvent that volatilizees, as shown in Figure 2.The compound L YP007 crystal that conventional containers obtains as shown in Figure 3.
embodiment 2
Diffusion crystallization: open A gas thread lid, add 3mL ethanol, open B gas thread lid, the concentration adding 0.5mL is the compound L YP007 acetonitrile solution of 7mg/mL, sealing AB two manages.Open tubule C, container D external tapping connects recirculated water, and bottom in and top out, water temperature controls, at 40 DEG C, to spread, and obtains LYP007 crystal, as shown in Figure 4 after 7 days.
The monocrystalline adopting apparatus of the present invention to obtain in embodiment 1 and embodiment 2 has more regular pattern than the monocrystalline that conventional containers obtains.
embodiment 3
Crystallisation by cooling: open A gas thread lid, add 1.1 g of compound LYP506 and 1mL water, sealing AB two manages, and closes tubule C, container D external tapping connects recirculated water, water temperature rises to 70 DEG C, compound dissolution, by external water circulating pump, bottom in and top out, be cooled to 30 DEG C according to the cooling rates of 2 DEG C per hour, obtain LYP506 crystal, as shown in Figure 5.The LYP506 crystal that conventional containers obtains as shown in Figure 6.
The monocrystalline pattern that the monocrystalline adopting apparatus of the present invention to obtain in embodiment 3 obtains than conventional containers is more regular, and particle is larger.
It is apparent to one skilled in the art that the utility model can change into various ways, such change do not think depart from scope of the present utility model.All like this to the apparent amendment of the technician in described field, by be included in this claim scope within.
Claims (5)
1. a multi-functional volatilization crystallizer, is characterized in that: comprise two sample hoses connected by tubule, and outside can connect the container of temperature control water pump.
2. multi-functional volatilization crystallizer according to claim 1, is characterized in that: the position of two sample hoses has difference of height.
3. multi-functional volatilization crystallizer according to claim 1 and 2, is characterized in that: two sample hoses all have screw-cap, and the screw-cap of the higher sample hose in position has the valve of controllable bore diameter.
4. multi-functional volatilization crystallizer according to claim 1 and 2, is characterized in that: two sample hoses are connected by tubule, tubule have the valve of controllable bore diameter.
5. multi-functional volatilization crystallizer according to claim 1 and 2, is characterized in that: container to be connected with outside temperature control water pump by two interfaces and to circulate, and the level height of water outlet mouthpiece is not higher than the bottom of the higher sample hose in position.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420444653.4U CN204039542U (en) | 2014-08-07 | 2014-08-07 | Multi-functional volatilization crystallizer |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420444653.4U CN204039542U (en) | 2014-08-07 | 2014-08-07 | Multi-functional volatilization crystallizer |
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| CN204039542U true CN204039542U (en) | 2014-12-24 |
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| CN201420444653.4U Active CN204039542U (en) | 2014-08-07 | 2014-08-07 | Multi-functional volatilization crystallizer |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110655489A (en) * | 2019-11-11 | 2020-01-07 | 安徽瑞邦生物科技有限公司 | Method for purifying 4-cyanopyridine by volatilization and recrystallization |
-
2014
- 2014-08-07 CN CN201420444653.4U patent/CN204039542U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110655489A (en) * | 2019-11-11 | 2020-01-07 | 安徽瑞邦生物科技有限公司 | Method for purifying 4-cyanopyridine by volatilization and recrystallization |
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