CN203988470U - Radiation biological experiment blade inserting fixed support - Google Patents
Radiation biological experiment blade inserting fixed support Download PDFInfo
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- CN203988470U CN203988470U CN201420405468.4U CN201420405468U CN203988470U CN 203988470 U CN203988470 U CN 203988470U CN 201420405468 U CN201420405468 U CN 201420405468U CN 203988470 U CN203988470 U CN 203988470U
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- handle
- groove
- tongue
- chamber
- tongue bar
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- 238000002474 experimental method Methods 0.000 title claims abstract description 29
- 230000005855 radiation Effects 0.000 title claims abstract description 12
- 208000031481 Pathologic Constriction Diseases 0.000 claims abstract description 8
- 238000013461 design Methods 0.000 claims abstract description 8
- 210000001215 vagina Anatomy 0.000 claims abstract description 8
- 210000001364 upper extremity Anatomy 0.000 claims description 2
- 238000011580 nude mouse model Methods 0.000 abstract description 29
- 241000699660 Mus musculus Species 0.000 abstract description 27
- 241000699666 Mus <mouse, genus> Species 0.000 abstract description 21
- 230000007613 environmental effect Effects 0.000 abstract description 3
- 238000012360 testing method Methods 0.000 description 9
- 206010028980 Neoplasm Diseases 0.000 description 8
- 238000000034 method Methods 0.000 description 7
- 230000000694 effects Effects 0.000 description 6
- 230000001954 sterilising effect Effects 0.000 description 5
- 241001465754 Metazoa Species 0.000 description 4
- 238000004659 sterilization and disinfection Methods 0.000 description 4
- 238000006073 displacement reaction Methods 0.000 description 3
- 229920000742 Cotton Polymers 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 230000001678 irradiating effect Effects 0.000 description 2
- 206010002091 Anaesthesia Diseases 0.000 description 1
- 206010002660 Anoxia Diseases 0.000 description 1
- 241000976983 Anoxia Species 0.000 description 1
- 206010003497 Asphyxia Diseases 0.000 description 1
- 206010017533 Fungal infection Diseases 0.000 description 1
- 240000004859 Gamochaeta purpurea Species 0.000 description 1
- 206010021143 Hypoxia Diseases 0.000 description 1
- 208000031888 Mycoses Diseases 0.000 description 1
- 210000001744 T-lymphocyte Anatomy 0.000 description 1
- 241000053227 Themus Species 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000007953 anoxia Effects 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000003670 easy-to-clean Effects 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 231100000518 lethal Toxicity 0.000 description 1
- 230000001665 lethal effect Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 210000003141 lower extremity Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 238000001959 radiotherapy Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
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- Prostheses (AREA)
Abstract
The utility model discloses a kind of radiation biological experiment blade inserting fixed support, formed by support mainboard, Mus rhynchodaenm hole, stent foot locking structure, covering, groove, chamber, the fixing bayonet socket of shank, bitt and friction stricture of vagina; This structure adopts that fixing chamber is spacing, the principle of fixed hurdle grid resistance gear, acra split, will realize respectively braking, stop and the function of location, and the contrast that is applicable to long 5 ~ 7CM children Mus of many bodies (nude mice) etc. is irradiated and tested.This utility model is reasonable in design, simple in structure, makes easily, and meet nude mice completely and irradiate primary condition, easy to operate, safety, environmental protection, practicality and versatility are all stronger, are a kind of experiment of nude mice radiation exposure efficiently fixed supports.
Description
Technical field
This utility model belongs to experiment appliance.Relate to a kind of experimental mouse fixed mount, relate in particular to a kind of radiation biological experiment blade inserting fixed support.
background technology
Radiation oncology subject high speed development in recent years, the also fast development of associated basic and clinic studies.General, the checking of radiation biological result needs biology (animal) experiment to confirm.Modal is the experimentation of being undertaken by setting up animal model for tumour, i.e. experimenter's acral certain tumor model of setting up of animal of being everlasting, and at clinical and experimental study of the enterprising line correlation of this tumor model etc.In experiment, animal is fixedly a fixing difficult problem especially for problem, especially a meiofauna.And be a blank for the research of animal radiation auxiliary device both at home and abroad always.The irradiation experiment of common large and small Mus requires lower to environment, Mus state etc., our many employings mode more directly perceived, original, rough, as long as can reach the fixing means of requirement of experiment, generally can implement.The class experiment that nude mice etc. are had relatively high expectations to experimental situation, also lacks relevant Special experimental utensil.Test inevasible exist time-consuming, take a lot of work, the series of problems such as error is large.
Nude mice claims again nude mouse, principal character shows as without hair (Hairless), nude (Nacked) and athymism (Athymus), be widely used in immunobiology, immunopathology, transplantation immunity, tumour immunity, virus and bacterial immune by etc. the experimentation in field.Nude mice, owing to lacking T cell, is subject to the infringement of antibacterial, virus and fungal infection, if contacted with external environment, only has minority Mus can survive one month.In nude mice tumor model radiotherapy experiment, often for the nude mice time-to-live under different experiments scheme relatively, and require nude mice long-term surviving after radiation exposure.So nude mice, before experiment, in experiment, all lives in an aseptic environment requiring after experiment.
For experimental mouse physiological characteristics and experimental technique requirement, the conventional irradiation of muroid need to meet following basic demand simultaneously: 1. omnidistance position is fixed, repeatability; 2. experimental mouse keeps Consciousness, forbids to use spiritual inhibition and nerve anesthesia medicine; Nude mice also requires omnidistance gnotobasis meeting outside above-mentioned condition.
For example: the conventional method that nude mice tumor model irradiates is test tube method and plumbous box method, and concrete grammar is described below:
1. get a test tube of having sterilized, the nude mice of having numbered is filled in wherein with tweezers according to personal experience's skill is free-hand, head is advanced, fixes its activity with Cotton Gossypii, expose the long hind leg that has a tumor tissues or palmula (being tumor model) outside test tube, whole process must not note and injured Mus body;
2. ready experiment of nude mouse model is placed in to a box that sterilized, airtight (as transfer container), and arrives and irradiate machine room by it;
3. sterilization machine room and machine;
4. take out test tube and be positioned in irradiation field, and manage fixing test tube in case the test tube displacement that nude mice activity causes;
5. it is complete that .6. irradiation is irradiated in last start, sends sterilizing room back to, treats later analysis comparison.As need hyperfractionated (repeatedly) to irradiate, repeat above process.
The deficiency and the defect that exist:
1. experimental implementation (fixing Mus process) complexity, requires great effort time-consuming;
2. versatility is not high, and the Mus body of number of the same age need not used different test tubes or different plumbous box customized instead;
3. Mus degree of fixation is poor, has activity and displacement in experiment;
4. the wild time-consuming complexity of cloth, position, target area uncertain (according to fixed position, size need be adjusted at any time);
5. experimental procedure is various, needs the link of sterilization to increase, and aseptic degree is not good enough, greatly increases with extraneous touch opportunity, and danger coefficient increases;
6.(and be combined with the contrast of fixed case of this structure of equipment) be directly exposed in outside air while irradiating, do not reach the basic demand of experiment;
7. Mus survival rate is low, and the control of Mus solid mechanical strength does not slightly note easily injuring Mus body, and contact the easy death of external environment or anoxia asphyxia lethal;
The plumbous box method of 8.() cost of manufacture is high, has environmental pollution, not environmental protection;
9. repeatability is not high;
10. be unfavorable for protecting normal structure, unshielded existence.
summary of the invention
The purpose of this utility model is to overcome the deficiency that prior art exists, a kind of radiation biological experiment blade inserting fixed support is provided, the fixing chamber of this structure employing is spacing, fixed hurdle grid resistance keeps off, the principle of acra split, the function that will realize respectively braking, stops and locate.Experiment is irradiated in the contrast that is applicable to long 5 ~ 7CM children Mus of many bodies (nude mice) etc.
The purpose of this utility model is achieved through the following technical solutions: a kind of radiation biological experiment blade inserting fixed support, is made up of support mainboard, Mus rhynchodaenm hole, stent foot locking structure, covering, groove, chamber, the fixing bayonet socket of shank, bitt and friction stricture of vagina; Chamber is placed on support mainboard, chamber antetheca is provided with a Mus rhynchodaenm hole, chamber left and right wall upper limb is provided with groove, cover inserted sheet and insert groove, take out by drawing the capping that realizes chamber, the fixing bayonet socket of shank is positioned at chamber rear wall, with the fixing bayonet socket of shank corresponding position, bitt is set, bitt is provided with friction stricture of vagina, and support mainboard both sides are provided with support locking structure.
Described stent foot locking structure is by handle, and handle post, embeds post, left dead bolt, and right dead bolt composition, handle post is arranged on support mainboard, and end is connected with embedding post, and the top of two handle posts is connected by a handle; In handle post, traveling has tongue roofbolt, and in tongue roofbolt, traveling has push rod groove and tongue bar groove; The bottom design of tongue bar groove has two relative wedge portion spring, tops that tongue bar axle is installed; Traveling has two tongue bars in tongue bar groove, after tongue bar is sent by tongue bar axle along the cell wall traveling of tongue bar and be free on the lower ending opening that embeds post; Tongue bar is designed with wedge portion, and corresponding with wedge portion spring, tongue bar end connects left dead bolt and right dead bolt; In the middle of two wedge portions, accompany and push the ball; Top is provided with and pushes away seat in push rod groove, pushes away a top and is connected with and pushes away a spring; In handle, be provided with gangbar and be connected, push away a sidepiece and be connected with gangbar; Handle bottom surface opening, is provided with unlock button, and unlock button is connected with gangbar.
The beneficial effects of the utility model are: this utility model has designed the chamber of independent placement, be suitable for little (naked) Mus of any figure between 3 weeks to 8 weeks, use and irradiate in conjunction with fixed case, can be completely achieved the ingenious fixing of He Shouzhao position, sterile working, and ensured the clear-headed and existing state of nude mice.This utility model can be fixed simultaneously and irradiate many nude mices, is more convenient to contrast, also makes to test concrete operations time shorten and heavy dose of application, has avoided nude mice to be infected in external environment condition and has been subject to the displacement according to position; Entirety is used transparent pmma material to make, and operates and observe simple and clear, is easy to clean and sterilization.This utility model is reasonable in design, simple in structure, makes easily, and meet nude mice completely and irradiate primary condition, easy to operate, safety, environmental protection, practicality and versatility are all stronger, are a kind of experiment of nude mice radiation exposure efficiently fixed supports.
Brief description of the drawings
Fig. 1 is this utility model structural representation;
Fig. 2,3,4,5, the 6th, stent foot locking structure schematic diagram;
In figure, stent foot locking structure 103, emulsion sheet 133, groove 134, chamber 135, shank is fixed bayonet socket 136, bitt 137, friction stricture of vagina 138, support mainboard 18, unlock button 19, handle 23, handle post 24, ring is face 25 only, embed post 26, left dead bolt 27, right dead bolt 28, wedge portion spring 29, wedge portion 32, tongue bar groove 33, tongue bar 34, push rod 35, push the ball 36, push rod groove 37, tongue roofbolt 38, spacing hole 39, fixing base 40, gangbar 41, push away a spring 42, tongue bar axle 43, push away seat 44, Mus rhynchodaenm hole 74, I upper end, II lower end, III near-end, IV far-end.
Detailed description of the invention
This utility model is further described by reference to the accompanying drawings.
Embodiment 1, a kind of radiation biological experiment blade inserting fixed support.
With reference to Fig. 1, this utility model is made up of support mainboard 18, Mus rhynchodaenm hole 74, stent foot locking structure 103, covering 133, groove 134, chamber 135, the fixing bayonet socket 136 of shank, bitt 137 and friction stricture of vagina 138.Five chambers 135 independently in one line are set on support mainboard 18, and its size is just applicable to little (naked) Mus of any figure between 3 weeks to 8 weeks.The chamber 135 complete openings in top, draw to take out with the groove 134 that a covering inserted sheet 133 passes through and realize capping.Chamber 2 antethecas arrange the nude mice rhynchodaenm hole 74 of a 1.5CM diameter, and it act as nude mice rhynchodaenm by this hole and outside exchange respiratory.The chamber 135 rear wall right side 1/3rd disappearances, form strip space and be called the fixing bayonet socket 136 of shank, just admit stretching out of a nude mice back leg, corresponding with the fixing bayonet socket 136 of shank is the bitt 137 of fixing nude mice back leg, pillar surface is provided with friction stricture of vagina 138, nude mice back leg, is stretched out and is fixed on bitt 137 from the fixing bayonet socket 136 of shank tractive by a common process sterilization cotton cord, makes it become all the time straight state.Consider the individual variation of experiment nude mice and adapt to the versatility of section in each in age, the distance that each bitt 137 is fixed bayonet socket 136 to corresponding shank is set as 5CM.Therefore the corresponding bitt 137 of this row and shank fixing bayonet socket 136 has formed the territory, rectangle target area of irradiation that width is 5CM.
With reference to Fig. 2,3,4,5 and 6.The place that keeps to the side, the both sides that 103 stent foot locking structures are positioned at 18 support mainboards, in order to be fixed on the spacing hole 39 of the fixing base 40 in fixed case interior on.Be made up of handle 23, handle post 24, embedding post 26, left dead bolt 27, right dead bolt 28, handle post 24 is arranged on support mainboard 18, and end is connected with embedding post 26, and the top of two handle posts 24 is connected by a handle 23; Embedding post is to embed in the spacing hole 39 of fixing base 40 in use, realizes the spacing activity on two-dimensional directional all around; Because the diameter that embeds post 26 is less than handle post 24, the contact surface that its diameter is greater than part has formed only face 25 of ring, and the ring only effect of face 25 is to prevent from embedding post 26 unrestrictedly to glide, and realizes D score single direction spacing; The interior traveling of handle post 24 has tongue roofbolt 38, and the interior traveling of tongue roofbolt 38 has push rod groove 37 and tongue bar groove 33; The bottom design of tongue bar groove 33 has two relative wedge portion spring 29, tops that tongue bar axle 43 is installed; The 33 interior travelings of tongue bar groove have two tongue bars 34, after tongue bar 34 is sent by tongue bar axle 43 along the 33 wall travelings of tongue bar groove and be free on and embed the lower ending opening of post 26; Tongue bar 34 is designed with wedge portion 32, and corresponding with wedge portion spring 29, two tongue bar 34 ends connect respectively left dead bolt 27 and right dead bolt 28; Wedge portion spring 29 force in two wedge portions 32, two tongue bars 34 are drawn close mutually, namely realized drawing close of left dead bolt 27 and right dead bolt 28.In the middle of two wedge portions 32, accompany and push the ball 36; The interior top of push rod groove 37 is provided with and pushes away seat 44, pushes away seat 44 tops and is connected with and pushes away a spring 42; In handle 23, be provided with gangbar and be connected 41, push away seat 44 sidepieces and be connected with gangbar 41; Handle 23 bottom surface openings, are provided with unlock button 19, and unlock button 19 is connected with gangbar 41.Push away forcing in of a spring 42 push away seat 44, the push rod 35 of indirectly having an effect, finally make to push the ball 36 have continue downward strength.The strength that mechanism design pushes away a spring 42 is greater than all the time wedge portion spring 29 and is decomposed to form elastic force upwards in wedge portion 32, namely pushes the ball 36 in the situation that there is no other external force, is lower end in wedge portion 32 all the time.So, left dead bolt 27 now and right dead bolt 28 have completed locking---the upward direction in last direction, realize latch functions.While needing release: by apply power (grip of common people's palm) upwards on unlock button 19, when the downward elastic force that pushes away a spring 42 is reduced to the elastic force upwards that is less than that wedge portion spring 29 is decomposed to form in wedge portion 32, push the ball and 36 be pushed to, tongue bar 34 is drawn close mutually, final left dead bolt 27 and right dead bolt 28 are drawn close, and realize release.
Bitt 137 and shank fixing bayonet socket 136 has formed the territory, rectangle target area of irradiation that width is 5CM and has combined stent foot locking structure 103, and the projection open country of this irradiated region on fixed case also become fixing position.Such design does not just again need for determining that target area has made a great fuss in the time irradiating, and is very easy to design launched field.Protect the normal structures such as nude mice breast abdominal part and brain simultaneously, improved target dose.
Claims (2)
1. a radiation biological experiment blade inserting fixed support, it is characterized in that, formed by support mainboard (18), Mus rhynchodaenm hole (74), stent foot locking structure (103), covering (133), groove (134), chamber (135), the fixing bayonet socket (136) of shank, bitt (137) and friction stricture of vagina (138); Chamber (135) is placed on support mainboard (18), chamber (135) antetheca is provided with Mus rhynchodaenm hole (74), chamber (135) left and right wall upper limb is provided with groove (134), cover inserted sheet (133) and insert groove (134), shank is fixed bayonet socket (136) and is positioned at chamber (135) rear wall, with the fixing bayonet socket (136) of shank corresponding position, bitt (137) is set, bitt (137) is provided with friction stricture of vagina (138), and support mainboard (18) both sides are provided with support locking structure (103).
2. a kind of radiation biological experiment blade inserting fixed support according to claim 1, it is characterized in that, described stent foot locking structure (103) is made up of handle (23), handle post (24), embedding post (26), left dead bolt (27), right dead bolt (28), handle post (24) is arranged on support mainboard (18), end is connected with embedding post (26), and the top of two handle posts (24) is connected by a handle (23); The interior traveling of handle post (24) has tongue roofbolt (38), and the interior traveling of tongue roofbolt (38) has push rod groove (37) and tongue bar groove (33); The bottom design of tongue bar groove (33) has two relative wedge portion spring (29), tops that tongue bar axle (43) is installed; The interior traveling of tongue bar groove (33) has two tongue bars (34), after tongue bar (34) is sent by tongue bar axle (43) along tongue bar groove (33) wall traveling and be free on embed post (26) lower ending opening; Tongue bar (34) is designed with wedge portion (32), corresponding with wedge portion spring (29), and tongue bar (34) end connects left dead bolt (27) and right dead bolt (28); In the middle of two wedge portions (32), accompany push the ball (36); The interior top of push rod groove (37) is provided with and pushes away seat (44), pushes away seat (44) top and is connected with and pushes away a spring (42); In handle (23), be provided with gangbar and be connected (41), push away seat (44) sidepiece and be connected with gangbar (41); Handle (23) bottom surface opening, is provided with unlock button (19), and unlock button (19) is connected with gangbar (41).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420405468.4U CN203988470U (en) | 2014-07-23 | 2014-07-23 | Radiation biological experiment blade inserting fixed support |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420405468.4U CN203988470U (en) | 2014-07-23 | 2014-07-23 | Radiation biological experiment blade inserting fixed support |
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| Publication Number | Publication Date |
|---|---|
| CN203988470U true CN203988470U (en) | 2014-12-10 |
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| CN201420405468.4U Expired - Fee Related CN203988470U (en) | 2014-07-23 | 2014-07-23 | Radiation biological experiment blade inserting fixed support |
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| Country | Link |
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| CN (1) | CN203988470U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110074891A (en) * | 2018-01-25 | 2019-08-02 | 中国辐射防护研究院 | Irradiation test rat fixing device |
-
2014
- 2014-07-23 CN CN201420405468.4U patent/CN203988470U/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110074891A (en) * | 2018-01-25 | 2019-08-02 | 中国辐射防护研究院 | Irradiation test rat fixing device |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20141210 |
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| CF01 | Termination of patent right due to non-payment of annual fee |