CN203988473U - Radiation biological experiment acra clamping position structure - Google Patents

Abstract

The utility model discloses a clamping and positioning structure for an extremity in a radiation biology experiment. , right crescent, two crescent shafts, shrink groove, shrink base, shrink spring, shrink main handle, two handle shafts, positioning base, clamp spring, positioning handle and shrink jacket Composition; the functions of clamping and positioning are respectively realized through the pressing and gathering of the clip body and the blocked positioning of the teeth; the utility model realizes the positioning and fixing of the irradiated part, making it possible to operate all the preparatory work in the aseptic room . The utility model has the advantages of reasonable design, convenient operation, safety, environmental protection, obvious fixing effect, strong practicability and versatility, and is an efficient accessory of a fixing device for animal irradiation experiments.

Description

Limb clamping and positioning structure for radiation biology experiment

technical field

The utility model relates to an accessory of an experimental appliance, in particular to an accessory of a small-sized limb biological experiment fixing device.

Background technique

The subject of radiation oncology has developed rapidly in recent years, and the related basic and clinical research has also developed rapidly. Generally, the verification of radiobiological results needs to be confirmed by biological (animal) experiments. The most common is experimental research on tumor animal models. That is to say, experimenters often establish a tumor model at the end of the animal's limbs, and conduct relevant clinical experimental research on this model. Immobilization of experimental animals (mice) is a difficult problem in animal experiments, especially in radiotherapy. Moreover, the research on animal radiation auxiliary devices has always been a blank both at home and abroad. Irradiation experiments on ordinary rats and mice have relatively low requirements on the environment and mouse state. We mostly use more intuitive, primitive, and rough methods. As long as the fixed method can meet the experimental requirements, it can generally be implemented. The nude mouse experiment, which requires a high experimental environment, also lacks relevant special experimental equipment, and the experiment inevitably has a series of problems such as time-consuming, labor-intensive, and large errors.

According to the physiological characteristics of experimental mice and the technical requirements of the experiment, the routine irradiation of mice needs to meet the following basic requirements at the same time: 1. The position is fixed throughout the whole process, and repeatability; 2. The experimental nude mice are kept awake, and the use of neuroleptic and neuronarcotic drugs is strictly prohibited ; Nude mice also require a sterile environment throughout.

For example: The conventional methods for irradiation of tumor models in nude mice are the test tube method and the lead box method. The specific methods are as follows:

1. Take a sterilized test tube, stuff the numbered nude mice into it with tweezers according to personal experience and skills, head first, fix its activities with cotton, and expose the hind limbs or paw pads with tumor tissue (that is, the tumor model ) outside the test tube, the whole process should be careful not to harm the mouse body;

2. Place the prepared nude mouse experimental model in a sterilized, airtight box (as a transfer container), and pass it to the irradiation room;

3. Disinfect the computer room and machines;

4. Take out the test tube and place it in the irradiation field, and try to fix the test tube to prevent the displacement of the test tube caused by the activity of nude mice;

5. Finally turn on the camera for irradiation;

6. After the irradiation is completed, send it back to the sterile room for analysis and comparison in the future. For hyperfractionated (multiple) irradiation, repeat the above process.

There are the following deficiencies and defects: the experimental operation (the process of fixing the mouse) is complicated, laborious and time-consuming; the versatility is not high, and the mice of different ages need to be replaced with different test tubes or different lead boxes; Movement and displacement; field deployment is time-consuming and complicated, and the position of the target area is uncertain (according to the fixed position, the size needs to be adjusted at any time); there are many experimental steps, more links need to be disinfected, the degree of sterility is not good, the chance of contact with the outside world is greatly increased, and the risk factor Rats are exposed directly to the outside air during irradiation, which does not meet the basic requirements of the experiment; the survival rate of rats is low, and a little carelessness in the control of rat fixed mechanical force can easily injure the rat body, and it is easy to die or die from hypoxia and suffocation when exposed to the external environment; ( Lead box method) has high production cost, environmental pollution, and is not environmentally friendly; the reproducibility is not high; it is not conducive to the protection of normal tissues.

Contents of the invention

The purpose of the utility model is to overcome the deficiencies in the prior art and provide a clamping and positioning structure for the extremities of radiobiological experiments. Function.

The purpose of this utility model is achieved through the following technical solutions. A clamping and positioning structure for the extremities of radiation biology experiments is composed of positioning slots, positioning springs, wedge-shaped positioning teeth, positioning guide rails, and positioning shrinking clip structures. , the positioning clamp structure consists of a left crescent clamp, a right crescent clamp, two crescent clamp shafts, a clamp groove, a clamp base, a clamp spring, a clamp main handle, two clamp shafts, a positioning base, and a clamp handle Composed of a spring, a positioning clamp handle and a shrinking clamp jacket; the positioning guide rail shown has a positioning slot; the wedge-shaped positioning teeth are equidistantly distributed on the inner wall of one side of the positioning slot; the wedge-shaped positioning teeth have thick and thin heads The thick head faces the far end; the positioning spring is placed in the positioning card slot, one end of which is fixed at the far end of the positioning card slot, and the other end is connected to the positioning base of the positioning clamp structure; the positioning clamp handle and the clamp main handle pass through The respective clamp handle shafts are fixed on the positioning base, and a clamp spring is arranged between the positioning clamp handle and the main handle of the shrink clamp; A shrinking clip spring is built in the groove, and the upper end of the shrinking clip spring is connected with the shrinking clip base; the left crescent clip and the right crescent clip are connected to the shrinking clip base through respective crescent clip shafts.

The beneficial effects of the utility model are: the utility model realizes the positioning and fixing of the irradiated parts, and makes it possible to operate all the preparatory work in the aseptic room. The utility model has the advantages of reasonable design, convenient operation, safety, environmental protection, obvious fixing effect, strong practicability and versatility, and is an efficient accessory of a fixing device for animal irradiation experiments.

Description of drawings

Fig. 1 is a structural representation of the utility model;

Fig. 2 is a schematic diagram of the structure of the positioning and shrinking clamp of the utility model;

Among the figure, positioning card slot 57, positioning spring 58, wedge-shaped positioning latch 59, positioning guide rail 60, positioning shrinking clip structure 104, left crescent clip 45, right crescent clip 46, crescent clip shaft 47, shrinking clip groove 48, shrinking clip Clamping base 49, clamping spring 50, clamping main handle 51, clamping handle shaft 52, positioning base 53, clamping handle spring 54, positioning clamping handle 55, clamping sleeve 56, upper end I, lower end II, proximal end III , Distal IV.

Detailed ways

Below in conjunction with accompanying drawing, the utility model is described in further detail.

As shown in Figures 1 and 2, the clamping and positioning structure of the extremity of the radiation biology experiment of the present utility model is composed of a positioning slot 57, a positioning spring 58, a wedge-shaped positioning latch 59, a positioning guide rail 60, and a positioning locking clip structure 104. , the positioning clamping structure 104 consists of a left crescent clamp 45, a right crescent clamp 46, two crescent clamp shafts 47, a clamping groove 48, a clamping base 49, a clamping spring 50, a main handle 51 of the clamping clamp, and two clamping handles The shaft 52, the positioning base 53, the clamping handle spring 54, the positioning clamping handle 55 and the shrinking clamp jacket 56 are composed; the positioning guide rail 60 is provided with a positioning card slot 57; the positioning card slot 57 is divided into upper and lower layers, and the upper layer presents a "V" on the left and right font, for the positioning clamp handle 55 to freely position and slide; the lower layer accommodates the positioning base 53, for the positioning base 53 to slide freely. There are wedge-shaped positioning teeth 59 equidistantly distributed on the side inner wall of the upper layer of the positioning groove 57, and the wedge-shaped positioning teeth 59 have thick and thin heads, and the thick head faces the far end; this design facilitates the clamping Fixed one-way positioning of the target, and the sense of positioning is clear. The positioning spring 58 is placed in the positioning slot 57, one end of which is connected to the far end of the positioning slot 57, and the other end is connected to the positioning base 53 of the positioning locking clip structure 104. The force direction of this spring is from the distal end to the proximal end, So that the positioning base 53 is always in the wedge-shaped positioning latch 59 . The positioning clamp handle 55 and the shrinking clamp main handle 51 are fixed on the positioning base 53 by respective clamping handle shafts 52, and a clamp spring 54 is arranged between the positioning clamp handle 55 and the shrinking clamp main handle 51. The purpose of this spring is to ensure The two clamping handles are in an open state, and are close to the edge of the "V" on the positioning slot 57. The bottom end of the shrinking clip jacket 56 is connected to the shrinking clip main handle 51, and the upper opening is provided with a shrinking clip groove 48, and the shrinking clip groove 48 is built with a shrinking clip spring 50, and the upper end of the shrinking clip spring 50 is connected with the shrinking clip base 49; the left crescent clip 45 and the right crescent clamp 46 are connected to the shrink clamp base 49 by respective crescent clamp shafts 47. The force direction of the lock clip spring 50 is from top to bottom. Under the action of elastic force, the left crescent clip 45 and the right crescent clip 46 follow the shrinking clip base 49 and descend in the clipping groove 48. Because the left crescent clip 45 and the right crescent clip The crescent clamp 46 is designed in an arc shape, and the opening of the shrinking clamp groove 48 gradually generates an inward force on the clamp body, causing the two clamp bodies to move closer to each other, and the more they descend, the closer they get together, thereby producing the fastening of the target object Clamping effect. This device can clamp the limbs, tail vertebrae and other ends of small four-limbed animals, and can be accurately positioned at a certain position for a long time.

The utility model has reasonable design and ingenious conception, can be perfectly connected with the existing animal fixing bracket, realizes double improvement of versatility and practicability, and fully meets the experimental requirements of animal radiation (aseptic) irradiation.

Claims (1)

1. An extremity clamping and positioning structure for radiobiological experiments, characterized in that it consists of positioning slots (57), positioning springs (58), wedge-shaped positioning teeth (59), positioning guide rails (60), and positioning shrink clips. Structure (104), wherein, the positioning clamping structure (104) is composed of a left crescent clamp (45), a right crescent clamp (46), two crescent clamp shafts (47), a clamping groove (48), a clamping Base (49), clamping spring (50), clamping main handle (51), two clamping handle shafts (52), positioning base (53), clamping handle spring (54), positioning clamping handle (55) It is composed of a shrink jacket (56); the positioning guide rail (60) is provided with a positioning slot (57); on the inner wall of one side of the positioning slot (57), the wedge-shaped positioning teeth (59) are equidistantly distributed; The wedge-shaped positioning latch (59) has a thick head and a thin head, and the thick head faces the far end; the positioning spring (58) is placed in the positioning card slot (57), and one end is fixed on the far end of the positioning card slot (57) , the other end is connected to the positioning base (53) of the positioning shrinking clamp structure (104); the positioning clamping handle (55) and the main clamping handle (51) are fixed to the positioning base (53) through their respective clamping handle shafts (52) On the top, a clamp spring (54) is arranged between the positioning clamp handle (55) and the main clamp handle (51); Clamping groove (48), shrinking clip groove (48) is built with shrinking clip spring (50), and the upper end of shrinking clip spring (50) is connected with shrinking clip base (49); left crescent clip (45) and right crescent clip (46 ) are connected to the shrink clamp base (49) through their respective crescent clamp shafts (47).