CN203929745U - Evaluate the dynamic similation decomposition apparatus of degradable ureter rack tube - Google Patents
Evaluate the dynamic similation decomposition apparatus of degradable ureter rack tube Download PDFInfo
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- CN203929745U CN203929745U CN201420319833.XU CN201420319833U CN203929745U CN 203929745 U CN203929745 U CN 203929745U CN 201420319833 U CN201420319833 U CN 201420319833U CN 203929745 U CN203929745 U CN 203929745U
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Abstract
The utility model relates to a kind of dynamic similation decomposition apparatus of evaluating degradable ureter rack tube, comprises constant temperature reservoir, electronic peristaltic pump, dynamic similation decomposition apparatus be connected silicone tube.Wherein dynamic similation decomposition apparatus comprises worktable, spray shunting cabin, body vermiculator and set cabin.The utility model has been realized Multi-example and has been tested simultaneously, accelerates test efficiency, can Real Time Observation degradation process and stopping state, and can collect catabolite and carry out post analysis.The utility model has made up the blank of current degradable ureter rack tube dynamic degradation device, for test and the evaluation of external degradation performance provides more accurate, the foundation of science.
Description
Technical field
The utility model relates to a kind of dynamic similation decomposition apparatus and method of testing thereof of evaluating degradable ureter rack tube, and the degradation property test for degradable ureter rack tube, belongs to bio-medical material application.
Background technology
In recent years, development along with degradation material and preparation technology, degradable ureter rack tube also becomes one of study hotspot, because it has temporary drainage and support effect, and after completing effect, can degrade voluntarily and excrete and avoided the required step that operation is taken out for the second time of non-degradable stand tube with urine, therefore there is better biocompatibility and complication still less, reduced misery on patient's health and loss economically.First case degradable ureter rack tube reported by people such as Lumiaho in 1998, and a variety of degradable ureter rack tubes have carried out in vitro and in vivo experiment thereafter, but up to the present, there is no commercial prod.
For the degradable ureter rack tube ubiquity degraded of finding in forefathers' research, lack rule, the shortcoming such as easily result in blockage in degradation process, also need to there is for the degradation property of degradable ureter rack tube further research, require its degradation time to be controlled in different range for different syndromes, to reach best curative effect; Degraded has controllability, from bladder end to renal plevis end but not arbitrarily fracture; Catabolite is as far as possible little, can excrete with urine.In body, test, experiment in vitro is easier to control experiment condition, and controllability is strong, is not subject to the vulnerant interference of operation, has standardization, quantitative and repeatable and quick, sensitive, easy, economic dispatch advantage.
External degradation experiment in research is at present static at constant temperature or dynamically in shaking table environment, completes, and degradation material can produce number acid alkaline bleach liquor degradation product in degradation process, have influence on the pH value of a certain amount of degradation solution in degraded container, and directly have influence on degradation results, sediment is separated out in the variation of degradation solution microenvironment sometimes in addition, its long-term accumulated can be attached to stand tube surface, for later stage sample test and observation, impacts, and therefore need to regularly replace degradation solution.Biodegradable stent pipe is vertically positioned in the interior ureter of human body, all the time in thering is the urine of steady temperature, constant density and constant eroding velocity and the environment of ureter wall mechanical stress effect, therefore traditional external degradation experiment state in analogue body truly, makes differing greatly of external degradation result and zoopery and clinical trial result.Therefore, be necessary to carry out for the degradation process of ureter rack tube in-vitro simulated, to reach by the degradation property of external dynamic simulation evaluation stand tube, thus the more simple and exactly degradation process of predict stent pipe.
By a large amount of documents and materials, find, dynamic test set for ureter rack tube is mainly the research for non-degradable stand tube surface crust phenomenon and body inner fluid mechanics, and for the test of the dynamic degradation performance of degradable ureter rack tube, without pertinent literature, report both at home and abroad.
Summary of the invention
The purpose of this utility model is to provide a kind of dynamic similation decomposition apparatus and method of testing thereof of evaluating degradable ureter rack tube, external degradation test can be simulated more realistically there is steady temperature, concentration and the liquid effects of eroding velocity and the internal milieu of ureter wall mechanical stress effect, thereby obtain the result of more accurate believable external degradation test.
In order to achieve the above object, the technical solution of the utility model has been to provide a kind of dynamic similation decomposition apparatus of evaluating degradable ureter rack tube, comprising: for holding the constant temperature reservoir of hydraulic fluid, constant temperature reservoir is placed in constant temperature blender with magnetic force, it is characterized in that, also comprise:
Dynamic similation decomposition apparatus, constant temperature reservoir connects the liquid inlet of dynamic similation decomposition apparatus via electronic peristaltic pump, the liquid outlet of dynamic similation decomposition apparatus takes back constant temperature reservoir, this dynamic similation decomposition apparatus comprises worktable and dismountable spray shunting cabin, body vermiculator, gathers cabin, spray shunting cabin, body vermiculator and set cabin are bonded into successively integral body from top to bottom when testing, and this integral body is fixed on worktable;
Spray shunting cabin comprises cabin body, the top of cabin body is shunting cabin liquid inlet, shunting cabin liquid inlet is also the liquid inlet of dynamic similation decomposition apparatus, below the body of cabin, be provided with shunting platform, upper surface and lower surface at shunting platform are respectively equipped with an arrangement conglobate N tap hole and N stand tube body ingate, each tap hole is connected from different stand tube body ingates by stand tube annular termination sealed cabin separately, hydraulic fluid branches to different tap holes from shunting after cabin liquid inlet flows into, via different stand tube annular termination sealed cabins, from different stand tube body ingates, flow out again,
Body vermiculator comprises body, middle part at body is formed with container cavity, body is wriggled and is deployed in this container cavity, body wriggling portion comprise when experiment stationary arrangement circularize for simulating ureteral N root flexible pipe, in each flexible pipe, insert ureter rack tube to be tested, the size of each flexible pipe matches with the size of inserting ureter rack tube wherein, N root flexible pipe is corresponding one by one with N stand tube body ingate, after spray shunting cabin engages with body vermiculator, each flexible pipe with and its corresponding stand tube body ingate be connected, the hydraulic fluid flowing out from different support pipe body ingate flows in different flexible pipes, body wriggling portion also comprises wriggling spinner, wriggling spinner is placed in the middle of the circular cylinder intracavity being surrounded by N root flexible pipe, the outer circumference surface of wriggling spinner is formed with spiral fashion projection, by reducing motor, drive wriggling spinner to rotate around the vertical axis of self, the internal circular surfaces of the circular cylinder that N root flexible pipe surrounds is close to the spiral fashion projection of wriggling spinner, and its outer round surface is close to the level and smooth cylindrical wall of container cavity,
Set cabin comprises stand tube outlet platform and is positioned at the degradation solution recovery capsule of stand tube outlet platform below, during the inherent experiment of stand tube outlet platform, the unsettled N of being fixed with root is arranged conglobate change diameter tube, it is corresponding one by one with N root flexible pipe that N root becomes diameter tube, after set cabin engages with body vermiculator, every becomes diameter tube and is connected with its corresponding flexible pipe, hydraulic fluid flows into different change diameter tube after different flexible pipes flows out, every become diameter tube from top to bottom diameter progressively reduce, hydraulic fluid flows out by confluxing after being filtered by filter net sheet to degradation solution recovery capsule from different change diameter tube, in degradation solution recovery capsule bottom, be provided with degradation solution and reclaim mouth, it is also the liquid outlet of dynamic similation decomposition apparatus that degradation solution reclaims mouth.
Preferably, in described spray shunting cabin, the diameter d of tap hole described in each
1for 1-2cm, the external diameter of a circle D of all described tap holes
1for 5.6-11.5cm, the height H of stand tube annular termination sealed cabin described in each
1for 4-6cm.
Preferably, in described body vermiculator, described body wriggling portion also comprises the end support platform of arranging up and down and goes out tube sheet, brace table and go out on tube sheet to distribute to be formed with and arrange conglobate N and enter the mouth of pipe and N outlet spout endways, N root flexible pipe and N enter the mouth of pipe and N outlet spout homogeneous one corresponding, the upper end of every flexible pipe and lower end enter the mouth of pipe with its corresponding respectively and an outlet spout is removably connected and fixed.
Preferably, described in, enter the diameter d of the mouth of pipe
2for 6-10cm, enter the external diameter of a circle D of the mouth of pipe described in all
2for 12.1-20.6cm, the height H of described body vermiculator
2for 16-20cm, the outer diameter D of described wriggling spinner
3for 12-20cm, the height H of described wriggling spinner
3for 14-18cm, the diameter d of the bottom of every described change diameter tube
3for 1-3mm, the diameter D of described degradation solution recovery capsule
4for 12.1-20.6cm.
Preferably, described spray shunting cabin, described end support platform, described in go out tube sheet, described spiral fashion projection, described stand tube outlet platform and described degradation solution recovery capsule and be organic glass, described flexible pipe is silica gel, the material of described filter net sheet is stainless steel.
Preferably, be formed with and arrange a conglobate N outlet opening on stand tube outlet platform, N outlet opening is corresponding one by one with described N root change diameter tube, and every upper end that becomes diameter tube is fastened on an outlet opening.
Preferably, described dynamic similation decomposition apparatus integral sealing is also placed on superclean bench, guarantees aseptic degraded environment.
Preferably, between between described spray shunting cabin and described body vermiculator and described body vermiculator and described set cabin, all employing fastening is closely connected.
Preferably, described hydraulic fluid is artificial urine or phosphoric acid buffer degradation solution.
Adopt technical scheme provided by the utility model, there is following obvious advantage:
The first, this device has been realized dynamic similation interior state, comprising the hydraulic fluid (artificial urine, phosphate buffer) that keeps temperature in homoeostat; Manufacture the electronic peristaltic pump and the shunting cabin liquid inlet that is positioned at sample vertical direction of liquid souring in body; The stand tube annular termination sealed cabin of renal plevis structure in analogue body; The silica gel hose of ureteral vertical orientations and material in analogue body; The body vermiculator of ureteral peristalsis effect in analogue body.A series of perfect analogue means are simulated stand tube degradation process in vivo better on instrument, can evaluate more accurately the degradation property of biodegradable stent pipe.
The second, this device is realized Multi-example and is tested simultaneously, accelerates test efficiency; Be applicable to the degraded test of J-shaped and straight tube simultaneously; Can observe the different degradation effects of stand tube in locating support pipe pipe shaft position; Whether the set cabin of device can observe catabolite can between ureter and bladder, stenosis stop up, and can collect catabolite and carry out post analysis.
Accompanying drawing explanation
Fig. 1 is the combination schematic diagram of dynamic similation decomposition apparatus;
Fig. 2 is the schematic appearance in the spray shunting cabin in dynamic similation decomposition apparatus;
Fig. 3 A is the schematic appearance of the body vermiculator in dynamic similation decomposition apparatus;
Fig. 3 B is the schematic cross-section before the body vermiculator assembling in dynamic similation decomposition apparatus;
Fig. 3 C is the half section schematic diagram after the body vermiculator assembling in dynamic similation decomposition apparatus;
Fig. 3 D is the schematic cross-section after the body vermiculator assembling in dynamic similation decomposition apparatus;
Fig. 4 is the set cabin in dynamic similation decomposition apparatus.
Embodiment
For the utility model is become apparent, hereby with preferred embodiment, and coordinate accompanying drawing to be described in detail below.Should be understood that these embodiment are only not used in restriction scope of the present utility model for the utility model is described.In addition should be understood that those skilled in the art can make various changes or modifications the utility model after having read the content of the utility model instruction, these equivalent form of values fall within the application's appended claims limited range equally.
The dynamic similation decomposition apparatus of the evaluation degradable ureter rack tube using in embodiment comprises constant temperature reservoir, electronic peristaltic pump, dynamic similation decomposition apparatus and the silicone tube for connecting.Constant temperature reservoir is positioned in constant temperature blender with magnetic force, constant temperature reservoir is by silicone tube connecting electronic peristaltic pump, electronic peristaltic pump connects the liquid inlet of dynamic similation decomposition apparatus by silicone tube, the liquid outlet of dynamic similation decomposition apparatus connects constant temperature reservoir by silicone tube, in constant temperature reservoir, hydraulic fluid is housed.
As shown in Figure 1, dynamic similation decomposition apparatus 3 comprises worktable 31, spray shunting cabin 32, body vermiculator 33 and set cabin 34.Spray shunting cabin 32, body vermiculator 33 and set cabin 34 are bonded into successively integral body from top to bottom when testing, and this integral body is fixed on worktable 31.
By the first chuck 312 clamping spray shunting cabins 32 of metallic support rod 311 topmosts, as shown in Figures 1 and 2, spray shunting cabin 32 comprises the cabin body of taper, the top of cabin body is shunting cabin liquid inlet 320, shunting cabin liquid inlet 320 is also the liquid inlet of dynamic similation decomposition apparatus, shunting cabin liquid inlet 320 is also the liquid inlet of dynamic similation decomposition apparatus, below the body of cabin, be provided with shunting platform 321, upper surface and lower surface at shunting platform 321 are respectively equipped with an arrangement conglobate N tap hole 322 and N stand tube body ingate 324, each tap hole 322 is connected from different stand tube body ingates 324 by stand tube annular termination sealed cabin 323 separately, hydraulic fluid branches to different tap hole 322 from shunting after cabin liquid inlet 320 flows into, again via 324 outflows from different stand tube body ingates of different stand tube annular termination sealed cabins 323.
By the second chuck 313 clamping cylindrical tube vermiculators 33 at metallic support rod middle part, as Fig. 1, Fig. 3 A, 3B, shown in 3C and 3D, the circular ring-type end support platform 331 that body vermiculator 33 upper surfaces have and spray shunting 32 bottoms, cabin closely engage, N the circle that distributing on end support platform 331 enters the mouth of pipe 332, and it is corresponding one by one with N stand tube body ingate 324 that N circle enters the mouth of pipe 332.Body vermiculator 33 lower ends clamping rings shape go out tube sheet 333, go out on tube sheet 333 and distributing and entering the vertical outlet spout of N one to one 334 of the mouth of pipe 332 with N, enter on the mouth of pipe 332 and corresponding outlet spout 334, be fixedly linked respectively for built-in ureter rack tube package size for simulating ureteral flexible pipe 335, the middle fixedly wriggling spinner 336 of cylindrical cavity that N root flexible pipe 335 forms, wriggling spinner 336 outer circumference surfaces have spiral fashion projection 3361 and are positioned at its inner decelerator 3362, decelerator 3362 is connected and is positioned at outside control panel 3363 its rotational speeies of control by electric wire.The right cylinder outer ring that N root flexible pipe 335 forms is the level and smooth cylindrical wall with its laminating.
314 clamping set cabins 34 of the 3rd chuck of metallic support rod bottom, as shown in Fig. 1 and Fig. 4, the stand tube outlet platform 341 closely engaging with body vermiculator 33 bottoms is arranged at set 34 tops, cabin, on stand tube outlet platform 341, have and N outlet spout 334 N outlet opening 342 one to one, N outlet opening 342 bottoms are equipped with shorter change diameter tube 343, change diameter tube 343 from top to bottom diameter progressively reduces, become diameter tube 343 bottoms into for filtering the filter net sheet 344 of hydraulic fluid, filter net sheet 344 bottoms are right cylinder degradation solution recovery capsule 345, degradation solution recovery capsule 345 bottoms are that degradation solution reclaims mouth 346, it is also the liquid outlet of dynamic similation decomposition apparatus that degradation solution reclaims mouth 346.
Dynamic similation decomposition apparatus 3 integral sealings are also placed on superclean bench, guarantee aseptic degraded environment.Hydraulic fluid is artificial urine or phosphoric acid buffer degradation solution.
As Fig. 2, shown in 3A and 4, tap hole 322 diameter d in the spray shunting cabin in described dynamic analog device
1for 1-2cm, the external diameter of a circle D of each tap hole 322
1for 5.6-11.5cm, stand tube annular termination sealed cabin 323 height H
1for 4-6cm, on body vermiculator 33 upper end end support platforms 331, enter the mouth of pipe 332 diameter d
2for 6-10mm, respectively enter the external diameter of a circle D of the mouth of pipe 332
2for 12.1-20.6cm, body vermiculator 33 height H
2for 16-20cm, wriggling spinner 336 outer diameter D
3for 12-20cm, length H3 is 14-18cm, 34 middle outlet holes 342, set cabin and its external diameter of a circle respectively with the diameter d that enters the mouth of pipe 332 and its circumscribed circle
2, D
2unanimously, become diameter tube 343 tail end diameter d
3for 1-3mm, the diameter D of degradation solution recovery capsule 345
4for 12.1-20.6cm.
Spray shunting cabin 32, end support platform 331, going out tube sheet 333, spiral fashion projection 3361, stand tube outlet platform 341 and degradation solution recovery capsule 345 and whole outside support material, to be organic glass equal, and flexible pipe 335 is silica gel, filter net sheet 334.
Between between spray shunting cabin 32 and body vermiculator 33 and body vermiculator 33 and set cabin 34, all employing fastening is closely connected.
Embodiment 1
A kind of method of testing of evaluating the dynamic similation decomposition apparatus of degradable ureter rack tube that the present embodiment is recorded, its concrete steps are as follows:
1) test is prepared: the ureter rack tube sample that 20 external diameters that preparation pipe shaft length is 15.0cm are 1mm, the diameter of the head end ring texture of sample is 1.0cm.Prepare the ureteral some flexible pipes 335 of simulation, the internal diameter of flexible pipe is 1mm, stand tube is inserted and bonded to each other with flexible pipe.Simulation ureter flexible pipe is arranged on respectively in body vermiculator 33, and head end and end are enclosed within on the mouth of pipe 332 and outlet spout 334 with rubber band respectively.On several outlet openings 342 on set 34 tops, cabin, put respectively with simulate ureter flexible pipe corresponding straighten footpath flexible pipe 343, thinner tail end diameter is 1mm freely unsettled in set cabin 34.
2) ureter rack tube sample is installed: ready ureter rack tube sample is inserted in the ureteral flexible pipe 335 of simulation, and the annular termination of stand tube is partly positioned on circular ring-type end support platform 331, and towards brace table center.Spray shunting 32 lower ends, cabin and body vermiculator 33 upper ends are interlocked, each above the corresponding body vermiculator of each annular termination sealed cabin 323 entered to the mouth of pipe 332, guarantee that the annular termination of each stand tube lays respectively in each sealed cabin.Wriggling spinner 336 is inserted the cylindrical cavity that several silica gel hoses 335 form from the lower end of body vermiculator, and bottom cover is tight, from bottom sides, draw the electric wire of motor, be connected with outside control panel 3363.Again body vermiculator 33 lower ends and set 34 upper ends, cabin are interlocked, make each stand tube tail end become diameter tube 343 inside in correspondence.
3) experiment condition is set: in dynamic similation decomposition apparatus, spray shunting cabin 32, body vermiculator 33 and set cabin 34 engage simultaneously, regulate three clip position, the monolithic stability after engaging is vertically fixed on worktable 31.By the interior injection 2/3 simulation urine of constant temperature reservoir 1, and be placed in constant temperature blender with magnetic force 11, set temperature is 37 ℃.By dynamic similation decomposition apparatus 3, constant temperature reservoir 1 is connected respectively by silicone tube 4 with electronic peristaltic pump 2, the frequency that electronic peristaltic pump 2 is set is 1Hz, makes the simulation urine in reservoir 1 become Pulsating Flow through the liquid inlet 320 in silicone tube importing spray shunting cabin 32 by electronic peristaltic pump 2.Open body vermiculator electric rotating machine 3362 switches, adjusting rotary speed is 40r/min.After waiting system is stable, start timing.Degraded Whole Equipment is positioned at superclean bench.
4) sampling: surrounding is carried out in test, the all devices of closing device wherein liquid derivation weekly, split spray shunting cabin 32, body vermiculator 33 and set cabin 34 and the careful stand tube sample that takes out from five simulation ureter flexible pipes 335, and collect the catabolite depositing on degradation solution filter net sheet, ressemble subsequently device, change the hydraulic fluid in reservoir, and running gear again.
5) evaluate the degradation property of stand tube: stand tube sample weekly and the catabolite sample in 1-4 week in the degradation process of taking-up, after freeze drying, observe respectively its mode of appearance, mechanical property and molecule structure change, with the sample comparison of not carrying out Degrading experiment, through test, stand tube is close before the sample appearance of first week and degraded, without significant change, compression brute force and pulling strengrth decline respectively 20% and 8%, at second week biodegradable stent tube-surface, there is a small amount of crackle, compression and tensile property decline respectively 70% and 56%, the 3rd week there is obvious volume crackle in biodegradable stent pipe, still keep a small amount of compression brute force and pulling strengrth, in flexible pipe, there is fracture in 4th week stand tube, almost without mechanical property.The powerful value of annular termination falls 80% at triple flyaway, and catabolite crystallinity slightly rose before degraded at first week, subsequently continuous decrease.The in the end one week inherent diameter tube tail end that becomes of stand tube has slight latch up phenomenon.
Embodiment 2
A kind of method of testing of evaluating the dynamic similation decomposition apparatus of degradable ureter rack tube that the present embodiment is recorded, its concrete steps are as follows:
1) test is prepared: the ureter rack tube sample that 12 external diameters that preparation pipe shaft length is 17.5cm are 3.5mm, the diameter of the head end ring texture of sample is 4cm.Prepare the ureteral some flexible pipes 335 of simulation, the internal diameter of flexible pipe is 3.5mm, stand tube is inserted and bonded to each other with flexible pipe.Simulation ureter flexible pipe is arranged on respectively in body vermiculator 33, and head end and end are enclosed within on the mouth of pipe 332 and outlet spout 334 with rubber band respectively.On several outlet openings 342 on set 34 tops, cabin, put respectively with simulate ureter flexible pipe corresponding straighten footpath flexible pipe 343, thinner tail end diameter is 2mm freely unsettled in set cabin 34.
2) ureter rack tube sample is installed: ready ureter rack tube sample is inserted in the ureteral flexible pipe 335 of simulation, and the annular termination of stand tube is partly positioned on circular ring-type end support platform 331, and towards brace table center.Spray shunting 32 lower ends, cabin and body vermiculator 33 upper ends are interlocked, each above the corresponding body vermiculator of each annular termination sealed cabin 323 entered to the mouth of pipe 332, guarantee that the annular termination of each stand tube lays respectively in each sealed cabin.Wriggling spinner 336 is inserted the cylindrical cavity that several silica gel hoses 335 form from the lower end of body vermiculator, and bottom cover is tight, from bottom sides, draw the electric wire of motor, be connected with outside control panel 3363.Again body vermiculator 33 lower ends and set 34 upper ends, cabin are interlocked, make each stand tube tail end become diameter tube 343 inside in correspondence.
3) experiment condition is set: in dynamic similation decomposition apparatus, spray shunting cabin 32, body vermiculator 33 and set cabin 34 engage simultaneously, regulate three clip position, the monolithic stability after engaging is vertically fixed on worktable 31.By the interior injection 2/3 simulation urine of constant temperature reservoir 1, and be placed in constant temperature blender with magnetic force 11, set temperature is 37 ℃.By dynamic similation decomposition apparatus 3, constant temperature reservoir 1 is connected respectively by silicone tube 4 with electronic peristaltic pump 2, the frequency that electronic peristaltic pump 2 is set is 5.5Hz, makes the simulation urine in reservoir 1 become Pulsating Flow through the liquid inlet 320 in silicone tube importing spray shunting cabin 32 by electronic peristaltic pump 2.Open body vermiculator electric rotating machine 3362 switches, adjusting rotary speed is 60r/min.After waiting system is stable, start timing.Degraded Whole Equipment is positioned at superclean bench.
4) sampling: test is carried out five weeks, the all devices of closing device wherein liquid derivation weekly, split spray shunting cabin 32, body vermiculator 33 and set cabin 34 and the careful stand tube sample that takes out from two simulation ureter flexible pipes 335, and collect the catabolite depositing on degradation solution filter net sheet, ressemble subsequently device, change the hydraulic fluid in reservoir, and running gear again.
5) evaluate the degradation property of stand tube: stand tube sample weekly and the catabolite sample in 1-5 week in the degradation process of taking-up, after freeze drying, observe respectively its mode of appearance, mechanical property and molecule structure change, with the sample comparison of not carrying out Degrading experiment, through test, stand tube is close before the sample appearance of first week and degraded, without significant change, compression brute force and pulling strengrth decline respectively 10% and 3%, at second week biodegradable stent pipe still without significant change, compression and tensile property decline respectively 35% and 20%, the 3rd week there is part crackle in sample surfaces, compression and tensile property decline respectively 50% and 30%, 4th week stand tube sample surfaces occurs compared with multiple cracks, compression and tensile property decline respectively 80% and 60%, within the 5th week, sample approaches breaking state, almost without mechanical property.The powerful value of annular termination declined 75% at the 5th week, and catabolite crystallinity slightly rises before degraded at second week, subsequently continuous decrease.In degradation process, become diameter tube tail end without latch up phenomenon.
Embodiment 3
A kind of method of testing of evaluating the dynamic similation decomposition apparatus of degradable ureter rack tube that the present embodiment is recorded, its concrete steps are as follows:
1) test is prepared: the ureter rack tube sample that 8 external diameters that preparation pipe shaft length is 20cm are 6mm, sample is Straight.Prepare the ureteral some flexible pipes 335 of simulation, the internal diameter of flexible pipe is 6mm, stand tube is inserted and bonded to each other with flexible pipe.Simulation ureter flexible pipe is arranged on respectively in body vermiculator 33, and head end and end are enclosed within on the mouth of pipe 332 and outlet spout 334 with rubber band respectively.On several outlet openings 342 on set 34 tops, cabin, put respectively with simulate ureter flexible pipe corresponding straighten footpath flexible pipe 343, thinner tail end diameter is 3mm freely unsettled in set cabin 34.
2) ureter rack tube sample is installed: ready ureter rack tube sample is inserted in the ureteral flexible pipe 335 of simulation.Spray shunting 32 lower ends, cabin and body vermiculator 33 upper ends are interlocked.Wriggling spinner 336 is inserted the cylindrical cavity that several silica gel hoses 335 form from the lower end of body vermiculator, and bottom cover is tight, from bottom sides, draw the electric wire of motor, be connected with outside control panel 3363.On the outlet platform of set upper end, cabin, place stainless steel fine-meshed screen, thereby make stand tube lower end be placed on fixed support pipe on wire side.Again body vermiculator 33 lower ends and set 34 upper ends, cabin are interlocked, make each stand tube tail end become diameter tube 343 inside in correspondence.
3) experiment condition is set: in dynamic similation decomposition apparatus, spray shunting cabin 32, body vermiculator 33 and set cabin 34 engage simultaneously, regulate three clip position, the monolithic stability after engaging is vertically fixed on worktable 31.By the interior injection 2/3 simulation urine of constant temperature reservoir 1, and be placed in constant temperature blender with magnetic force 11, set temperature is 37 ℃.By dynamic similation decomposition apparatus 3, constant temperature reservoir 1 is connected respectively by silicone tube 4 with electronic peristaltic pump 2, the frequency that electronic peristaltic pump 2 is set is 10Hz, makes the simulation urine in reservoir 1 become Pulsating Flow through the liquid inlet 320 in silicone tube importing spray shunting cabin 32 by electronic peristaltic pump 2.Open body vermiculator electric rotating machine 3362 switches, adjusting rotary speed is 80r/min.After waiting system is stable, start timing.Degraded Whole Equipment is positioned at superclean bench.
4) sampling: surrounding is carried out in test, the all devices of closing device wherein liquid derivation weekly, split spray shunting cabin 32, body vermiculator 33 and set cabin 34 and the careful stand tube sample that takes out from two simulation ureter flexible pipes 335, and collect the catabolite depositing on degradation solution filter net sheet, ressemble subsequently device, change the hydraulic fluid in reservoir, and running gear again.
5) evaluate the degradation property of stand tube: stand tube sample weekly and the catabolite sample in 1-4 week in the degradation process of taking-up, after freeze drying, observe respectively its mode of appearance, mechanical property and molecule structure change, with the sample comparison of not carrying out Degrading experiment, through test, stand tube is close before the sample appearance of first week and degraded, without significant change, compression brute force and pulling strengrth decline respectively 14.5% and 8%, on second week surface still without significant change, compression and tensile property decline respectively 42% and 31%, the 3rd week there is part crackle in biodegradable stent tube-surface, compression and tensile property decline respectively 70% and 47%, 4th week stand tube sample surfaces occurs compared with multiple cracks, compression and tensile property decline respectively 95% and 83%, within the 5th week, sample all ruptures, almost without mechanical property.Catabolite crystallinity slightly rose before degraded at first week, subsequently continuous decrease.Stand tube had slight latch up phenomenon at the 5th week at change diameter tube tail end.
Claims (9)
1. a dynamic similation decomposition apparatus of evaluating degradable ureter rack tube, comprising: for holding the constant temperature reservoir of hydraulic fluid, constant temperature reservoir is placed in constant temperature blender with magnetic force, it is characterized in that, also comprises:
Dynamic similation decomposition apparatus, constant temperature reservoir connects the liquid inlet of dynamic similation decomposition apparatus via electronic peristaltic pump, the liquid outlet of dynamic similation decomposition apparatus takes back constant temperature reservoir, this dynamic similation decomposition apparatus comprises worktable (31) and dismountable spray shunting cabin (32), body vermiculator (33), gathers cabin (34), spray shunting cabin (32), body vermiculator (33) and set cabin (34) are bonded into successively integral body from top to bottom when testing, and this integral body is fixed on worktable (31);
Spray shunting cabin (32) comprises cabin body, the top of cabin body is shunting cabin liquid inlet (320), shunting cabin liquid inlet (320) is also the liquid inlet of dynamic similation decomposition apparatus, below the body of cabin, be provided with shunting platform (321), upper surface and lower surface at shunting platform (321) are respectively equipped with an arrangement conglobate N tap hole (322) and N stand tube body ingate (324), each tap hole (322) is connected from different stand tube body ingates (324) by stand tube annular termination sealed cabin (323) separately, hydraulic fluid branches to different tap hole (322) from shunting after cabin liquid inlet (320) flows into, via different stand tube annular termination sealed cabins (323), from different stand tube body ingates (324), flow out again,
Body vermiculator (33) comprises body, middle part at body is formed with container cavity, body is wriggled and is deployed in this container cavity, body wriggling portion comprise when experiment stationary arrangement circularize for simulating ureteral N root flexible pipe (335), in each flexible pipe (335), insert ureter rack tube to be tested, the size of each flexible pipe (335) matches with the size of inserting ureter rack tube wherein, N root flexible pipe (335) is corresponding one by one with N stand tube body ingate (324), after spray shunting cabin (32) engages with body vermiculator (33), each flexible pipe (335) with and its corresponding stand tube body ingate (324) be connected, the hydraulic fluid flowing out from different support pipe body ingate (324) flows in different flexible pipe (335), body wriggling portion also comprises wriggling spinner (336), wriggling spinner (336) is placed in the middle of the circular cylinder intracavity being surrounded by N root flexible pipe (335), the outer circumference surface of wriggling spinner (336) is formed with spiral fashion projection (3361), by reducing motor (3362), drive wriggling spinner (336) around the vertical axis rotation of self, the internal circular surfaces of the circular cylinder that N root flexible pipe (335) surrounds is close to the spiral fashion projection (336) of wriggling spinner (336), and its outer round surface is close to the level and smooth cylindrical wall of container cavity,
Set cabin (34) comprises stand tube outlet platform (341) and is positioned at the degradation solution recovery capsule (345) of stand tube outlet platform (341) below, during the inherent experiment of stand tube outlet platform (341), the unsettled N of being fixed with root is arranged conglobate change diameter tube (343), it is corresponding one by one with N root flexible pipe (335) that N root becomes diameter tube (343), after set cabin (34) engages with body vermiculator (33), every becomes diameter tube (343) and is connected with its corresponding flexible pipe (335), hydraulic fluid flows into different change diameter tube (343) after different flexible pipe (335) flows out, every change diameter tube (343) from top to bottom diameter progressively reduces, hydraulic fluid flows out after being filtered by filter net sheet (334) and confluxes to degradation solution recovery capsule (345) from different change diameter tube (343), in degradation solution recovery capsule (345) bottom, be provided with degradation solution and reclaim mouthful (346), it is also the liquid outlet of dynamic similation decomposition apparatus that degradation solution reclaims mouthful (346).
2. a kind of dynamic similation decomposition apparatus of evaluating degradable ureter rack tube as claimed in claim 1, is characterized in that: at described spray, shunt in cabin (32) diameter d of tap hole described in each (322)
1for 1-2cm, the external diameter of a circle D of all described tap holes (322)
1for 5.6-11.5cm, the height H of stand tube annular termination sealed cabin (323) described in each
1for 4-6cm.
3. a kind of dynamic similation decomposition apparatus of evaluating degradable ureter rack tube as claimed in claim 1, it is characterized in that: in described body vermiculator (33), described body wriggling portion also comprises the end support platform (331) of arranging up and down and goes out tube sheet (333), endways brace table (331) and go out tube sheet (333) upper distribute to be formed with arrange conglobate N and enter the mouth of pipe (332) and N outlet spout (334), N root flexible pipe (335) and N enter the mouth of pipe (332) and N outlet spout (334) homogeneous one corresponding, the upper end of every flexible pipe (335) and lower end enter the mouth of pipe (332) with its corresponding respectively and an outlet spout (334) is removably connected and fixed.
4. a kind of dynamic similation decomposition apparatus of evaluating degradable ureter rack tube as claimed in claim 3, is characterized in that: described in enter the diameter d of the mouth of pipe (332)
2for 6-10cm, enter the external diameter of a circle D of the mouth of pipe (332) described in all
2for 12.1-20.6cm, the height H of described body vermiculator (33)
2for 16-20cm, the outer diameter D of described wriggling spinner (336)
3for 12-20cm, the height H of described wriggling spinner (336)
3for 14-18cm, the diameter d of the bottom of every described change diameter tube (343)
3for 1-3mm, the diameter D of described degradation solution recovery capsule (345)
4for 12.1-20.6cm.
5. a kind of dynamic similation decomposition apparatus of evaluating degradable ureter rack tube as claimed in claim 3, it is characterized in that: described spray shunting cabin (32), described end support platform (331), described in go out tube sheet (333), described spiral fashion projection (3361), described stand tube outlet platform (341) and described degradation solution recovery capsule (345) and be organic glass, described flexible pipe (335) is silica gel, and the material of described filter net sheet (334) is stainless steel.
6. a kind of dynamic similation decomposition apparatus of evaluating degradable ureter rack tube as claimed in claim 1, it is characterized in that: on stand tube outlet platform (341), be formed with and arrange a conglobate N outlet opening (342), N outlet opening (342) is corresponding one by one with described N root change diameter tube (343), and every upper end that becomes diameter tube (343) is fastened on an outlet opening (342).
7. a kind of dynamic similation decomposition apparatus of evaluating degradable ureter rack tube as claimed in claim 1, is characterized in that: described dynamic similation decomposition apparatus integral sealing is also placed on superclean bench, guarantees aseptic degraded environment.
8. a kind of dynamic similation decomposition apparatus of evaluating degradable ureter rack tube as claimed in claim 1, is characterized in that: between between described spray shunting cabin (32) and described body vermiculator (33) and described body vermiculator (33) and described set cabin (34), all employing fastening is closely connected.
9. a kind of dynamic similation decomposition apparatus of evaluating degradable ureter rack tube as claimed in claim 1, is characterized in that: described hydraulic fluid is artificial urine or phosphoric acid buffer degradation solution.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420319833.XU CN203929745U (en) | 2014-06-16 | 2014-06-16 | Evaluate the dynamic similation decomposition apparatus of degradable ureter rack tube |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420319833.XU CN203929745U (en) | 2014-06-16 | 2014-06-16 | Evaluate the dynamic similation decomposition apparatus of degradable ureter rack tube |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN203929745U true CN203929745U (en) | 2014-11-05 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201420319833.XU Withdrawn - After Issue CN203929745U (en) | 2014-06-16 | 2014-06-16 | Evaluate the dynamic similation decomposition apparatus of degradable ureter rack tube |
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| CN (1) | CN203929745U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104020258A (en) * | 2014-06-16 | 2014-09-03 | 东华大学 | Dynamic simulation degradation device and testing method for evaluating degradable ureter bracket tube |
| CN114452033A (en) * | 2022-04-13 | 2022-05-10 | 深圳市库珀科技发展有限公司 | Ureteral stent and test device thereof |
-
2014
- 2014-06-16 CN CN201420319833.XU patent/CN203929745U/en not_active Withdrawn - After Issue
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104020258A (en) * | 2014-06-16 | 2014-09-03 | 东华大学 | Dynamic simulation degradation device and testing method for evaluating degradable ureter bracket tube |
| CN114452033A (en) * | 2022-04-13 | 2022-05-10 | 深圳市库珀科技发展有限公司 | Ureteral stent and test device thereof |
| CN114452033B (en) * | 2022-04-13 | 2022-07-01 | 深圳市库珀科技发展有限公司 | Ureteral stent and test device thereof |
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