CN210572232U - Dynamic simulation device for metal in-vitro degradation research - Google Patents
Dynamic simulation device for metal in-vitro degradation research Download PDFInfo
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- CN210572232U CN210572232U CN201921451191.8U CN201921451191U CN210572232U CN 210572232 U CN210572232 U CN 210572232U CN 201921451191 U CN201921451191 U CN 201921451191U CN 210572232 U CN210572232 U CN 210572232U
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Abstract
A dynamic simulation device for metal in-vitro degradation research is disclosed, wherein a thermostatic water bath system (1) comprises a thermostatic control system (10) and a water bath tank (9), a liquid storage and PH detection system (3) comprises a liquid storage container (6), a liquid collection container (5) and a portable PH meter, one end of a silica gel hose (8) sequentially penetrates through three rolling shafts of a peristaltic pump (7) along the rotation direction of the peristaltic pump (7), the silica gel hose enters the water bath tank from the upper part of the left side of the water bath tank (9), is wound and fixed on the inner wall of the water bath tank (9) from bottom to top, penetrates through the upper part of the right side of the water bath tank (9) and is connected with a sample chamber (2), the other end of the sample chamber (2) is connected with a three-way joint (4), the other joints of the three-way joint (4) are connected with a liquid inlet of the liquid storage container (6), a liquid outlet of the liquid storage container (6) is connected with the peristaltic pump (, and the hose is placed in the liquid collecting container (5).
Description
Technical Field
The utility model relates to the field of a biomedical degradable metal external degradation experimental device, which is a constant temperature dynamic simulation technology for simulating the flowing of human blood, the body temperature and measuring the PH value.
Background
With the progress of medical level and the development of metal materials, degradable metals with good biocompatibility become hot spots for research, and the research on the adjustable problem of metal degradability is helpful for further popularization in the medical field. At present, the research aiming at the metal degradability mainly adopts an animal in-vivo implantation experiment and an in-vitro soaking experiment. In the former, the degradation environment is a real physiological environment, and the degradation behavior of the material and the change of the physiological environment need to be observed in real time by adopting a CT (computed tomography) technology and a related technology thereof, so that the result is reliable, but the operation is complex, the professional requirement is high, and the detection technology cost is high. The latter calculates the quality loss of degradable metals, the release amount of hydrogen or the change of pH value at each stage by setting experiments with different time gradients, considers the degradation behavior, studies the influence of the metal degradation process on the actual physiological environment, neglects the influence of temperature, fluid flow rate and hydraulic pressure generated micro stress on the metal degradation in the actual physiological environment, and has larger deviation between the degradation rates measured by an in-vitro soaking experiment and an animal in-vivo implantation experiment, so the experimental results are mostly used for in-group comparison study, and can not provide reliable basis for pre-clinical evaluation.
Disclosure of Invention
The utility model aims at providing a dynamic simulation device for metal external degradation research.
The utility model relates to a dynamic simulation device for research of metal external degradation, by thermostatic water bath system 1, sample room 2, stock solution and PH detecting system 3, peristaltic pump 7 constitutes, thermostatic water bath system 1 includes thermostatic control system 10 and water bath 9, stock solution and PH detecting system 3 includes stock solution container 6, collecting container 5 and portable PH meter, connects through wear-resisting anticorrosive silica gel hose 8 between each part of device, starts to pass the three roll axis of peristaltic pump 7 along the direction of rotation of peristaltic pump 7 in proper order with silica gel hose 8, enters the water bath from the upper portion of water bath 9 left side, twines from bottom to top and fixes at water bath 9 inner wall, connects after wearing out through water bath 9 right side upper portion and connects sample room 2, the sample room 2 other end is connected with three way connection 4, three way connection 4 all the other splices connect the inlet of stock solution container 6, a liquid outlet of the liquid storage container 6 is connected with a peristaltic pump 7, the other end of the three-way joint 4 is connected with a silica gel hose 8, and the hose is arranged in the liquid collection container 5; the whole device forms a communicated loop.
The utility model discloses an useful part is simple structure, and is with low costs. The most common 51 single-chip microcomputer is used as a control core, so that each container is manufactured by using an acrylic plate which is easy to process, good in transparency, wear-resistant and corrosion-resistant and a soft plate heat insulation material which is good in heat insulation, expected effects are achieved, the structure is simple, and the cost is low. The error is small, and the data is reliable. The influence on the metal degradation process due to the unstable flow of the simulated body fluid is avoided through the size and shape design, the constant-temperature dynamic simulation condition is closer to the real physiological environment, and therefore compared with a static soaking experiment, the measured PH value has small error and reliable data.
Has wide application. Because the temperature, the controllable of velocity of flow parameter, this utility model not only is used for studying the degradation process of specific metal, still can study the degradation process of same metal under different parameter environment, is used for studying the degradation process of different metals under different parameter environment even, and then carries out multi-angle analysis, summary to the degradation action. In addition, because the three-way joint simulates the body fluid flow direction and is selected by using the metal chuck, the in-vitro simulation under different temperature conditions in a dynamic state and a static state can be realized by only using one set of device, and the influence of reaction products on metal degradation and the change condition of pH value can be contrastingly researched in the dynamic in-vitro simulation.
Drawings
Fig. 1 is a schematic view of a structure of a constant temperature dynamic simulation apparatus, fig. 2 is a schematic view of a water bath box, and fig. 3 is a schematic view of a sample chamber.
Detailed Description
As shown in fig. 1-3, the utility model relates to a dynamic simulation device for the research of metal external degradation, which comprises a thermostatic water bath system 1, a sample chamber 2, a stock solution and PH detection system 3, and a peristaltic pump 7, wherein the thermostatic water bath system 1 comprises a thermostatic control system 10 and a water bath tank 9, the stock solution and PH detection system 3 comprises a stock solution container 6, a liquid collecting container 5 and a portable PH meter, all the components of the device are connected through a wear-resistant and corrosion-resistant silica gel hose 8, one end of the silica gel hose 8 starts to sequentially pass through three rolling shafts of the peristaltic pump 7 along the rotation direction of the peristaltic pump 7, enters the water bath tank from the upper part of the left side of the water bath tank 9, winds from bottom to top and is fixed on the inner wall of the water bath tank 9, penetrates out through the upper part of the right side of the water bath tank 9 and then is connected with the sample chamber 2, the other end of the sample chamber 2 is connected with a three, a liquid outlet of the liquid storage container 6 is connected with a peristaltic pump 7, the other end of the three-way joint 4 is connected with a silica gel hose 8, and the hose is arranged in the liquid collection container 5; the whole device forms a communicated loop.
The utility model discloses a for solving the great problem of data error between external soaking experiment and the animal internal implantation experiment, with the help of the method based on 51 singlechips and DS18B20 temperature sensor design temperature control system, provide a constant temperature dynamic simulation device that is used for the external degradation research of metal.
As shown in fig. 1 and 2, the water bath tank 9 has four layers, namely an outer wall layer 11, a heat insulation layer 12, a heating layer 13 and a sealing layer 14 from outside to inside.
As shown in fig. 1, in the constant temperature system 10, the 51 single chip microcomputer is a minimum module, the DS18B20 temperature sensor is a temperature measurement module, the heating wire is a heating module, the four-position common anode nixie tube is a display module, the relay is a temperature control module, and the reset key and the temperature adjustment key are setting modules.
As shown in FIG. 1, the water bath tank 9 has four holes in one side thereof.
As shown in fig. 1 and 3, the sample chamber 2 is a transparent acrylic plate, and adopts a thin and long structure and a plug-in top cover 15, the centers of two sides of the sample chamber in the length direction are provided with round holes 18, the bottom 17 of the sample chamber is provided with two layers of acrylic plates, and the width of the plug-in part of the top cover 15 is slightly smaller than the width of the inner wall of the sample chamber.
As shown in fig. 1 and 3, the sample chamber 2 is sealed by a raw material tape 16.
As shown in fig. 1, the reservoir 6 is a suction bottle with upper and lower spouts.
As shown in fig. 1, the liquid collecting container 5 is a beaker with a scale.
The embodiments of the present invention will be described in detail with reference to the accompanying drawings, and the present invention is implemented on the premise of the technical solution of the present embodiment, and a detailed implementation manner and a specific operation process are given, but the scope of the present invention is not limited to the following embodiments.
Example 1:
as shown in fig. 1, the present embodiment includes: the device comprises a constant-temperature water bath system 1, a sample chamber 2, a stock solution and PH detection system 3, a peristaltic pump 7 and a silica gel hose 8. One end of the silica gel hose 8 sequentially penetrates through three rolling shafts of the peristaltic pump along the rotation direction of the peristaltic pump 7, enters the water bath box 9 from the upper part of the left side of the water bath box 9, is wound from bottom to top and is fixed on the inner wall of the water bath box 9, penetrates out of the upper part of the right side of the water bath box 9 and is connected with the sample chamber 2, the other end of the sample chamber 2 is connected with the three-way joint 4, the other joint of the three-way joint 4 is connected with a liquid inlet of the liquid storage container 6, the liquid outlet of the liquid storage container 6 is connected with the peristaltic pump 7, the other end of the three-way joint 4 is connected with the silica gel hose 8 of about 15cm, the hose is placed in the liquid collection container 5, water is added into. Fixing a sample in a sample chamber 2, clamping a liquid inlet of a liquid collecting container 5 by a metal chuck, preheating prepared simulated body fluid (usually PBS simulated body fluid), adding the preheated simulated body fluid into a liquid storing container 6, connecting power supplies, and starting a peristaltic pump 7. When the simulated body fluid flows out of the water bath tank 9, the peristaltic pump 7 is closed, the singlechip is started 51 to set the temperature, and heating is started. After the temperature has stabilized for a certain time, the peristaltic pump 7 is started. The simulation body fluid in the liquid storage container needs to be supplemented according to the situation in the whole process, and when the whole loop is filled with the liquid, the simulation body fluid is added to enable the liquid level height to be about two thirds of that of the liquid storage container. Observing and recording the appearance change of the sample at certain time intervals, continuously working the peristaltic pump 7 for preset experimental time, taking out the sample, discharging the simulated body fluid in the device, and sucking out the residual fluid by using a disposable syringe. After the samples were replaced, the above steps were repeated until all experiments were completed.
Example 2:
as shown in fig. 1, the present embodiment includes: the device comprises a constant-temperature water bath system 1, a sample chamber 2, a stock solution and PH detection system 3, a peristaltic pump 7 and a silica gel hose 8. One end of the silica gel hose 8 sequentially penetrates through three rolling shafts of the peristaltic pump along the rotation direction of the peristaltic pump 7, enters the water bath box 9 from the upper part of the left side of the water bath box 9, is wound from bottom to top and is fixed on the inner wall of the water bath box 9, penetrates out of the upper part of the right side of the water bath box 9 and is connected with the sample chamber 2, the other end of the sample chamber 2 is connected with the three-way joint 4, the other joint of the three-way joint 4 is connected with a liquid inlet of the liquid storage container 6, the liquid outlet of the liquid storage container 6 is connected with the peristaltic pump 7, the other end of the three-way joint 4 is connected with the silica gel hose 8 of about 15cm, the hose is placed in the liquid collection container 5, water is added into. Fixing a sample in the sample chamber 2, clamping a liquid inlet of the liquid storage container 6 by a metal chuck, preheating the prepared simulated body fluid (usually PBS simulated body fluid), adding the preheated simulated body fluid into the liquid storage container 6, connecting each power supply, and starting the peristaltic pump 7. When the simulated body fluid flows out of the water bath tank 9, the peristaltic pump 7 is closed, the singlechip is started 51 to set the temperature, and heating is started. After the temperature has stabilized for a certain time, the peristaltic pump 7 is started. In the whole experiment process, simulated body fluid in the liquid storage container needs to be supplemented according to the condition, the appearance change of the sample is observed and recorded after a certain time interval, the liquid collection container 5 is replaced by a new one, and the pH value of the collected simulated body fluid is detected by using a pH meter until the experiment is finished.
Example 3:
as shown in fig. 2, the present embodiment includes: the device comprises a constant-temperature water bath system 1, a sample chamber 2, a stock solution and PH detection system 3, a peristaltic pump 7 and a silica gel hose 8. One end of a silica gel hose 8 sequentially penetrates through three rolling shafts of the peristaltic pump 7 along the rotation direction of the peristaltic pump 7, after a sufficient length is reserved, the silica gel hose is connected with the sample chamber 2, the other end of the sample chamber 2 is reserved with a sufficient length and then is connected with the three-way joint 4, the other joint of the three-way joint is connected with a liquid inlet of the liquid storage container 6, the liquid outlet of the liquid storage container 6 is connected with the peristaltic pump 7, the remaining end of the three-way joint is connected with the silica gel hose 8 of about 15cm, the hose is placed in the liquid collection container 5, a sample is fixed, and the sample chamber 2 is fixed in the water bath box 9 according to the lengths of the. After the tightness is checked, water with a certain temperature is added into the water bath tank 9, a temperature sensor is juxtaposed on the water body, and each power supply is connected to complete the installation. The peristaltic pump 7 is started, the peristaltic pump 7 is closed when the simulated body fluid flows through the sample chamber 2, and the metal clamping head clamps the liquid inlet and the liquid outlet of the sample chamber. The temperature is set in a constant temperature control system and heating is performed. After the experiment is carried out for a period of time, the sample is taken out, and the simulated body fluid after the reaction is collected at the liquid collecting container. And (5) replacing the sample, and repeating the steps until the experiment is finished.
When a fluid communication loop is formed, the liquid level of the liquid storage container 6 preferably occupies two thirds of the total height of the container, the highest liquid level cannot be higher than the lowest position of a liquid inlet of the liquid storage container, and the lowest liquid level cannot be lower than the highest position of a liquid outlet of the liquid storage container.
The silica gel hose 8 is corrosion-resistant ageing resistance material, and the external diameter is 10 mm. Due to wear and ageing in the peristaltic pump 7 rolling shaft arrangement, it is desirable to replace it in time after a period of time.
During operation, the water level of the water added into the water bath tank 9 is slightly higher than that of the silica gel hose 8, and the preset temperature is 38-43 ℃ for heating in consideration of heat loss.
Claims (8)
1. A dynamic simulation device for metal in-vitro degradation research is composed of a constant temperature water bath system (1), a sample chamber (2), a liquid storage and PH detection system (3) and a peristaltic pump (7), and is characterized in that the constant temperature water bath system (1) comprises a constant temperature control system (10) and a water bath box (9), the liquid storage and PH detection system (3) comprises a liquid storage container (6), a liquid collection container (5) and a portable PH meter, all the parts of the device are connected through a wear-resistant and corrosion-resistant silica gel hose (8), one end of the silica gel hose (8) sequentially penetrates through three rolling shafts of the peristaltic pump (7) along the rotation direction of the peristaltic pump (7), enters the water bath box from the upper part of the left side of the water bath box (9), is wound and fixed on the inner wall of the water bath box (9) from bottom to top, penetrates out of the upper part of the right side of the water bath box (9) and then is, the other end of the sample chamber (2) is connected with a three-way joint (4), the other joint of the three-way joint (4) is connected with a liquid inlet of a liquid storage container (6), a liquid outlet of the liquid storage container (6) is connected with a peristaltic pump (7), the remaining end of the three-way joint (4) is connected with a silica gel hose (8), and the hose is placed in a liquid collection container (5); the whole device forms a communicated loop.
2. The dynamic simulation device for metal in-vitro degradation study according to claim 1, characterized in that: the water bath box (9) has four layers, namely an outer wall layer (11), a heat insulation layer (12), a heating layer (13) and a sealing layer (14) from outside to inside.
3. The dynamic simulation device for metal in-vitro degradation study according to claim 1, characterized in that: a51 single chip microcomputer in the constant temperature control system (10) is a minimum module, a DS18B20 temperature sensor is a temperature measurement module, a heating wire is a heating module, a four-position common anode nixie tube is a display module, a relay is a temperature control module, and a reset key and a temperature adjustment key are setting modules.
4. The dynamic simulation device for metal in-vitro degradation study according to claim 1, characterized in that: four holes are arranged on one side surface of the water bath box (9).
5. The dynamic simulation device for metal in-vitro degradation study according to claim 1, characterized in that: the sample chamber (2) is a transparent acrylic plate, a thin and long structure and a plug-in top cover (15) are adopted, round holes (18) are formed in the centers of two sides of the sample chamber in the length direction, two layers of acrylic plates are arranged at the bottom (17) of the sample chamber, and the width of a plug-in part of the top cover (15) is slightly smaller than the width of the inner wall of the sample chamber.
6. The dynamic simulation device for metal in-vitro degradation study according to claim 1, characterized in that: the sample chamber (2) is sealed by a raw material tape (16).
7. The dynamic simulation device for metal in-vitro degradation study according to claim 1, characterized in that: the liquid storage container (6) is a suction bottle with an upper nozzle and a lower nozzle.
8. The dynamic simulation device for metal in-vitro degradation study according to claim 1, characterized in that: the liquid collecting container (5) is a beaker with scales.
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| CN201921451191.8U CN210572232U (en) | 2019-09-03 | 2019-09-03 | Dynamic simulation device for metal in-vitro degradation research |
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| CN201921451191.8U CN210572232U (en) | 2019-09-03 | 2019-09-03 | Dynamic simulation device for metal in-vitro degradation research |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111965065A (en) * | 2020-08-28 | 2020-11-20 | 上海浦景化工技术股份有限公司 | Method for testing and evaluating degradation performance of organic temporary plugging agent for oil and gas field |
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2019
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111965065A (en) * | 2020-08-28 | 2020-11-20 | 上海浦景化工技术股份有限公司 | Method for testing and evaluating degradation performance of organic temporary plugging agent for oil and gas field |
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