CN203838159U - Colloidal gold test paper strip for detecting anti-cyclic citrullinated peptide antibodies and rheumatoid factors - Google Patents
Colloidal gold test paper strip for detecting anti-cyclic citrullinated peptide antibodies and rheumatoid factors Download PDFInfo
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- CN203838159U CN203838159U CN201420082575.8U CN201420082575U CN203838159U CN 203838159 U CN203838159 U CN 203838159U CN 201420082575 U CN201420082575 U CN 201420082575U CN 203838159 U CN203838159 U CN 203838159U
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- membrane
- nitrocellulose filter
- human igg
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- glass fibre
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- 108090000765 processed proteins & peptides Proteins 0.000 title claims abstract description 27
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 title claims abstract description 19
- 238000012360 testing method Methods 0.000 title abstract description 19
- 239000000020 Nitrocellulose Substances 0.000 claims abstract description 49
- 229920001220 nitrocellulos Polymers 0.000 claims abstract description 49
- 239000012528 membrane Substances 0.000 claims abstract description 43
- 239000003365 glass fiber Substances 0.000 claims abstract description 24
- 238000010521 absorption reaction Methods 0.000 claims abstract description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 11
- FJWGYAHXMCUOOM-QHOUIDNNSA-N [(2s,3r,4s,5r,6r)-2-[(2r,3r,4s,5r,6s)-4,5-dinitrooxy-2-(nitrooxymethyl)-6-[(2r,3r,4s,5r,6s)-4,5,6-trinitrooxy-2-(nitrooxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-3,5-dinitrooxy-6-(nitrooxymethyl)oxan-4-yl] nitrate Chemical compound O([C@@H]1O[C@@H]([C@H]([C@H](O[N+]([O-])=O)[C@H]1O[N+]([O-])=O)O[C@H]1[C@@H]([C@@H](O[N+]([O-])=O)[C@H](O[N+]([O-])=O)[C@@H](CO[N+]([O-])=O)O1)O[N+]([O-])=O)CO[N+](=O)[O-])[C@@H]1[C@@H](CO[N+]([O-])=O)O[C@@H](O[N+]([O-])=O)[C@H](O[N+]([O-])=O)[C@H]1O[N+]([O-])=O FJWGYAHXMCUOOM-QHOUIDNNSA-N 0.000 claims description 44
- 239000000427 antigen Substances 0.000 claims description 22
- 102000036639 antigens Human genes 0.000 claims description 20
- 108091007433 antigens Proteins 0.000 claims description 20
- 108010061103 cyclic citrullinated peptide Proteins 0.000 claims description 17
- 238000006116 polymerization reaction Methods 0.000 claims description 16
- 229960002173 citrulline Drugs 0.000 claims description 14
- RHGKLRLOHDJJDR-BYPYZUCNSA-N L-citrulline Chemical compound NC(=O)NCCC[C@H]([NH3+])C([O-])=O RHGKLRLOHDJJDR-BYPYZUCNSA-N 0.000 claims description 13
- RHGKLRLOHDJJDR-UHFFFAOYSA-N Ndelta-carbamoyl-DL-ornithine Natural products OC(=O)C(N)CCCNC(N)=O RHGKLRLOHDJJDR-UHFFFAOYSA-N 0.000 claims description 13
- 235000013477 citrulline Nutrition 0.000 claims description 13
- 238000001514 detection method Methods 0.000 claims description 13
- 230000002745 absorbent Effects 0.000 claims description 10
- 239000002250 absorbent Substances 0.000 claims description 10
- 239000010931 gold Substances 0.000 claims description 6
- 229910052737 gold Inorganic materials 0.000 claims description 6
- 239000000084 colloidal system Substances 0.000 claims description 4
- 239000000835 fiber Substances 0.000 claims description 3
- 239000005401 pressed glass Substances 0.000 claims description 3
- 230000035945 sensitivity Effects 0.000 abstract 1
- 239000007788 liquid Substances 0.000 description 7
- 206010039073 rheumatoid arthritis Diseases 0.000 description 7
- 238000010586 diagram Methods 0.000 description 6
- 239000000700 radioactive tracer Substances 0.000 description 6
- 101001018064 Homo sapiens Lysosomal-trafficking regulator Proteins 0.000 description 4
- 102100033472 Lysosomal-trafficking regulator Human genes 0.000 description 4
- 244000038561 Modiola caroliniana Species 0.000 description 4
- 235000010703 Modiola caroliniana Nutrition 0.000 description 4
- 238000004587 chromatography analysis Methods 0.000 description 4
- 101710135378 pH 6 antigen Proteins 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 3
- 125000004122 cyclic group Chemical group 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 244000061458 Solanum melongena Species 0.000 description 2
- 210000000988 bone and bone Anatomy 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000003018 immunoassay Methods 0.000 description 2
- 238000005507 spraying Methods 0.000 description 2
- 201000004595 synovitis Diseases 0.000 description 2
- 101100046775 Arabidopsis thaliana TPPA gene Proteins 0.000 description 1
- 208000006820 Arthralgia Diseases 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 206010003246 arthritis Diseases 0.000 description 1
- 210000001188 articular cartilage Anatomy 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000005784 autoimmunity Effects 0.000 description 1
- 210000000845 cartilage Anatomy 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 230000009266 disease activity Effects 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000013399 early diagnosis Methods 0.000 description 1
- 230000008407 joint function Effects 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 201000003068 rheumatic fever Diseases 0.000 description 1
- 230000000405 serological effect Effects 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- XZZNDPSIHUTMOC-UHFFFAOYSA-N triphenyl phosphate Chemical compound C=1C=CC=CC=1OP(OC=1C=CC=CC=1)(=O)OC1=CC=CC=C1 XZZNDPSIHUTMOC-UHFFFAOYSA-N 0.000 description 1
- 210000001364 upper extremity Anatomy 0.000 description 1
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- Peptides Or Proteins (AREA)
Abstract
The utility model belongs to the technical field of test strips and in particular relates to a colloidal gold test paper strip for detecting anti-cyclic citrullinated peptide antibodies and rheumatoid factors. The test paper strip comprises a base plate, wherein a sample gasket, a glass fiber membrane, a nitrocellulose membrane, a water absorption membrane and a water absorption filter paper are attached to the base plate and closely connected from left to right; when the sample gasket is closely connected with the glass fiber membrane, the glass fiber membrane is pressed by the sample gasket; when the glass fiber membrane is closely connected with the nitrocellulose membrane, the nitrocellulose membrane is pressed by the glass fiber membrane; when the nitrocellulose membrane is closely connected with the water absorption membrane, the nitrocellulose membrane is pressed by the water absorption membrane; when the water absorption membrane is closely connected with the water absorption filter paper, the water absorption membrane is pressed by the water absorption filter paper. The colloidal gold test paper strip for detecting anti-cyclic citrullinated peptide antibodies and rheumatoid factors is simple in design, capable of effectively reducing the error, simple and quick to operate, vivid, intuitive and accurate in display of results, low in cost and high in sensitivity.
Description
technical field
The utility model belongs to Lateral Flow Strip field, is specifically related to a kind of colloidal gold strip that detects anti-cyclic citrulline peptide antibody and rheumatoid factor.
background technology
Rheumatoid arthritis (Rheumatoid arthritis abridge RA.) is rheumatismal a kind of, is mainly to cause because carry out for a long time contact or the wind of cold water.Rheumatoid disease activity generally usually continues 3-6 month, and wandering pain is body arthralgia, and migration is indefinite, time and at shoulder, time and at elbow, time and at upper limbs.It is a kind of general autoimmunity disease that chronic aggressivity arthritis is feature of take.The lesion characteristic of rheumatoid arthritis is synovitis, and the articular cartilage causing thus and destruction of bone, finally causes joint deformity.Synovitis is outbreak repeatedly lastingly, the destruction that can cause cartilage and bone in joint, and joint function disturbance, if without regular treatment, approximately 75% patient there will be maimed person in 3 years.
Rheumatoid arthritis is distributed in all over the world, and the morbidity rate in different crowd is 0.18% ~ 1.07%, and its morbidity has certain racial difference, and Indians are higher than white people, and white people are higher than Asia yellow, at total number of patients of China, surpasses 5,000,000.Rheumatoid arthritis all can be fallen ill in each age, and the peak age, general women's morbidity was more than the male sex about 30 ~ 50 years old.
Up to now, main still according to clinical manifestation for the early diagnosis of RA; And serology means are mainly to detect rheumatoid factor (RF).RF can be used as the sensitive serologic marker thing of RA, and specificity is approximately 70%.1998, external, the anti-cyclic citrulline peptide antibody of reported first (anti-cyclic cirullinated peptide antibodies, anti-CCP antibody) detection, RA being had to higher specificity, can make up the defect of the poor specificity of RF, is the blood serum designated object that RA is new.Domestic The People's Hospital of Peking University in 2012 take the lead criteria for classification that national 12Jia hospital participates in having proposed early stage rheumatoid arthritis (ERA) jointly wherein Serological testing have one: anti-citrulline protein antibodies (comprising anti-CCP antibody and anti-MCV antibody), has at least a high titre positive.
Therefore, anti-cyclic citrullinated peptide (CCP) antibody and rheumatoid factor (RF) joint-detection diagnostics classes rheumatic arthritis promptly and accurately.Therefore, diagnosis morning for rheumatoid arthritis has very important significance.
Anti-cyclic citrullinated peptide (CCP) antibody and rheumatoid factor (RF) detection kit (colloidal gold method) adopt antigen-antibody reaction and the immunochromatographiassays assays technology of high degree of specificity.
Anti-cyclic citrullinated peptide (CCP) TPPA adopts dual-antigen sandwich method immunoassays principle: in test strips, contain and be coated in advance anti-cyclic citrullinated peptide (CCP) antigen of colloid gold label on glass fibre membrane and be coated on anti-cyclic citrullinated peptide (CCP) antigen on nitrocellulose filter.During detection, if sample contains anti-cyclic citrullinated peptide (CCP) antibody, can in anti-cyclic citrullinated peptide (CCP) antibody test district, form double antigens sandwich compound, have mauve band; If negative sample, does not have aubergine band in anti-cyclic citrullinated peptide (CCP) antibody test district.
Rheumatoid factor (RF) is measured and is adopted dual-antigen sandwich method immunoassays principle: in test strips, contain the coated in advance hot polymerization human IgG (as antigen) on glass fibre membrane and be coated on the hot polymerization human IgG (as antigen) on nitrocellulose filter.During detection, if sample is positive, can on rheumatoid factor (RF) test section, form double antigens sandwich compound, have mauve band; If negative sample, does not have aubergine band on rheumatoid factor (RF) test section.
summary of the invention
The purpose of this utility model is to provide a kind of colloidal gold strip that simultaneously detects anti-cyclic citrulline peptide antibody and rheumatoid factor.
The utility model is by the following technical solutions:
A kind of colloidal gold strip that detects anti-cyclic citrulline peptide antibody and rheumatoid factor, comprise base plate, on base plate, be attached with tight connected sample pad from left to right, glass fibre membrane, nitrocellulose filter and absorbing membrane and absorbent filter, when print pad is connected with glass fibre film close, sample pad is being pressed glass fibre membrane 1-3mm, when glass fibre membrane is connected with cellulose nitrate film close, glass fibre mould nitrocellulose filter 1-3mm, the nitrocellulose filter mould that absorbs water while being closely connected with absorbing membrane nitrocellulose filter 1-3mm, when absorbing membrane is closely connected with absorbent filter, absorbent filter is being pressed absorbing membrane 1-3mm.
On described glass fibre element film, absorption has cyclic citrullinated peptide antigen and the hot polymerization human IgG of colloid gold label.
On described nitrocellulose filter, be coated with cyclic citrullinated peptide antigen, hot polymerization human IgG (as antigen) and mouse-anti human IgG.
Cyclic citrullinated peptide antigen, hot polymerization human IgG and mouse-anti human IgG are all ribbon and are coated on nitrocellulose filter successively from left to right.
Absorbent filter can absorb the liquid that is not less than 500 microlitres.
The utility model adds to tracer liquid in sample pad while using, sample pad can fully absorb tracer liquid, the first chromatography of tracer liquid contacts abundant reaction completely with the gold mark antigen of spraying to glass fibre membrane, chromatography reacts to nitrocellulose filter again, when anti-cyclic citrullinated peptide (CCP) antibody and rheumatoid factor (RF), the content in sample, has mauve band in corresponding test section higher than test strips to its lowest detection in limited time.Anti-cyclic citrullinated peptide (CCP) antibody and the content of rheumatoid factor (RF) in sample, do not have mauve band in corresponding test section lower than test strips to its lowest detection in limited time.
Negative findings: only have purple line to occur at the coated place of mouse-anti human IgG of nitrocellulose filter, as shown in Figure 2 b.
Positive findings: there is purple line at coated place except the mouse-anti human IgG at nitrocellulose filter, at the coated place of cyclic citrullinated peptide antigen, hot polymerization human IgG of nitrocellulose filter, also there are one or two purple lines appearance, specifically: at the coated place of mouse-anti human IgG of nitrocellulose filter, the antigen coated place of cyclic citrullinated peptide of nitrocellulose filter, all have purple line to occur (seeing Fig. 2 d), show cyclic citrullinated peptide antibody positive; At the coated place of mouse-anti human IgG of nitrocellulose filter,, the coated place of hot polymerization human IgG of nitrocellulose filter all has purple line to occur (seeing Fig. 2 c), show that rheumatoid factor is positive; The coated place of mouse-anti human IgG, the cyclic citrullinated peptide antigen of nitrocellulose filter, the coated place of hot polymerization human IgG at nitrocellulose filter all have purple line to occur (seeing Fig. 2 e), illustrate that cyclic citrulline peptide antibody, rheumatoid factor are all positive.
Invalid: when nature controlling line (the coated place of mouse-anti human IgG of nitrocellulose filter) does not demonstrate red stripes, no matter whether detection line demonstrates red stripes, and it is invalid that this test card is judged to, as shown in Figure 2 a.
Simplicity of design of the present utility model, can reduce error effectively, and easy and simple to handle fast result shows image, directly perceived accurately, cost is low, highly sensitive.
accompanying drawing explanation
Fig. 1 is structural representation of the present utility model;
Fig. 2 is colour developing schematic diagram of the present utility model, 2a is that test card is judged to schematic diagram when invalid, the negative result schematic diagram of 2b, 2c is that rheumatoid factor positive findings schematic diagram, 2d are that cyclic citrullinated peptide antibody positive result schematic diagram, 2e are that cyclic citrulline peptide antibody, rheumatoid factor are positive findings schematic diagram.
embodiment
The anti-cyclic citrulline peptide antibody of detection as shown in Figure 1 and the colloidal gold strip of rheumatoid factor, comprise base plate 8, on base plate 8, be attached with tight connected sample pad 1 from left to right, glass fibre membrane 2, nitrocellulose filter 3, absorbing membrane 7 and absorbent filter 9, when print pad 1 is closely connected with glass fibre membrane 2, sample pad 1 is being pressed glass fibre membrane 2 1-3mm, when glass fibre membrane 2 is closely connected with nitrocellulose filter 3, glass fibre membrane 2 is being pressed nitrocellulose filter 3 1-3mm, when nitrocellulose filter 3 is closely connected with absorbing membrane 7, absorbing membrane 7 is being pressed nitrocellulose filter 3 1-3mm, when absorbing membrane 7 is closely connected with absorbent filter 9, absorbent filter 9 is being pressed absorbing membrane 7 1-3mm, on glass fibre element film 2, absorption has cyclic citrullinated peptide antigen and the hot polymerization human IgG of colloid gold label.; On nitrocellulose filter 3, be coated with and be all from left to right banded cyclic citrullinated peptide antigen 4, hot polymerization human IgG (as antigen) 5 and mouse-anti human IgG 6.
During use, tracer liquid is added in sample pad 1, sample pad 1 can fully absorb tracer liquid, and the first chromatography of tracer liquid contacts abundant reaction completely with the gold mark antigen of spraying to glass fibre membrane 2, then chromatography reacts to nitrocellulose filter 3.Concrete result judgement is as follows:
Negative findings: only the mouse-anti human IgG at control zone C(nitrocellulose filter 3 is coated with place) there is purple line to occur, as shown in Figure 2 b.
Positive findings: except (the coated place of mouse-anti human IgG 6 of nitrocellulose filter 3) has purple line in control C district, at surveyed area (the cyclic citrullinated peptide antigen 4 of nitrocellulose filter 3, the coated place of hot polymerization human IgG 5), also there are one or two purple lines appearance, specifically: at the coated place of mouse-anti human IgG 6 of nitrocellulose filter 3,, the coated place of cyclic citrullinated peptide antigen 4 of nitrocellulose filter 3 all has purple line to occur (seeing Fig. 2 d), show cyclic citrullinated peptide antibody positive; At the coated place of mouse-anti human IgG 6 of nitrocellulose filter 3,, the coated place of hot polymerization human IgG 5 of nitrocellulose filter 3 all has purple line to occur (seeing Fig. 2 c), show that rheumatoid factor is positive; At the coated place of mouse-anti human IgG 6 of nitrocellulose filter 3,, the cyclic citrullinated peptide antigen 4 of nitrocellulose filter 3, the coated place of hot polymerization human IgG 5 all have purple line to occur (seeing Fig. 2 e), illustrate that cyclic citrulline peptide antibody, rheumatoid factor are all positive.
Invalid: when nature controlling line (the coated place of mouse-anti human IgG 6 of nitrocellulose filter 3) does not demonstrate red stripes, no matter whether detection line demonstrates red stripes, and it is invalid that this test card is judged to, as shown in Figure 2 a.
Claims (4)
1. a colloidal gold strip that detects anti-cyclic citrulline peptide antibody and rheumatoid factor, comprise base plate, it is characterized in that, on base plate, be attached with tight connected sample pad from left to right, glass fibre membrane, nitrocellulose filter and absorbing membrane and absorbent filter, when print pad is connected with glass fibre film close, sample pad is being pressed glass fibre membrane, when glass fibre membrane is connected with cellulose nitrate film close, glass fibre mould nitrocellulose filter, the nitrocellulose filter mould that absorbs water while being closely connected with absorbing membrane nitrocellulose filter, when absorbing membrane is closely connected with absorbent filter, absorbent filter is being pressed absorbing membrane.
2. the colloidal gold strip of the anti-cyclic citrulline peptide antibody of detection as claimed in claim 1 and rheumatoid factor, is characterized in that, on described glass fibre element film, absorption has cyclic citrullinated peptide antigen and the hot polymerization human IgG of colloid gold label.
3. the colloidal gold strip of the anti-cyclic citrulline peptide antibody of detection as claimed in claim 1 or 2 and rheumatoid factor, is characterized in that, is coated with cyclic citrullinated peptide antigen, hot polymerization human IgG and mouse-anti human IgG on described nitrocellulose filter.
4. the colloidal gold strip of the anti-cyclic citrulline peptide antibody of detection as claimed in claim 3 and rheumatoid factor, is characterized in that, cyclic citrullinated peptide antigen, hot polymerization human IgG and mouse-anti human IgG are all ribbon and are coated on nitrocellulose filter successively from left to right.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420082575.8U CN203838159U (en) | 2014-02-26 | 2014-02-26 | Colloidal gold test paper strip for detecting anti-cyclic citrullinated peptide antibodies and rheumatoid factors |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420082575.8U CN203838159U (en) | 2014-02-26 | 2014-02-26 | Colloidal gold test paper strip for detecting anti-cyclic citrullinated peptide antibodies and rheumatoid factors |
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| Publication Number | Publication Date |
|---|---|
| CN203838159U true CN203838159U (en) | 2014-09-17 |
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| CN201420082575.8U Expired - Lifetime CN203838159U (en) | 2014-02-26 | 2014-02-26 | Colloidal gold test paper strip for detecting anti-cyclic citrullinated peptide antibodies and rheumatoid factors |
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| CN (1) | CN203838159U (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104360083A (en) * | 2014-12-05 | 2015-02-18 | 重庆乾德生物技术有限公司 | Detection kit for quantitatively detecting rheumatoid factors and antistreptolysin O and C reactive proteins |
| CN104374911A (en) * | 2014-12-05 | 2015-02-25 | 重庆乾德生物技术有限公司 | Detection kit for quantitative detection of rheumatoid factors and anti streptolysin O |
| CN104459140A (en) * | 2014-12-05 | 2015-03-25 | 重庆乾德生物技术有限公司 | Detection kit for quantitative detection of rheumatoid factor, antistreptolysin O, anti cyclic citrullinated peptide antibody and C reactive protein |
| CN111077321A (en) * | 2020-01-02 | 2020-04-28 | 北京森美希克玛生物科技有限公司 | anti-MCV antibody quantitative detection kit and preparation method thereof |
-
2014
- 2014-02-26 CN CN201420082575.8U patent/CN203838159U/en not_active Expired - Lifetime
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104360083A (en) * | 2014-12-05 | 2015-02-18 | 重庆乾德生物技术有限公司 | Detection kit for quantitatively detecting rheumatoid factors and antistreptolysin O and C reactive proteins |
| CN104374911A (en) * | 2014-12-05 | 2015-02-25 | 重庆乾德生物技术有限公司 | Detection kit for quantitative detection of rheumatoid factors and anti streptolysin O |
| CN104459140A (en) * | 2014-12-05 | 2015-03-25 | 重庆乾德生物技术有限公司 | Detection kit for quantitative detection of rheumatoid factor, antistreptolysin O, anti cyclic citrullinated peptide antibody and C reactive protein |
| CN104360083B (en) * | 2014-12-05 | 2016-08-17 | 重庆乾德生物技术有限公司 | A kind of detection by quantitative rheumatoid factor, antistreptolysin O (ASO), the detection kit of c reactive protein |
| CN111077321A (en) * | 2020-01-02 | 2020-04-28 | 北京森美希克玛生物科技有限公司 | anti-MCV antibody quantitative detection kit and preparation method thereof |
| CN111077321B (en) * | 2020-01-02 | 2023-05-23 | 北京森美希克玛生物科技有限公司 | Quantitative detection kit for anti-MCV antibody and preparation method thereof |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CP03 | Change of name, title or address | ||
| CP03 | Change of name, title or address |
Address after: 450016 Zhengzhou City, Henan Province, Zhengzhou city free trade test district Zhengzhou section (open) nautical East Road No. 1356 super sub Garden No. 5 floor east of the East Co-patentee after: Liu Qi Patentee after: Zhengzhou Bangqi Bio Technology Co.,Ltd. Address before: 450000, No. five, building No. 18, Henan Province University Science Park, No. 11, Changchun Road, Zhengzhou City, Henan Co-patentee before: Liu Qi Patentee before: ZHENGZHOU LANGFENG BIOTECHNOLOGY CO.,LTD. |
|
| CX01 | Expiry of patent term | ||
| CX01 | Expiry of patent term |
Granted publication date: 20140917 |