CN203750416U - Disposable circulating transferring multilayer co-extrusion bag for ultrafiltration - Google Patents
Disposable circulating transferring multilayer co-extrusion bag for ultrafiltration Download PDFInfo
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- CN203750416U CN203750416U CN201320888549.XU CN201320888549U CN203750416U CN 203750416 U CN203750416 U CN 203750416U CN 201320888549 U CN201320888549 U CN 201320888549U CN 203750416 U CN203750416 U CN 203750416U
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- bag
- conduit
- soldering opening
- disposable
- ultrafiltration
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Abstract
The utility model belongs to the technical field of ultrafiltration technical equipment, and in particular relates to a disposable circulating transferring multilayer co-extrusion bag for ultrafiltration. The disposable circulating transferring multilayer co-extrusion bag for ultrafiltration comprises a bag body, a liquid inlet and an internal circulating liquid inlet which are formed in the top of the bag body, a liquid outlet pipeline and an internal circulating liquid outlet which are formed in the bottom of the bag body, a circulating pump which is arranged between the internal circulating liquid inlet and the internal circulating liquid outlet, and a ventilating pipeline which is arranged on the bag body and is used for feeding gas. The disposable circulating transferring multilayer co-extrusion bag provided by the utility model replaces a conventional stainless steel material storage tank which is high in cost, high in operation and maintenance difficulty and low in usability; due to disposable use, cleaning and storage and cross contamination of a product are avoided; due to a unique liquid circulating technology, the problem of inactivity, which is caused by uniform stirring and mixing, of a sample can be effectively solved; by the use of a foldable pre-sterilization bag body material, the disposable circulating transferring multilayer co-extrusion bag is conveniently and quickly used and does not occupy a space; the production efficiency is greatly improved, and the running cost is lowered.
Description
Technical field
The utility model belongs to the technical field of ultrafiltration technology equipment, is specifically related to the multi-layer co-extruded bag of disposable circulation transfer for ultrafiltration.
Background technology
Tangential flow filtration (TFF) is a kind of filter operation mode being widely adopted in pharmaceutical technology, mainly comprises slipstream micro-filtration and ultrafiltration.As very important separation and means of purification, its application has contained that clarification filtration, product are concentrated, depyrogenation, except various aspects such as small molecular weight impurity, desalination and buffer solution displacements, be widely used in monoclonal antibody, recombinant protein, vaccine, biogenetic products, blood product, small-molecule drug, the products such as Chinese medicine and natural products.
The course of work of tangential flow filtration (TFF) system, as shown in Figure 1, stoste is pumped in storage tank 11, in storage tank 11, fully stir and evenly mix, pump in ultrafiltration apparatus 13 through peristaltic pump 12, be separated into phegma and waste liquid through milipore filter, shown in phegma be back in storage tank 11 to stir and again to enter ultrafiltration apparatus 13 and carry out ultrafiltration, waste liquid imports in waste liquid tank 14 and collects, and finally from storage tank 11, derives satisfactory product through loop ultrafiltration repeatedly.
In prior art, storage tank is stainless cylinder of steel, before each use, need to carry out sterilization thoroughly, this process complexity, consuming time and operating cost is higher, and the mode of passing through to stir and evenly mix in storage tank easily causes the inactivation of biological sample, the control of harsh technological parameter has increased the difficulty of operation.
Utility model content
Technical problem to be solved in the utility model is that current storage tank operating cost is high but efficiency is low, in order to overcome above deficiency, provides a kind of disposable circulation transfer for ultrafiltration multi-layer co-extruded bag.
In order to solve the problems of the technologies described above, the technical solution of the utility model is: the multi-layer co-extruded bag of the described disposable circulation transfer for ultrafiltration, comprise bag, be arranged on bag top inlet and interior circulation liquid inlet, be arranged on bag bottom fluid pipeline and interior circulation liquid outlet, be arranged on the circulating pump between interior circulation liquid inlet and interior circulation liquid outlet and be arranged on bag for passing into the vent line of gas.Stoste is imported in bag, is passed through circulating pump by inlet, liquid in bag out enters from the liquid inlet that circulates in top from the liquid outlet that circulates in bottom, realize mixing of the interior liquid of bag, avoid stirring and evenly mixing the sample inactivation problem causing, the liquid mixing enters ultrafiltration apparatus through fluid pipeline, phegma after ultrafiltration is back in bag again through inlet, after ultrafiltration repeatedly, pass into compressed air by vent line the product in bag is all extruded from fluid pipeline, empty circulation transfer bag can directly abandon without clean and maintenance.
Preferably, described inlet comprises the soldering opening being arranged on bag and the welding chuck on soldering opening is set, described interior circulation liquid inlet comprises and is arranged on the soldering opening on bag and the welding chuck on soldering opening is set, and described interior circulation liquid outlet comprises and is arranged on the soldering opening on bag and the welding chuck on soldering opening is set.
Preferably, described vent line comprises the soldering opening being arranged on bag, the conduit being connected with soldering opening, the welding chuck being connected with conduit and extends the conduit sealing of welding chuck, described conduit is provided with hose clip, described conduit is fixedly connected with by band with soldering opening, and described welding chuck is fixedly connected with by band with conduit.
Preferably, described fluid pipeline comprises the soldering opening being arranged on bag, the conduit being connected with soldering opening, the welding chuck being connected with conduit and extends the conduit sealing of welding chuck, described conduit is provided with hose clip, and described welding chuck is fixedly connected with by band with conduit.
Preferably, described bag top is also provided with the first sampling line, and described bag bottom is also provided with the second sampling line.Described the first sampling line detects for the sampling of sample introduction and process, and sampling when described the second sampling line finishes sample for ultrafiltration detects.
Preferably, described the first sampling line comprises the soldering opening being arranged on bag, the conduit being connected with soldering opening, the female Luer being connected with conduit and is arranged on the calparine cap in female Luer, described conduit is provided with hose clip, described soldering opening is fixedly connected with by band with conduit, and described female Luer is fixedly connected with by band with conduit.
Preferably, the soldering opening of described the first sampling line is twin adapter soldering opening, and described twin adapter soldering opening one end is connected with the probe tube in bag, and the other end is connected with the conduit outside bag.The probe tube going deep in bag can pick up multiposition place sample in bag as required.
Preferably, described the second sampling line comprises the soldering opening being arranged on bag, the conduit being connected with soldering opening, the female Luer being connected with conduit and is arranged on the calparine cap in female Luer, described conduit is provided with hose clip, and described conduit is fixedly connected with by band with female Luer.
Described hose clip is for clamping and loosening conduit, thus the flow of control liquid.
Preferably, described bag is cuboid, and the sealing of described bag is positioned at bag top, bottom and/or sidepiece.
Preferably, the sealing of described bag is diagonal angle and intersects, and bag top or bag bottom are divided into four regions, and one of them region is interface area, all described soldering openings are all positioned at interface area, and the interface area of the interface area at bag top and bag bottom is oppositely arranged up and down.Can ensure shared region minimum when stored collapsed like this.
Preferably, described conduit is medical silicone tube or welding plastic tube, and described bag is formed by three-layer extrusion film or five-layer co-squeezing film production.Described welding plastic tube can be the pipe fitting of TPE (thermoplastic elastomer (TPE)) material.
The technical scheme that the utility model provides has substituted traditional stainless steel material storage tank that cost is high, operation maintenance difficulty is large and service efficiency is low, the cross pollution of clean and preservation and product has been avoided in disposable use, exclusive liquid-circulating technology can solve the sample inactivation problem causing that stirs and evenly mixs effectively, folding pre-sterilized bag material makes to use more convenient and quicker, do not take up space, the production efficiency greatly having improved, has saved operating cost.
Brief description of the drawings
Fig. 1 is the schematic diagram of tangential flow filtration system in prior art;
Fig. 2 is the structural representation of the multi-layer co-extruded bag of the disposable circulation transfer for ultrafiltration described in the utility model one detailed description of the invention;
Fig. 3 is described bag top structure schematic diagram;
Fig. 4 is described bag polycrystalline substance schematic diagram.
Shown in figure:
11-storage tank, 12-peristaltic pump, 13-ultrafiltration apparatus, 14-waste liquid tank; 21-bag, 211-sealing, 212-interface area, 22-inlet, circulation liquid inlet in 23-, 24-the first sampling line, 25-fluid pipeline, circulation liquid outlet in 26-, 27-the second sampling line, 28-circulating pump, 29-vent line; 100-soldering opening, 101-welds chuck, 102-conduit, the sealing of 103-conduit, 104-hose clip, 105-band, 106-twin adapter soldering opening, 107-probe tube, 108-female Luer, 109-calparine cap.
Detailed description of the invention
Below in conjunction with accompanying drawing, the utility model is described in detail:
As shown in Figure 2, the multi-layer co-extruded bag of disposable circulation transfer for ultrafiltration described in the utility model, comprises bag 21, is arranged on the inlet 22 at bag 21 tops, interior circulation liquid inlet 23 and the first sampling line 24, is arranged on the fluid pipeline 25 of bag 21 bottoms, interior circulation liquid outlet 26 and the second sampling line 27, is arranged on the circulating pump 28 between interior circulation liquid inlet 23 and interior circulation liquid outlet 26 and is arranged on bag 21 tops for passing into the vent line 29 of gas.Described bag 21 is cuboid, the sealing 211 of described bag 21 is positioned at bag 21 tops and bottom, described sealing 211 is diagonal angle and intersects, bag 21 tops or bag 21 bottoms are divided into four regions, one of them region is interface area 212, and the interface area 212 at bag top is oppositely arranged up and down with the interface area 212 of bag bottom.
As shown in Figure 3, described bag 21 tops set gradually inlet 22, vent line 29, the first sampling line 24 and interior circulation liquid inlet 23 from left to right, and described inlet 22 comprises the soldering opening 100 being arranged on bag 21 and the welding chuck 101 on soldering opening 100 is set; Described vent line 29 comprises the soldering opening 100 being arranged on bag 21, the conduit 102 being connected with soldering opening 100, the welding chuck 101 being connected with conduit 102 and extends the conduit sealing 103 of welding chuck 101, described conduit 102 is provided with hose clip 104, described conduit 102 is fixedly connected with by band 105 with soldering opening 100, and described welding chuck 101 is fixedly connected with by band 105 with conduit 102; Described the first sampling line 24 comprises that the twin adapter soldering opening 106 being arranged on bag 21, described twin adapter soldering opening 106 one end are connected with the probe tube 107 in bag 21, the female Luer 108 that the other end is connected with the conduit 102 outside bag 21, is connected with conduit 102 and be arranged on the calparine cap 109 in female Luer 108, described conduit 102 is provided with hose clip 104, described twin adapter soldering opening 106 is fixedly connected with by band 105 with conduit 102, and described female Luer 108 is fixedly connected with by band 105 with conduit 102; Described interior circulation liquid inlet 23 comprises and is arranged on the soldering opening on bag 21 100 and the welding chuck 101 on soldering opening 100 is set.
As shown in Figure 4, described bag 21 bottoms set gradually the second sampling line 27, interior circulation liquid outlet 26 and fluid pipeline 25 from left to right, described the second sampling line 27 comprises the soldering opening 100 being arranged on bag 21, the conduit 102 being connected with soldering opening 100, the female Luer 108 being connected with conduit 102 and is arranged on the calparine cap 109 in female Luer 108, described conduit 102 is provided with hose clip 104, and described conduit 102 is fixedly connected with by band 105 with female Luer 108; Described interior circulation liquid outlet 26 comprises and is arranged on the soldering opening on bag 21 100 and the welding chuck 101 on soldering opening 100 is set; Described fluid pipeline 25 comprises the soldering opening 100 being arranged on bag 21, the conduit 102 being connected with soldering opening 100, the welding chuck 101 being connected with conduit 102 and extends the conduit sealing 103 of welding chuck 101, described conduit 102 is provided with hose clip 104, and described welding chuck 101 is fixedly connected with by band 105 with conduit 102.
As shown in Figure 1, all described soldering openings 100 are all positioned at interface area 212.
Described conduit 102 is medical silicone tube, and described bag 21 is formed with film production by three-layer co-extruded film for transfusion or five-layer coextrusion transfusion.It is pointed out that described conduit 102 can be also welding TPE pipe.
The use procedure of the multi-layer co-extruded bag of the disposable circulation transfer for ultrafiltration described in the utility model is as follows:
Before using, bag is put into and supported container, import stoste from inlet 22, then inlet 22 is connected with ultrafiltration apparatus 13 phegma outlets, described fluid pipeline 25 is connected with the inlet of ultrafiltration apparatus 13, the external circulation line that forms ultrafiltration, meanwhile the liquid in phegma and bag 21 mixes by the inner loop pipeline that is recycled into liquid interruption-forming in interior circulation liquid outlet 26, circulating pump 28; In ultra-filtration process, sample tracking and monitoring by the first sampling line 24, loop ultrafiltration repeatedly after, pass into compressed air or nitrogen from vent line 29, the product in bag 21 is emitted from fluid pipeline 25.
These are only preferred embodiment of the present utility model, the utility model is not played to any restriction.Any person of ordinary skill in the field; not departing from the scope of the technical solution of the utility model; the technical scheme that the utility model is disclosed and technology contents make any type of variations such as replacement or amendment that are equal to; all belong to the content that does not depart from the technical solution of the utility model, within still belonging to protection domain of the present utility model.
Claims (10)
1. the multi-layer co-extruded bag of the disposable circulation transfer for ultrafiltration, it is characterized in that, comprise bag, be arranged on bag top inlet and interior circulation liquid inlet, be arranged on bag bottom fluid pipeline and interior circulation liquid outlet, be arranged on the circulating pump between interior circulation liquid inlet and interior circulation liquid outlet and be arranged on bag for passing into the vent line of gas.
2. the multi-layer co-extruded bag of a kind of disposable circulation transfer for ultrafiltration according to claim 1, is characterized in that, described bag top is also provided with the first sampling line, and described bag bottom is also provided with the second sampling line.
3. the multi-layer co-extruded bag of a kind of disposable circulation transfer for ultrafiltration according to claim 2, it is characterized in that, described the first sampling line comprises the soldering opening being arranged on bag, the conduit being connected with soldering opening, the female Luer being connected with conduit and is arranged on the calparine cap in female Luer, described conduit is provided with hose clip, described soldering opening is fixedly connected with by band with conduit, and described female Luer is fixedly connected with by band with conduit.
4. the multi-layer co-extruded bag of a kind of disposable circulation transfer for ultrafiltration according to claim 3, it is characterized in that, the soldering opening of described the first sampling line is twin adapter soldering opening, and described twin adapter soldering opening one end is connected with the probe tube in bag, and the other end is connected with the conduit outside bag.
5. the multi-layer co-extruded bag of a kind of disposable circulation transfer for ultrafiltration according to claim 2, it is characterized in that, described the second sampling line comprises the soldering opening being arranged on bag, the conduit being connected with soldering opening, the female Luer being connected with conduit and is arranged on the calparine cap in female Luer, described conduit is provided with hose clip, and described conduit is fixedly connected with by band with female Luer.
6. the multi-layer co-extruded bag of a kind of disposable circulation transfer for ultrafiltration according to claim 1, it is characterized in that, described inlet comprises the soldering opening being arranged on bag and the welding chuck on soldering opening is set, described interior circulation liquid inlet comprises and is arranged on the soldering opening on bag and the welding chuck on soldering opening is set, and described interior circulation liquid outlet comprises and is arranged on the soldering opening on bag and the welding chuck on soldering opening is set.
7. the multi-layer co-extruded bag of a kind of disposable circulation transfer for ultrafiltration according to claim 1, it is characterized in that, described vent line comprises the soldering opening being arranged on bag, the conduit being connected with soldering opening, the welding chuck being connected with conduit and extends the conduit sealing of welding chuck, described conduit is provided with hose clip, described conduit is fixedly connected with by band with soldering opening, and described welding chuck is fixedly connected with by band with conduit.
8. the multi-layer co-extruded bag of a kind of disposable circulation transfer for ultrafiltration according to claim 1, it is characterized in that, described fluid pipeline comprises the soldering opening being arranged on bag, the conduit being connected with soldering opening, the welding chuck being connected with conduit and extends the conduit sealing of welding chuck, described conduit is provided with hose clip, and described welding chuck is fixedly connected with by band with conduit.
9. according to the multi-layer co-extruded bag of the arbitrary described a kind of disposable circulation transfer for ultrafiltration of claim 3-8, it is characterized in that, described bag is cuboid, the sealing of described bag is positioned at bag top, bottom and/or sidepiece, the sealing of described bag is diagonal angle and intersects, bag top or bag bottom are divided into four regions, one of them region is interface area, all described soldering openings are all positioned at interface area, and the interface area of the interface area at bag top and bag bottom is oppositely arranged up and down.
10. according to the multi-layer co-extruded bag of a kind of disposable circulation transfer for ultrafiltration described in claim 3,4,5,7 or 8, it is characterized in that, described conduit is medical silicone tube or welding plastic tube, and described bag is formed by three-layer extrusion film or five-layer co-squeezing film production.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201320888549.XU CN203750416U (en) | 2013-12-30 | 2013-12-30 | Disposable circulating transferring multilayer co-extrusion bag for ultrafiltration |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201320888549.XU CN203750416U (en) | 2013-12-30 | 2013-12-30 | Disposable circulating transferring multilayer co-extrusion bag for ultrafiltration |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN203750416U true CN203750416U (en) | 2014-08-06 |
Family
ID=51245726
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201320888549.XU Expired - Fee Related CN203750416U (en) | 2013-12-30 | 2013-12-30 | Disposable circulating transferring multilayer co-extrusion bag for ultrafiltration |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN203750416U (en) |
-
2013
- 2013-12-30 CN CN201320888549.XU patent/CN203750416U/en not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20140806 Termination date: 20161230 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |