CN203619954U - Skin repair membrane - Google Patents
Skin repair membrane Download PDFInfo
- Publication number
- CN203619954U CN203619954U CN201320783427.4U CN201320783427U CN203619954U CN 203619954 U CN203619954 U CN 203619954U CN 201320783427 U CN201320783427 U CN 201320783427U CN 203619954 U CN203619954 U CN 203619954U
- Authority
- CN
- China
- Prior art keywords
- membrane
- skin
- polyurethane
- nano fibers
- polyurethane non
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000012528 membrane Substances 0.000 title claims abstract description 49
- 239000002121 nanofiber Substances 0.000 claims abstract description 22
- 229920002635 polyurethane Polymers 0.000 claims abstract description 15
- 239000004814 polyurethane Substances 0.000 claims abstract description 15
- 239000000853 adhesive Substances 0.000 claims abstract description 5
- 230000001070 adhesive effect Effects 0.000 claims abstract description 5
- 239000011148 porous material Substances 0.000 claims abstract description 4
- 239000000835 fiber Substances 0.000 claims description 4
- 238000010041 electrostatic spinning Methods 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 2
- 239000004745 nonwoven fabric Substances 0.000 abstract description 4
- 239000002131 composite material Substances 0.000 abstract description 2
- 230000000694 effects Effects 0.000 abstract description 2
- 208000015181 infectious disease Diseases 0.000 abstract description 2
- 239000010410 layer Substances 0.000 abstract 7
- 244000052616 bacterial pathogen Species 0.000 abstract 1
- 230000009286 beneficial effect Effects 0.000 abstract 1
- 239000002355 dual-layer Substances 0.000 abstract 1
- 210000005260 human cell Anatomy 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
- 210000003491 skin Anatomy 0.000 description 35
- 208000027418 Wounds and injury Diseases 0.000 description 7
- 206010052428 Wound Diseases 0.000 description 6
- 239000000463 material Substances 0.000 description 6
- 229920000747 poly(lactic acid) Polymers 0.000 description 6
- 239000004626 polylactic acid Substances 0.000 description 6
- 230000001939 inductive effect Effects 0.000 description 5
- 229920006264 polyurethane film Polymers 0.000 description 5
- 210000001519 tissue Anatomy 0.000 description 5
- 208000028990 Skin injury Diseases 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- 230000002500 effect on skin Effects 0.000 description 4
- 239000011159 matrix material Substances 0.000 description 4
- 230000036560 skin regeneration Effects 0.000 description 4
- 230000029663 wound healing Effects 0.000 description 4
- 229920001661 Chitosan Polymers 0.000 description 3
- 230000000844 anti-bacterial effect Effects 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 230000007812 deficiency Effects 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 229920002379 silicone rubber Polymers 0.000 description 2
- 239000004945 silicone rubber Substances 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 208000010392 Bone Fractures Diseases 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 206010016326 Feeling cold Diseases 0.000 description 1
- 206010016334 Feeling hot Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 241000282898 Sus scrofa Species 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 210000003850 cellular structure Anatomy 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 244000000010 microbial pathogen Species 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 238000009418 renovation Methods 0.000 description 1
- 238000004088 simulation Methods 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
Images
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- Materials For Medical Uses (AREA)
Abstract
The utility model discloses a skin repair membrane, which is of a dual-layer composite structure. The skin repair membrane comprises an inner layer made of a biodegradable nanofiber membrane and an outer layer made of polyurethane non-woven fabrics. The biodegradable nanofiber membrane is a whole with a double-layer structure, the nano fibers at the inner layer are longitudinally arranged in parallel, and the nano fibers at the outer layer are disorderly arranged; the biodegradable nanofiber membrane and the polyurethane non-woven fabrics are stuck into a whole through a medical adhesive. The nano fibers which are longitudinally arranged in parallel at the inner layer of the biodegradable nanofiber membrane are beneficial to attached growth of human cells, the nano fibers which are disorderly arranged at the outer layer form abundant micro-pores, can effectively block pathogenic bacteria and avoid infection; the nanofiber membrane can be degraded and absorbed by a human body; and the skin repair membrane is free of toxic and side effects on the human body. The polyurethane non-woven fabrics have good breathability and flexibility, and can play a protection role; and after the wound is healed, the polyurethane membrane automatically falls off and is not adhered to skin tissues.
Description
Technical field
This utility model relates to a kind of medical composite material, specifically relates to a kind of skin reparative membrane.
Background technology
Skin refers to that body surface wraps in the tissue of muscle outside, is the organ of human body maximum, is mainly bearing the function of protecting health, perspire, feeling cold and hot and pressure.Skin covers whole body, and it makes the interior various tissues of body and organ avoid the invasion and attack of physical property, mechanicalness, chemical and pathogenic microorganism.Therefore when skin is subject to the infringements such as wound, burn, inflammation, especially, in the time that large-area skin is subject to grievous injury, wound should be protected immediately.
The skin injury being caused by extensive deep burn, wound etc. is commonly encountered diseases and frequently-occurring disease clinically, is characterized in that skin injury area is large, and it is damaged to be accompanied by skin corium in various degree.For this tissue defect, the methods that adopt auto-skin grafting at present more, this not only causes for the new wound of district's skin, and is often subject to the restriction for skin source.Therefore preparing artificial skin repair materials has become the study hotspot for the treatment of skin injury.Desirable skin repair material should have following characteristics: the pliability close with human body skin, no antigen, good biocompatibility, can inducing self-body skin regeneration, support is finally degraded, can presses close to wound surface, has the effect of resistance bacterium, can adapt to irregular wound surface, to be easy to preserve, easily to observe wound healing situation, price expensive etc., there is no at present the artificial skin substitute that meets above-mentioned condition completely and come out.
A kind of skin reparative membrane of patent (200920106362.3) discloses a kind of skin reparative membrane, it is characterized in that being provided with the acellular dermal matrix of penetrance otch, acellular dermal matrix derives from the acellular dermal matrix of the mammiferous skins such as cattle, pig, sheep, its deficiency is to be mainly difficult to cause epidermis cell and the intradermal cell component of host immune rejection except deenergizing completely, causes immunological rejection.A kind of compound artificial skin of patent (201220583941.9) discloses a kind of compound artificial skin, comprise silicone rubber membrane and chitosan film, chitosan film is connected on a side of silicone rubber membrane, fit into the structure that is made into integration compound artificial skin, its deficiency is mainly that chitosan non-woven fabrics fiber diameter is larger, is unfavorable for the growth of depending on of cell.
Polylactic acid has tight security and can be absorbed by tissue human body, in addition its good physical and mechanical properties, be widely used in biomedicine field, torn type operation suture thread, the agent of agents alleviate packing, artificial bone fracture internal fixation material, tissue renovation material, artificial skin etc. as exempted from open.The structure of polylactic acid nano fiber membrane simulation human body dermal matrix, the framework that can provide cell to depend on growth, inducing self-body skin regeneration is repaired.Polyurethane material has excellent physical and mechanical properties, the good advantage such as blood and histocompatibility, hypotoxicity, increasingly extensive in purposes medically, the wearability of the elasticity that it is good and toughness, excellence, having and the similar mechanical property of human body skin and sense of touch, is the excellent material of preparing artificial skin.
Summary of the invention
In the problem for the deficiencies in the prior art and existence, the purpose of this utility model is to provide a kind of simple in structure, skin reparative membrane safely and effectively.
The technical solution of the utility model is achieved in that
Skin reparative membrane provided by the utility model, comprises degradable nano fibrous membrane and polyurethane non-woven membrane, and described degradable nano fibrous membrane is connected on a side of polyurethane film by medical adhesive.
In order to improve the adhesiveness of Skin Cell and to prevent that antibacterial from infecting, described degradable nano fibrous membrane is the double-decker nano fibrous membrane of being prepared by electrostatic spinning, and internal layer is made up of the nanofiber of longitudinal arrangement, and skin is made up of the nanofiber of lack of alignment.Nanofiber film thickness is 0.01-0.5mm, is uniformly distributed micropore on film, and pore size scope is 0.05-0.5 μ m.
In order to improve intensity of the present utility model and breathability, the polyurethane non-woven membrane of being prepared by meltblown at the outer bonding of degradable nano fibrous membrane one deck, described polyurethane non-woven membrane thickness is 0.1-1.5mm.
This utility model adopts degradable nano fibrous membrane and polyurethane film through the compound skin reparative membrane of medical adhesive all-in-one-piece processed, polylactic acid membrane has the biocompatibility structure similar with human body skin substrate of height, can repair by inducing self-body skin regeneration, wound healing, and can be absorbed by the body.Micropore on film can also stop antibacterial to pass through, and protects from infection; Polyurethane film has excellent pliability, the flexibility close with skin and good breathability, and when after wound healing, polyurethane film can Automatic-falling, can not stick together with skin, avoid secondary insult, and polyurethane film is transparent, easy to use and observe wound healing situation.
Of the present utility model simple in structure, easily manufactured, safe, can inducing self-body skin regeneration repair, can be applicable to the reparation of the skin injury that a variety of causes causes, there is higher actual application value at medical domain.
Accompanying drawing explanation
Fig. 1 is the perspective view of skin reparative membrane.
Fig. 2 is the side view of skin reparative membrane.
The specific embodiment
As shown in Figure 1,1 represents polyurethane nonwoven layer to perspective view of the present utility model, and 2 represent the skin of polylactic acid nano fiber film, fiber lack of alignment, and 3 represent the internal layer of polylactic acid nano fiber film, fiber parallel longitudinal is arranged.Polyurethane nonwoven layer and polylactic acid nano fiber rete connect as one with medical adhesive, and integral thickness is 0.1-2mm.
In order to make to the utlity model has the regeneration of inducing self-body skin repair and prevent the function that antibacterial infects, above-mentioned degradable nano fibrous membrane is the double-decker nano fibrous membrane of being prepared by electrostatic spinning, internal layer is made up of the nanofiber of longitudinal arrangement, and skin is made up of the nanofiber of lack of alignment.Nanofiber film thickness is 0.01-0.5mm, is uniformly distributed micropore on film, and pore size scope is 0.05-0.5 μ m.
In order to make the utlity model has the pliability close with autologous skin and intensity, the polyurethane non-woven membrane of being prepared by meltblown at the outer bonding of degradable nano fibrous membrane one deck, described polyurethane non-woven membrane thickness is 0.1-1.5mm.
Claims (5)
1. a skin reparative membrane, is characterized in that comprising degradable nano fibrous membrane and polyurethane non-woven membrane, and described degradable nano fibrous membrane is connected on a side of polyurethane non-woven membrane by medical adhesive.
2. skin reparative membrane according to claim 1, is characterized in that described degradable nano fibrous membrane is the double-deck entirety that has of being prepared by method of electrostatic spinning, and its internal layer nanofiber parallel longitudinal is arranged, its outer nanofiber lack of alignment.
3. skin reparative membrane according to claim 1, is characterized in that skin repair film thickness is 0.1-2mm.
4. skin reparative membrane according to claim 1, the thickness that it is characterized in that polyurethane non-woven membrane is 0.1-1.5mm.
5. skin reparative membrane according to claim 2, is characterized in that above-mentioned degradable nano fibrous membrane general thickness is 0.01-0.5mm; The internal layer thickness of parallel fiber composition is 10-100 μ m, and unordered fibrous outer layer thickness is 50-500 μ m; Nanofiber diameter is 10-1000nm, and pore size scope is 0.05-0.5 μ m.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201320783427.4U CN203619954U (en) | 2013-12-03 | 2013-12-03 | Skin repair membrane |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201320783427.4U CN203619954U (en) | 2013-12-03 | 2013-12-03 | Skin repair membrane |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN203619954U true CN203619954U (en) | 2014-06-04 |
Family
ID=50806489
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201320783427.4U Expired - Lifetime CN203619954U (en) | 2013-12-03 | 2013-12-03 | Skin repair membrane |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN203619954U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104941011A (en) * | 2015-06-09 | 2015-09-30 | 烟台森森环保科技有限公司 | Medical film with cell scaffold for preventing tissue adhesion in medical surgery |
| CN112076022A (en) * | 2020-09-29 | 2020-12-15 | 苏州永沁泉智能设备有限公司 | Wound dressing paste and preparation method thereof |
-
2013
- 2013-12-03 CN CN201320783427.4U patent/CN203619954U/en not_active Expired - Lifetime
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104941011A (en) * | 2015-06-09 | 2015-09-30 | 烟台森森环保科技有限公司 | Medical film with cell scaffold for preventing tissue adhesion in medical surgery |
| CN112076022A (en) * | 2020-09-29 | 2020-12-15 | 苏州永沁泉智能设备有限公司 | Wound dressing paste and preparation method thereof |
| CN112076022B (en) * | 2020-09-29 | 2022-02-22 | 苏州永沁泉智能设备有限公司 | Wound dressing paste and preparation method thereof |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C56 | Change in the name or address of the patentee | ||
| CP01 | Change in the name or title of a patent holder |
Address after: 621 room 3, B, factory building, 32 overseas Chinese Pioneer Park, Yantai Development Zone, Shandong, Zhujianglu Road 264006, China Patentee after: SHANDONG JUNXIU BIOTECHNOLOGY CO.,LTD. Address before: 621 room 3, B, factory building, 32 overseas Chinese Pioneer Park, Yantai Development Zone, Shandong, Zhujianglu Road 264006, China Patentee before: YANTAI JUANXIU BIOLOGICAL SCIENCE & TECHNOLOGY CO.,LTD. |
|
| C56 | Change in the name or address of the patentee | ||
| CP02 | Change in the address of a patent holder |
Address after: 264006 Shandong District, Yantai Development Zone, Zhujianglu Road, 32 studying abroad Pioneer Park No. 3 workshop E zone 539, Shandong Jun Xiu biological Polytron Technologies Inc Patentee after: SHANDONG JUNXIU BIOTECHNOLOGY CO.,LTD. Address before: 621 room 3, B, factory building, 32 overseas Chinese Pioneer Park, Yantai Development Zone, Shandong, Zhujianglu Road 264006, China Patentee before: SHANDONG JUNXIU BIOTECHNOLOGY CO.,LTD. |
|
| CX01 | Expiry of patent term |
Granted publication date: 20140604 |
|
| CX01 | Expiry of patent term |