CN203595694U - Device for simulating in vitro dynamic release of buccal smokeless tobacco - Google Patents
Device for simulating in vitro dynamic release of buccal smokeless tobacco Download PDFInfo
- Publication number
- CN203595694U CN203595694U CN201320696505.7U CN201320696505U CN203595694U CN 203595694 U CN203595694 U CN 203595694U CN 201320696505 U CN201320696505 U CN 201320696505U CN 203595694 U CN203595694 U CN 203595694U
- Authority
- CN
- China
- Prior art keywords
- constant
- smokeless tobacco
- tobacco
- buccal smokeless
- storage bottle
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 235000002637 Nicotiana tabacum Nutrition 0.000 title abstract description 24
- 241000208125 Nicotiana Species 0.000 title abstract description 20
- 238000000338 in vitro Methods 0.000 title abstract description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 10
- 235000019505 tobacco product Nutrition 0.000 claims description 28
- 239000002904 solvent Substances 0.000 claims description 8
- 239000000203 mixture Substances 0.000 abstract description 7
- 239000000126 substance Substances 0.000 abstract description 7
- 239000007788 liquid Substances 0.000 abstract description 4
- 238000012827 research and development Methods 0.000 abstract description 2
- 238000004090 dissolution Methods 0.000 abstract 4
- 238000004445 quantitative analysis Methods 0.000 abstract 1
- 210000000214 mouth Anatomy 0.000 description 7
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 description 6
- 229960002715 nicotine Drugs 0.000 description 6
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 description 6
- 239000000120 Artificial Saliva Substances 0.000 description 5
- 244000061176 Nicotiana tabacum Species 0.000 description 4
- 238000011160 research Methods 0.000 description 4
- 238000004458 analytical method Methods 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 210000003296 saliva Anatomy 0.000 description 3
- 238000012356 Product development Methods 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 230000036760 body temperature Effects 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 238000012113 quantitative test Methods 0.000 description 2
- 101100298222 Caenorhabditis elegans pot-1 gene Proteins 0.000 description 1
- 244000166124 Eucalyptus globulus Species 0.000 description 1
- 244000246386 Mentha pulegium Species 0.000 description 1
- 235000016257 Mentha pulegium Nutrition 0.000 description 1
- 235000004357 Mentha x piperita Nutrition 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 230000006399 behavior Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 238000009795 derivation Methods 0.000 description 1
- 230000003670 easy-to-clean Effects 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 235000001050 hortel pimenta Nutrition 0.000 description 1
- XKLJHFLUAHKGGU-UHFFFAOYSA-N nitrous amide Chemical compound ON=N XKLJHFLUAHKGGU-UHFFFAOYSA-N 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000002937 thermal insulation foam Substances 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
Landscapes
- Manufacture Of Tobacco Products (AREA)
Abstract
A device for simulating in vitro dynamic release of buccal smokeless tobacco belongs to the field of novel tobacco. The device comprises a constant-temperature water bath kettle (1), a storage bottle (2), a constant-current pump (3), a constant-temperature case (4), a dissolution tank (5), a collecting bottle (6), and a bracket (7), wherein the storage bottle (2) is arranged in the constant-temperature water bath kettle (1), and filled with a menstruum; the constant-current pump (3) is connected with the storage bottle (2) through a pipeline; the constant-temperature case (4) is connected with the constant-current pump (3) through a pipeline; the dissolution tank (5) is arranged in the constant-temperature case (4) , and used for containing buccal smokeless tobacco; the collecting bottle (6) is arranged under the dissolution tank (5), and used for collecting released matters; the bracket (7) is used for fixing the dissolution tank (5). The device has the advantages that the device is simple in structure and convenient to dismount and clean; releasing speed rate, trend and degree of main chemical compositions of various buccal smokeless tobacco can be obtained easily, conveniently and quickly by adopting a quantitative analysis apparatus to the collected releasing liquid; the device is time-saving and labor-saving, and can provide a unitary experimental platform and experimental science data for research and development of like products.
Description
Technical field:
The utility model belongs to novel tobacco field, is specifically related to the external dynamic similation releasing means of a kind of buccal smokeless tobacco product, and it is applicable to crucial chemical composition in buccal smokeless tobacco product and discharges and external dynamic similation and the analysis and research of collecting.
Background technology:
Containing taking that type smoke-free tobacco product mainly comprises buccal smokeless tobacco product and containing change type smoke-free tobacco product, buccal smokeless tobacco product mainly contains two kinds of North America style and Sweden's styles.The buccal smokeless tobacco product (Moist snuff) of North America style is comparatively welcome in North America and Europe, is a kind of smoke-free tobacco product of current American market share maximum
[1].It is generally tobacco powder or the pipe tobacco shape tobacco product of a kind of humidity of being processed by air-curing of tobacco leaves or fire-cured tobacco, and moisture is usually above 40%
[2], there are in bulk and packed two types, between the lip being normally contained in and gum, to consume, saliva can be swallowed.The buccal smokeless tobacco product (Snus) of Sweden's style, it is the main mouth smoke-free tobacco product of one that Nordics consume, very popular in Sweden, normally mixed by dry tobacco powder that appropriate fragrance material, salt (sodium chloride), water, NMF, buffer reagent (sodium carbonate) make through heat treatment process
[3], moisture, between 30% – 60%, has in bulk and packed two types, between the lip being normally contained in and gum, consumes, and saliva generally need not spue.It is a kind of mouth smoke-free tobacco product being pressed into by the tobacco powder that has added peppermint and eucalyptus wet goods adjuvant containing change type smoke-free tobacco product (Dissolvable tobacco), these goods may be dissolved in oral cavity, conventionally putting into oral cavity uses containing changing, become various ways containing change type smoke-free tobacco product derivation at home, for example, have the product that adds the hard sugar of tobacco extract, the refreshing tablets and the diaphragm etc. that contain tobacco component more to meet domestic consumer's taste.
In oral type smoke-free tobacco product, crucial chemical composition release conditions is the important indicator of this based article safety and quality, can study burst size and the rate of release of crucial chemical composition in this based article by in-vitro simulated release experiment, understand and grasp its release rule and influence factor, thus the product development that can be used to weigh the quality quality of this based article and instruct this based article.As far back as eighties of last century the nineties, the transnational tobacco companies such as company of R. J. Reynolds Tobacco, Fei Mo tobacco company and British American Tobacco have spent huge sums and have researched and developed this series products, but about the in-vitro simulated releasing arrangement in oral cavity of this based article is there are no open report.This device is to design for buccal smokeless tobacco product (Snus, Snuff type) with containing the in-vitro simulated stripping experiment of change type smoke-free tobacco product (hard sugar, refreshing tablets and diaphragm-type etc.) specially.
List of references:
[1]Alpert?H?R,Koh?H,Connolly?G?N.Free?nicotine?content?and?strategic?marketing?of?moist?snuff?tobacco?products?in?the?United?States:2000-2006[J].Tobacco?Control,2008,17,(5):332-338.
[2]Richter?P,Spierto?FW.Surveillance?of?smokeless?tobacco?nicotine,pH,moisture,and?unprotonated?nicotine?content[J].Nicotine&Tobacco?Research,2003,5:885-889.
[3]Digard?H,Errington?G,Richter?A,et?al.Patterns?and?behaviors?of?snus?consumption?in?Sweden[J].Nicotine&Tobacco?Research,2009,11:1175-1181.
Summary of the invention:
The purpose of this utility model is to provide a kind of is convenient to disassembly, cleaning, can be used for simulating buccal smokeless tobacco product takes the external dynamic release device of release and the collection of chemical composition in process at human oral cavity.
The external dynamic similation releasing means of buccal smokeless tobacco product of the present utility model, by thermostat water bath (1), be placed in thermostat water bath (1) and the storage bottle (2) of solvent is housed in it, the constant flow pump (3) being connected with storage bottle (2) by pipeline, the constant temperature oven (4) being connected with constant flow pump (3) by pipeline, be placed in constant temperature oven (4) for holding the stripping pond (5) of buccal smokeless tobacco product, be placed in stripping pond (5) below for collecting the receiving flask (6) of releaser, and form for the support (7) in fixing stripping pond (5).
Wherein: the solvent in storage bottle (2) is artificial saliva, and the configuration of its artificial saliva is selected suitable formula according to the difference of analytical test object, general following formula, the K of adopting such as the analysis of nicotine and tobacco-specific nitrosamine etc.
2hPO
40.44～1.32g, NaH
2pO
40.29～0.87g, KHCO
31.50～3.00g, NaCl0.58～1.74g, MgCl
20.14～0.42g, CaCl
20.11～0.22g, Citric Acid0.029～0.087g, adds deionized water and is settled to 1000mL, and pH value is 6.6～7.1.
The material that the utility model adopts market to buy is prepared from according to conventional method.
The beneficial effects of the utility model are: simple in structure, take apart and easy to clean, time saving and energy saving; Can simulate the release conditions of buccal smokeless tobacco product chemical composition in human oral cavity, adopt quantitative test instrument can obtain simply and rapidly rate of release, releasing trend and the releasing degree of main chemical compositions in various buccal smokeless tobacco products to the release liquid of collecting, after applying in the research of smoke-free tobacco product and product development field, provide unified experiment porch and experimental science data by the research and development of series products for this reason.
Accompanying drawing explanation:
Accompanying drawing is the external dynamic similation releasing means of the utility model structural representation.
Embodiment:
Be below embodiment of the present utility model, be further described by reference to the accompanying drawings, but content of the present invention is not limited to this.
As shown in drawings, the external dynamic similation releasing means of buccal smokeless tobacco product of the present utility model, by thermostat water bath 1, be placed in thermostat water bath 1 and the storage bottle 2 of solvent is housed in it, the constant flow pump 3, the constant temperature oven 4 being connected with constant flow pump 3 by pipeline that are connected with storage bottle 2 by pipeline, be placed in constant temperature oven 4 stripping pond 5 for holding buccal smokeless tobacco product, be placed in 5 belows, stripping pond for collecting the receiving flask 6 of releaser and forming for the support 7 in fixing stripping pond 5.The material that the utility model adopts market to buy is prepared from according to conventional method.
Wherein: the solvent in storage bottle B is artificial saliva, fill a prescription and be: K
2hPO
42.5mmol/L, NaH
2pO
42.4mmol/L, KHCO
315.0mmol/L, NaCl10.0mmol/L, MgCl
21.5mmol/L, CaCl
21.5mmol/L, Citric Acid0.15mmol/L.
The course of work of the present utility model is: the artificial saliva preparing is poured in solvent storage bottle 2, the temperature of setting constant temperature waters pot 1 is 37 ℃, whole pipeline wraps heat insulation foam, to guarantee that the solvent that flows into stripping pond 5 maintains the human body temperature of 37 ℃, and realize fresh solvent (artificial saliva) by constant flow pump and constantly flow into stripping pond 5 with the speed of human secretory saliva, the release liquid receiving flask 6 continuously outflowing is collected, whole stripping pond 5 and receiving flask 6 are fixed in constant temperature oven 4 by stripping pond support 7, the temperature of constant temperature oven 4 is also controlled at 37 ℃ of human body temperature, multiple release liquid of collecting are analyzed mensuration by quantitative test instrument.
Practical application shows, the utility model reaches purpose of design completely.
Claims (1)
1. one kind contains the external dynamic release device that takes smoke-free tobacco product for Mouthsimulator, it is characterized in that this external dynamic release device is by thermostat water bath (1), be placed in thermostat water bath (1) and the storage bottle (2) of solvent is housed in it, the constant flow pump (3) being connected with storage bottle (2) by pipeline, the constant temperature oven (4) being connected with constant flow pump (3) by pipeline, be placed in constant temperature oven (4) for holding the stripping pond (5) of buccal smokeless tobacco product, be placed in stripping pond (5) below for collecting the receiving flask (6) of releaser, and form for the support (7) in fixing stripping pond (5).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201320696505.7U CN203595694U (en) | 2013-11-06 | 2013-11-06 | Device for simulating in vitro dynamic release of buccal smokeless tobacco |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201320696505.7U CN203595694U (en) | 2013-11-06 | 2013-11-06 | Device for simulating in vitro dynamic release of buccal smokeless tobacco |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN203595694U true CN203595694U (en) | 2014-05-14 |
Family
ID=50676563
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201320696505.7U Expired - Lifetime CN203595694U (en) | 2013-11-06 | 2013-11-06 | Device for simulating in vitro dynamic release of buccal smokeless tobacco |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN203595694U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105021741A (en) * | 2015-05-28 | 2015-11-04 | 云南中烟工业有限责任公司 | Analytical method and apparatus for bionic absorption liquid used for main stream smoke |
| CN109324153A (en) * | 2018-09-30 | 2019-02-12 | 云南中烟工业有限责任公司 | It is a kind of based on the mouth of electronic tongues type smoke-free tobacco product sense of taste characterizing method |
-
2013
- 2013-11-06 CN CN201320696505.7U patent/CN203595694U/en not_active Expired - Lifetime
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105021741A (en) * | 2015-05-28 | 2015-11-04 | 云南中烟工业有限责任公司 | Analytical method and apparatus for bionic absorption liquid used for main stream smoke |
| CN105021741B (en) * | 2015-05-28 | 2017-05-10 | 云南中烟工业有限责任公司 | Analytical method and apparatus for bionic absorption liquid used for main stream smoke |
| CN109324153A (en) * | 2018-09-30 | 2019-02-12 | 云南中烟工业有限责任公司 | It is a kind of based on the mouth of electronic tongues type smoke-free tobacco product sense of taste characterizing method |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CX01 | Expiry of patent term |
Granted publication date: 20140514 |
|
| CX01 | Expiry of patent term |