CN203513663U - Grasping device used in instrument for extracting biologic active substance by using magnetic bar method - Google Patents
Grasping device used in instrument for extracting biologic active substance by using magnetic bar method Download PDFInfo
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- CN203513663U CN203513663U CN201320517867.5U CN201320517867U CN203513663U CN 203513663 U CN203513663 U CN 203513663U CN 201320517867 U CN201320517867 U CN 201320517867U CN 203513663 U CN203513663 U CN 203513663U
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Abstract
The utility model provides a grasping device used in an instrument for extracting biologic active substances by using a magnetic bar method. The grasping device is characterized by comprising a rack and a grasping mechanism, wherein the grasping mechanism comprises a first grasping hand and a second grasping hand; the first grasping hand and the second grasping hand are respectively provided with thimbles (5); the first grasping hand and the second grasping hand can move relatively close to or away from each other under the driving of a grasping hand component driving device, so as to drive the thimbles fixed on the grasping hands to be respectively inserted into or dissociated from bulges on four corners of a sleeve plate. By adopting the grasping device, the sleeve plate with sleeves can be lifted, the original shape of the sleeve plate is maintained, the sleeve plate is prevented from deformation, and the sleeves inside the sleeve plate can be well cooperated with magnetic bars to generate magnetism.
Description
Technical field
The utility model relates to biological apparatus field.Concrete, the utility model provides the self-reacting device for bar magnet method extraction biologically active substance to capture the grabbing device of casing board, and the self-reacting device that the bar magnet method extraction biologically active substance that adopts described grabbing device is provided.
Background technology
At multiple fields such as modern clinic medical diagnosis on disease, transfusion safety, Forensic Identification, environmental microorganism detection, food safety detection, molecular biology researches, extract biologically active substance, the biologically active substances such as for example cell, and protein, nucleic acid have vital role.Along with the development of bio-science, need high-throughout sample biologically active substance extracts and automatically biologically active substance extracts method and instrument.
Utilize paramagnetic particle method extract biologically active substance particularly active macromole be the technology that developed recently gets up.Paramagnetic particle method be utilize can specific recognition cell, the magnetic bead of protein or nucleic acid, this magnetic bead can be combined specifically with nucleic acid molecule, then under the effect in magnetic field, the active macromole from blood, animal tissues, food, pathogenic micro-organism equal samples is separated.
The instrument that utilizes paramagnetic particle method to extract biologically active substance can be divided into bar magnet method and suction method.Wherein the extraction of bar magnet method is the technology that developed recently gets up, and its principle is that magnetic separating device is immersed to liquid, by the action of a magnetic field, makes can be concentrated on separating device surface by the particle of magnetic attraction in mixture.Wherein, in a kind of mode, magnetic separating device is a sleeve pipe, by inserting bar magnet, makes sleeve pipe produce magnetic, attract can be adsorbed onto sleeve surface by the particle of magnetic attraction in mixture, when bar magnet is detached, sleeve pipe loses magnetism, and by the particle of magnetic attraction, is departed from sleeve pipe.The flux of bar magnet method instrument for extracting nucleic acid has 8,16,32,96 passages conventionally, and with respect to suction method, the advantage of bar magnet method is that the liquid of each step is not residual, because bar magnet is only taken away magnetic bead, transfers in the corresponding reacting hole of next step.In bar magnet method instrument, drive the mechanism of sleeve pipe or bar magnet motion can drive bar magnet to move up and down in sleeve pipe, and drive sleeve pipe in liquid sample, move up and down or vibrate, contribute to cracking, absorption, rinsing and the purifying etc. of sample in leaching process.
In bar magnet method instrument, sleeve pipe is the pipe with closed bottom and hollow tube chamber.Sleeve pipe can have for example elongated cylinder form.The material of sleeve pipe is normally nonmagnetic.The Choice and design of its material and thickness is for weakened field not or only affect a little magnetic field, but need to guarantee when inserting needle can to attract magnetic bead or with the magnetic field of the biological sample of magnetic bead in the outer generation of sleeve pipe.
In bar magnet method, extract in the instrument of biologically active substance and method and can adopt casing board to carry simultaneously and a plurality of sleeve pipes are provided.Casing board can, by being fixed, capture and moved by the grasping mechanism in bar magnet method instrument, be handled location and the movement of the sleeve pipe that assembles or be fixed thereon.The grasping mechanism that current extraction apparatus adopts is to pick up this casing board by hook, the sleeve pipe that easily causes this casing board generation deformation or generation displacement and make to be placed in this casing board tilts or moves in the horizontal direction, can not finely coordinate with bar magnet and produce magnetic, and often cause the failure of whole experiment, make these instruments be difficult to realize automatization.
Summary of the invention
The utility model provides a kind of self-reacting device for bar magnet method extraction biologically active substance to capture the grabbing device of casing board.On the other hand, the utility model also provides a kind of self-reacting device that utilizes efficiently bar magnet method extraction biologically active substance that comprises this grabbing device.Device of the present utility model and instrument can solve the sleeve pipe that easily causes this casing board generation deformation or generation displacement to make to be placed in this casing board because grasping mechanism is picked up casing board by hook in prior art and tilt or move in the horizontal direction, and can not finely coordinate the technical problem that produces magnetic with bar magnet.
The utility model can be applicable to the multiple fields such as clinical disease diagnosis, transfusion safety, Forensic Identification, environmental microorganism detection, food safety detection, molecular biology research, for example, for extracting and purifying biological active substance, cell, albumen and nucleic acid.
Concrete, the utility model provides a kind of grabbing device that extracts the instrument of biologically active substance for bar magnet method, and it can be for capturing the casing board using in bar magnet method.The middle casing board adopting of instrument, equipment, articles for use, test kit (kit) that bar magnet method is extracted biologically active substance has tetragonal dull and stereotyped seat conventionally, in the centre of described dull and stereotyped seat, fix or releasably arrange the sleeve pipe of some amount, for example a 4x6 or 8x12 sleeve pipe.The dull and stereotyped seat of casing board has tetragonal frame, and on four angles of this flat board seat, having can be for the hollow projection of grasping mechanism contact.Described casing board can be commercially available normal sleeve plate.
The utility model provides a kind of instrument for bar magnet method extraction biologically active substance to capture the grabbing device of casing board, it is characterized in that, described grabbing device comprises frame 1 and grasping mechanism, wherein said frame 1 has four frame frames corresponding to the square frame of casing board, described grasping mechanism comprises handle component 2 and handle component drive unit, described handle component 2 comprises the first handgrip and the second handgrip, on described the first handgrip and the second handgrip, there is respectively thimble 5, wherein, described the first handgrip and the second handgrip are under the driving of handle component drive unit, can occur relative near or away from move, thereby drive the thimble be fixed thereon occur relative near or away from move, can leave respectively or insert thus the projection on four angles of casing board.
Of the present utility model aspect one of them, described grabbing device is characterised in that, described the first handgrip comprises the first compression bar 21, the second handgrip comprises the second compression bar 22, the 3rd compression bar 23 and the axle 6 that connects the second compression bar 22 and the 3rd compression bar 23, described axle 6 is fixedly connected with the 3rd compression bar 23 with the second compression bar 22, by connection and the gearing of axle 6, the 3rd compression bar 23 and the second compression bar 22 be synchronizing moving in the same way
Wherein, the first compression bar 21 and the second compression bar 22 be arranged in parallel, be installed on respectively the outside of two relative frames of described frame 1, the first compression bar 21 and the 3rd compression bar 23 are arranged on the homonymy of a frame of framework 1, the first compression bar 21 and the 3rd compression bar 23 can be done synchronous backward and move under the driving of handle component drive unit, the first compression bar 21 and the second compression bar 22 are done reverse sync and are moved thus
Wherein, described thimble is four thimbles (51,52,53,54), thimble 51 and 52 is arranged on the first compression bar 21, thimble 53 and 54 is arranged on the second compression bar 22, four thimbles (51,52,53,54) position corresponds respectively to the projection on four angles of casing board, compression bar 21 and 22 under the driving of handle component drive unit, can occur relative to away from or the moving of close motion, thereby drive thimble (51,52,53,54) synchronously insert respectively or leave the projection on four angles of casing board, compress in the horizontal direction or unclamp casing board.
Of the present utility model aspect one of them, described grabbing device is characterised in that, the middle part of described the first compression bar 21 and the 3rd compression bar 23 has respectively the first compression bar inclined-plane (213,214) and the 3rd compression bar inclined-plane (233,234).
Of the present utility model aspect one of them, described grabbing device is characterised in that, described handle component drive unit comprises tensioning block 3, motor 4 and bearing 7, described tensioning block 3 comprises upper reel 31 and the lower shaft disk 32 at axle bed 33 and axle bed two ends, described head bearing 71 and lower bearing 72 are set in described upper reel 31 and lower shaft disk 32 outsides, the motor shaft that described axle bed 33 has power supply machine 4 passes and fixing hole 331
Wherein, upper reel 31 and lower shaft disk 32 can be respectively by the inclined-planes (213 of head bearing 71 and lower bearing 72 and the first compression bar 21, 214) inclined-plane (233 of the and three compression bar 23, 234) come in contact, thus, when motor 4 drives tensioning block 3 to seesaw, the upper reel 31 of tensioning block 3 and lower shaft disk 32 can push respectively the first compression bar inclined-plane (213 by head bearing 71 and lower bearing 72, 214) the and three compression bar inclined-plane (233, 234), promote thus the first compression bar 21 and the 3rd compression bar 23 generation synchronous backward motions, thereby drive the thimble lay respectively at the first compression bar 21 and the second compression bar 22 occur relative away from or close motion.Of the present utility model, aspect one of them, described head bearing 71 and lower bearing 72 are rolling bearing.
Of the present utility model aspect one of them, described grabbing device is characterised in that, described handle component drive unit also comprises two guide rails 8 of the motor shaft both sides that minute are located at motor 4, tensioning block 3 by the hole 332 in its axle bed 33 through guide rail 8 and be slidably connected with guide rail 8.Of the present utility model aspect one of them, the two ends of described guide rail 8 are erected on leading rail chair 81 and rear rail seat 82, leading rail chair 81 and rear rail seat 82 can be fixed on the base plate 17 of frame outside framework by modes such as welding or screw threads, tensioning block 3 is slidably connected with guide rail 8 by the hole 332 in its axle bed 33, and can, under the driving of motor 4, in the scope of leading rail chair 81 and rear rail seat 82, move forward and backward.
Of the present utility model aspect one of them, described grabbing device is characterised in that, described frame 1 has outside framework 15, and the first compression bar 21 and the 3rd compression bar 23 of described handle component drive unit and handle component 2 are arranged in described outside framework 15.
Of the present utility model aspect one of them, described grabbing device is characterised in that, the frame of described frame 1 is set to, and when the thimble 5 of grasping mechanism inserts or leave casing board protruding, the surface of the frame of described frame 1 contact with the frame of casing board and the flat board of clamping sleeve tube sheet.
Of the present utility model aspect one of them, described grabbing device is characterised in that, described frame 1 also has for the compressing member 16 of clamping sleeve tube sheet in vertical direction, the surface level of the frame of the surface of described compressing member 16 and frame 1, be set in thimble 5(51,52,53,54), while inserting or leaving casing board protruding, its surface contact with the plate face of casing board and flat board of clamping sleeve tube sheet.
Of the present utility model aspect one of them, described grabbing device is characterised in that, described thimble is hard parts.Described thimble is the hard parts that have anchorage force, can insert thus projection hollow on four angles of the dull and stereotyped seat of casing board and enough holding powers are provided, play promptly and permanent sleeve tube sheet, and the effect of the dull and stereotyped seat of tensioning.The material of described thimble can be for metal, for example iron or stainless steel, aluminum products as aluminium alloy.The material of described thimble also can be for nonmetallic, as hard plastics etc.
The utility model also provides a kind of instrument that extracts biologically active substance for bar magnet method, it is characterized in that, described instrument comprise aforementioned for capture casing board grabbing device.Described instrument has for supporting and be controlled at bar magnet method and extracts needle that biologically active substance uses and the mechanism of sleeve pipe, and its middle sleeve is to be assemblied on casing board regularly or removably.The described instrument that extracts biologically active substance for bar magnet method can be for extracting the instrument with purification of nucleic acid.
The grabbing device that the utility model provides or the instrument that adopts the biologically active substance of this grabbing device to extract are compared with prior art more reliable and more stable.Device of the present utility model and instrument have the hard thimble that has anchorage force by adopting in grasping mechanism, can steadily firmly the casing board that is placed with sleeve pipe be lifted and the fixing original shape of maintainance set tube sheet.And because the design of device of the present utility model makes the casing board and the laminating of frame frame that are lifted, thereby make the further permanent sleeve tube sheet of frame guarantee that deformation does not occur casing board, thereby guarantee when adopting bar magnet method to extract biologically active substance, sleeve pipe in casing board can well coordinate generation magnetic with bar magnet, attract can be adsorbed onto sleeve surface by the particle of magnetic attraction in mixture, for extracting and purifying biological active substance, cell for example, albumen and nucleic acid, can be extensively and be effectively applied in clinical disease diagnosis, transfusion safety, Forensic Identification, environmental microorganism detects, food safety detection, the multiple fields such as molecular biology research.Device of the present utility model has solved in prior art and has made to be placed in the sleeve pipe inclination in this casing board or move in the horizontal direction because grasping mechanism easily causes this casing board generation deformation or produce displacement, can not finely coordinate the technical problem that produces magnetic with bar magnet, thereby realize the automatization of bar magnet method biologically active substance extraction apparatus.
Accompanying drawing explanation
By reading the detailed description that non-limiting example is done of doing with reference to the following drawings, it is more obvious that other features, objects and advantages of the present utility model will become:
Fig. 1-1 is according to the schematic perspective view of the first direction of a kind of grabbing device of a preferred embodiment of the utility model;
Fig. 1-2 is according to the exploded perspective view of the second direction of a kind of grabbing device of a preferred embodiment of the utility model;
Fig. 2-1 is according to the structural representation of the first compression bar of a preferred embodiment of the utility model;
Fig. 2-2 are according to the structural representation of the second compression bar of a preferred embodiment of the utility model;
Fig. 2-3 are according to the structural representation of the 3rd compression bar of a preferred embodiment of the utility model;
Fig. 2-4 are according to the assembling schematic diagram of the second compression bar of a preferred embodiment of the utility model and the 3rd compression bar;
Fig. 3 is according to the structural representation of the tensioning block of a preferred embodiment of the utility model;
Fig. 4 is according to the structural representation of the thimble of a preferred embodiment of the utility model;
Fig. 5 is according to the structural representation of the casing board of the grabbing device crawl of a preferred embodiment of the utility model;
Fig. 6 is according to the schematic diagram of the frame of the grabbing device of a preferred embodiment of the utility model;
Fig. 7-1 is the schematic diagram of the instrument of the extraction biologically active substance of the grabbing device of a preferred embodiment of employing the utility model;
Fig. 7-2 are according to the grabbing device of a preferred embodiment of the utility model, to capture the schematic diagram of casing board.
Reference numeral
Grasping mechanism
1 frame
11,12,13,14 frame frames
15 outside frameworks
16 compressing members
17 base plates
2 compression bars
21 first compression bars
211 first holes
212 second holes
213,214 first compression bar inclined-planes
215,216 axis holes
22 second compression bars
221 the 3rd holes
222 the 4th holes
225,226 axis holes
23 the 3rd compression bars
235,236 axis holes
233,234 the 3rd compression bar inclined-planes
3 tensioning blocks
Reel 32 lower shaft disks on 31
33 axle bed 331 332 holes
4 motors
5 thimbles
51 first thimbles
52 second thimbles
53 the 3rd thimbles
54 the 4th thimbles
6 axles
61 first axles
62 second axles
7 bearings
71 head bearings
72 lower bearings
8 guide rails
81 leading rail chairs
82 rear rail seats
9 casing boards
91 the 5th holes
92 the 6th holes
93 seven apertures in the human heads
94 octals
95,96,97,98 casing board frames
99 sleeve pipes
1001 bar magnet methods are extracted the instrument of biologically active substance
1002 needles
1003 connecting rods
Embodiment
In order to understand better and to explain the utility model, below with reference to accompanying drawings the utility model is described in further detail.
Fig. 1-1st, according to the first direction stereographic map of a kind of grabbing device of a preferred embodiment of the present utility model, Fig. 1-2 is according to the exploded perspective view of the second direction of a kind of grabbing device of a preferred embodiment of the present utility model.As shown in Fig. 7-1, the working order direction that the view directions of Fig. 1-2 is grabbing device of the present utility model.Above-mentioned grabbing device can be used for adopting bar magnet method to extract the instrument of biologically active substance.In the instrument of said extracted biologically active substance, grabbing device of the present utility model can be used for capturing the casing board using in bar magnet method.As shown in Figure 5, casing board has tetragonal dull and stereotyped seat conventionally, and in the centre of described dull and stereotyped seat regularly or the sleeve pipe 99 of the some amount releasably arranging, for example a 4x6 or 8x12 sleeve pipe.As shown in Figure 5, the dull and stereotyped seat of casing board 9 has casing board frame (95,96,97,98), and in addition, on four angles of dull and stereotyped of above-mentioned casing board 9, having can be for grasping mechanism contact and hollow projection (91,92,93,94) or the groove fixed.
As shown in Fig. 1-1 and Fig. 1-2, above-mentioned grabbing device of the present utility model comprises frame 1 and grasping mechanism, described grasping mechanism comprises four thimble 5(51,52,53,54), handle component (comprising the first handgrip and the second handgrip) and compacting part drive unit (comprising tensioning block 3, motor 4, guide rail 8 and rolling bearing 7).
The grasping mechanism of above-mentioned grabbing device of the present utility model can be arranged in frame, and frame is to the grasping mechanism effect of providing support.In addition, described frame 1 has and the frame of the same or analogous shape and size of frame of the casing board that needs to capture.In diagram preferred embodiment of the present utility model, frame 1 has 4 frame frames (11,12,13,14) of the casing board square frame (95,96,97,98) capturing corresponding to need.In addition, in preferred embodiment of the present utility model, described frame is set to, in thimble 5(51,52,53,54) insert the projection (91 of casing board, 92,93,94) when capturing with movable sleeving tube sheet, the surface of frame frame (wherein two, three or four) contacts with the frame of casing board, thereby the dull and stereotyped seat of clamping sleeve tube sheet, makes dull and stereotyped seat maintenance level in vertical direction, produces deformation while avoiding casing board to be lifted.
The frame 1 of above-mentioned grabbing device of the present utility model also can have extra for the compressing member 16 of clamping sleeve tube sheet in vertical direction.In preferred embodiment as shown in Figure 6, the compressing member 16 in the central authorities of frame 1 with its surface and surface (being the lower surface of frame shown in Fig. 6) level of the frame of frame 1, at thimble 5(51,52,53,54), while inserting or leaving casing board protruding, its surface (being the lower surface of frame shown in Fig. 6) contacts with the plate face of casing board, can play further the dull and stereotyped seat of clamping sleeve tube sheet in vertical direction, while avoiding casing board to be lifted, produce the effect of deformation.Described compressing member can be cruciform or other shape as shown in the figure.Described compressing member can by with frame monoblock casting, or be fixed in frame 1 by welding or the mode such as screw thread.Performance vital role very when described compressing member is avoided producing deformation when guaranteeing that casing board is captured and lifts by grabbing device of the present utility model.
The frame 1 of above-mentioned grabbing device of the present utility model also can have and is connected with the sleeve pipe travel mechanism that adopts bar magnet method to extract the instrument of biologically active substance and fixing parts, if connecting rod 1003(is referring to Fig. 7-1), grabbing device can move in vertical and horizontal direction as required thus, makes sleeve pipe be movable to specified location and moves up and down or vibrate.
Above-mentioned grabbing device of the present utility model has handle component, and it comprises the first handgrip and the second handgrip, on described the first handgrip and the second handgrip, has respectively thimble 5.Described thimble is the hard parts that have anchorage force, can insert thus projection hollow on four angles of the dull and stereotyped seat of casing board and enough holding powers are provided, play promptly and permanent sleeve tube sheet, and the effect of the dull and stereotyped seat of tensioning.The material of described thimble can be for metal, for example iron or stainless steel, aluminum products as aluminium alloy.The material of described thimble also can be for nonmetallic, as hard plastics etc.
In preferred embodiment as shown in the figure, above-mentioned grabbing device there are four thimble 5(51,52,53,54).Described the first handgrip comprises that axle 6(that the first compression bar 21, the second handgrips comprise the second compression bar 22, the 3rd compression bar 23 and connect the second compression bar 22 and the 3rd compression bar 23 is referring to Fig. 2-4).
The first compression bar 21 and the second compression bar 22 are arranged on respectively the frame 12 of square framework 1 and 14 outside.Thimble 51 and 52 is arranged on the first compression bar 21, and thimble 53 and 54 is arranged on the second compression bar 22.Four thimble 5(51,52,53,54) position corresponds respectively to overhead, four angles of aforementioned casing board cardiac prominence and plays (91,92,93,94). Compression bar 21 and 22 is under the driving of compacting part drive unit, can occur relatively near or away from motion (be separated from one another or close up), thereby drive thimble 51,52,53,54 synchronously insert respectively or leave the projection 91 of casing board, 92,93,94, play the effect that compresses in the horizontal direction or unclamp casing board, thereby realize, capture or decontrol casing board.
The frame 1 as shown in Fig. 1-1 and 1-2 also have for hold and fix as described in the outside framework (15) of compacting part drive unit of grabbing device.Aspect one of the present utility model, described frame can also have the base plate (17) of cover framework or outside framework.In the environment of the compacting part drive unit that base plate can help to realize described grabbing device in sealing, avoid polluting or the impact of other adverse environmental factors.
As shown in Figure 1-2, the grasping mechanism of device of the present utility model has handle component, and it comprises the first handgrip and the second handgrip.Handgrip comprises compression bar and the thimble being fixed thereon, compression bar is under the driving of compacting part drive unit, on can occurred level direction relative near or away from move, thereby drive a plurality of thimbles be positioned at frame two ends occur relative near or away from move, leave respectively or insert the projection of casing board, play the effect that captures casing board.
The structural representation of above-mentioned the first compression bar 21, above-mentioned the second compression bar 22 and above-mentioned the 3rd compression bar 23 is respectively as shown in Fig. 2-1, Fig. 2-2 and Fig. 2-3.Above-mentioned the first compression bar 21 comprises for fixedly the first hole 211 and second hole 212 of thimble, and above-mentioned the second compression bar 22 comprises for fixedly the 3rd hole 221 and the 4th hole 222 of thimble.Fig. 2-4 are the wiring layout of above-mentioned the second compression bar 22, above-mentioned the 3rd compression bar 23 and axle 6.
In addition, as shown in Fig. 1-2, Fig. 2-1, Fig. 2-3 and Fig. 3, the middle part of above-mentioned the first compression bar 21 and above-mentioned the 3rd compression bar 23 has the first compression bar inclined-plane (213,214) and the 3rd compression bar inclined-plane (233,234).As below described in detail, described inclined-plane be arranged so that compacting part drive unit of the present utility model can be simply with realize reliably the first compression bar 21 and the 3rd compression bar 23 and relative (oppositely) occur be synchronized with the movement.
As shown in Figure 1-2, the first compression bar 21 and the second compression bar 22 are arranged on respectively the square frame two ends of framework 1.In preferred illustrated embodiment, the first compression bar 21 and the second compression bar 22 are arranged on respectively the outside of frame 11 and 13, and are slided and be fixed on framework 1 by axle 6.Illustrate in device of the present utility model, above-mentioned axle 6 comprises 2 axles, i.e. the first axle 61 and the second axle 62, and it through on the frame 11 and 13 of framework 1, is fixed on the framework of the utility model grabbing device respectively thus.
As shown in Figure 2, the first compression bar 21 has the axis hole 215 that can pass for the first axle 61 and the second axle 62 and 216, the first axles 61 and the second axle 62 and can through axis hole 215 and 216, the first compression bars 21, slidably be connected to thus in above-mentioned crawl frame 1 respectively.
The first compression bar 21 and the 3rd compression bar 23 are arranged on the same side of the frame of framework 1.The second compression bar 22 and the 3rd compression bar 22 are arranged on the frame two ends of framework 1.The second compression bar 22 and the 3rd compression bar 23 have respectively the axis hole 225 and 226 that supplies the first axle 61 and the second axle 62 to pass, and axis hole 235 and 236.The first axle 61 is through axis hole 225 and 235, and above-mentioned the second axle 62 is through axis hole 226 and 236.The 3rd compression bar 23 is fixedly connected with the second axle 62 with the first axle 61 by modes such as screw thread or welding with the second compression bar 22.By connection and the gearing of axle 6, the 3rd compression bar 23 and the second compression bar 22 be synchronizing moving in the same way.
Grabbing device of the present utility model be arranged so that the first compression bar 21 and the second compression bar 22 in the horizontal direction reverse sync move, realize thus the first compression bar 21 and the second compression bar 22 occur relative away from or close motion, thereby drive the thimble lay respectively at the first compression bar 21 and the second compression bar 22 occur relative away from or close motion, play the effect of crawl casing board.
As shown in Fig. 1-1 and Fig. 1-2, aspect one of the present utility model, the first compression bar 21 and the 3rd compression bar 23 are arranged on the same side of the frame of framework 1, in the upper and lower stacked outside framework 15 that is arranged on above-mentioned frame 1.The 3rd compression bar 23 is fixedly connected with by modes such as screw thread or welding with the second compression bar 22 by axle 6.By connection and the gearing of axle 6, the 3rd compression bar 23 and the second compression bar 22 be synchronizing moving in the same way.Following mask body is set forth, and the reverse sync that is arranged so that the first compression bar 21 and the 3rd compression bar 23 of the utility model device moves, and the reverse sync that realizes thus the first compression bar 21 and the second compression bar 22 moves.
The compacting part drive unit of the grasping mechanism of the utility model device can drive above-mentioned compression bar occur relatively away from or close motion, thereby drive the thimble lay respectively at the first compression bar 21 and the second compression bar 22 occur relative away from or close motion, play the effect of crawl casing board.
The compacting part drive unit that illustrates preferred embodiment devices of the present utility model comprises tensioning block 3, motor 4, guide rail 8 and bearing 7(head bearing 71 and lower bearing 72).
The structural representation of tensioning block 3 as shown in Figure 3.Above-mentioned tensioning block 3 comprises columniform upper reel 31 and the lower shaft disk 32 at axle bed 33 and axle bed two ends.Described head bearing 71 and lower bearing 72 are set in reel 31 and lower shaft disk 32 outsides.The motor shaft that axle bed 33 has power supply machine 4 passes and fixing hole 331.Motor shaft can be fixing with tensioning block 3 in hole 331 by axle sleeve, realizes thus the driving to tensioning block.As shown in Fig. 1-1 and 1-2, upper reel 31 and lower shaft disk 32 can pass through respectively head bearing 71 and the inclined-plane (213,214) of lower bearing 72 and the first compression bar 21 and the inclined-plane (233,234) of the 3rd compression bar 23 and come in contact.Thus, when motor 4 drives tensioning block 3 to seesaw, can pass through respectively described inclined-plane (213 by head bearing 71 and lower bearing 72,214) or inclined-plane (233,234) contact and extruding the first compression bar 21 or the 3rd compression bar 23, promote thus the first compression bar 21 and the 3rd compression bar 23 and relative (oppositely) occur be respectively synchronized with the movement, thus drive the thimble that lays respectively at the first compression bar 21 and the second compression bar 22 occur relative away from or close motion, play the effect of crawl casing board.
Aspect one of the present utility model, described head bearing 71 and lower bearing 72 are rolling bearing.Adopt rolling bearing more effectively passing through the inclined-plane (213 of the first compression bar 21,214) inclined-plane of the and three compression bar 23 (233,234) comes in contact and pushes to promote the first compression bar 21 and the 3rd compression bar 23 and relative (oppositely) occur respectively more effectively avoid occurring clamping stagnation while being synchronized with the movement.
Aspect one of the present utility model, the compacting part drive unit of device of the present utility model also comprises guide rail 8.The axle bed 33 of tensioning block 3 has the described guide rail of confession and passes and fixing hole 332.Of the present utility model aspect one of them, the compacting part drive unit of device comprises two circular guides of the motor shaft both sides that minute are located at motor 4.The two ends of guide rail 8 are erected on leading rail chair 81 and rear rail seat 82.Leading rail chair 81 and rear rail seat 82 can be fixed on the base plate 17 of frame outside framework by modes such as welding or screw threads.Tensioning block 3 is slidably connected by hole 332 and guide rail 8.Tensioning block 3 can be under the driving of motor 4, in the scope of leading rail chair 81 and rear rail seat 82, move forward and backward, and foregoing, by the inclined-plane (213 of head bearing 71 and lower bearing 72 and the first compression bar 21,214) inclined-plane (233 of the and three compression bar 23,234) come in contact and push to promote the first compression bar 21 and the 3rd compression bar 23 reverse sync in the horizontal direction moves, the reverse sync of the first compression bar 21 and the second compression bar 22 moves.By dividing two circular guides that are located at motor shaft both sides, can assist fixed electrical machinery, tensioning block 3 and bearing 7, and effectively prevent that tensioning block 3 and bearing 7 from rotating around axle mirror image relative to motor shaft occurring.
As shown in Figure 4, in a preferred embodiment of the present utility model, the thimble 5 of the utility model grabbing device has pyramid type top and columniform bottom.Described thimble can releasably be assemblied on compression bar by columniform bottom.In addition, described thimble can pass through the hollow projection that casing board is inserted at top (for example cylindrical or pyramid type).The thimble of the utility model grabbing device inserts the hollow projection of casing board or the top of groove (91,92,93,94) can be designed to circular cone build.Thus, thimble, when inserting the hollow projection of casing board, expands gradually with the contact surface of this hollow projection or groove, plays the fixing effect of tensioning and more firm and this hollow projection or groove.This design has improved the utility model grabbing device widely in the firm degree that captures casing board.
The mode of operation of grabbing device of the present utility model or principle of work:
Grabbing device of the present utility model captures casing board for extract the instrument of biologically active substance in bar magnet method.In extracting the bar magnet method of biologically active substance, magnetic sleeve pipe need to be immersed to sample (normally liquid), by the action of a magnetic field, make can be concentrated on sleeve surface by the particle of magnetic attraction in mixture.Sleeve pipe is the pipe with closed bottom and hollow tube chamber, can have for example elongated cylinder form.In the method, by inserting bar magnet, make sleeve pipe produce magnetic, attract can be adsorbed onto sleeve surface by the particle of magnetic attraction in mixture, when bar magnet is detached, sleeve pipe loses magnetism, and by the particle of magnetic attraction, is departed from sleeve pipe.In bar magnet method, extract in the instrument of biologically active substance, sleeve pipe need to move up and down, and can insert thus the setting container that holds sample thereunder, thereby realizes the absorption of biologically active substance, rinsing and purifying.
Bar magnet method is extracted in the instrument or method of biologically active substance, and described sleeve pipe can provide with the form of casing board.As shown in Figure 5, the dull and stereotyped seat of casing board has tetragonal frame, and on four angles of its dull and stereotyped seat, having can be for the hollow projection of grasping mechanism contact.
Fig. 7-1 and Fig. 7-2 are that the utility model grabbing device captures work and the structural representation of casing board in the instrument of bar magnet method extraction biologically active substance.
As shown in Fig. 7-1, the instrument 1001 of described extraction biologically active substance has needle 1002 and controls the mechanism that needle moves up and down.Grabbing device 1 of the present utility model can capture and permanent sleeve tube sheet 9, thereby realizes being arranged on the crawl of the sleeve pipe 99 on casing board and fixing.Grabbing device 1 can be connected with the mechanism that controls the horizontal or vertical movement of this grabbing device by connecting rod 1003, realizes sleeve pipe to the location of specified location and moves up and down or vibrate.
(schematic diagram that Fig. 7-1 and Fig. 7-2 are contrary visual angle) shown in Fig. 7-2 is the working order of grabbing device crawl casing board of the present utility model.The thimble 51,52,53 and 54 of grabbing device of the present utility model inserts respectively in four holes of casing board 9, thereby simultaneously, the frame frame of frame 1 can be close to the frame of casing board, thereby while assisting above-mentioned casing board 9 is lifted, not producing deformation, there is not relative displacement in the sleeve pipe in above-mentioned casing board 9 yet.
When above-mentioned grabbing device need to capture above-mentioned casing board 9, motor 4 is by driving tensioning block 3 to move forward and backward, respectively by described inclined-plane (213,214) or inclined-plane (233,234) contact and extruding the first compression bar 21 or the 3rd compression bar 23, make above-mentioned the first compression bar 21 and with synchronization-moving the second compression bar 22 relative separation of the 3rd compression bar 23 or close up, make in four holes that the first thimble 51 in above-mentioned the first compression bar 21 and the 3rd thimble 53 in the second thimble 52 and the second compression bar 22 and the 4th thimble 54 left respectively or inserted casing board 9.
Above-mentioned grabbing device and comprise that the self-reacting device of above-mentioned grabbing device is a kind of preferred embodiment of the present utility model, what structure and function was identical with it all falls in protection domain of the present utility model.Such as fixing casing board according to the thimble of the shape of casing board and the different numbers of size setting, for example four thimbles in the utility model preferred embodiment also can replace to two thimbles, capture casing board from both sides.Thimble can also replace to other hard gripper components that has anchorage force, such as with thimble compared with the big or small identical centrum of butt diameter or right cylinder, material is partially hard anchorage force, such as irony product and aluminium alloy.
Although describe in detail about example embodiment of the present invention and advantage thereof, be to be understood that in the situation that do not depart from the protection domain that spirit of the present invention and claims limit, can carry out various variations, substitutions and modifications to these embodiment.For other examples, when those of ordinary skill in the art should easily understand within keeping protection domain of the present invention, the order of processing step can change.
In addition, range of application of the present invention is not limited to technique, mechanism, manufacture, means, method and the step of the specific embodiment of describing in specification sheets.From disclosure of the present invention, as those of ordinary skill in the art, will easily understand, for the technique, mechanism, manufacture, means, method or the step that have existed or be about to develop at present later, wherein they carry out identical function or the identical result of acquisition cardinal principle of corresponding embodiment cardinal principle of describing with the present invention, according to the present invention, can apply them.Therefore, claims of the present invention are intended to these technique, mechanism, manufacture, means, method or step to be included in its protection domain.
Claims (7)
1. an instrument that extracts biologically active substance for bar magnet method captures the grabbing device of casing board, it is characterized in that described grabbing device comprises frame (1) and grasping mechanism, wherein said frame (1) has four frame frames corresponding to the square frame of casing board, described grasping mechanism comprises handle component (2) and handle component drive unit, described handle component (2) comprises the first handgrip and the second handgrip, on described the first handgrip and the second handgrip, there is respectively thimble (5)
Wherein, described the first handgrip and the second handgrip under the driving of handle component drive unit, can occur relative near or away from move, thereby drive the thimble be fixed thereon occur relative near or away from move, can leave respectively or insert thus the projection on four angles of casing board
Wherein, described the first handgrip comprises the first compression bar (21), the second handgrip comprises the second compression bar (22), the 3rd compression bar (23) and the axle (6) that connects the second compression bar (22) and the 3rd compression bar (23), described axle (6) is fixedly connected with the 3rd compression bar (23) with the second compression bar (22), by connection and the gearing of axle (6), the 3rd compression bar (23) and the second compression bar (22) be synchronizing moving in the same way
Wherein, the first compression bar (21) and the second compression bar (22) be arranged in parallel, be installed on respectively two relative frame outsides of described frame (1), the first compression bar (21) and the 3rd compression bar (23) are arranged on the frame homonymy of framework (1), the first compression bar (21) can be done synchronous backward with the 3rd compression bar (23) and move under the driving of handle component drive unit, the first compression bar (21) and the second compression bar (22) are done reverse sync and are moved thus
Wherein, described thimble is four thimbles (51, 52, 53, 54), thimble (51) and (52) are arranged on the first compression bar (21), thimble (53) and (54) are arranged on the second compression bar (22), four thimbles (51, 52, 53, 54) position corresponds respectively to the projection on four angles of casing board, compression bar (21) and (22) are under the driving of handle component drive unit, can occur relative to away from or the moving of close motion, thereby drive thimble (51, 52, 53, 54) synchronously insert respectively or leave the projection on four angles of casing board, compress in the horizontal direction or unclamp casing board,
Wherein, the middle part of the first compression bar (21) and the 3rd compression bar (23) has respectively the first compression bar inclined-plane (213, 214) the and three compression bar inclined-plane (233, 234), wherein, described handle component drive unit comprises tensioning block (3), motor (4) and bearing (7), described tensioning block (3) comprises upper reel (31) and the lower shaft disk (32) at axle bed (33) and axle bed two ends, head bearing (71) and lower bearing (72) are set in reel (31) and lower shaft disk (32) outside, the motor shaft that described axle bed (33) has power supply machine (4) passes and fixing hole (331),
Wherein, upper reel (31) and lower shaft disk (32) can be respectively by the inclined-planes (213 of described head bearing (71) and lower bearing (72) and the first compression bar 21, 214) inclined-plane (233 of the and three compression bar 23, 234) come in contact, thus, when motor (4) drives tensioning block (3) to seesaw, the upper reel (31) of tensioning block (3) and lower shaft disk (32) can be pushed respectively and be pushed respectively the first compression bar inclined-plane (213 by head bearing (71) and lower bearing (72), 214) the and three compression bar inclined-plane (233, 234), promote thus the first compression bar (21) and the 3rd compression bar (23) synchronous backward motion occurs, thereby drive lay respectively at the thimble generation of the first compression bar (21) and the second compression bar (22) relative away from or close motion.
2. grabbing device claimed in claim 1, is characterized in that, described head bearing (71) and lower bearing (72) are rolling bearing.
3. grabbing device claimed in claim 1, it is characterized in that, described handle component drive unit also comprises two guide rails (8) of the motor shaft both sides that minute are located at motor (4), tensioning block (3) by the hole (332) in its axle bed (33) through and be slidably connected with guide rail (8).
4. grabbing device claimed in claim 1, it is characterized in that, described frame (1) has outside framework (15), and first compression bar (21) of described handle component drive unit and handle component (2) and the 3rd compression bar (23) are arranged in described outside framework (15).
5. grabbing device claimed in claim 1, it is characterized in that, the frame frame of described frame (1) is set to, when the thimble (5) of grasping mechanism inserts or leave casing board protruding, the surface of frame frame of described frame (1) and the frame of casing board contact and the dull and stereotyped seat of clamping sleeve tube sheet.
6. grabbing device claimed in claim 5, it is characterized in that, described frame (1) also has for the compressing member of clamping sleeve tube sheet (16) in vertical direction, the surface level of the frame of the surface of described compressing member (16) and frame (1), be set to when thimble (5) inserts or leave casing board protruding, its surface contact with the plate face of casing board and flat board of clamping sleeve tube sheet.
7. grabbing device claimed in claim 1, is characterized in that, described thimble has pyramid type top.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201320517867.5U CN203513663U (en) | 2013-08-23 | 2013-08-23 | Grasping device used in instrument for extracting biologic active substance by using magnetic bar method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201320517867.5U CN203513663U (en) | 2013-08-23 | 2013-08-23 | Grasping device used in instrument for extracting biologic active substance by using magnetic bar method |
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| Publication Number | Publication Date |
|---|---|
| CN203513663U true CN203513663U (en) | 2014-04-02 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201320517867.5U Expired - Fee Related CN203513663U (en) | 2013-08-23 | 2013-08-23 | Grasping device used in instrument for extracting biologic active substance by using magnetic bar method |
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| CN (1) | CN203513663U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103805498A (en) * | 2013-08-23 | 2014-05-21 | 北京金麦格生物技术有限公司 | Gripping device and bioactive substance extracting instrument with same |
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2013
- 2013-08-23 CN CN201320517867.5U patent/CN203513663U/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103805498A (en) * | 2013-08-23 | 2014-05-21 | 北京金麦格生物技术有限公司 | Gripping device and bioactive substance extracting instrument with same |
| CN103805498B (en) * | 2013-08-23 | 2015-11-25 | 常州金麦格生物技术有限公司 | Grabbing device and there is the instrument of extraction biologically active substance of this grabbing device |
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Owner name: CHANGZHOU GENMAG BIOLOGICAL TECHNOLOGY CO., LTD. Free format text: FORMER NAME: BEIJING GENMAGBIO BIOTECHNOLOGY CO., LTD. |
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| CP03 | Change of name, title or address |
Address after: Wujin District of Jiangsu city of Changzhou province Changzhou 213000 West Road No. 9, Taihu science and technology industry director B1 Patentee after: CHANGZHOU GENMAG BIOTECHNOLOGY CO., LTD. Address before: 100176 No. 3 north Yongchang Road, Daxing District economic and Technological Development Zone, Beijing, 707 Patentee before: Beijing Genmagbio Biotechnology Co., Ltd. |
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| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20140402 Termination date: 20150823 |
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| EXPY | Termination of patent right or utility model |