CN207632777U - Beads enrichment mechanism and nucleic acid-extracting apparatus - Google Patents
Beads enrichment mechanism and nucleic acid-extracting apparatus Download PDFInfo
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- CN207632777U CN207632777U CN201721398746.8U CN201721398746U CN207632777U CN 207632777 U CN207632777 U CN 207632777U CN 201721398746 U CN201721398746 U CN 201721398746U CN 207632777 U CN207632777 U CN 207632777U
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- bar magnet
- kit
- component
- magnetic
- beads enrichment
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Abstract
The utility model provides a kind of Beads enrichment mechanism and nucleic acid-extracting apparatus, the Beads enrichment mechanism includes the kit for filling magnetic bead, kit can be stretched into and adsorbable magnetic bead bar magnet component, and for drive bar magnet component stretch into or far from kit bar magnet drive component, Beads enrichment mechanism further includes the bar magnet set being sheathed on bar magnet component, the magnetic sheet of adsorbable bar magnet set and the magnetic sheet drive component for being connect with magnetic sheet and being used to that magnetic sheet to be driven to move, and bar magnet set is every between bar magnet component and kit.Beads enrichment mechanism provided by the utility model and nucleic acid-extracting apparatus, by setting bar magnet set at the interval of bar magnet component and kit, so that the nucleic acid-extracting apparatus is not necessarily to clean bar magnet component when handling multiple samples, the working efficiency when nucleic acid-extracting apparatus mass disposal sample is improved.
Description
Technical field
The utility model belongs to technical field of medical equipment, is to be related to a kind of Beads enrichment mechanism and packet more specifically
Include the nucleic acid-extracting apparatus of the Beads enrichment mechanism.
Background technology
With the rapid development of medical field, there are more and more biological experiments based on nucleic acid, by right
Extraction, the detection of nucleic acid can make quick diagnosis to the disease of patient.The main method of extraction nucleic acid is paramagnetic particle method at present, fortune
Improvement is carried out with after surface modification to the surface of superparamagnetic nano particle with nanotechnology, superparamagnetism silica is prepared into and receives
Rice magnetic bead, which can specifically identify with nucleic acid molecules on micro interface and efficiently combine, to detach nucleic acid.In order to
, there is large batch of nucleic acid-extracting apparatus in the efficiency for improving nucleic acid extraction, most crucial for magnetic bead point in nucleic acid-extracting apparatus
It disembarks structure, Beads enrichment mechanism includes the bar magnet that can be mutually adsorbed with magnetic bead, to be stained with the magnetic bead of nucleic acid from blood
It is detached in liquid, and carries out subsequent experiment.
But usually Beads enrichment mechanism needs to handle multiple samples, so being needed under treatment by bar magnet before a sample
On the upper sample be infected with clean after come into operation again, bar magnet cleaning step is complicated, causes Beads enrichment mechanism large quantities of
It is less efficient when amount processing sample.
Utility model content
The purpose of this utility model is to provide a kind of Beads enrichment mechanisms, to solve bar magnet existing in the prior art point
It needs during handling multiple samples to clean the ineffective technical problem caused by bar magnet from device.
To achieve the above object, the technical solution adopted in the utility model is：A kind of Beads enrichment mechanism is provided, including is held
Set the kit of magnetic bead, can stretch into the kit and the bar magnet component of the adsorbable magnetic bead, and with the bar magnet group
Part connects and for driving the bar magnet component to stretch into the bar magnet drive component of the kit, the Beads enrichment mechanism is also wrapped
Include the bar magnet set being sheathed on the bar magnet component and can stretch into the kit, the magnetic sheet that the adsorbable bar magnet covers, with
And the magnetic sheet drive component of the magnetic sheet movement is connect and is used to drive with the magnetic sheet, the bar magnet set is every set on the bar magnet
Between component and the kit.
Further, the magnetic sheet is equipped with the first magnetic pole, and the bar magnet, which is put on, to be equipped with and can be adsorbed with first magnetic pole
The first Attraction block.
Further, the second magnetic pole is additionally provided on the magnetic sheet, the kit, which is equipped with, to be inhaled with second magnetic pole
The second attached Attraction block.
Further, first magnetic pole and second magnetic pole are electromagnet.
Further, the magnetic sheet includes the plate body being connect with the magnetic sheet drive component, and the bar magnet component is arranged in
On the plate body, first magnetic pole and second magnetic pole are fixedly connected on the plate body.
Further, the bar magnet set includes the lid that can be covered in the kit and array in the lid one
Side and multiple bodies in the kit can be stretched into, first Attraction block is set on the lid.
Further, the body have a side opening and for housing the bar magnet chamber of bar magnet component.
Further, the bar magnet component includes the connecting plate being connect with the bar magnet drive component and array in described
The side of connecting plate and multiple bar magnets in each bar magnet chamber can be stretched into.
Further, the lid is equipped with the lug boss that can be abutted with the kit.
The advantageous effect of Beads enrichment mechanism provided by the utility model is：Compared with prior art, the utility model
Beads enrichment mechanism between bar magnet component and kit by being equipped with bar magnet set so that bar magnet component is under the protection that bar magnet covers
It is not polluted by sample, when handling other samples without cleaning bar magnet component, only needs to change new bar magnet set, improve the magnetic
Working efficiency when pearl separating mechanism mass disposal sample.
The utility model also provides a kind of nucleic acid-extracting apparatus, including above-mentioned Beads enrichment mechanism, Beads enrichment mechanism
By the way that bar magnet set is arranged so that the nucleic acid-extracting apparatus, without cleaning bar magnet component, improves the core when handling other samples
Working efficiency when sour extraction element mass disposal sample.
Description of the drawings
It, below will be to embodiment or the prior art in order to illustrate more clearly of the technical scheme in the embodiment of the utility model
Attached drawing needed in description is briefly described, it should be apparent that, the accompanying drawings in the following description is only that this practicality is new
Some embodiments of type for those of ordinary skill in the art without having to pay creative labor, can be with
Obtain other attached drawings according to these attached drawings.
Fig. 1 is the structure chart for the Beads enrichment mechanism that the utility model embodiment provides；
Fig. 2 is the structure chart of magnetic sheet used by the utility model embodiment；
Fig. 3 is the structure chart that bar magnet covers used by the utility model embodiment；
Fig. 4 is the structure chart of kit used by the utility model embodiment；
Fig. 5 is the structure chart of bar magnet component used by the utility model embodiment.
Wherein, each reference numeral in figure：
2- Beads enrichments mechanism；21- bar magnet drive components；22- bar magnet components；221- connecting plates；222- bar magnets；23- magnetic
Plate drive component；24- magnetic sheets；241- plate bodys；The second magnetic poles of 242-；The first magnetic poles of 243-；25- bar magnet sets；251- lids；
The first Attraction blocks of 2511-；2512- lug bosses；252- bodies；26- kits；260- solution cavities；The second Attraction blocks of 261-.
Specific implementation mode
In order to make technical problem to be solved in the utility model, technical solution and advantageous effect be more clearly understood, with
Lower combination accompanying drawings and embodiments, the present invention will be further described in detail.It should be appreciated that specific reality described herein
It applies example to be only used to explain the utility model, is not used to limit the utility model.
It should be noted that when element is referred to as " being fixed on " or " being set to " another element, it can be directly another
On one element or it is connected on another element.When an element is known as " being connected to " another element, it can
To be directly to another element or be indirectly connected on another element.
It is to be appreciated that term " length ", " width ", "upper", "lower", "front", "rear", "left", "right", "vertical",
The orientation or positional relationship of the instructions such as "horizontal", "top", "bottom" "inner", "outside" is that orientation based on ... shown in the drawings or position are closed
System, is merely for convenience of describing the present invention and simplifying the description, does not indicate or imply the indicated device or element is necessary
With specific orientation, with specific azimuth configuration and operation, therefore should not be understood as limiting the present invention.
In addition, term " first ", " second " are used for description purposes only, it is not understood to indicate or imply relative importance
Or implicitly indicate the quantity of indicated technical characteristic.Define " first " as a result, the feature of " second " can be expressed or
Implicitly include one or more this feature.The meaning of " plurality " is two or two in the description of the present invention,
More than, unless otherwise specifically defined.
Also referring to Fig. 1, now Beads enrichment mechanism 2 provided by the utility model is illustrated.The Beads enrichment
Mechanism 2, including kit 26, bar magnet component 22 and bar magnet drive component 21：Magnetic bead is equipped in kit 26, magnetic bead is super suitable
Magnetic silicon oxide nanometer magnetic bead can be combined with nucleic acid molecules specific recognition and efficiently on micro interface, be opened in kit 26
Equipped with the solution cavity 260 for housing sample and magnetic bead；Bar magnet component 22 can stretch into kit 26, the solution cavity of kit 26
Sample and magnetic bead are filled in 260, bar magnet component 22 has magnetism, can adsorb magnetic bead, to detach magnetic bead from sample；Magnetic
Stick drive component 21 can drive bar magnet component 22 toward renaturation to stretch into or stretch into reagent when detaching magnetic bead far from kit 26
Box 26, when bar magnet component 22 is taken out together with magnetic bead, far from kit 26.The Beads enrichment mechanism 2 further includes bar magnet set 25, magnetic
Plate 24 and magnetic sheet drive component 23：Bar magnet set 25 is sheathed on bar magnet component 22, and bar magnet set 25 is every set on bar magnet component 22 and examination
Between agent box 26, when detaching magnetic bead, bar magnet set 25 and bar magnet component 22 stretch into kit 26, and bar magnet component 22 is across magnetic
Magnetic bead is adsorbed on the surface of bar magnet set 25 by stick set 25；24 adsorbable bar magnet of magnetic sheet set 25 covers 25 convenient for independent adsorption magnetic bar,
Consequently facilitating transfer magnetic bead and the bar magnet set 25 more renewed；Magnetic sheet drive component 23 can drive magnetic sheet 24 closer or far from bar magnet set
25, convenient for adsorbing and loosening bar magnet set 25.
Beads enrichment mechanism 2 provided by the utility model, compared with prior art, the utility model Beads enrichment mechanism 2
By the interval of bar magnet component 22 and kit 26 set bar magnet set 25 so that bar magnet component 22 bar magnet set 25 protection under not
It is polluted by sample, when handling other samples without cleaning bar magnet component 22, only needs to change new bar magnet set 25, improve this
Working efficiency when 2 mass disposal sample of Beads enrichment mechanism.
Further, Fig. 2 and Fig. 3 is please referred to, a kind of specific reality as Beads enrichment mechanism 2 provided by the utility model
Mode is applied, magnetic sheet 24 is equipped with the first magnetic pole 243, and bar magnet set 25 is equipped with the first Attraction block 2511, the first magnetic pole 243 and first
Attraction block 2511 can be adsorbed mutually, i.e. magnetic sheet 24 and bar magnet set 25 can be adsorbed mutually.Under the drive of magnetic sheet drive component 23, magnetic
Stick set 25 can stretch into kit 26, to make magnetic bead be adsorbed in the surface of bar magnet set 25；Under the drive of magnetic sheet drive component 23,
Bar magnet set 25 can also be removed from kit 26, be adsorbed in the magnetic bead on 25 surfaces of bar magnet set convenient for transfer, and magnetic bead is turned
It moves in the kit used in subsequent step.
Further, Fig. 2 and Fig. 4 is please referred to, a kind of specific reality as Beads enrichment mechanism 2 provided by the utility model
Mode is applied, is additionally provided with the second magnetic pole 242 on magnetic sheet 24, kit 26 is equipped with the second Attraction block 261, the second magnetic pole 242 and the
Two Attraction blocks 261 can be adsorbed mutually, i.e. magnetic sheet 24 and kit 26 can be adsorbed mutually.Under the drive of magnetic sheet drive component 23,
Second magnetic pole 242 can move back and forth in the direction toward and away from kit 26, when the second magnetic pole 242 is adsorbed close to second
When block 261, the second magnetic pole 242 is powered, kit 26 can be picked up, transfering reagent box 26 is convenient for, consequently facilitating carrying out follow-up
Experiment.First magnetic pole 243 and the second magnetic pole 242 are simultaneously operable so that magnetic sheet 24 can be simultaneously by bar magnet set 25 and kit 26
It picks up, convenient for bar magnet set 25 and kit 26 to be transferred to elsewhere simultaneously.
Further, referring to Fig. 1, a kind of specific embodiment party as Beads enrichment mechanism 2 provided by the utility model
Formula, the first magnetic pole 243 and the second magnetic pole 242 are electromagnet.Specifically, after bar magnet component 22 stretches into bar magnet set 25, bar magnet group
Part 22 and bar magnet set 25 stretch into kit 26 together, and bar magnet component 22 is permanent magnet and attracts each other with magnetic bead, and then by magnetic
Pearl detaches from sample, and when bar magnet component 22 is far from bar magnet set 25, magnetic bead can be covered on 25 from bar magnet and be fallen off；First magnetic pole 243
It is close to each other or when abutting against with the first Attraction block 2511, the first magnetic pole 243 is powered, the first magnetic pole 243 and bar magnet cover 25 phases
Mutually attracting, bar magnet set 25 can follow moving up and down and moving for magnetic sheet 24, and the bar magnet set 25 convenient for that will be adsorbed with magnetic bead takes out, the
Bar magnet set 25 can be put down after the power-off of one magnetic pole 243；Second magnetic pole 242 and the second Attraction block 261 are close to each other or when abutting against,
Second magnetic pole 242 is powered, the second magnetic pole 242 and kit 26 attract each other, kit 26 can follow magnetic sheet 24 on move down
It moves and moves, kit 26 easy to remove, kit 26 can be put down after the power-off of the second magnetic pole 242.
Further, referring to Fig. 2, a kind of specific embodiment party as Beads enrichment mechanism 2 provided by the utility model
Formula, magnetic sheet 24 include plate body 241, and bar magnet component 22 is arranged on plate body 241, offer and multiple are passed through for bar magnet component 22 on plate
Hole, plate body 241 is connected with magnetic sheet drive component 23, and magnetic sheet 24 moves up and down under the drive of drive component, the first magnetic pole
243 and second magnetic pole 242 be fixedly connected on plate body 241.Specifically, the first magnetic pole 243 and the second magnetic pole 242 are set to plate body
241 homonymy.The quantity of first magnetic pole 243 and the second magnetic pole 242 can be multiple, preferably the first magnetic pole 243 and the second magnetic pole 242
It is set to the four corners of 241 side of plate body.
Further, referring to Fig. 3, a kind of specific embodiment party as Beads enrichment mechanism 2 provided by the utility model
Formula, bar magnet set 25 includes lid 251 and multiple bodies 252, and lid 251 and kit 26 are mutually parallel, and can be placed on kit 26
On, avoid the sample in kit 26 from being contaminated during the experiment, the first Attraction block 2511 is set on lid 251.It is multiple
In the side of lid 251, body 252 can stretch into kit 26 252 array of body under the drive of magnetic sheet 24, and move up and down
Nucleic acid is set to detach.Quantity, the kit 26 of body 252 house the quantity phase of the quantity and bar magnet 222 of the solution cavity 260 of sample
Deng herein the quantity of above-mentioned all parts, is not construed as limiting determines according to actual conditions.
Further, please continue to refer to Fig. 3, a kind of specific reality as Beads enrichment mechanism 2 provided by the utility model
Mode is applied, there is body 252 bar magnet chamber, a side opening of bar magnet chamber bar magnet component 22 to be made to be stretched into body 252 from the opening.
When detaching magnetic bead, each bar magnet 222 of bar magnet component 22 is located at bar magnet intracavitary, and bar magnet chamber is located in kit 26, magnetic bead quilt
It is adsorbed on the outside of body 252, the outside of sample contamination and body 252 is next detaching without being infected with bar magnet component 22
When the magnetic bead of sample, bar magnet set 25 can be directly replaced, without cleaning bar magnet component 22, substantially increases the Beads enrichment mechanism 2
Separative efficiency.
Further, referring to Fig. 5, a kind of specific embodiment party as Beads enrichment mechanism 2 provided by the utility model
Formula, bar magnet component 22 include connecting plate 221 and multiple bar magnets 222.Connecting plate 221 and bar magnet drive component 21 connect, in bar magnet
It is moved up and down under the drive of drive component 21, so that bar magnet 222 is stretched into or cover 25 far from bar magnet.222 array of multiple bar magnets is in connection
The side of plate 221, and can be stretched under the drive of connecting plate 221 in bar magnet chamber.
Further, referring to Fig. 3, a kind of specific embodiment party as Beads enrichment mechanism 2 provided by the utility model
Formula, lid 251 are equipped with the lug boss 2512 that can be abutted against with kit 26.The quantity of lug boss 2512 can be it is multiple, at least
Set on the opposite sides of lid 251, make that there is spacing between lid 251 and kit 26.It is stretched into kit 26 in body 252
And after detaching nucleic acid, bar magnet need to be covered 25 and be taken out from kit 26, the setting of lug boss 2512 is so that bar magnet covers 25 lid
251 and kit 26 will not under the action of atmospheric pressure stick to each other, convenient for take out bar magnet set 25.
The utility model also provides a kind of nucleic acid-extracting apparatus, which includes above-mentioned Beads enrichment mechanism
2。
Nucleic acid-extracting apparatus provided by the utility model uses above-mentioned Beads enrichment mechanism 2, Beads enrichment mechanism 2
25 are covered by the way that bar magnet is arranged so that the nucleic acid-extracting apparatus, without cleaning bar magnet component 22, is improved when handling other samples
Working efficiency when the nucleic acid-extracting apparatus mass disposal sample.
The above is only the preferred embodiment of the utility model only, is not intended to limit the utility model, all at this
All any modification, equivalent and improvement etc., should be included in the utility model made by within the spirit and principle of utility model
Protection domain within.
Claims (10)
1. Beads enrichment mechanism, including the kit of accommodating magnetic bead, can stretch into the kit and the adsorbable magnetic bead
Bar magnet component, and connect with the bar magnet component and the bar magnet driving for driving the bar magnet component to stretch into the kit
Component, it is characterised in that：The Beads enrichment mechanism further includes being sheathed on the bar magnet component and can stretching into the kit
In bar magnet set, adsorbable bar magnet set magnetic sheet, and connect with the magnetic sheet and for driving the magnetic sheet to move
Magnetic sheet drive component, the bar magnet set is every between the bar magnet component and the kit.
2. Beads enrichment mechanism as described in claim 1, it is characterised in that：The magnetic sheet is equipped with the first magnetic pole, the magnetic
Stick is put on equipped with the first Attraction block that can be adsorbed with first magnetic pole.
3. Beads enrichment mechanism as claimed in claim 2, it is characterised in that：The second magnetic pole is additionally provided on the magnetic sheet, it is described
Kit is equipped with the second Attraction block that can be adsorbed with second magnetic pole.
4. Beads enrichment mechanism as claimed in claim 3, it is characterised in that：First magnetic pole and second magnetic pole are
Electromagnet.
5. Beads enrichment mechanism as claimed in claim 3, it is characterised in that：The magnetic sheet includes and the magnetic sheet drive component
The plate body of connection, the bar magnet component are arranged on the plate body, and first magnetic pole and second magnetic pole are fixedly connected with
In on the plate body.
6. Beads enrichment mechanism as claimed in claim 2, it is characterised in that：The bar magnet set includes that can be covered on the reagent
Lid and array on box in the lid side and can stretch into multiple bodies in the kit, first Attraction block
On the lid.
7. Beads enrichment mechanism as claimed in claim 6, it is characterised in that：The body have a side opening and for holding
Set the bar magnet chamber of bar magnet component.
8. Beads enrichment mechanism as claimed in claim 7, it is characterised in that：The bar magnet component includes being driven with the bar magnet
The connecting plate and array of component connection in the side of the connecting plate and can stretch into multiple bar magnets in each bar magnet chamber.
9. Beads enrichment mechanism as claimed in claim 6, it is characterised in that：The lid is equipped with and can be supported with the kit
The lug boss connect.
10. nucleic acid-extracting apparatus, it is characterised in that：Including claim 1-9 any one of them Beads enrichments mechanism.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201721398746.8U CN207632777U (en) | 2017-10-26 | 2017-10-26 | Beads enrichment mechanism and nucleic acid-extracting apparatus |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201721398746.8U CN207632777U (en) | 2017-10-26 | 2017-10-26 | Beads enrichment mechanism and nucleic acid-extracting apparatus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN207632777U true CN207632777U (en) | 2018-07-20 |
Family
ID=62858939
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201721398746.8U Active CN207632777U (en) | 2017-10-26 | 2017-10-26 | Beads enrichment mechanism and nucleic acid-extracting apparatus |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN207632777U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111218398A (en) * | 2020-03-25 | 2020-06-02 | 广州高盛生物科技股份有限公司 | Magnetic bead extraction module and extraction method |
-
2017
- 2017-10-26 CN CN201721398746.8U patent/CN207632777U/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111218398A (en) * | 2020-03-25 | 2020-06-02 | 广州高盛生物科技股份有限公司 | Magnetic bead extraction module and extraction method |
| CN111218398B (en) * | 2020-03-25 | 2024-02-13 | 广州高盛生物科技股份有限公司 | Magnetic bead extraction module and extraction method |
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