CN203425605U

CN203425605U - Diaphragm filter for refining oxaliplatin

Info

Publication number: CN203425605U
Application number: CN201320493286.2U
Authority: CN
Inventors: 苏曼; 曲春生; 张宁
Original assignee: SHANDONG BOYUAN PHARMACEUTICAL CO Ltd
Current assignee: Shandong Baoyuan Pharmaceutical Co ltd
Priority date: 2013-08-13
Filing date: 2013-08-13
Publication date: 2014-02-12
Anticipated expiration: 2023-08-13

Abstract

The utility model discloses a diaphragm filter for refining oxaliplatin, which relates to a medicine liquor filter and is used for solving the problems that a metal shell and medicine liquor come into direct contact to cause substandard quality of the medicine liquor and working temperature is not constant in filtering when the existing filter is used for filtering oxaliplatin. The diaphragm filter comprises a shell and a filter bag, the filter bag is arranged in the cavity of the shell, a steam inlet and a steam outlet which are used for steam to enter and exit out of the diaphragm filter are formed in the shell, and the constant working temperature needed in filtering can be maintained through introducing circulating steam; polyvinyl fluoride is coated on the inner wall of the shell so as to avoid direct contact between the medicine liquor and the metal shell. According to the diaphragm filter for refining oxaliplatin, the problems that working temperature is not constant and a metal shell and medicine liquor come into direct contact to cause the substandard quality of the medicine liquor during filtering when the existing filter is used for filtering oxaliplatin can be effectively solved, and the refining and filtering quality of the medicine liquor can be enhanced.

Description

The refining membrane filter of using of a kind of oxaliplatin

Technical field

The utility model relates to a kind of liquid medicine filter, the membrane filter specifically using in a kind of oxaliplatin subtractive process.

Background technology

Oxaliplatin belongs to third generation platinum series antineoplastic medicament, although with cis-platinum, the same platinum medicine that all belongs to of carboplatin, but there is very big-difference with them aspect drug effect, medicine power, antitumor spectrum and cytotoxicity in oxaliplatin, be not produce intercrossing resistance the most significantly, oxaliplatin also has activity to the tumour of resistance to carboplatin, cis-platinum.The knot of fluorouracil resistance, the carcinoma of the rectum are also had to certain curative effect simultaneously.Oxaliplatin is to the strongest medicine of cancer cell lethal effect in platinum medicine, its pt atom and left-handed-anti-form-1,2-cyclohexanediamine and an oxalate base combination, it is single enantiomorph, be white in color or the loose block of off-white color freeze-drying, be usually used in metastatic colorectal carcinoma treatment, or auxiliary curing primary tumor excises rear three phase colon cancers completely.

Can not contacting metal in oxaliplatin production process, otherwise can affect product quality.In addition, oxaliplatin process for refining is that oxaliplatin crude product is dropped in purified water, be heated to filter while hot after 90 ℃ of stirring and dissolving, and the crystallization of then lowering the temperature, so filter should be incubated, and just can reach technological requirement.Current existing plain filter is mostly stainless steel, is difficult to the temperature that maintenance needs in filter process simultaneously.A kind of insulation filter that Chinese patent 2012204211633 is announced, a kind of filter of realizing insulation by pass into the mode of hot water or steam from be arranged at the interlayer main body is provided, but filter inwall is metalwork, while being applied to oxaliplatin refining filtering, liquid directly contacts with metal shell, affects quality of liquid medicine.

Utility model content

The purpose of this utility model is to provide a kind of refining membrane filter of using of oxaliplatin with heat insulation function, and the metal shell of oxaliplatin liquid and filter is isolated in filter process, for solve existing plain filter in oxaliplatin subtractive process because not keeping the direct problem that can not meet filtering technique requirement that contacts with metal shell of steady temperature and liquid.

The technical scheme in the invention for solving the technical problem is: a kind of oxaliplatin is refining with membrane filter, comprise housing and filter bag, in the upper and lower of described housing, be respectively equipped with inlet and liquid outlet, described filter bag is movable to be arranged and is fixed on the dividing plate in housing cavity, it is characterized in that, in the outside of described housing, be also provided with a toroidal cavity for heating, and on the shell of described cavity, be respectively equipped with steam inlet and steam (vapor) outlet, by cyclic steam, provide suitable temperature for filter; In described inner walls, scribble polyvinyl fluoride.

Further, in the filter cavity between described liquid outlet and filter bag, be provided with filter, and described filter is the round plastic plate having compared with small through hole.

Further, described housing is carbon-steel parts.

Further, the filter cylinder of described housing in the middle of comprising and be positioned at the end cap up and down at two ends, is connected by flange between described filter cylinder and upper and lower end cap, and is provided with silicone rubber O-ring in assembling place of end cap and filter cylinder up and down.

The beneficial effects of the utility model are: by a kind of membrane filter with heat insulation function is provided, efficiently solve in oxaliplatin subtractive process and do not reach the problem of technological requirement because filter can not keep steady temperature, and subtractive process middle filtrator shell does not directly contact with liquid, solved existing plain filter product quality problem not up to standard when filtering oxaliplatin.

Accompanying drawing explanation

Fig. 1 is the utility model front half sectional view;

Fig. 2 is the utility model top view;

In figure: 1 upper end cover, 11 inlets, 2 filter cylinders, 21 steam inlets, 22 steam (vapor) outlets, 3 bottom end covers, 31 liquid outlets, 4 slip-on welding flanges, 5 collar nuts, 6 handles, 7 filter holders, 8 cavitys, 91 micro-porous filtration plates, 92 porous support plates, 10 sealing rings, 12 otic placodes, 13 annulus, 14 breach, 15 filter bags, 16 installing plates.

The specific embodiment

As shown in Figure 1 to Figure 2, the utility model comprises upper end cover 1, filter cylinder 2 and bottom end cover 3.

Upper end cover 1 and bottom end cover 3 are for having the carbon-steel parts of thin-wall construction, and its profile can be regarded the part that is less than hemisphere of cutting a spheroid gained by a plane as, can obtain by the method for casting.At upper end cover 1 and bottom end cover 3 open-mouths, be respectively equipped with annulus 13, and along even circumferential, be provided with eight U-shaped breach 14 on above-mentioned annulus 13.On the center of upper end cover 1 and bottom end cover 3 arc-shaped structures, be respectively equipped with a through hole, and in through hole, be vertically welded with respectively a carbon steel pipe, this through hole and carbon steel pipe form the passage of liquid turnover filter jointly; Wherein, the through hole on upper end cover 1 and carbon steel pipe have formed inlet 11, and the through hole on bottom end cover 3 and carbon steel pipe have formed liquid outlet 31, for ease of filter, are connected with external pipe, on inlet 11 and liquid outlet 31, are provided with slip-on welding flange 4.For ease of the handling of filter, at upper and lower side, cover and be also respectively equipped with handle 6, for grasping end cap.Filter cylinder 2 is columnar structured carbon-steel parts, can guarantee certain intensity.Open-mouth at filter cylinder 2 two ends is provided with the annulus 13 for being connected with upper and lower end cap, and along even circumferential, is provided with eight U-shaped breach 14 on above-mentioned annulus 13; Between the annulus 13 at two ends, be respectively equipped with the otic placode 12 that is fixed on annulus 13 inner sides, otic placode 12 is provided with through hole, and this otic placode 12 is vertical with annulus 13 and be located at U-shaped breach 14 places.During installation, upper and lower end cap is placed in respectively to the two ends of filter cylinder 2, and the U-shaped breach 14 that upper and lower side is covered is corresponding with the U-shaped breach 14 on filter cylinder 2, by the collar nut 5 hinged with otic placode 12, upper and lower end cap is fixedly connected with filter cylinder 2, wherein the fastening effect of collar nut 5 is known technology, repeats no more.

For reaching good sealing effectiveness, in the cooperation place of upper and lower end cap and filter cylinder 2, be respectively equipped with sealing ring 10, sealing ring 10 adopts silicone rubber O-ring.For preventing that oxaliplatin liquid from directly contacting with the metal shell of filter, at the inwall of upper and lower end cap and filter cylinder 2, all scribble polyvinyl fluoride.For realizing, filter, on filter cylinder 2 tops, be provided with filter holder 7, filter holder 7 is the cylindrical shape of an end closure, and is provided with through hole on filter holder 7; On these filter holder 7 inwalls, be provided with filter bag 15.For increasing filter effect, in bottom end cover 3 and filter cylinder 2 assemblings place, be provided with circular porous support plate 92, this porous support plate 92 is for being provided with the plastic plate of some through holes; On porous support plate 92, be provided with micro-porous filtration plate 91, micro-porous filtration plate 91, for being provided with the round plastic plate compared with small through hole, can carry out essence to liquid and filter, to improve quality of liquid medicine.For meeting the technological requirement in medical filtration process, under the temperature conditions of 90 ℃, after stirring and dissolving, filter while hot, outside filter cylinder 2, be arranged with an annular cavity 8, and the housing along cavity 8 is furnished with steam inlet 21 and steam (vapor) outlet 22 up and down, and at steam inlet 21 and steam (vapor) outlet 22 places, be provided with slip-on welding flange 4 so that with good being connected of other seals for pipe joints; By pass into steam in filter cavity, liquid is incubated, to realize the filtration under optimum temperature; Operating temperature is subject to the impact of filter bag simultaneously, is up to 94 ℃.For ease of the fixed installation of filter, in the outside of filter cylinder 2, be arranged with installing plate 16, installing plate 16 is provided with screwed hole, is convenient to be fixedly connected with other parts.

Claims

1. oxaliplatin is refining comprises housing and filter bag with a membrane filter, in the upper and lower of described housing, is respectively equipped with inlet and liquid outlet, and described filter bag is movable to be arranged and is fixed on the dividing plate in housing cavity, it is characterized in that,

In the outside of described housing, be also provided with a toroidal cavity for heating, and on the shell of described cavity, be respectively equipped with steam inlet and steam (vapor) outlet;

In described inner walls, scribble polyvinyl fluoride.

2. a kind of oxaliplatin according to claim 1 is refining is characterized in that with membrane filter, be provided with filter, and described filter is the round plastic plate with through hole in the filter cavity between described liquid outlet and filter bag.

3. a kind of oxaliplatin according to claim 2 is refining is characterized in that with membrane filter, and described housing is carbon-steel parts.

4. a kind of oxaliplatin according to claim 3 is refining with membrane filter, it is characterized in that, filter cylinder in the middle of described housing comprises and the end cap up and down that is positioned at two ends, between described filter cylinder and upper and lower end cap, by flange, be connected, and be provided with silicone rubber O-ring in assembling place of upper and lower end cap and filter cylinder.