CN103394229A - Diaphragm filter for refining oxaliplatin - Google Patents
Diaphragm filter for refining oxaliplatin Download PDFInfo
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- CN103394229A CN103394229A CN2013103521608A CN201310352160A CN103394229A CN 103394229 A CN103394229 A CN 103394229A CN 2013103521608 A CN2013103521608 A CN 2013103521608A CN 201310352160 A CN201310352160 A CN 201310352160A CN 103394229 A CN103394229 A CN 103394229A
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- filter
- oxaliplatin
- liquid medicine
- shell
- refining
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Abstract
The invention discloses a diaphragm filter for refining oxaliplatin, and relates to a liquid medicine filter for solving the problem that when the existing filter is used to filter oxaliplatin, the quality of the liquid medicine does not reach the standard caused by indirect contact of a metal shell and the liquid medicine, and the work temperature during filtration is inconstant. The filter comprises a shell and a filter bag arranged in a cavity of the shell, wherein the shell is provided with a steam inlet and a steam outlet to allow steam to pass in and out, and circulating steam is introduced to maintain required constant work temperature during filtration. Polyvinyl fluoride is coated on the inner wall of the shell to avoid direct contact of the liquid medicine and the metal shell. According to the filter disclosed by the invention, the problems that the work temperature of the existing filter for refining and filtering oxaliplatin is inconstant and the quality of the liquid medicine does not reach the standard because the filter shell directly is contacted with the liquid medicine can be effectively solved, and the refining and filtering quality of the liquid medicine is improved.
Description
Technical field
The present invention relates to a kind of liquid medicine filter, the membrane filter that specifically uses in a kind of oxaliplatin subtractive process.
Background technology
Oxaliplatin belongs to third generation platinum series antineoplastic medicament, although with cis-platinum, the same platinum medicine that all belongs to of carboplatin, but there is very big-difference in oxaliplatin with them aspect drug effect, medicine power, antitumor spectrum and cytotoxicity, be not produce the intercrossing resistance the most significantly, namely oxaliplatin also has activity to the tumour of anti-carboplatin, cis-platinum.Simultaneously knot, the carcinoma of the rectum of fluorouracil resistance also there is certain curative effect.Oxaliplatin is to the strongest medicine of cancer cell lethal effect in platinum medicine, its pt atom and left-handed-anti-form-1,2-cyclohexanediamine and an oxalate base combination, it is single enantiomorph, be white in color or the loose block of off-white color freeze-drying, be usually used in the metastatic colorectal carcinoma treatment, or the supplemental treatment primary tumor excises rear three phase colon cancers fully.
Can not contacting metal in the oxaliplatin production process, otherwise can affect product quality.In addition, the oxaliplatin process for refining is that the oxaliplatin crude product is dropped in purified water, be heated to filter while hot after 90 ℃ of stirring and dissolving, and the crystallization of then lowering the temperature, so filter should be incubated, and just can reach technological requirement.Present existing plain filter is mostly stainless steel, is difficult to simultaneously keep the temperature that needs in filter process.A kind of insulation filter that Chinese patent 2012204211633 is announced, provide a kind of and realized by the mode that passes into hot water or steam the interlayer outside being arranged at main body the filter that is incubated, but the filter inwall is metalwork, while being applied to the oxaliplatin refining filtering, liquid directly contacts with metal shell, affects quality of liquid medicine.
Summary of the invention
The object of the present invention is to provide a kind of refining membrane filter of using of oxaliplatin with heat insulation function, and in filter process, the metal shell of oxaliplatin liquid and filter is isolated, be used for solving existing plain filter in the oxaliplatin subtractive process because not keeping the direct problem that can not meet the filtering technique requirement that contacts with metal shell of steady temperature and liquid.
The present invention solves the technical scheme that its technical problem takes: the refining membrane filter of using of a kind of oxaliplatin, comprise housing and filter bag, be respectively equipped with inlet and liquid outlet in the upper and lower of described housing, described filter bag is movable to be arranged and is fixed on dividing plate in the housing cavity, it is characterized in that, also be provided with a toroidal cavity that is used for heating in the outside of described housing, and be respectively equipped with steam inlet and steam (vapor) outlet on the shell of described cavity, by cyclic steam, for filter, provide suitable temperature; Scribble polyvinyl fluoride on described inner walls.
Further, be provided with filter in the filter cavity between described liquid outlet and filter bag, and described filter is the round plastic plate that has than small through hole.
Further, described housing is carbon-steel parts.
Further, described housing in the middle of comprising filter cylinder and be positioned at the end cap up and down at two ends, described filter cylinder be connected by flange between end cap up and down, and in assembling place of up and down end cap and filter cylinder, be provided with silicone rubber O-ring.
The invention has the beneficial effects as follows: by a kind of membrane filter with heat insulation function is provided, efficiently solve in the oxaliplatin subtractive process and do not reach the problem of technological requirement because filter can not keep steady temperature, and subtractive process middle filtrator shell does not directly contact with liquid, product quality problem not up to standard while having solved existing plain filter for the filtration oxaliplatin.
Description of drawings
Fig. 1 is front of the present invention half sectional view;
Fig. 2 is top view of the present invention;
In figure: 1 upper end cover, 11 inlets, 2 filter cylinders, 21 steam inlets, 22 steam (vapor) outlets, 3 bottom end covers, 31 liquid outlets, 4 slip-on welding flanges, 5 collar nuts, 6 handles, 7 filter holders, 8 cavitys, 91 micro-porous filtration plates, 92 porous support plates, 10 sealing rings, 12 otic placodes, 13 annulus, 14 breach, 15 filter bags, 16 installing plates.
The specific embodiment
As shown in Figure 1 to Figure 2, the present invention includes upper end cover 1, filter cylinder 2 and bottom end cover 3.
For reaching good sealing effectiveness, be respectively equipped with sealing ring 10 in the cooperation place of up and down end cap and filter cylinder 2, sealing ring 10 adopts silicone rubber O-ring., for preventing that the oxaliplatin liquid from directly contacting with the metal shell of filter, at the inwall of up and down end cap and filter cylinder 2, all scribble polyvinyl fluoride.For realizing filtering, be provided with filter holder 7 on filter cylinder 2 tops, filter holder 7 is the cylindrical shape of an end closure, and is provided with through hole on filter holder 7; Be provided with filter bag 15 on these filter holder 7 inwalls.For increasing filter effect, be provided with circular porous support plate 92 in bottom end cover 3 and filter cylinder 2 assemblings place, this porous support plate 92 is for being provided with the plastic plate of some through holes; Be provided with micro-porous filtration plate 91 on porous support plate 92, micro-porous filtration plate 91, for being provided with the round plastic plate than small through hole, can carry out essence to liquid and filter, to improve quality of liquid medicine.For meeting the technological requirement in the medical filtration process, namely filter while hot after stirring and dissolving under the temperature conditions of 90 ℃, be arranged with the cavity 8 of an annular outside filter cylinder 2, and the housing along cavity 8 is furnished with steam inlet 21 and steam (vapor) outlet 22 up and down, and be provided with slip-on welding flange 4 at steam inlet 21 and steam (vapor) outlet 22 places so that with good being connected of other seals for pipe joints; By pass into steam in filter cavity, liquid is incubated, to realize the filtration under optimum temperature; Operating temperature is subjected to the impact of filter bag simultaneously, is up to 94 ℃.For ease of the fixed installation of filter, be arranged with installing plate 16 in the outside of filter cylinder 2, installing plate 16 is provided with screwed hole, is convenient to be fixedly connected with other parts.
Claims (4)
1. an oxaliplatin is refining use membrane filter, comprises housing and filter bag, in the upper and lower of described housing, is respectively equipped with inlet and liquid outlet, and described filter bag activity arranges and is fixed on dividing plate in the housing cavity, it is characterized in that,
Also be provided with a toroidal cavity that is used for heating in the outside of described housing, and be respectively equipped with steam inlet and steam (vapor) outlet on the shell of described cavity;
Scribble polyvinyl fluoride on described inner walls.
2. a kind of oxaliplatin according to claim 1 is refining uses membrane filter, it is characterized in that, be provided with filter in the filter cavity between described liquid outlet and filter bag, and described filter is the round plastic plate that has than small through hole.
3. a kind of oxaliplatin according to claim 2 is refining uses membrane filter, it is characterized in that, described housing is carbon-steel parts.
4. a kind of oxaliplatin according to claim 3 is made with extra care and is used membrane filter, it is characterized in that, filter cylinder in the middle of described housing comprises and the end cap up and down that is positioned at two ends, described filter cylinder is connected by flange between end cap with up and down, and in assembling place of up and down end cap and filter cylinder, is provided with silicone rubber O-ring.
Priority Applications (1)
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CN2013103521608A CN103394229A (en) | 2013-08-13 | 2013-08-13 | Diaphragm filter for refining oxaliplatin |
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CN2013103521608A CN103394229A (en) | 2013-08-13 | 2013-08-13 | Diaphragm filter for refining oxaliplatin |
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CN103394229A true CN103394229A (en) | 2013-11-20 |
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CN2013103521608A Pending CN103394229A (en) | 2013-08-13 | 2013-08-13 | Diaphragm filter for refining oxaliplatin |
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Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5547638A (en) * | 1993-08-30 | 1996-08-20 | Morton International, Inc. | Pyrotechnic air bag inflator with unitary filter |
CN2759560Y (en) * | 2004-12-24 | 2006-02-22 | 上海万森水处理有限公司 | Interlayer type filtering machine |
CN101269280A (en) * | 2008-05-08 | 2008-09-24 | 常熟市联邦化工有限公司 | Foreign body filter |
CN101596377A (en) * | 2009-06-16 | 2009-12-09 | 常熟市联邦化工有限公司 | Ultra-fine foreign material filter |
CN203425605U (en) * | 2013-08-13 | 2014-02-12 | 山东铂源药业有限公司 | Diaphragm filter for refining oxaliplatin |
-
2013
- 2013-08-13 CN CN2013103521608A patent/CN103394229A/en active Pending
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5547638A (en) * | 1993-08-30 | 1996-08-20 | Morton International, Inc. | Pyrotechnic air bag inflator with unitary filter |
CN2759560Y (en) * | 2004-12-24 | 2006-02-22 | 上海万森水处理有限公司 | Interlayer type filtering machine |
CN101269280A (en) * | 2008-05-08 | 2008-09-24 | 常熟市联邦化工有限公司 | Foreign body filter |
CN101596377A (en) * | 2009-06-16 | 2009-12-09 | 常熟市联邦化工有限公司 | Ultra-fine foreign material filter |
CN203425605U (en) * | 2013-08-13 | 2014-02-12 | 山东铂源药业有限公司 | Diaphragm filter for refining oxaliplatin |
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Application publication date: 20131120 |