CN203388852U - Magnetic resonance elastography detecting device - Google Patents
Magnetic resonance elastography detecting device Download PDFInfo
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- CN203388852U CN203388852U CN201320230593.1U CN201320230593U CN203388852U CN 203388852 U CN203388852 U CN 203388852U CN 201320230593 U CN201320230593 U CN 201320230593U CN 203388852 U CN203388852 U CN 203388852U
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Abstract
The utility model relates to a magnetic resonance elastography monitoring device. The device comprises a high-magnetic-field nuclear magnetic resonance whole-body imaging system which comprises a scanning rack, a magnetic resonance scanning coil and a support plate, wherein the support plate is flexibly connected with the scanning rack, the magnetic resonance scanning coil is connected with the support plate, one end of the support plate is connected with an excitation source, a carbon fiber bar is connected onto the excitation source, the support plate is provided with a groove, the excitation source is installed in the groove, the groove is matched with the excitation source installed in the groove in shape and size, the excitation source is connected with a vibration pushing piece through the carbon fiber bar, and the vibration pushing piece is arranged on a phantom or a position to be detected. According to preliminary experiments of the magnetic resonance elastography monitoring device on the phantom, the imaging quality is excellent and the effects are obvious, thereby laying foundations for follow-up MRE researches of liver tissues and providing guidance and reference for elastic researches of other parts.
Description
Technical field
This utility model relates to a kind of checkout gear of hepatic disease, specifically a kind of magnetic resonance elastography checkout gear.
Background technology
It is hepatic fibrosis that the main early stage pathology of all kinds of hepatic disease changes, and fibrosis can reverse, make liver to recover normal by treatment in theory, once fibrosis, further develops liver cirrhosis, can not reverse.Therefore the accurate judgement of degree of hepatic fibrosis and fibrosis speed is all vital for selection and the treatment prognosis evaluation of corresponding treatment operation, clinically important in inhibiting.
Liver biopsy is at present the goldstandard that hepatic fibrosis is judged, but liver biopsy is to have wound inspection, and Most patients is difficult to accept the method, the method samples less simultaneously, error is large, poor repeatability, can not be applied to the patient that is in a bad way, the mortality rate that its complication causes is also up to 0.1%.Because biopsy lacks time continuity, the process that is difficult to fibrosis to form detects, and also cannot evaluate the curative effect of anti-fibrosis medicine, so liver puncture is restricted in clinical practice simultaneously.Clinically in the urgent need to developing the hepatic fibrosis detection methods of a kind of Noninvasive, accuracy and quantification.
Traditional mr imaging technique cannot be realized sensitivity and all quantitative assessments good, hepatic fibrosis of specificity.Liver fibrosis tissue embodies the dramatic difference of mechanical property (as elasticity or hardness) in various degree.Normal liver hardness is about 2.7kPa, and different fibrosis liver average hardness are 5.6kPa.Liver after sclerosis is also hard than stone completely.Based on this notable difference, can reflect that the nuclear magnetic resonance, NMR elasticity technology of tissue elasticity parameter differences becomes one of choice of technology most with prospects realizing liver fibrosis classification.
The ultimate principle of nuclear magnetic resonance, NMR elastogram technology is to utilize mr imaging technique, the particle displacement that detection bodies inner tissue produces under certain External Force Acting, by motion sensitive gradient (Motion Sensitive Gradient, MSG) MRI phase image is obtained in effect, based on this by the contrary of Elasticity solved, draw the scattergram (being resonance elastic diagram) of the coefficient of elasticity of each point in tissue, using the foundation of tissue elasticity mechanics parameter as liver fibrosis classification.
Utility model content
This utility model is for clinical hepatic disease pathological study required liver fibrosis classification and rate detection, to provide a magnetic resonance elastography checkout gear.
The technical scheme that realizes above-mentioned purpose is as follows:
Magnetic resonance elastography checkout gear, comprise high-field nuclear magnetic resonance whole body imaging system, high-field nuclear magnetic resonance whole body imaging system comprises scanning gantry, magnetic resonance imaging coil, gripper shoe, described gripper shoe is flexibly connected with scanning gantry, magnetic resonance imaging coil is connected with gripper shoe, one end of gripper shoe is connected with driving source, on driving source, connect carbon fiber rod, it is characterized in that: in gripper shoe, there is a groove, driving source is arranged in groove, described groove be arranged on the driving source shape in groove, size adapts, driving source is connected with vibration push jack by carbon fiber rod, described vibration push jack is placed on phantom Huo Shoujian position.
Described phantom refer to adopt that agarose material makes in order to imitate the model of liver organization.Different according to configuration concentration, there is different hardness, in order to imitate the liver of different degree of hepatic fibrosis, when needs detect, vibration push jack is placed on phantom or the inspected liver of human body position.
Further, have single-chip microcomputer in driving source, described single-chip microcomputer is Mega16 type single-chip microcomputer.
Parameter-adjustable audio signal that single-chip microcomputer produces produces scissoring vibration by the digital-to-analogue conversion on Mega16 type single-chip microcomputer, low-pass filtering, Audio power amplifier, nuclear magnetic resonance scanning chamber filtering conduction door-plate, electro-magnetic shielding cover by electromagnetic oscillation device.
Further, described carbon fiber rod is hollow structure, and its external diameter is 5 ± 0.5mm, and internal diameter is 3 ± 0.5mm, and length is 2.5m ± 0.5m.
Further, described carbon fiber rod is two, and be arranged in parallel.
Further, the conical structure that described carbon fiber rod is hollow, the one end that connects driving source is large end, described circular cone ratio is 1: 10.
Further, described push jack is lucite.
Further, described lucite push jack is of a size of 50mm * 40mm * 8mm.
Phantom or person under inspection's liver organization position are adopted respectively to head coil or after body coil, navigate to magnet center greatly; open after nuclear magnetic resonance equipment; start driving source and motion sensitive imaging sequence; electromagnetic oscillation device produces vibration; by carbon fiber rod, conduct to push jack, push jack moves along directions X, makes to vibrate feed-in phantom Huo Shoujian position tissue; make to organize interior particle to produce the vibration repeatedly of Z direction, vibration wave is propagated along Y-direction in tissue.
It is high, simple in structure that this utility model detects degree of accuracy.
Accompanying drawing explanation
Fig. 1 is structural representation of the present invention
Fig. 2 is the cutaway view of Fig. 1
Fig. 3 is this utility model displacement phase imaging sequence schematic diagram
Figure number explanation: driving source 1, carbon fiber rod 2, scanning coil 3, vibration push jack 4, phantom 5, scanning gantry 6, gripper shoe 7
The specific embodiment
Below in conjunction with accompanying drawing and embodiment, the present invention is further illustrated.In this utility model, except the present invention's point, remaining is all same as the prior art.Therefore, prior art is not described in detail, and only does simple introduction.
In figure, magnetic resonance elastography checkout gear, comprise high-field nuclear magnetic resonance whole body imaging system, high-field nuclear magnetic resonance whole body imaging system comprises scanning gantry 6, magnetic resonance imaging coil 3, gripper shoe 7, gripper shoe 7 is flexibly connected with scanning gantry 6, scanning coil 3 is connected with gripper shoe 7, one end of gripper shoe 7 is connected with driving source 1, on driving source, connect carbon fiber rod 2, in gripper shoe, there is a groove, (not shown), driving source is arranged in groove, groove be arranged on the driving source shape in groove, size adapts, driving source 1 is connected with vibration push jack 4 by the carbon fiber rod 2 of hollow, carbon fiber rod 2 can be two, parallel is arranged between driving source 1 and vibration push jack 4, in driving source 1, there is Mega16 type single-chip microcomputer, described Mega16 type single-chip microcomputer is prior art, adopt the carbon fiber rod of hollow, the weight that alleviates carbon fiber rod on the one hand, the 2nd, the structure of hollow, the vibration meeting producing is more accurate, responsive.Certainly the structure of carbon fiber rod can also adopt the structure of circular cone or truncated cone-shaped, can further alleviate the weight of carbon fiber rod, and taper ratio can adopt 1: 10 or other tapering.
The concrete way of this utility model is: the magnet center by phantom 5 or person under inspection's liver organization spots localization to magnetic resonance imaging coil 3, phantom 5 or person under inspection's liver organization position adopt respectively the head coil of the magnetic resonance imaging coil 3 being arranged in scanning gantry 6 or large body coil (or software coil) to carry out sweep signal, large body coil is fixed in scanning gantry, can directly use, head coil need to be put and check position, start driving source and motion sensitive imaging sequence, then after exciting bank line is good according to Fig. 1 line, driving source is connected together with phantom 5 Huo Shoujian positions, open after nuclear magnetic resonance equipment, start the sequence shown in Fig. 2, sequence can provide gate-control signal when carrying out, control single chip computer produces setpoint frequency and sets the audio frequency sine wave signal of first phase, after audio frequency power amplifier filtering, deliver to electromagnetic oscillation device and produce vibration, finally by carbon fiber rod 2, conduct to push jack 4, push jack 4 moves along Z direction, make to vibrate feed-in tissue, the vibration repeatedly that in tissue, particle also can produce Z direction, but vibration wave is propagated along Y-direction in tissue.
The ultimate principle of nuclear magnetic resonance, NMR elastogram technology is to utilize mr imaging technique, the particle displacement that detection bodies inner tissue produces under certain External Force Acting, by motion sensitive gradient (Motion Sensitive Gradient, MSG) MRI phase image is obtained in effect, based on this by the contrary of Elasticity solved, draw the scattergram (being resonance elastic diagram) of the coefficient of elasticity of each point in tissue, using the foundation of tissue elasticity mechanics parameter as liver fibrosis classification.
Driving source adopts Mega16 type single-chip microcomputer as the production part of excitation source signal, owing to need to realizing adjusting and the demonstration of frequency, initial phase, actuation duration, also need to accept the gate of MRI sequencer, add the output of 8 bit digital driving sources, therefore adopt the stronger medium-sized Mega16 model single-chip microcomputer of versatility with 4 I/O mouths to realize, the 8 bit digital driving sources that single-chip microcomputer produces pass through the adjustable amplification output audio of audio frequency analogue signal after D/A conversion and low-pass filtering again, through the idle filter interface on MRI scanning room filtering conduction door-plate, electromagnetic oscillation device in strip line is delivered to electro-magnetic shielding cover, produce horizontal mechanical vibration, vibration will be by external diameter 5mm internal diameter 3mm, length is that the hollow carbon fiber rod 2 (weight is only 25g/m) of 2.5m ± 0.5m is transmitted to (50mm * 40mm * 8mm) on lucite push jack 4, surface or human liver position that push jack 4 is placed on phantom 5 are set up, push jack 4 vibrations get final product feed-in phantom 5 or Liver Tissue is propagated.
The experiment porch that this utility model is developed mainly for carrying out degree of hepatic fibrosis classification research.Except carrying out, the elasticity research at liver position, can also carrying out the elastogram research experiment platform of other tissue sites such as muscle, mammary gland and prostate.Adopt the present invention to carry out the preliminary experiment of phantom simultaneously and carry out the research of background phase noise and shearing wave is propagated and shearing wave frequency between the experimentation of relation, good image quality, successful.For the MRE research of follow-up liver organization, lay a good foundation, also the elasticity research for other positions provides guidance and reference.
These are only the preferred embodiment of this utility model embodiment; not in order to limit this utility model embodiment; all within the spirit and principle of this utility model embodiment; any modification of doing, be equal to replacement, improvement etc., all should be included in the protection domain of this utility model embodiment.
Claims (7)
1. magnetic resonance elastography checkout gear, comprise high-field nuclear magnetic resonance whole body imaging system, high-field nuclear magnetic resonance whole body imaging system comprises scanning gantry, magnetic resonance imaging coil, gripper shoe, described gripper shoe is flexibly connected with scanning gantry, magnetic resonance imaging coil is connected with gripper shoe, one end of gripper shoe is connected with driving source, on driving source, connect carbon fiber rod, it is characterized in that: in gripper shoe, there is a groove, driving source is arranged in groove, described groove be arranged on the driving source shape in groove, size adapts, driving source is connected with vibration push jack by carbon fiber rod, described vibration push jack is placed on phantom Huo Shoujian position.
2. magnetic resonance elastography checkout gear according to claim 1, is characterized in that: in driving source, have single-chip microcomputer, described single-chip microcomputer is Mega16 type single-chip microcomputer.
3. magnetic resonance elastography checkout gear according to claim 1, is characterized in that: described carbon fiber rod is hollow structure, and its external diameter is 5 ± 0.5mm, and internal diameter is 3 ± 0.5mm, and length is 2.5m ± 0.5m.
4. magnetic resonance elastography checkout gear according to claim 1, is characterized in that: described carbon fiber rod is two, and be arranged in parallel.
5. magnetic resonance elastography checkout gear according to claim 1, is characterized in that: the conical structure that described carbon fiber rod is hollow, and the one end that connects driving source be to hold greatly, described circular cone ratio is 1:10.
6. magnetic resonance elastography checkout gear according to claim 1, is characterized in that: described push jack is lucite.
7. magnetic resonance elastography checkout gear according to claim 6, is characterized in that: described lucite push jack is of a size of 50mm * 40mm * 8mm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201320230593.1U CN203388852U (en) | 2013-04-28 | 2013-04-28 | Magnetic resonance elastography detecting device |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201320230593.1U CN203388852U (en) | 2013-04-28 | 2013-04-28 | Magnetic resonance elastography detecting device |
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| CN203388852U true CN203388852U (en) | 2014-01-15 |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106859646A (en) * | 2017-02-16 | 2017-06-20 | 苏州大学张家港工业技术研究院 | It is a kind of for animal and the drive device of in vitro sample magnetic resonance elastography |
| CN108618781A (en) * | 2017-03-23 | 2018-10-09 | 冯原 | Chest and abdomen magnetic resonance elastography driving device |
| CN110123323A (en) * | 2019-04-02 | 2019-08-16 | 佛山瑞加图医疗科技有限公司 | Magnetic resonance imaging equipment and localization method |
| CN110916663A (en) * | 2019-12-05 | 2020-03-27 | 无锡鸣石峻致医疗科技有限公司 | Portable nuclear magnetic resonance organ elasticity noninvasive quantitative detection method |
-
2013
- 2013-04-28 CN CN201320230593.1U patent/CN203388852U/en not_active Expired - Fee Related
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106859646A (en) * | 2017-02-16 | 2017-06-20 | 苏州大学张家港工业技术研究院 | It is a kind of for animal and the drive device of in vitro sample magnetic resonance elastography |
| WO2018148980A1 (en) * | 2017-02-16 | 2018-08-23 | 苏州大学张家港工业技术研究院 | Driving device used for magnetic resonance elastography of animal and extra-corporeal sample |
| CN108618781A (en) * | 2017-03-23 | 2018-10-09 | 冯原 | Chest and abdomen magnetic resonance elastography driving device |
| CN110123323A (en) * | 2019-04-02 | 2019-08-16 | 佛山瑞加图医疗科技有限公司 | Magnetic resonance imaging equipment and localization method |
| CN110123323B (en) * | 2019-04-02 | 2023-10-20 | 佛山瑞加图医疗科技有限公司 | Magnetic resonance scanning device and positioning method |
| CN110916663A (en) * | 2019-12-05 | 2020-03-27 | 无锡鸣石峻致医疗科技有限公司 | Portable nuclear magnetic resonance organ elasticity noninvasive quantitative detection method |
| CN110916663B (en) * | 2019-12-05 | 2020-12-01 | 无锡鸣石峻致医疗科技有限公司 | Portable nuclear magnetic resonance organ elasticity noninvasive quantitative detection method |
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| Date | Code | Title | Description |
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20140115 Termination date: 20170428 |