CN102085096B - Injection current type magnetoacoustic coupling imaging device - Google Patents
Injection current type magnetoacoustic coupling imaging device Download PDFInfo
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Abstract
The invention relates to the technical field of acquisition of electrical characteristic information for biological tissues. The invention provides an injection current type magnetoacoustic coupling imaging device, which provides conditions for developing experiments for injection current type magnetoacoustic coupling imaging. The technical scheme is that: the injection current type magnetoacoustic coupling imaging device comprises a center control unit, an exciting unit, a stable and constant magnetic field unit, a medium phantom, a motor drive scanning unit, a detection processing unit and a data storage and display unit, wherein the center control unit is connected with other units so as to supply synchronizing and control signals to other units; the exciting unit is used for generating any wave form exciting pulse signals for the medium phantom; the stable and constant magnetic field unit is used for supplying stable and constant magnetic fields to a medium unit; acoustic signals generated by the medium phantom are scanned, received and converted into electrical signals by using the motor drive scanning unit to drive a sensor; and the electrical signals are processed by the detection processing unit and are stored and displayed by the data storage and display unit. The injection current type magnetoacoustic coupling imaging device is mainly applied to the acquisition of the electrical characteristic information for the biological tissues.
Description
Technical field
The present invention relates to biological tissue electrical characteristics technology for information acquisition field, specifically, relate to injection current formula magnetosonic coupling imaging device.
Background technology
Biological tissue's electrical characteristics information helps to understand organizes electrophysiological characteristics, thereby foundation is provided for the early diagnosis of disease.Because electrical impedance technology imaging space resolution is not high; Magnetosonic is coupled into picture and has overcome above-mentioned shortcoming; Have the functional parameter high-contrast of electrical impedance imaging and the advantage of ultra sonic imaging high spatial resolution concurrently; This method also has the simple relatively advantage of the good attitude of inverse problem, algorithm for reconstructing simultaneously, has become the new research focus in functional imaging field at present.
Mode according to excitation is different, magnetosonic be coupled into picture be divided into electric current pouring-in with two kinds of vicariouss.Because the induction type magnetic acoustical coupling, the faradic current that produces through the magnetic field coupling encourages, and the detector of imaging receives magnetic interference easily, will make a big impact for the detection of signal.And the ability change of variable through magnetic field has been avoided in pouring-in magnetosonic coupling, thereby has avoided detector to receive the interference in magnetic field,
There are a lot of research institutions that this method is launched research both at home and abroad.Yet present research mainly is in theoretical model and analog simulation stage, and present experiment also only rests in the research of better simply biological tissue neuroelectricity detection, and the imaging experiment that utilizes this principle to carry out is not carried out in a deep going way.
Summary of the invention
For overcoming the deficiency of prior art, a kind of injection current formula magnetosonic coupling imaging device is provided, the condition that provides is carried out in the experiment that is coupled into picture for injection current formula magnetosonic; Thereby be the more deep research of this theoretical method research and experiment, and clinical medicine in the future uses and lay the first stone, the technical scheme that the present invention adopts is; Injection current formula magnetosonic coupling imaging device comprises: centralized control unit, exciting unit; The steady magnetic field unit, the motor-driven scanning element detects processing unit, data storage and display unit; Each unit of centralized control unit and other is connected, so that other each unitary synchronous and control signals to be provided; Exciting unit produces the random waveform excitation pulse signal to tested organism; The steady magnetic field unit provides steady magnetic field to media units; The acoustical signal that tested organism produces scans, receives and convert to the signal of telecommunication by motor-driven scanning element driving sensor; The signal of telecommunication is through detecting the processing of processing unit, stored and shown by data storage and display unit.
Said centralized control unit comprises computer, gpib interface, and LabVIEW virtual instrument operating platform, said centralized control unit is connected through each unit of gpib interface and other, and centralized control unit provides other each unitary synchronous and control signals.
Said exciting unit is by functional generator, and power amplifier is formed, and is used to provide the random waveform excitation pulse signal.
Said steady magnetic field unit provides steady magnetic field, comprises electric magnet, dc power supply, and magnetic field sensor, and measurement of magnetic field device.
Said tested Biomedia links to each other through electrode with said exciting unit, realizes excitation.
Said motor-driven scanning element realizes pick off to testing the scanning of imitative body, and said motor-driven scanning element is by stepper motor driver, and motor is formed.
Said detection processing unit receives the acoustical signal that tested Biomedia excited target produces, and carries out amplification filtering and handle, and carries out the synchronous triggering acquired signal by data collecting card; And utilize data processing module to handle; Form output at last, said detection processing unit is by sonic transducer, low-noise amplifier; Wave filter is formed, and data collecting card constitutes.
Said data storage and display unit are accomplished the storage and the demonstration of data under the driving of synchronizing signal, said data storage and display unit are made up of disk array and oscillograph.
The present invention has following technique effect: because the present invention has adopted centralized control unit, exciting unit, steady magnetic field unit; The motor-driven scanning element; Detect processing unit and data storage and display cell structure, thereby the present invention can realize measured object is applied galvanism; Measure the acoustic signals that measured object produces, form pictorial display; In addition, the present invention also has the characteristics accurately and reliably of testing.
Description of drawings
Fig. 1 is a system construction drawing of the present invention.
Fig. 2 is an exciting unit of the present invention.
Fig. 3 is steady magnetic field of the present invention unit.
Fig. 4 is a motor-driven scanning element of the present invention.
Fig. 5 is a tested Biomedia of the present invention.
Fig. 6 is a detection processing unit of the present invention.
Fig. 7 is data storage of the present invention and display unit.
Fig. 8 is a system work process of the present invention.
Wherein,
1: centralized control unit
2: exciting unit
3: the steady magnetic field unit
4: tested Biomedia
5: the motor-driven scanning element
6: detect processing unit
7: the data storage display unit
8: functional generator
9: power amplifier
10: electric magnet
11: dc power supply
12: magnetic field sensor
13: the measurement of magnetic field device
14: electrode
15: stepper motor driver
16: motor
17: sonic transducer
18: low-noise amplifier
19: wave filter
20: data collecting card
21: data processing module
22: disk array
23: oscillograph.
The specific embodiment
Injection current formula magnetosonic coupling imaging device comprises: centralized control unit, and exciting unit, the steady magnetic field unit, the motor-driven scanning element detects processing unit and data storage and display unit.
Said centralized control unit is by computer, and gpib interface reaches LabVIEW virtual instrument operating platform and realizes.Said centralized control unit is connected with each subelement through gpib interface, and centralized control unit provides other each unitary synchronous and control signals.
Said exciting unit provides the random waveform excitation pulse signal.Said exciting unit is by functional generator, and power amplifier is formed.In the experiment, the exciting unit impulse waveform is selected or programming produces sine pulse, rectangular pulse, and Gaussian pulse or other random waveforms, pulsewidth are the pulse of μ s-ms level, to reach the resolution of cm level, output voltage range is 100mV-100V.
Said steady magnetic field unit provides steady magnetic field, comprises electric magnet, dc power supply, and magnetic field sensor, and measurement of magnetic field device.Said steady magnetic field unit is used to provide the magnetostatic field of magnetosonic coupling effect.The magnetic induction that said steady magnetic field unit produces magnetic field is 1mT-1T, and can detect in real time.
Said tested Biomedia can be selected according to experiment purpose.
Said tested Biomedia links to each other through electrode with said exciting unit, realizes excitation.
Said motor-driven scanning element realizes pick off to testing the scanning of imitative body, and said motor-driven scanning element is by stepper motor driver, and motor is formed.Scanning stepping angle is 1.8 °, and sweep limits is 360 °.
Said detection processing unit receives the acoustical signal that tested Biomedia excited target produces, and carries out amplification filtering and handle, and carries out the synchronous triggering acquired signal by data collecting card, and utilizes data processing module to handle, and forms output at last.Said detection processing unit is by sonic transducer, and the low-noise amplifier wave filter is formed, and data collecting card and data processing module are formed.Said detection processing unit accuracy of detection reaches the 10-3Pa magnitude, and bandwidth is 1MHz.
Said data storage and display unit are accomplished the storage and the demonstration of data under the driving of synchronizing signal.Said data storage and display unit are made up of disk array and oscillograph.Said storage and display unit deposits capacity in can reach 1TB.
Said a kind of injection current formula magnetosonic is coupled into the picture experimental system, and concrete work process is following:
During system works, communicate by letter with each subelement through gpib interface, send order to other each subelements by centralized control unit,
1. each subelement starts.
2. by centralized control unit each subelement is carried out the parameter setting.
3. by exciting unit output drive signal, inject in the tested Biomedia, provide in the steady magnetic field unit under the situation of steady magnetic field, can excite the generation acoustical signal through electrode.
4. detecting processing unit receives signal.
5. detect processing unit signal detection is handled, comprise amplification filtering etc.
6. carry out data storage by the data storage display unit, with real-time demonstration.
7. if scanning does not finish, then move certain angle, and repeat the job step of 3-6 by motor-driven scanning element drive stepping motor; If the end of scan, then whole system end-of-job.
For further understanding summary of the invention of the present invention, characteristics and effect, the following examples of giving an example now, and conjunction with figs. specifies as follows:
See also Fig. 6, the ultimate principle that magnetosonic is coupled into picture is to be opposite to the imitative body of medium in the steady magnetic field; Through the imitative body injection current of electrode pair medium, electric current receives the effect of Lorentz force, produces the displacement of moment; Form acoustic vibration, and the frequency of vibration is identical with the power frequency of injection.At this moment, utilize acoustic wave transducer can detect acoustic response,, can reconstruct medium and put the image that the electrical characteristics of body (like electrical conductivity) distribute in conjunction with corresponding image reconstruction algorithm in the imitative external of medium.Biological tissue is an electrolyte, and different biological tissue and same is organized in that its electrical characteristics can change under the pathological changes situation, the coupled formation method of magnetosonic, and purpose is to obtain the information of electrical characteristics in the biological tissue, thereby realizes early stage functional diagnosis.
According to electromagnetic theory, medium inside receives Lorentz force action,
dF＝Idl×B
Wherein l is a length cell, and F is a Lorentz force, and B is a magnetostatic field, and I is the electric current of the imitative body of injected media.
According to Ohm's law,
I＝U/R
When voltage one timing that exciting unit provides, then the imitative intravital electric current distribution of medium is relevant with medium parameter.
Simultaneously, can know by electromagnetism and acoustic theory, acoustic pressure size and steady magnetic field, medium internal current density, the electrical quantity of the imitative body of medium is closely related
Wherein,
Be ultrasonic spread speed in the imitative body of medium, ρ
0Be Media density, β
sBe adiabatic compression coefficient, p is an acoustic pressure, and J is an electric current density, and B is a steady magnetic field.
To sum up, can derive draws, and under the situation of known steady magnetic field and driving voltage, for the imitative body of medium that an electrical conductivity parameter distribution is confirmed, the acoustic pressure size is relevant with electrical conductivity, promptly vibrates intensity at the interface that sound source is positioned at the variation of medium internal conductance rate greatly.Utilize transducer to imitate the detected ultrasonic pulsative signal of external curve over time, reflected along the variation of medium internal electrical conductance on this direction of propagation at medium.Therefore, can obtain along the position at the electrical conductivity interface of the direction of propagation through the acoustical signal that is positioned at the imitative external transducer detection of medium.
A kind of injection current formula magnetosonic is coupled into the picture experimental system, comprises centralized control unit, exciting unit, and the steady magnetic field unit, medium is imitated body, and the motor-driven scanning element detects processing unit and data storage and display unit.
Said centralized control unit is by computer, and gpib interface reaches LabVIEW virtual instrument operating platform and realizes.Said centralized control unit is connected with each subelement through gpib interface, and centralized control unit provides other each unitary synchronous and control signals.
Said exciting unit is by functional generator, and power amplifier is formed, and the functional generator model is Tyke AFG3252, and the power amplifier model is HSA4104.Said driver element provides the random waveform current pulse signal.
By centralized control unit functional generator and power amplifier are carried out parameter setting and output control.The voltage signal of output forms injection current through electrode in imitative body medium,
Existing research shows; The imaging resolution of MAT-MI is relevant with pulse width; And it is proportional to the velocity of sound and pulse width is long-pending; In order to obtain more high-resolution tissue conductivities distributed image, the pumping signal of pulsed magnetic field should adopt the big and very narrow waveform of pulsewidth of rate of change under the ideal situation.Consideration is target (like the tumor in the tissue) imaging of Δ l to size in the medium, is then detected former and later two signal pulses on imageable target border by transducer, and is as shown in Figure 2, establishes it and is spaced apart Δ t, has
Δl＝c
s·Δt
In order to make imaging resolution reach the millimeter level, the pulse signal pulsewidth of exciting unit output should be less than 1 μ s magnitude.Driving pulse can select to use sine pulse or rectangular pulse.
Said steady magnetic field unit provides steady magnetic field, comprises electric magnet, dc power supply, and magnetic field sensor, and measurement of magnetic field device.The general SBV-380 of electric magnet model English can reach the magnetic induction of maximum 2.4T, and electric magnet dc power supply model is Agilent-6684A, and the magnetic field sensor model is Lakeshore HMNT-4E04-VR, and measurement of magnetic field device model is Lakeshore 460.
Said steady magnetic field unit is used to provide the magnetostatic field of magnetosonic coupling effect.By centralized control unit dc power supply is controlled, the controlling magnetic field test set is measured magnetic induction by magnetic field sensor simultaneously.
Said tested Biomedia can design its size according to experiment purpose.Can use like animal tissues such as Carnis Sus domesticas, or be added with the agar block of certain proportion salt, perhaps metal derby such as copper billet etc. experimentize.
Said tested Biomedia links to each other through electrode with said exciting unit, realizes excitation.Electrode is realized by the copper tinsel or the aluminum metal silk in 0.5mm-1mm line footpath.
Said motor-driven scanning element is by stepper motor driver, and motor is formed.During system works, by stepper motor driver drive stepping motor rotation special angle, scan as 1.8 °, sweep limits is 360 °.In the time of scanning, under the excitation of exciting unit, the acoustical signal by tested Biomedia produces receives through detecting processing unit.The motor model is NI-NEMA23, and drive model is P70530.
Said detection processing unit is by sonic transducer, and the low-noise amplifier wave filter is formed, and data collecting card and data processing module are formed.
Said detection processing unit receives the acoustical signal that tested Biomedia excited target produces, and carries out amplification filtering and handle, and carries out the synchronous triggering acquired signal by data collecting card, and utilizes data processing module to handle, and forms output at last.The sonic transducer model is Olympus V303, and the low-noise amplifier model is NF-SA230F5, and the wave filter model is nf 3628, and the data collecting card model is NI PXIe-5122.The superposed average that data processing module can adopt average superposition algorithm to carry out more than 1000 times calculates.
Said data storage and display unit are made up of disk array and oscillograph.Said data storage and display unit are accomplished the storage and the demonstration of data under the driving of synchronizing signal.The disk array model is NI-8262, and the oscillograph model is Tyke TDS2012B.
In sum, said a kind of injection current formula magnetosonic is coupled into the picture experimental system, and concrete work process is following, referring to Fig. 9:
During system works, communicate by letter with each subelement through gpib interface, send order to other each subelements by centralized control unit,
1. each subelement starts.
2. by centralized control unit each subelement is carried out the parameter setting.
3. by the exciting unit output drive, in the imitative body of electrode injected media, provide in the steady magnetic field unit under the situation of steady magnetic field, can excite the generation acoustical signal.
4. detecting processing unit receives signal.
5. detect processing unit signal detection is handled, comprise amplification filtering etc.
6. carry out data storage by the data storage display unit, with real-time demonstration.
7. if scanning does not finish, then move certain angle, and repeat the job step of 3-6 by motor-driven scanning element drive stepping motor; If the end of scan, then whole system end-of-job.
Although combine accompanying drawing that the preferred embodiments of the present invention are described above, the present invention is not limited to the above-mentioned specific embodiment, and the above-mentioned specific embodiment only is schematically, is not restrictive.Centralized control unit among the present invention also can use single-chip microcomputer, and perhaps digital processing system is accomplished.Demonstration memory element described in the present invention also can be used liquid crystal display, and solid state hard disc is formed.Those of ordinary skill in the art not breaking away under the scope situation that aim of the present invention and claim protects, can also make a lot of forms under enlightenment of the present invention, these all belong within protection scope of the present invention.
Claims (8)
1. an injection current formula magnetosonic coupling imaging device is characterized in that, comprising: centralized control unit; Exciting unit, steady magnetic field unit, motor-driven scanning element; Detect processing unit; With data storage and display unit, each unit of centralized control unit and other is connected, so that other each unitary synchronous and control signals to be provided; Exciting unit produces the random waveform excitation pulse signal to media units; The steady magnetic field unit provides steady magnetic field to media units; The acoustical signal that media units produces scans, receives and convert to the signal of telecommunication by motor-driven scanning element driving sensor; The signal of telecommunication is through detecting the processing of processing unit, stored and shown by data storage and display unit.
2. a kind of injection current formula magnetosonic coupling imaging device according to claim 1; It is characterized in that; Said centralized control unit comprises computer, gpib interface, LabVIEW virtual instrument operating platform; Said centralized control unit is connected through each unit of gpib interface and other, and centralized control unit provides other each unitary synchronous and control signals.
3. a kind of injection current formula magnetosonic coupling imaging device according to claim 1 is characterized in that said exciting unit is by functional generator, and power amplifier is formed, and is used to provide the random waveform excitation pulse signal.
4. a kind of injection current formula magnetosonic coupling imaging device according to claim 1 is characterized in that said steady magnetic field unit provides steady magnetic field, comprises electric magnet, dc power supply, and magnetic field sensor, and measurement of magnetic field device.
5. a kind of injection current formula magnetosonic coupling imaging device according to claim 1 is characterized in that media units links to each other through electrode with said exciting unit, realizes excitation.
6. a kind of injection current formula magnetosonic coupling imaging device according to claim 1 is characterized in that said motor-driven scanning element realizes the scanning of pick off to media units, and said motor-driven scanning element is by stepper motor driver, and motor is formed.
7. a kind of injection current formula magnetosonic coupling imaging device according to claim 1 is characterized in that the acoustical signal that said detection processing unit receiver media unit excited target produces; And carry out amplification filtering and handle, carry out the synchronous triggering acquired signal by data collecting card, and utilize data processing module to handle; Form output at last, said detection processing unit is by sonic transducer, low-noise amplifier; Wave filter, data collecting card constitutes.
8. a kind of injection current formula magnetosonic coupling imaging device according to claim 1; It is characterized in that; Said data storage and display unit are accomplished the storage and the demonstration of data under the driving of synchronizing signal, said data storage and display unit are made up of disk array and oscillograph.
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| EP1885243A4 (en) * | 2005-05-11 | 2014-05-21 | Univ Minnesota | Methods and apparatus for imaging with magnetic induction |
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