CN203269832U - 96-channel semiautomatic polypeptide synthesizer - Google Patents

96-channel semiautomatic polypeptide synthesizer Download PDF

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Publication number
CN203269832U
CN203269832U CN 201320114211 CN201320114211U CN203269832U CN 203269832 U CN203269832 U CN 203269832U CN 201320114211 CN201320114211 CN 201320114211 CN 201320114211 U CN201320114211 U CN 201320114211U CN 203269832 U CN203269832 U CN 203269832U
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CN
China
Prior art keywords
tubes
row
reaction
single row
passage
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Expired - Fee Related
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CN 201320114211
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Chinese (zh)
Inventor
王锡平
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SUZHOU CHINAPEPTIDES BIOLOGICAL CO Ltd
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SUZHOU CHINAPEPTIDES BIOLOGICAL CO Ltd
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Priority to CN 201320114211 priority Critical patent/CN203269832U/en
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Publication of CN203269832U publication Critical patent/CN203269832U/en
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Abstract

The utility model discloses a 96-channel semiautomatic polypeptide synthesizer, belonging to the field of medicine production. The synthesizer comprises a reaction rack, an air bubbling device and a waste liquid collection device, wherein the reaction rack is provided with four rows of single-row tubes, each row of single-row tubes is provided with 18-channel reaction columns, each of the two ends of each single-row tube is provided with a valve, inlet valves are connected with the air bubbling device, outlets are connected with the waste liquid collection device, channels of the four rows of single-row tubes are fixed on the stainless-steel-plate reaction rack in parallel, ports of the channels are upward, and each of the valves at the two ends of each of the four rows of single-row tubes is connected with a five-way joint, so that waste liquid can be drained into the waste liquid collection device while air intake. Compared with the prior art, the synthesizer has the advantages that the reaction efficiency is high, the labor cost is low, the manufacture is easy, and the like.

Description

96 passage semi-automatic polypeptide synthesizers
Technical field
The utility model relates to a kind of 96 passage semi-automatic polypeptide synthesizers of medical production field.
Background technology
Polypeptide is various cell functions relevant biologically active substance all in a kind of and organism, usually be applied to functional analysis, the fields such as antibody research, especially medicament research and development, Peptide synthesizer refers to the instrument of synthetic polypeptide, First Peptide synthesizer truly appears at nineteen sixty for the initial stage in the end to 1970's in the world, it is to utilize nitrogen bubble that reactant is stirred, and is the first-generation Peptide synthesizer that summary is afterwards summarized.Although aspect alr mode and other various functions, obvious defective is being arranged, it frees the people after all in the laboratory, greatly improved working efficiency.Along with the polypeptide the reach of science, driven the development of synthesizer.At present Peptide synthesizer is various in style, from resultant quantity minute, can be divided into Gamma Magnitude, the milligram level, the gram level with feather weight; From function minute, can be divided into research, the lab scale type, the pilot scale type, common type of production with the GMP type of production; Divide from level of automation, can be divided into full automatic, automanual and manual.96 passage Peptide synthesizer devices in the market are substantially all import instruments, and be substantially all full-automatic polypeptide synthetic instrument, its advantage is, fast synthetic, but full-automatic shortcoming is expensive, up to a hundred just in case platform easily, accessory is expensive, maintenance is inconvenient, can only do the polypeptide of little equivalent, and the present utility model is that the 96 passage full-automatic polypeptide synthetic instruments of using for reference import are developed in conjunction with the production practical situation.
Summary of the invention
The purpose of the present utility model is to overcome the deficiencies in the prior art, a kind of 96 passage semi-automatic polypeptide synthesizers that 96 passage full-automatic polypeptide synthetic instruments of reference import are developed in conjunction with the production practical situation.
The purpose of the present utility model is achieved through the following technical solutions:
a kind of 96 passage semi-automatic polypeptide synthesizers, comprise the reaction frame, air bubbling device and waste collecting device, the reaction frame has 4 row's single row of tubes, every row's single row of tubes is provided with the reaction column of 18 passages, the two ends of single row of tubes respectively are provided with a valve, imported valve connects the air bubbling device, outlet connects waste collecting device, four single row of tubes channel parallel are fixed on a stainless steel plate reaction frame, the porthole upwards, four single row of tubes two ends valves are connected with a five-way joint respectively, air inlet is simultaneously also arranged waste liquid into waste collecting device simultaneously, described air bubbling device is air pump, air pressurization pump after filtering with a small power pneumatic pump advances above-mentioned four passages and carries out blistering reaction, after completing, reaction turns off the inlet mouth valve, open outlet valve, reaction liquid is detached into waste collecting device.Forced air is filtered and enters the reaction column passage, and described waste collecting device is connected with vacuum pump.
The utility model compared with prior art has following beneficial effect:
1.: reaction efficiency is high;
2. cost of labor is low;
3. make easily.
Description of drawings
Fig. 1 is 96 passage semi-automatic polypeptide synthesizer structural representations.
In figure: reaction frame 1, air bubbling device 2, waste collecting device 3 and reaction column 4.
Embodiment
Below in conjunction with accompanying drawing, content of the present utility model is further described:
Be 96 passage semi-automatic polypeptide synthesizer structural representations as Fig. 1, comprise reaction frame 1, air bubbling device 2 and waste collecting device 3, four these single row of tubes channel parallel are fixed on a stainless steel plate reaction frame 1, the porthole upwards, the two ends of four single row of tubes connect with a five-way joint respectively, and air inlet is simultaneously also arranged waste liquid in waste collecting device simultaneously.Air pressurization pump after filtering with a small power pneumatic pump advances above-mentioned four passages and carries out blistering reaction, after completing, reaction turns off the inlet mouth valve, open outlet valve, reaction liquid is detached into waste collecting device, waste collecting device is a large filter flask, the standby vacuum pump is pumped into negative pressure with filter flask when needs are collected, and allows liquid automatically compress into filter flask.

Claims (4)

1. passage semi-automatic polypeptide synthesizer, comprise reaction frame, air bubbling device and waste collecting device, it is characterized in that: described reaction frame has 4 row's single row of tubes, every row's single row of tubes is provided with the reaction column of 18 passages, the two ends of single row of tubes respectively are provided with a valve, imported valve connects the air bubbling device, and outlet connects waste collecting device.
2. a kind of 96 passage semi-automatic polypeptide synthesizers according to claim 1 is characterized in that: four single row of tubes channel parallel are fixed on a stainless steel plate reaction frame, the porthole upwards, four single row of tubes two ends valves are connected with a five-way joint respectively.
3. a kind of 96 passage semi-automatic polypeptide synthesizers according to claim 1, it is characterized in that: described air bubbling device is air pump, forced air is filtered and enters the reaction column passage.
4. a kind of 96 passage semi-automatic polypeptide synthesizers according to claim 1, it is characterized in that: described waste collecting device is connected with vacuum pump.
CN 201320114211 2013-03-14 2013-03-14 96-channel semiautomatic polypeptide synthesizer Expired - Fee Related CN203269832U (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN 201320114211 CN203269832U (en) 2013-03-14 2013-03-14 96-channel semiautomatic polypeptide synthesizer

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN 201320114211 CN203269832U (en) 2013-03-14 2013-03-14 96-channel semiautomatic polypeptide synthesizer

Publications (1)

Publication Number Publication Date
CN203269832U true CN203269832U (en) 2013-11-06

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CN 201320114211 Expired - Fee Related CN203269832U (en) 2013-03-14 2013-03-14 96-channel semiautomatic polypeptide synthesizer

Country Status (1)

Country Link
CN (1) CN203269832U (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106674324A (en) * 2016-12-16 2017-05-17 吕胜战 Full-automatic peptide synthesizer with environmental protection
CN108912207A (en) * 2018-06-19 2018-11-30 南京肽业生物科技有限公司 High-throughput Solid phase peptide synthssis device
CN114130346A (en) * 2021-02-02 2022-03-04 申联生物医药(上海)股份有限公司 Full-automatic solid-phase organic synthesis modular equipment

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106674324A (en) * 2016-12-16 2017-05-17 吕胜战 Full-automatic peptide synthesizer with environmental protection
CN108912207A (en) * 2018-06-19 2018-11-30 南京肽业生物科技有限公司 High-throughput Solid phase peptide synthssis device
CN114130346A (en) * 2021-02-02 2022-03-04 申联生物医药(上海)股份有限公司 Full-automatic solid-phase organic synthesis modular equipment

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C14 Grant of patent or utility model
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20131106

Termination date: 20190314

CF01 Termination of patent right due to non-payment of annual fee