CN203200270U - Collection box for collecting and storing tumor samples - Google Patents
Collection box for collecting and storing tumor samples Download PDFInfo
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- CN203200270U CN203200270U CN 201320079833 CN201320079833U CN203200270U CN 203200270 U CN203200270 U CN 203200270U CN 201320079833 CN201320079833 CN 201320079833 CN 201320079833 U CN201320079833 U CN 201320079833U CN 203200270 U CN203200270 U CN 203200270U
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- box body
- storage area
- collecting cassette
- temperature
- tumour
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Abstract
The utility model provides a collection box for collecting and storing tumor samples. The collection box comprises a box body, a liner support body and a temperature regulating device, wherein the box body comprises a lower box body and a box cover; a sealing ring is arranged at the box cover; the liner support body is placed in the lower box body, and the external size of the liner support body is matched with that of an inner cavity of the lower box body; a plurality of storing regions are formed in the liner support body and used for storing appliances for sampling and storing the tumor samples; the temperature regulating device is used for controlling the temperature in the box body. The collected tumor samples and the appliances can be placed in the collection box sequentially, thereby bringing great convenience for collection work. In addition, the liner support body in the collection box has excellent buffering performance, thereby further guaranteeing the safety of the appliances. The collection box has good sealing performance and has the function of controlling the temperature in the box body, thereby effectively protecting the collected tumor samples.
Description
Technical field
The utility model relates to the tumor sample collection and deposits the field, in particular to a kind of collecting cassette for gathering and deposit tumor sample.
Background technology
Tumour (Tumor) be body under various carcinogenic factor effects, some cells of local organization lose normal regulation to its growth at gene level, cause its clonal abnormality hyperplasia and the abnormality that forms.Educational circles generally is divided into tumour optimum and pernicious two large classes.
The form that naked eyes are seen tumour is varied, and can reflect to a certain extent the very pernicious of tumour.
(1) number of tumour and size: the number of tumour, not of uniform size.Mostly be one, sometimes also can be a plurality of.The size of tumour and the character of tumour (optimum, pernicious), growth time and happening part have certain relation.Grow in body surface or larger endoceliac tumour can be grown very greatly sometimes, and the tumour that grows in the airtight narrow and small cavity is generally less.The very big person of tumour, poor growth mostly is optimum usually; Malignant growth is rapid, can bring adverse consequences in a short time, and is therefore normal childlike.
(2) shape of tumour: the shape of tumour is varied, and polypoid (exophytic growth), corpora mammillaria (exophytic growth), nodositas (expansive growth), lobulated (expansive growth), cryptomere (expansive growth), wetting property enclosed mass shape (infiltrative growth), the plump shape (external companion's infiltrative growth) of diffusivity, ulcer shape companion infiltrative growth are arranged.Difference in shape and its happening part, tissue-derived, growth pattern and tumour good pernicious closely related.Show according to recent experiment both at home and abroad, negative aeroion has restraining effect to the growth of transplanted tumor.
(3) color of tumour: the tangent plane of general tumour is greyish white or bois de rose, on its contain blood volume number, have or not hemorrhage, sex change, necrosis etc. to decide.Some tumour can present distinct colors because it contains pigment.Therefore can be inferred as according to the color of tumour which kind of tumour.Be yellow such as lipoma, malignant melanoma is black, and vascular tumor takes on a red color or garnet.
(4) hardness of tumour: with the ratio of the essence of the kind of tumour, tumour and a matter and have or not sex change, downright bad relevant.Essence is generally softer more than the tumour of a matter; On the contrary, a matter is generally harder more than the tumour of essence.Softer when tumor tissue necroses, calcification occurs or then harder when ossified.Lipoma is very soft, and osteoma is very hard.
The weave construction of tumour is varied, but the structural constituent of all tumours all can be divided into essence and matter two portions.
(1) essence of tumour: tumor epithelial cell is the general name of tumour cell, is the main component of tumour.It determines the Biological characteristics of tumour and the singularity of every kind of tumour.Usually identify the tissue-derived of various tumours according to the essence form of tumour, carry out classification, name and the histodiagnosis of tumour, and determine the grade malignancy of the good pernicious and tumour of tumour according to its differentiation and maturation degree and atypia size.
(2) tumour between matter: the matter composition is not had a specificity between tumour, plays a part to support and the nutrition tumor epithelial cell.Generally be comprised of reticular tissue and blood vessel, a matter also has lymphatic vessel sometimes.Usually growth fraction tumour faster, the matter blood vessel is generally abundant and reticular tissue is less therebetween; Poky tumour, the matter blood vessel is usually less therebetween.In addition, tumour often has the monocyte infiltrations such as lymphocyte, and this is that body is to the immune response of tumor tissues.In addition, in the tumour reticular tissue, can also see fibroblast and myofibroblast.Myofibroblast has the dual characteristics of fibroblast and smooth muscle cell, this cell can produce collegen filament, has again contractile function, may the infiltration of tumour cell be limited to some extent, the hyperplasia of this cell can be explained the nipple retraction of mammary cancer, and the intestinal tube that the esophageal carcinoma and intestinal cancer cause is stiff and narrow.
In order to detect, treat, study tumour, hospital and research institution generally need tumour is taken a sample.The researchist wish by to the gene information of different tumor samples and with the comparative studies of health tissues gene information, discovery causes the transgenation clue of cancer, comprise the important informations such as mechanism that gene is carcinogenic, and then provide comprehensive, valuable science clue for diagnosis, prevention and the treatment of cancer.A kind of cancer of every research all needs to collect a hundreds of sample, to find out real carcinogenic reason by analysis.
But (freezing, fixing etc.) causes in sample collection process and the preserving process hot ischemic and sample aging.The result of excision and biopsy same patient liver organization has been compared in a report in the AACR meeting in 2010, study and entered group 46 routine patients in 2003 ~ 2008 years, all carry out biopsy in operation in front 3 months, and carry out the hepatotomy operation, the histochemical stain of row histogenic immunity detects the phosphorylation ERK(p-ERK in the tumor sample) and phosphorylation Akt(p-Akt).The result shows ERK and Akt expression correlation poor (r=0.219, r=0.418) in the detection sample of dual mode, ERK and Akt expression amount all higher (summary number 3759) in the biopsy sample.Spruessel etc. have studied the impact that surgery for colorectal carcinoma excises rear 30 minutes inner tissue's ischemics.Result's demonstration, along with the prolongation of Ischemia Time, protein expression descends gradually in the tissue samples.Mirlacher etc. have studied the aging impact on the immunohistochemical staining result of breast cancer tissue's section, and the result shows that HER2, ER express all apparently higher than aging sample in the fresh sample.Studies show that tumor sample can constantly change with environmental evolution in time.
Therefore sampling tumor sample out need to be preserved under certain environment, guarantees that tumor sample does not change as far as possible, for example preserves constant temperature, the sealing property that needs.
At present, also there is not unified tumor sample collecting cassette on the market.The tumor sample of normal operation gathers the keeping of article; only use the soft packagings such as transparent plastics folder or plastics bag to replace; this type of is packaged in and is difficult to the apparatus that protection fills in the transportation; bring great inconvenience and trouble for user and custodian, bring great hidden danger also for security and the accuracy of sample collection.
The utility model content
Based on prior art, the utility model technical issues that need to address provide a kind of collecting cassette for gathering, deposit tumor sample.
For solving the problems of the technologies described above, the utility model provides a kind of collecting cassette for gathering and deposit tumor sample, and described collecting cassette comprises:
Box body, described box body comprises lower box body and lid, this lid is provided with sealing-ring;
The liner supporter, described liner supporter is placed in the described lower box body, and the inner cavity size of its outside dimension and described lower box body is complementary, and is provided with a plurality of storage areas in the described liner supporter, and described storage area is used for placing the utensil that gathers, deposits tumor sample;
Register, it is used for the temperature in the control box body.
A kind of advantage for gathering and deposit the collecting cassette of tumor sample of the utility model is: the apparatus that is used for the collection tumor sample is placed in the collecting cassette in an orderly manner, and this brings great convenience for collecting work; The position of utensil in the collecting cassette of the present utility model in collecting cassette is relatively fixing, can mutually not collide in transit, and the liner supporter in the collecting cassette of the present utility model has excellent shock-absorbing capacity, and this has further guaranteed the security of utensil; Other collecting cassette good seal performance of the present utility model, and have the function that can control temperature in the box body, can effectively protect like this tumor sample of collection.
As the improvement on the one hand of a kind of collecting cassette for gathering and deposit tumor sample of the utility model, described liner supporter is the rigid foamed liner supporter of making of polystyrene, or the liner supporter of making for the polyurethane foam resilient material.
As a kind of collecting cassette improvement on the one hand for gathering and deposit tumor sample of the utility model, described storage area comprises having a plurality of grooves and be used for placing the first storage area that pipe, tumor tissues, cancer beside organism, healthy tissues, standby pipes are deposited in the tumour special use.
As a kind of collecting cassette improvement on the one hand for gathering and deposit tumor sample of the utility model, described the first storage area comprises six grooves, and three grooves of upper row are used for placing the tumour special use and deposit pipe, deposit tumor tissues, cancer beside organism, healthy tissues; Three grooves of lower row are used for placing standby pipes.
As a kind of collecting cassette improvement on the one hand for gathering and deposit tumor sample of the utility model, described storage area comprises the second storage area that is provided with groove and is used for placing the collection bag that gathers patient's hydrothorax.In order to prevent that collection bag from being polluted, and generally should be contained in collection bag in the Biosafety bag before using.
As a kind of collecting cassette improvement on the one hand for gathering and deposit tumor sample of the utility model, described storage area comprises the 3rd storage area that is provided with groove and is used for placing vacuum test tube, supporting blood taking needle, Biosafety bag and Biosafety label, and the size of described groove and heparin tube external diameter are complementary.Described vacuum test tube is generally the 5ml vacuum test tube, and this vacuum test tube and supporting blood taking needle are used for gathering patient's peripheral blood, all should leave in the Biosafety bag before and after using.
As the improvement on the one hand of a kind of collecting cassette for gathering and deposit tumor sample of the utility model, described storage area comprises and is provided with the 4th storage area that groove and this groove size and the container of depositing tumor tissues protection liquid are complementary.
As a kind of collecting cassette improvement on the one hand for gathering and deposit tumor sample of the utility model, be provided with carry hand in the both sides of described box body.
As the improvement on the one hand of a kind of collecting cassette for gathering and deposit tumor sample of the utility model, the temperature adjusting unit that described register comprises the Temperature Setting parts, is electrical connected with these Temperature Setting parts; Described Temperature Setting parts comprise input block and temperature display; Described temperature adjusting unit comprises respectively the controller that is electrical connected with this input block and temperature display, be arranged in the box body and the temperature sensor that is electrical connected with this controller, the heating and cooling device that is electrically connected with this controller.
As a kind of collecting cassette improvement on the one hand for gathering and deposit tumor sample of the utility model, it also comprises the excess temperature alarm device that is electrically connected with described controller.This warning device generally can be set to hummer.
Description of drawings
Fig. 1 is the schematic perspective view of an embodiment of a kind of collecting cassette for gathering and deposit tumor sample of the utility model.
Fig. 2 is the vertical view of liner supporter of an embodiment of a kind of collecting cassette for gathering and deposit tumor sample of the utility model.
The utility model part Reference numeral gathers as follows:
Carry hand 30; Liner supporter 40;
The first storage area 41; The second storage area 42;
The 3rd storage area 43; The 4th storage area 44;
Embodiment
Describe in more detail below with reference to accompanying drawings embodiment of the present utility model, still, the utility model can be implemented in a different manner, should not be interpreted as being subject to the restriction of the listed embodiment of this paper.In addition, it is in order to make this specification sheets fully and complete that these embodiment are provided, and fully passes on scope of the present utility model to those skilled in the art.Should be noted in the discussion above that accompanying drawing and nonessential according to the substantial proportion drafting, and in some cases, zoom in or out processing in order clearly to express feature of the present utility model, to do in proportion.
Fig. 1 is the schematic perspective view according to an embodiment of a kind of collecting cassette for gathering and deposit tumor sample of the utility model.As shown in Figure 1, described collecting cassette comprises: box body, described box body comprise lower box body 20 and lid 10, and this lid 10 is provided with sealing-ring 70; Liner supporter 40, described liner supporter 40 is placed in the described lower box body 20, and the inner cavity size of its outside dimension and described lower box body 20 is complementary, and is provided with a plurality of storage areas in the described liner supporter 40, and described storage area is used for placing the utensil that gathers, deposits tumor sample; Register 50, it is used for the temperature in the control box body.When described sealing-ring 70 is harmonious at lid 10 and lower box body, be used for sealing box body.In addition, Fig. 2 has clearly described the vertical view of liner supporter of an embodiment of the utility model collecting cassette.
As the improvement on the one hand of the collecting cassette in above-described embodiment, described liner supporter is the rigid foamed liner supporter of making of polystyrene, or the liner supporter of making for the polyurethane foam resilient material.
As the improvement on the one hand of the collecting cassette in above-described embodiment, described storage area comprises having a plurality of grooves and be used for placing the first storage area that pipe, tumor tissues, cancer beside organism, healthy tissues, standby pipes are deposited in the tumour special use.
As the improvement on the one hand of the collecting cassette in above-described embodiment, described the first storage area comprises six grooves, and three grooves of upper row are used for placing the tumour special use and deposit pipe, deposit tumor tissues, cancer beside organism, healthy tissues; Three grooves of lower row are used for placing standby pipes.
As the improvement on the one hand of the collecting cassette in above-described embodiment, described storage area comprises the second storage area that is provided with groove and is used for placing the collection bag that gathers patient's hydrothorax.In order to prevent that collection bag from being polluted, and generally should be contained in collection bag in the Biosafety bag before using.
As the improvement on the one hand of the collecting cassette in above-described embodiment, described storage area comprises the 3rd storage area that is provided with groove and is used for placing vacuum test tube, supporting blood taking needle, Biosafety bag and Biosafety label, and the size of described groove and heparin tube external diameter are complementary.Described vacuum test tube is generally the 5ml vacuum test tube, and this vacuum test tube and supporting blood taking needle are used for gathering patient's peripheral blood, all should leave in the Biosafety bag before and after using.
One preferred embodiment in, storage area 43 also is placed with and can gathers and store the temperature label of heparin tube surrounding temperature information in described the 3rd storage area further groove.Described temperature label is radio frequency identification (RFID) temperature label that is built-in with temperature sensor, it has certain storage space, can gather and storage temperature information on every side with the predetermined time interval after the startup, after blood is transported to blood bank, the temperature information that the staff stores in can reading tag, thus judge whether blood status is normal.
As the improvement on the one hand of the collecting cassette in above-described embodiment, described storage area comprises and is provided with the 4th storage area that groove and this groove size and the container of depositing tumor tissues protection liquid are complementary.
Certainly, as the collecting cassette preferred embodiment, described storage area comprises above-mentioned the first storage area 41, the second storage area 42, the 3rd storage area 43, the 4th storage area 44 simultaneously shown in Fig. 1-2.
As the improvement on the one hand of the collecting cassette in above-described embodiment, be provided with carry hand 30 in the both sides of described box body, described carry hand 30 is fixed in the both sides of described lower box body 20 outsides, is convenient to like this user's transportation, moves.This carry hand 30 that arranges as shown in Figure 1 is raised types, and for example rivet and box body limit are integral by fastening piece for they.Carry hand 30 can also be the (not shown) of internally-inlaid in addition, for example can inlay in the corresponding position of box case and forms a carry hand at interior edge position.
As the improvement on the one hand of the collecting cassette in above-described embodiment, described carry hand is that the flexible PVC material is made.
As the improvement on the one hand of the collecting cassette in above-described embodiment, the temperature adjusting unit that described register 50 comprises the Temperature Setting parts, is electrical connected with these Temperature Setting parts; Described Temperature Setting parts comprise input block and temperature display; Described temperature adjusting unit comprises respectively the controller that is electrical connected with this input block and temperature display, be arranged in the box body and the temperature sensor that is electrical connected with this controller, the heating and cooling device that is electrically connected with this controller.As further improvement, described collecting cassette can also comprise the excess temperature alarm device (not shown) that is electrically connected with described controller.This warning device generally can be set to hummer.The user can be by described input block input temp set(ting)value, and controller detects temperature in the box by the temperature sensor in the box, and when the temperature that detects is lower than set(ting)value, controller control heating and cooling device heats; When the temperature that detects is higher than set(ting)value, controller control heating and cooling device cools off.The user can also arrange the high temperature alarm temperature, and temperature reaches or is higher than this high temperature alarm temperature in the box that detects, and controller control excess temperature alarm device is reported to the police.
As the improvement on the one hand of the collecting cassette in above-described embodiment, described lower box body 20 is connected by bayonet unit 60 with lid 10.Certainly, also can be connected by other means with lid 10 at the described lower box body 20 of other embodiment.
As the improvement on the one hand of the collecting cassette in above-described embodiment, there is the clear area in the inner lining body top of described collecting cassette inside.This clear area can be used for placing the sample collecting handbook, and can gather with the storage of collected box in radio frequency identification (RFID) temperature label of temperature information.Can also place tumor sample collecting flowchart figure.
As the improvement on the one hand of the collecting cassette in above-described embodiment, also be provided with barcode (not shown) in the outside of box body, described barcode is used for the information binding with the user, can play the effect of tracing to the source.
As the improvement on the one hand of the collecting cassette in above-described embodiment; inboard at lid 10 also can be provided with sponge buffer layer (not shown); the sponge buffer layer is attached to the inboard of lid 10; preferably; the sponge buffer layer has shape for lugs with the surface that liner supporter 40 contacts; the sponge buffer layer can further improve the shock absorption of collecting cassette, thereby protects better the article in the collecting cassette.
Although with the formal description of embodiment the utility model, it will be apparent to those skilled in the art that in the situation that does not break away from the spirit and scope of the present utility model that appended claims limits, can carry out variations and modifications.
Claims (10)
1. a collecting cassette that is used for gathering and depositing tumor sample is characterized in that, described collecting cassette comprises:
Box body, described box body comprises lower box body and lid, this lid is provided with sealing-ring;
The liner supporter, described liner supporter is placed in the described lower box body, and the inner cavity size of its outside dimension and described lower box body is complementary, and is provided with a plurality of storage areas in the described liner supporter, and described storage area is used for placing the utensil that gathers, deposits tumor sample;
Register, it is used for the temperature in the control box body.
2. according to claim 1 collecting cassette is characterized in that, described liner supporter is the rigid foamed liner supporter of making of polystyrene, or the liner supporter of making for the polyurethane foam resilient material.
3. according to claim 1 collecting cassette is characterized in that, described storage area comprises having a plurality of grooves and be used for placing the first storage area that pipe, tumor tissues, cancer beside organism, healthy tissues, standby pipes are deposited in the tumour special use.
4. according to claim 3 collecting cassette is characterized in that, described the first storage area comprises six grooves, and three grooves of upper row are used for placing the tumour special use and deposit pipe, deposit tumor tissues, cancer beside organism, healthy tissues; Three grooves of lower row are used for placing standby pipes.
5. according to claim 1 collecting cassette is characterized in that, described storage area comprises the second storage area that is provided with groove and is used for placing the collection bag that gathers patient's hydrothorax.
6. according to claim 1 collecting cassette, it is characterized in that, described storage area comprises the 3rd storage area that is provided with groove and is used for placing vacuum test tube, supporting blood taking needle, Biosafety bag and Biosafety label, and the size of described groove and heparin tube external diameter are complementary.
7. according to claim 1 collecting cassette is characterized in that, described storage area comprises and is provided with the 4th storage area that groove and this groove size and the container of depositing tumor tissues protection liquid are complementary.
8. according to claim 1 collecting cassette is characterized in that, is provided with carry hand in the both sides of described box body.
9. according to claim 1 collecting cassette is characterized in that, the temperature adjusting unit that described register comprises the Temperature Setting parts, is electrical connected with these Temperature Setting parts; Described Temperature Setting parts comprise input block and temperature display; This temperature adjusting unit comprises respectively the controller that is electrical connected with this input block and temperature display, be arranged in the box body and the temperature sensor that is electrical connected with this controller, the heating and cooling device that is electrically connected with this controller.
10. according to claim 9 collecting cassette characterized by further comprising the excess temperature alarm device that is electrically connected with described controller.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201320079833 CN203200270U (en) | 2013-02-20 | 2013-02-20 | Collection box for collecting and storing tumor samples |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201320079833 CN203200270U (en) | 2013-02-20 | 2013-02-20 | Collection box for collecting and storing tumor samples |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN203200270U true CN203200270U (en) | 2013-09-18 |
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ID=49144398
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201320079833 Expired - Lifetime CN203200270U (en) | 2013-02-20 | 2013-02-20 | Collection box for collecting and storing tumor samples |
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| Country | Link |
|---|---|
| CN (1) | CN203200270U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103932714A (en) * | 2014-04-21 | 2014-07-23 | 山东省医学科学院 | Blood sample transportation storage box special for circulating tumor cell detecting |
-
2013
- 2013-02-20 CN CN 201320079833 patent/CN203200270U/en not_active Expired - Lifetime
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103932714A (en) * | 2014-04-21 | 2014-07-23 | 山东省医学科学院 | Blood sample transportation storage box special for circulating tumor cell detecting |
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Legal Events
| Date | Code | Title | Description |
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20151118 Address after: 14 building, No. 800, Jiefang East Road, Nanchang District, Jiangsu, Wuxi, 214000 Patentee after: Wuxi baby Cell Engineering Co.,Ltd. Address before: Ma Shan Mei Binhu District 214092 in Jiangsu province Wuxi City Road No. 88 beam Patentee before: BOYALIFE Inc. |
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| CP01 | Change in the name or title of a patent holder | ||
| CP01 | Change in the name or title of a patent holder |
Address after: 14 building, No. 800, Jiefang East Road, Nanchang District, Jiangsu, Wuxi, 214000 Patentee after: Jiangsu Intco Purcell Biotechnology Co.,Ltd. Address before: 14 building, No. 800, Jiefang East Road, Nanchang District, Jiangsu, Wuxi, 214000 Patentee before: Wuxi Intco Purcell Cell Engineering Co.,Ltd. Address after: 14 building, No. 800, Jiefang East Road, Nanchang District, Jiangsu, Wuxi, 214000 Patentee after: Wuxi Intco Purcell Cell Engineering Co.,Ltd. Address before: 14 building, No. 800, Jiefang East Road, Nanchang District, Jiangsu, Wuxi, 214000 Patentee before: Wuxi baby Cell Engineering Co.,Ltd. |
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| CX01 | Expiry of patent term | ||
| CX01 | Expiry of patent term |
Granted publication date: 20130918 |