CN203178280U - Detection device for quickly quantifying and detecting FSHs - Google Patents
Detection device for quickly quantifying and detecting FSHs Download PDFInfo
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- CN203178280U CN203178280U CN 201220729548 CN201220729548U CN203178280U CN 203178280 U CN203178280 U CN 203178280U CN 201220729548 CN201220729548 CN 201220729548 CN 201220729548 U CN201220729548 U CN 201220729548U CN 203178280 U CN203178280 U CN 203178280U
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- ovarian follicle
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Abstract
The utility model discloses a detection device for quickly quantifying and detecting FSHs (Follicle-stimulating Hormone). The device adopts the integrated structure formed by a detecting unit, an FSH colorimetric card and a hormone secretion table which are all fixed on a bottom plate. The device has the benefits of portability and high detection speed.
Description
Technical field
The utility model relates to a kind of technical field of medicine equipment external diagnosis reagent, and particularly a kind of fast quantification detects and urgees the plain pick-up unit of the short ovarian follicle generation of fast quantification detection that ovarian follicle generates plain (FSH) in the urine sample.
Background technology
Short ovarian follicle generates plain (FSH) by a kind of hormone of anterior pituitary basicyte secretion, and composition is glycoprotein.Mainly act as the promotion follicle maturity.Short ovarian follicle generates the relevant a series of physiology courses of growth, growth, sexal maturity in puberty and reproduction of plain regulation and control human body, particularly stimulates the maturation of reproduction cell.Short ovarian follicle generates plain (FSH) by promoting stratum granulosum of ovarian follicle hyperplasia differentiation, promotes whole ovary to grow up.Acting on convoluted tubule of testis can promote sperm to form.Injection FSH only increases the ovarian follicle number, and follicle maturity be there is no effect.The secretion of the follicle stimulating hormone releasing hormone control follicular stimulating hormone of hypothalamus secretion.In the menstrual cycle, FSH concentration and every day are changed with the cycle by the amount of the FSH of homaluria in the blood.After menelipsis, the FSH discharge rate increases in blood and the urine.
Then promote the production of sperm pipe to form and Spermatogenic action the male sex, its function is to promote the maturation of convoluted tubule of testis and the generation of sperm; In the women, the function of FSH is to promote follicular development and maturation, and collaborative interstitialcellstimulating hormone (ICSH) (LH) impels fully-developed ovarian follicle secretion estrogen and ovulation, the formation of participation menorrhea.Its generation is subjected to the control of hypothalamus gonadotropin releasing hormone, is subjected to the feedback regulation of ovary female hormone (E2) simultaneously.Property, the reproductive function of the men and women's both sexes of FSH play a decisive role.The concentration of blood FSH the preovulatory phase be 1.5～10mIU/ml, be 8～20mIU/ml the onset of ovulation, the ovulation later stage is 2～10mIU/ml.Generally with 5～40mIU/ml as normal value.
By FSH is measured, can understand the hypophysis endocrine function, also can understand the functional status of hypothalamus and ovary indirectly.This antidiastole to hypophysis or the amenorrhoea of hypothalamus type is helpful.
Short ovarian follicle generates the plain Clinical significance of abnormal that detects
The FSH level increases and sees
A) male testical seminoma;
B) prompting women ovarian function height is low,, nervous centralis low as congenital anovaria or ovarian hypoplasia (as Turner syndrome etc.), primary amenorrhea, primary gonad function and hypophysis sex premature, ovary (sexual hypofunction) obesity etc.;
C) menopausal syndrome or menopausal women.
The reduction of FSH level sees
A) the prompting pathology may be returned hypothalamus at hypophysis, and is low inferior as the short gonad function of sheehan's syndrome, pituitary chromophobe cell knurl, basicyte knurl (Cushing syndrome), oxyphilic granular cell adenoma's (acromegalia) and primary hypophysis;
B) dysdrophia adiposogenitalis, hypothalamic lesion (as galactorrhea-amenorrhea syndrome, PCOS) etc.
C) take contraceptive for a long time, widely apply sex hormone.
Immunochromatography reagent since it easy and simple to handle, have directly perceived, fast, detection efficiency is high, method is easy, pollution-free, advantages such as expense is cheap, highly sensitive, high specificity, be widely used in clinical diagnosis, field condition and the oneself of family and detect.
Summary of the invention
The purpose of this utility model is in order to address the above problem, to have designed a kind of fast quantification and detected the pick-up unit that short ovarian follicle generates element.
Realize that the above-mentioned purpose the technical solution of the utility model is, a kind of fast quantification detects short ovarian follicle and generates plain pick-up unit, and this device is to generate the integrative-structure that plain colorimetric card and hormone secretion information slip three partial fixings constitute at base plate by detecting unit, short ovarian follicle.
Described detecting unit can be and detects reagent card, bar or pen.
Described detecting unit inner structure comprises sample pad, labeling pad, nitrocellulose filter, suction sample pad and liner plate, pastes successively on the liner plate and goes up sample pad, labeling pad, nitrocellulose filter and suction sample pad.
The fast quantification that utilizes the technical solution of the utility model to make detects short ovarian follicle and generates plain pick-up unit, easy and simple to handle, reasonable in design, the patient can be at any time, everywhere its FSH content is detected, to understand the hypophysis endocrine function, also can understand the functional status of hypothalamus and ovary indirectly, this antidiastole to hypophysis or the amenorrhoea of hypothalamus type is helpful.
Description of drawings
Fig. 1 is that fast quantification described in the utility model detects the structural representation that short ovarian follicle generates plain pick-up unit;
Fig. 2 is that fast quantification described in the utility model detects the detection reagent inner structure synoptic diagram that short ovarian follicle generates plain pick-up unit;
Among the figure, 1, go up the sample pad; 2, labeling pad; 3, nitrocellulose filter; 4, inhale the sample pad; 5, liner plate; 6, detect the T line; 7, Quality Control C line; 8, detecting unit; 9, short ovarian follicle generates plain colorimetric card; 10, hormone distribution situation table; 11, base plate.
Embodiment
Below in conjunction with accompanying drawing the utility model being specifically described, is that fast quantification described in the utility model detects the structural representation that short ovarian follicle generates plain pick-up unit as Fig. 1; Fig. 2 is that fast quantification described in the utility model detects the detection reagent inner structure synoptic diagram that short ovarian follicle generates plain pick-up unit, as shown in the figure, a kind of fast quantification detects short ovarian follicle and generates plain pick-up unit, and this device is to generate the integrative-structure that plain colorimetric card 9 and hormone secretion information slip 10 3 partial fixings constitute at base plate 11 by detecting unit 8, short ovarian follicle.Wherein, described detecting unit is for detecting reagent card, bar or pen; The structure of described detection reagent comprises sample pad 1, labeling pad 2, nitrocellulose filter 3, inhales sample pad 4 and liner plate 5, wrap by the mouse-anti FSH-β monoclonal antibody of colloid gold label on the labeling pad simultaneously, be coated with the detection T line 6 of mouse-anti FSH-Alpha antibodies formation and the Quality Control C line 7 that sheep anti-mouse igg antibody constitutes on the nitrocellulose filter respectively, paste successively on the liner plate and go up sample pad, labeling pad, nitrocellulose filter and suction sample pad.
This pick-up unit is to adopt double antibody sandwich method to detect FSH's.Testing process with the detection reagent strip is example, after test fluid is soaked or is splashed into the last sample pad of test strips, by inhaling the capillary action of the water-absorption fiber on the sample pad, test fluid is drenched labeling pad rapidly, collaurum bond on the labeling pad is dissolved, and moves forward along chromatographic material with test fluid.If have determined antigen Ag in the test fluid, then it will with the collaurum bond in antibody generation specific immune response, form the immune complex of collaurum bond-determined antigen.Flow through with test fluid then and be fixed on the capture agent that nitrocellulose filter (subtract and claim nitrocellulose filter) is gone up the T line.The capture agent of T line is caught collaurum bond-determined antigen immune complex, namely with this immune complex generation specific immune response, form the immune complex of collaurum bond-determined antigen-capture agent, thereby make collaurum bond-determined antigen immune complex be trapped in T line place.Test fluid continues reach, when the nitrocellulose filter of flowing through fixedly has the C line of sheep anti-mouse igg antibody, not sheep anti-mouse antibody generation immune response on the collaurum bond that reacts with determined antigen Ag and the C line, thus make free collaurum bond be trapped in C line place.This moment, T line and C line place all had the collaurum bond to be detained, and namely T line and C line place all can observe color (redness or purple), then represent the positive result of testing result, namely in the test fluid determined antigen are arranged; If only C line place observes color, and T line place does not observe color, then represents the negative result of testing result, does not namely have determined antigen in the test fluid; FSH content difference in the liquid to be measured, the T line color depth that produces is also inequality, and along with the increase of FSH content, the T line color will be more dark.The color of T line and the color on plain (FSH) colorimetric card of short ovarian follicle generation are compared, select corresponding numerical value interval, find corresponding interval to draw testing result at the hormone secretion information slip then.
Technique scheme has only embodied the optimal technical scheme of technical solutions of the utility model; those skilled in the art to some part wherein some changes that may make all embodied principle of the present utility model, belong within the protection domain of the present utility model.
Claims (3)
1. a fast quantification detects short ovarian follicle and generates plain pick-up unit, it is characterized in that, this device is to generate plain colorimetric card (9) and hormone secretion information slip (10) three partial fixings at the integrative-structure of base plate (11) formation by detecting unit (8), short ovarian follicle.
2. fast quantification according to claim 1 detects short ovarian follicle and generates plain pick-up unit, it is characterized in that, described detecting unit is for detecting reagent card or bar or pen.
3. fast quantification according to claim 2 detects short ovarian follicle and generates plain pick-up unit, it is characterized in that, the inner structure of described detecting unit comprises sample pad (1), labeling pad (2), nitrocellulose filter (3), inhales sample pad (4) and liner plate (5), pastes successively on the liner plate and goes up sample pad, labeling pad, nitrocellulose filter and suction sample pad.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201220729548 CN203178280U (en) | 2012-12-27 | 2012-12-27 | Detection device for quickly quantifying and detecting FSHs |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201220729548 CN203178280U (en) | 2012-12-27 | 2012-12-27 | Detection device for quickly quantifying and detecting FSHs |
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| Publication Number | Publication Date |
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| CN203178280U true CN203178280U (en) | 2013-09-04 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201220729548 Expired - Lifetime CN203178280U (en) | 2012-12-27 | 2012-12-27 | Detection device for quickly quantifying and detecting FSHs |
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| CN (1) | CN203178280U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106959326A (en) * | 2017-05-19 | 2017-07-18 | 量准（上海）实业有限公司 | Multi-parameter based on saliva property quantitatively detects ovulation device |
-
2012
- 2012-12-27 CN CN 201220729548 patent/CN203178280U/en not_active Expired - Lifetime
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106959326A (en) * | 2017-05-19 | 2017-07-18 | 量准（上海）实业有限公司 | Multi-parameter based on saliva property quantitatively detects ovulation device |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of utility model: Detection device for quickly quantifying and detecting FSHs Effective date of registration: 20150204 Granted publication date: 20130904 Pledgee: Tianjin TEDA Small Enterprise Credit Guarantee Center Pledgor: Tianjin NewScen Coast Bio-Pharmaceutical Co.,Ltd. Registration number: 2015120000009 |
|
| PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20160307 Granted publication date: 20130904 Pledgee: Tianjin TEDA Small Enterprise Credit Guarantee Center Pledgor: Tianjin NewScen Coast Bio-Pharmaceutical Co.,Ltd. Registration number: 2015120000009 |
|
| PLDC | Enforcement, change and cancellation of contracts on pledge of patent right or utility model | ||
| CP01 | Change in the name or title of a patent holder | ||
| CP01 | Change in the name or title of a patent holder |
Address after: 300457 Tianjin Development Zone, Sixth Street, No. 65 Patentee after: NEWSCEN COAST BIO PHARMACEUTICAL CO.,LTD. Address before: 300457 Tianjin Development Zone, Sixth Street, No. 65 Patentee before: Tianjin NewScen Coast Bio-Pharmaceutical Co.,Ltd. |
|
| CX01 | Expiry of patent term | ||
| CX01 | Expiry of patent term |
Granted publication date: 20130904 |