CN203074709U - Human body blood component non-invasive monitoring device based on time gate - Google Patents
Human body blood component non-invasive monitoring device based on time gate Download PDFInfo
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- CN203074709U CN203074709U CN 201220199072 CN201220199072U CN203074709U CN 203074709 U CN203074709 U CN 203074709U CN 201220199072 CN201220199072 CN 201220199072 CN 201220199072 U CN201220199072 U CN 201220199072U CN 203074709 U CN203074709 U CN 203074709U
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Abstract
The utility model relates to a portable monitor which monitors blood sugar concentration of human body through a time-resolved transmission spectrum measurement method and Laplace analysis. The portable monitor comprises an optical platform, a photoelectric detection system and a computer, wherein the optical platform comprises a laser light source module, a finger frame and a pneumatic sleeve. The photoelectric detection system comprises a photomultiplier, a photomultiplier gain module and a single-photon counter module. The output end of the laser light source module is connected with one input end of the finger frame. The output end of the pneumatic sleeve is connected with the other input end of the finger frame. The output end of the finger frame is connected with the input end of the photomultiplier. The photomultiplier gain module is connected with the other input end of the photomultiplier. The output end of the photomultiplier is connected with the input end of the single-photon counter module. The output end of the single-photon counter module is connected with the input end of the computer. The portable monitor detects concentration of acetone in breathing air of human body through cavity ringdown spectroscopy and furthermore diagnosing diabetes.
Description
Technical field
This utility model relates to a kind of portable detector that blood of human body composition noinvasive triage is surveyed that is used for, and particularly adopts the comprehensive Laplce of time-resolved transmitted spectrum measuring method to analyze and measures human blood glucose concentration.
Background technology
Detection to the blood of human body composition is the important means of medical diagnosis and medical research, and the non-invasive blood component detection method has attracted numerous scholars to study in recent years.Glucose in the blood constituent, albumin, globulin, triglyceride, cholesterol, carbamide, uric acid, compositions such as bilirubin all have very important significance for clinical diagnosis, but up to the present above-mentioned blood constituent does not also realize the survey of noinvasive triage.
Because it is closely related that the no wound of blood of human body composition was measured with the quality of life of improving people ' s health level and patient, the various countries scientist has carried out unremitting research from each possible technical standpoint with multiple scheme during the last ten years.To the detection research of non-invasive blood composition, mainly be to measure the blood samples of patients constituent concentration by extracting optical information.The noinvasive triage survey method of blood of human body composition comprise near infrared spectrum, in (far) infrared spectrum, Raman spectrum, optoacoustic spectroscopy, light scattering, millimeter wave detection, colouring and polarized light optically-active etc.Detect that the position comprises finger tip, refers to tripe, forehead, arm, ear-lobe, eyeball etc.Detect medium and comprise blood, tissue fluid, aqueous humor, sweat etc.There is external collection tissue fluid to detect and directly detects in soma.The data reappearance that the noinvasive triage is surveyed, sensitivity, selectivity, the result that the indexs such as adaptability of individuality are still surveyed not as Wicresoft's triage.No matter be laboratory research, or the exploitation of instrument and checking all are in and explore and the improvement stage.The noinvasive detection that realizes blood component is human dream, it also is an at present international research focus, many famous major companies and university, institute drop into huge fund and study, but individual variation and weak output signal, the extremely low progress of research that seriously hindered of signal to noise ratio.But because scientific meaning, social value and economic interests that the noinvasive blood constituent is measured, the government of major country never abandons the support to this technology, and research worker is constantly breeding new measuring principle and method on the empirical basis of accumulation somatometry.
For the further precision that improves the no wound measurement of blood constituent, and then reach clinical requirement, blood of human body composition noinvasive triage is surveyed the innovation that needs measuring method.In numerous measuring methods, to measure and all under state of normal blood flow, carry out, measuring-signal also is the relevant signal of pulsation.The blood flow that utilizes pressure to stop tested part can be induced the gathering of erythrocyte, causes transmission signal that the enhancing of one 10 times amount is arranged thereby the erythrocyte that gathers together reduces the scattering coefficient of blood gradually.This change can provide the signal to noise ratio an of necessity for the accurate measurement that blood of human body noinvasive triage is surveyed.This technology is applied in the blood of human body composition noinvasive triage survey technology in recent years, becomes the noinvasive new tool that the body blood constituent detects of hurting sb.'s feelings, and has obtained good effect.There is not the precision that wound is measured in order further to improve the blood of human body composition, thereby reach clinical requirement, we have proposed the blood of human body composition does not have a kind of new method that wound is measured, this method is under blood flow is obstructed condition, advanced person's time gate technology and Laplace transform method are combined, the blood of human body composition is not had wound measure.What we proposed is utilizing pressure to stop under the tested part blood flow condition, the measuring method that advanced person's time gate technology and Laplace transform method combined, having comprised the blood flow that utilizes pressure to stop tested part induces transmission signal obviously to strengthen, to the measurement of the time resolution transmission signal under the multi-wavelength incident, utilize the Laplace transform means to increase by three parts of sensitivity of blood constituent measurement of concetration.Inducing the enhanced principle of transmission signal that the blood of human body composition is not had the wound measurement about the blood flow that utilizes pressure to stop tested part has had report, and body blood constituent detection method yet there are no report but a noinvasive that the blood flow that utilizes pressure to stop tested part induces enhanced principle of transmission signal and time gate technology and Laplace transform method to combine is hurted sb.'s feelings.The theory of this method and the research of key technology will be significant to realizing that the blood of human body composition will not have the wound high-acruracy survey with realization.
The utility model content
The purpose of this utility model is a kind of blood of human body composition non-invasive detector of the high accuracy based on the time gate technology.There is not the precision that wound is measured in order further to improve the blood of human body composition, thereby reach clinical requirement, we have proposed the blood of human body composition does not have a kind of new method that wound is measured, this method is under blood flow is obstructed condition, and advanced person's time gate technology and Laplace transform method combined.Under blood flow is obstructed condition, because thereby the transmitted spectrum that erythrocytic gathering makes scattering coefficient obviously reduce to cause light to transmit in biological tissue has the enhancing of tangible 10 times of amounts, thereby the accurate measurement of the transmitted spectrum that transmits in biological tissue for light provides a good signal-to-noise, under blood flow was obstructed condition, the Laplace transform of the time resolution transmitted spectrum f (t) that the light of measurement transmits in biological tissue was
Wherein p=σ+j ω is a plural number, (σ and ω are real numbers).P treating excess syndrome number here.F (p) is the weighting of the time integral of transmits diffuse light, if when p gets positive number, will emphasize the contribution of that part of photon that early arrives, if when p gets negative, will emphasize the contribution of that part of photon of later arrival.Because in the time gate technology, because early the photon that arrives is more responsive for biological tissue's signal, so we have proposed to utilize time gate technological synthesis Laplce to analyze, the suitable further precision of raising blood of human body composition noinvasive triage survey of Laplce's parameter expectation of choosing.
For achieving the above object, this utility model adopts technical scheme to be: it comprises optical table, Photodetection system and computer, wherein optical table comprises laser light source module, finger frame and pneumatic cover, and Photodetection system comprises photomultiplier tube, gain of photomultiplier module and single photon counter module.The outfan of laser light source module links to each other with an input of finger frame.The outfan of pneumatic cover links to each other with another input of finger frame.The outfan of finger frame links to each other with the input of photomultiplier tube.The gain of photomultiplier module links to each other with another input of photomultiplier tube, and the outfan of photomultiplier tube links to each other with the input of single photon counting module.The outfan of single photon counting module links to each other with input end and computer.
Described laser light source module comprises that all working wavelength is at visible and near infrared pulse laser.The pulse laser that this laser instrument sends incides on the finger by incident optical.
Described finger-stall is the support that is used for fixing finger, are furnished with three mouths on the finger frame, one is the input port that links to each other with incident optical, another input port links to each other with pneumatic cover, the 3rd mouth on the finger-stall links to each other with photomultiplier tube by output optical fibre, thereby output signal is outputed in the detection system.
Described pneumatic cover links to each other with an input of finger-stall, act as finger is exerted pressure, thereby reduce finger end velocity of blood flow, finger end erythrocyte is produced to be assembled, the erythrocyte that gathers together obviously strengthens the transillumination that incides the finger end, and this change can provide the signal to noise ratio an of necessity for the accurate measurement that blood of human body noinvasive triage is surveyed.
Described photomultiplier tube adopts the PMC-100 type refrigeration high speed PMT of German Becker-Hickl company, wave-length coverage is 300-900nm, SMA interface, the light that is used for collecting finger-stall output carry out that signal amplifies and conversion, and will be optically coupled to the single photon counting module.
Described time correlation single photon counting module (TCSPC Model).Adopt the SPC-134 module of German Becker-Hickl company.This module is made up of four SPC-130 modules, can realize the four path parallel signals collecting.Technical specification: its single pass peak count rate is that 8MHz, minimum electronics are distinguished as 8ps.
Described computer 4 is present general microcomputer or video work station, is used to carry out date processing.
This utility model has following advantage owing to adopted technique scheme:
By the human finger blood flow is imposed control, measure the transmitted spectrum and the comprehensive Laplace transform method of human finger, thereby do not have wound, human blood glucose concentration is determined on high accuracy ground.
Description of drawings
Fig. 1 is a structured flowchart of the present utility model;
Fig. 2 is the structured flowchart of optical table;
Fig. 3 is the structured flowchart of Photodetection system;
The specific embodiment
The utility model is described in further detail below in conjunction with drawings and Examples: as Figure 1-3, it comprises optical table 1, Photodetection system 2 and computer 3.Wherein optical table 1 comprises laser light source module 1.1, finger frame 1.2 and pneumatic cover 1.3.Photodetection system 2 comprises photomultiplier tube 2.1, gain of photomultiplier module 2.2 and single photon counter module 2.3.The outfan of laser light source module 1.1 links to each other with an input of finger frame 1.2.The outfan of pneumatic cover 1.3 links to each other with another input of finger frame 1.2.The outfan of finger frame 1.2 links to each other with the input of photomultiplier tube 2.1.Gain of photomultiplier module 2.2 links to each other with another input of photomultiplier tube 2.1, and the outfan of photomultiplier tube 2.1 links to each other with the input of single photon counting module 2.3.The outfan of single photon counting module 2.3 links to each other with the input of computer 3.
Described laser light source module 1.1 comprises that all working wavelength is at visible and near infrared pulse laser.The pulse laser that this laser instrument sends incides on the finger by incident optical.
Described finger frame 1.2 is for being used for fixing the support of finger, are furnished with three mouths on the finger frame 1.2, one is the input port that links to each other with incident optical, another input port links to each other with pneumatic cover 1.3, the 3rd mouth on the finger frame 1.2 links to each other with photomultiplier tube 2.1 by output optical fibre, thereby output signal is outputed in the Photodetection system 2.Described pneumatic cover 1.3 links to each other with an input of finger frame 1.2, act as finger is exerted pressure, thereby reduce finger end velocity of blood flow, finger end erythrocyte is produced to be assembled, the erythrocyte that gathers together obviously strengthens the transillumination that incides the finger end, and this change can provide the signal to noise ratio an of necessity for the accurate measurement that blood of human body noinvasive triage is surveyed.
The PMC-100 type refrigeration high speed PMT of the German Becker-Hickl of described photomultiplier tube 2.1 employings company, wave-length coverage is 300-900nm, SMA interface, the light that is used for collecting finger frame 1.2 outputs carry out that signal amplifies and conversion, and will be optically coupled to single photon counting module 2.3.
Described time correlation single photon counting module 2.3 (TCSPC Model).Adopt the SPC-134 module of German Becker-Hickl company.This module is made up of four SPC-130 modules, can realize the four path parallel signals collecting.Technical specification: its single pass peak count rate is that 8MHz, minimum electronics are distinguished as 8ps.
Described computer 3 is present general microcomputer or video work station, is used to carry out date processing.
Claims (8)
1. based on the blood of human body composition non-invasive monitoring device of time gate, it is characterized in that: it comprises optical table, Photodetection system and computer, wherein optical table comprises laser light source module, finger frame and pneumatic cover, and Photodetection system comprises photomultiplier tube, gain of photomultiplier module and single photon counter module; The outfan of laser light source module links to each other with an input of finger frame; The outfan of pneumatic cover links to each other with another input of finger frame; The outfan of finger frame links to each other with the input of photomultiplier tube; The gain of photomultiplier module links to each other with another input of photomultiplier tube, and the outfan of photomultiplier tube links to each other with the input of single photon counting module; The outfan of single photon counting module links to each other with input end and computer.
2. the blood of human body composition non-invasive monitoring device based on time gate as claimed in claim 1, it is characterized in that: optical table comprises laser light source module, finger frame and pneumatic cover.
3. the blood of human body composition non-invasive monitoring device based on time gate as claimed in claim 1, it is characterized in that: Photodetection system comprises photomultiplier tube, gain of photomultiplier module and single photon counter module.
4. the blood of human body composition non-invasive monitoring device based on time gate as claimed in claim 1, it is characterized in that: laser light source module can send operation wavelength at visible and near infrared pulse laser, and the pulse laser that this laser instrument sends incides on the finger by incident optical.
5. the blood of human body composition non-invasive monitoring device based on time gate as claimed in claim 1, it is characterized in that: finger-stall is the support that is used for fixing finger, are furnished with three mouths on the finger frame, one is the input port that links to each other with incident optical, another input port links to each other with pneumatic cover, the 3rd mouth on the finger-stall links to each other with photomultiplier tube by output optical fibre, thereby output signal is outputed in the Photodetection system.
6. described blood of human body composition non-invasive monitoring device based on time gate as claimed in claim 1, it is characterized in that: pneumatic cover links to each other with an input of finger-stall.
7. the blood of human body composition non-invasive monitoring device based on time gate as claimed in claim 1, it is characterized in that: the wave-length coverage of photomultiplier tube is 300-900nm, the SMA interface, the light of collecting finger-stall output carries out signal amplification and conversion, and will be optically coupled to the single photon counting module.
8. the blood of human body composition non-invasive monitoring device based on time gate as claimed in claim 1 is characterized in that: computer is used to carry out date processing for present general microcomputer or video work station.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 201220199072 CN203074709U (en) | 2012-05-07 | 2012-05-07 | Human body blood component non-invasive monitoring device based on time gate |
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| CN 201220199072 CN203074709U (en) | 2012-05-07 | 2012-05-07 | Human body blood component non-invasive monitoring device based on time gate |
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| CN203074709U true CN203074709U (en) | 2013-07-24 |
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| CN 201220199072 Expired - Fee Related CN203074709U (en) | 2012-05-07 | 2012-05-07 | Human body blood component non-invasive monitoring device based on time gate |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104288854A (en) * | 2014-10-28 | 2015-01-21 | 北京麦邦光电仪器有限公司 | Method and device for high-precision closed-loop blood constituent real-time separation blood sampling |
| CN104330348A (en) * | 2014-10-16 | 2015-02-04 | 中国科学院上海技术物理研究所 | Blood corpuscle classification system based on flow-type super-continuum spectrum ringdown spectroscopy and method thereof |
-
2012
- 2012-05-07 CN CN 201220199072 patent/CN203074709U/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104330348A (en) * | 2014-10-16 | 2015-02-04 | 中国科学院上海技术物理研究所 | Blood corpuscle classification system based on flow-type super-continuum spectrum ringdown spectroscopy and method thereof |
| CN104288854A (en) * | 2014-10-28 | 2015-01-21 | 北京麦邦光电仪器有限公司 | Method and device for high-precision closed-loop blood constituent real-time separation blood sampling |
| CN104288854B (en) * | 2014-10-28 | 2016-11-09 | 北京麦邦光电仪器有限公司 | High precision closed loop blood constituent separates blood-sampling method and blood-taking device in real time |
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20130724 Termination date: 20140507 |