CN104288854A - Method and device for high-precision closed-loop blood constituent real-time separation blood sampling - Google Patents
Method and device for high-precision closed-loop blood constituent real-time separation blood sampling Download PDFInfo
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- 238000010241 blood sampling Methods 0.000 title claims abstract description 13
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/02—Blood transfusion apparatus
- A61M1/0281—Apparatus for treatment of blood or blood constituents prior to transfusion, e.g. washing, filtering or thawing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/38—Removing constituents from donor blood and storing or returning remainder to body, e.g. for transfusion
- A61M1/382—Optimisation of blood component yield
- A61M1/385—Optimisation of blood component yield taking into account of the patient characteristics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
- A61M2202/0413—Blood
- A61M2202/0415—Plasma
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61M2202/00—Special media to be introduced, removed or treated
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- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
- A61M2202/0413—Blood
- A61M2202/0429—Red blood cells; Erythrocytes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
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- A—HUMAN NECESSITIES
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- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2230/00—Measuring parameters of the user
- A61M2230/20—Blood composition characteristics
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Abstract
The invention relates to a method and device for high-precision closed-loop blood constituent real-time separation blood sampling. The method includes the steps that the blood drawn from the body of a blood donor is separated in real time, blood constituents which should be infused back are infused back to the body of the blood donor in a field, the required blood constituents are stored in a corresponding required blood constituent container, indexes of the blood constituents in the body of the blood donor are detected in real time in a non-invasive mode in the blood drawing process, blood sampling is stopped when the indexes of the blood constituents in the body of the blood donor are reduced below safety threshold values, the separated blood constituents are detected in real time so that the operation speed of a blood centrifugal machine can be controlled according to a detection result, and the optimal separation effect is achieved. The device for high-precision closed-loop blood constituent real-time separation blood sampling comprises a blood drawing unit, a blood separation unit, a storage unit, a back infusion unit, a constituent quality detection unit, a fluid infusion unit, a real-time physiological monitoring unit and a central processing unit. According to the method and device, on the premise that safety is guaranteed, the maximum blood donation volume can be accurately determined according to physical indexes of the blood donor, and the blood separation quality can be improved and guaranteed.
Description
Technical Field
The invention relates to a high-precision closed-loop blood component real-time separation blood sampling method and a blood sampling device.
Background
The existing blood sampling device is generally a blood drawing blood pump and a corresponding blood storage bag, the blood drawing blood pump draws blood from a human body through a blood drawing pipe and a blood drawing needle and sends the blood to the blood storage bag for storage, because the whole blood is collected in the mode, and the blood may be part of useful components in the blood when actually needed, a novel separation blood sampling mode is developed, the device for sampling blood through a blood separation technology is mainly a blood separator, and after the adopted whole blood is separated, unnecessary components (such as blood plasma) are returned to a blood donor, so that the adverse effect of the blood donor on the blood donor is reduced, and the utilization efficiency of the blood is improved, and the existing technology has the following defects: firstly, can't confirm accurately donor's the biggest blood donation volume, the maximum blood collection volume of once often controls at a relatively conservative level, is unfavorable for utilizing blood donation resource furthest under the circumstances of guaranteeing safety, especially to some special blood, because blood donation source is very few, the phenomenon that the blood source is not enough easily appears, and to autologous reinfusion, then be difficult to obtain sufficient reinfusion blood volume from patient on the body even more, secondly, the blood separating centrifuge is open loop, quantitative type only, do not carry out real-time detection to the separation composition in the separation process, separation quality is difficult to control.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provides a high-precision closed-loop blood component real-time separation and blood collection method and a blood collection device, so that the maximum blood donation amount can be accurately determined according to the physiological indexes of blood donors on the premise of ensuring safety.
It is a further object of the present invention to provide real-time detection of separated blood components, and to improve and ensure separation quality through feedback control.
The technical scheme adopted by the invention is as follows:
a high-precision closed-loop blood component real-time separation and blood sampling method is used for separating blood extracted from a blood donor body into different blood components in real time, the different blood components including a return-to-transfused blood component and one or more desired blood components, the return-to-transfused blood component (the blood component that is not required to be collected and that is to be returned to the donor) being returned to the donor on-site, the desired blood component being stored in a corresponding desired blood component container, in the process of extracting blood from a blood donor, the blood component index in the blood donor is detected in real time and non-invasively, with an index of blood components in the donor (e.g., an index of concentration of one or more blood components) as an independent index defining the maximum amount of blood collected, when the blood component index in the donor body is reduced to a safety threshold value (lower threshold value), blood collection is stopped. Besides the maximum blood collection amount determined by the invention according to the physiological information of the blood donor, particularly the in-vivo blood component detection information, the blood collection should be correspondingly detected and judged according to other existing standards and standards (if any) corresponding to the condition of stopping blood collection, and when any condition of stopping blood collection occurs, the blood collection should be stopped according to the corresponding standards and standards.
Preferably, the blood components during and/or after separation are detected in real time, the blood separation device is subjected to online real-time feedback control according to the detection information, and the running speed of the blood centrifugal separator for blood separation is adjusted to achieve the optimal separation effect.
Preferably, when the desired blood component comprises platelets, the real-time detection of the separating and/or separated blood component comprises at least a purity detection of the separating and/or separated platelets.
Preferably, the algorithm for real-time non-invasive detection of blood component indicators in a donor uses a dynamic spectral integration auto-normalization solution multivariate equation method, m spectral frequencies f1, f2.. fm are set in a full spectral analysis range, corresponding spectral powers are p1, p2.. pm, integral of the ith power spectrum pi at 0-fdc (e.g. 0.5Hz) and fac1 (e.g. 0.5Hz) -fac2 (e.g. 25Hz), respectively pidc and picc,
pidc＝∫ pidf f∈(0-fdc)
piac＝∫ pidf f∈(fac1-fac2)
for dynamic spectral integration with interference, the pic integration limit selects the half-power region of the pulse spectral distribution:
pi ac ═ pi df f epsilon (f0.51-f0.5h), wherein f0.51 and f0.5h are respectively an upper half-power point and a lower half-power point,
taking the logarithmic ratio of the two, ln (pic)/ln (pidc) ═ ri, column matrix equation:
the i-th component Ci ═ a1 ═ r1+ a2 ═ r2+. + an · rn
And solving the n equations to obtain the component ci.
Preferably, the algorithm for real-time detection of blood components during and/or after separation adopts a spectral integral proportionality coefficient method to automatically control the running speed of the blood centrifuge system, so as to achieve the purpose of controlling the precision, specifically:
let n be n components in blood, x1, x2.... times.n be the spectral density function of each component, the spectral density being related to the operating speed v when the system is operating, let xi be the spectral density function of the i-th useful component (e.g. hemoglobin), the ratio of the spectral energy of the useful component to the total spectral energy:
y ═ xidf/{ [ x1df + ] x2df +. ] x { [ n ] xndf }, where f is the spectral frequency
For the derivative of y, dy/dv { [ integral ] xidf/[ [ integral ] x1df + ] integral x2df +. ] integral ] xndf ] }/dv
Let dy/dv equal to 0, obtain the optimal running speed,
in the case that different components affect different weight considerations, the ratio of the spectral energy of the useful component to the total spectral energy is:
y ═ xidf/{ k1 × 1df + k2 × 2df +. kn ×. xndf }, where k1, k2... kn are weight coefficients and the other formulae are unchanged.
A high-precision closed-loop blood component real-time separation and blood sampling device adopting any one of the methods comprises the following steps:
the blood drawing unit is provided with a blood drawing blood pump, and the blood drawing blood pump is provided with a blood drawing pipe;
a blood separation unit, which is provided with a separator for separating blood components, preferably a blood centrifugal separator, wherein an inlet of the separator is connected with an output of the blood drawing blood pump for separating the components of the blood from the blood drawing blood pump, a plurality of output pipelines for outputting different blood components are provided, for example, one output pipeline for outputting blood components to be transfused and one or more output pipelines for outputting required blood components are provided, and when the required blood components are multiple, the different blood components are respectively output through the different blood component output pipelines;
the storage unit is provided with one or more blood pumps and one or more storage containers, such as blood storage bags, for storing one or more required blood components matched with the one or more blood pumps, the inlet of the blood pump is connected with the corresponding blood component output pipeline of the separator, and the outlet of the blood pump is connected with the corresponding storage container for the required blood components;
the real-time physiological monitoring unit is used for collecting the physiological information of a blood donor in real time, and at least comprises an in-vivo blood component real-time noninvasive detection device, and the in-vivo blood component real-time noninvasive detection device is provided with a signal transmission cable and/or a wireless communication module and is used for being in communication connection with the central control unit;
and the central control unit is mainly composed of a central control computer or a central control data processor and is used for controlling the blood-drawing blood pump to work so as to draw blood from the body of a blood donor, receiving the physiological information of the blood donor from the physiological monitoring unit, analyzing and comparing the physiological information, controlling the blood-drawing blood pump to stop working when the physiological index of the blood donor is reduced to a blood-drawing safety threshold value (lower threshold value) or the collected blood component reaches a set amount, and the information of the blood donor at least comprises the index information of the blood component in the body of the blood donor obtained by the real-time non-invasive detection device for the blood component in the body.
Preferably, the device further comprises a component quality detection unit, wherein the component quality detection unit is provided with a blood separation component real-time detection device and is used for detecting blood components newly separated by the separator (including during and/or after separation), the blood separation component real-time detection device transmits corresponding detection information to the central processing unit in a wired and/or wireless mode, the central processing unit analyzes the detection information of the blood separation component real-time detection device and controls working parameters of the separator according to an analysis result (for example, when the separator adopts a blood separator, the separation rotating speed is adjusted to obtain the required separation component purity).
Preferably, the device further comprises a feedback unit, the feedback unit is provided with a feedback blood pump, an inlet of the feedback blood pump is connected with an output pipeline of the separator, which is used for returning blood components, an outlet of the feedback blood pump is connected with a feedback pipe, and the central control unit controls the blood pumping blood pump to stop working during and/or after blood pumping is finished, and then controls the feedback blood pump to work so as to return the blood components separated by the separator, which are used for returning blood components to the blood donor.
Preferably, the device also comprises a fluid infusion unit, the fluid infusion unit is provided with a fluid infusion blood pump, the fluid infusion blood pump is provided with a fluid inlet pipe and a fluid infusion pipe, when fluid infusion is needed for a blood donor, the central control unit controls the blood drawing blood pump to stop working and then controls the fluid infusion blood pump to work so as to send the fluid infusion liquid into the blood donor, a bag (or a bottle and the like) filled with fluid for infusion can be connected through the fluid inlet pipe for fluid infusion, and medicine injection can be carried out through the fluid infusion blood pump by preparing needed medicine in the bottle.
Preferably, the fluid infusion tube and the feedback tube are connected to the same input tube, the input tube is provided with an ultrasonic bubble/pressure detection device for detecting bubble information and pressure information in the tube, the ultrasonic bubble/pressure detection device transmits corresponding detection information to the central processing unit in a wired and/or wireless manner, the central processing unit analyzes the detection information from the ultrasonic bubble/pressure detection device of the input tube, and when bubbles exist in the input tube, the central processing unit controls the fluid infusion blood pump or the feedback blood pump to stop working.
Preferably, the storage unit is provided with a storage liquid level ultrasonic detection device for detecting liquid level information in the storage container of the required blood components, the storage liquid level ultrasonic detection device transmits corresponding detection information to the central processing unit in a wired and/or wireless mode, the central processing unit analyzes the detection information from the storage liquid level ultrasonic detection device, and when the liquid level in the storage container of the required blood components reaches a set height, the central processing unit controls the blood pump to stop working.
Preferably, the in vivo blood component real-time non-invasive detection device is an in vivo blood component real-time non-invasive detection device capable of detecting at least one of red blood cell, plasma and platelet concentrations (any index of cell, plasma and platelet concentrations) in vivo blood, and various suitable non-invasive detection techniques can be adopted, for example, by selecting infrared rays with suitable frequency/frequency range to irradiate fingers of blood donors or other suitable parts of bodies, detecting transmission spectrum, utilizing different components to have different absorption conditions for infrared rays with different frequencies, and analyzing the infrared ray absorption conditions for specific frequency/frequency range to analyze the concentration of the corresponding component in blood.
Preferably, the real-time detection device for the separated blood components is a real-time detection device capable of detecting at least the purity of platelets, and various suitable detection technologies, such as a spectral substance detection technology and a spectral detection device suitable for platelets, can be adopted for on-line real-time feedback control of the platelet purity, so as to improve the purity and quality of the platelets.
The invention has the beneficial effects that: because the blood component index in the blood donor body is detected in a real-time and noninvasive mode, and the blood drawing is stopped when the blood component index in the blood donor body is reduced to a safe threshold value, a scientific basis is provided for determining the maximum blood taking amount, so that the accurate control of the maximum blood taking amount is realized, and particularly, the blood donation resource is favorably and fully utilized under the special conditions of blood source shortage and the like; the separation device is controlled in a feedback control mode due to the real-time detection of the blood separation, so that the separation quality is improved; due to the fact that the proper algorithm related to the blood component index and separation quality control in the blood donor is provided, the corresponding detection and control purposes are achieved, and the detection and control quality is guaranteed.
Drawings
FIG. 1 is a block diagram of the system architecture of the present invention.
Detailed Description
Referring to fig. 1, the implementation of such a device mainly comprises: the blood drawing unit, the blood separation unit, the storage unit, the feedback unit and the fluid infusion unit are controlled by the central processing unit to draw blood (collect whole blood), separate blood, store required blood components, return blood components to be returned and optionally supplement fluid (such as nutrient fluid and liquid medicine determined according to actual needs), the central control unit analyzes information obtained by the in-vivo blood component real-time noninvasive detection device in the real-time physiological monitoring unit and the blood separated component real-time detection device in the component quality detection unit and controls the blood drawing blood pump of the blood drawing unit, the separator of the blood separation unit, the storage of the storage unit, the feedback blood pump of the blood pump feedback unit and the fluid infusion blood pump of the fluid infusion unit to work according to corresponding operating specifications and the like to realize blood drawing, separation and storage, And the functions of back transfusion, fluid infusion and the like. Wherein,
and the blood drawing unit is used for collecting whole blood.
The blood separation unit is used for separating blood components in whole blood, and mainly separates plasma, red blood cells and platelets in the blood from each other.
The real-time physiological monitoring unit is used for monitoring physiological information of a blood donor in the blood donation process and feeding back the physiological information to the central processing unit, is mainly used for non-invasive detection of blood components in vivo, and can also collect other physiological information of the blood donor according to actual needs, for example, in blood collection, the number of red blood cells in vivo is dynamically detected in a non-invasive manner, an expert system operation model is established, and the blood collection time and times are reduced as much as possible under the condition of ensuring the oxygen supply capacity of organism tissues.
The feedback unit and the liquid supplementing unit: the central processing unit dynamically calculates the components and the dosage of the fluid infusion according to the non-invasive detection information of the dynamic blood components in the body, and respectively inputs the blood components to be back-infused and the fluid infusion into the human body through the back-infusion unit and the fluid infusion unit so as to achieve the aim of safely sampling blood.
The working process of the device is as follows:
firstly, a central control data processor (computer) of a central processing unit instructs an in-vivo blood component real-time non-invasive detection device to detect the in-vivo blood component of a blood donor, determines whether the in-vivo blood component index is in a safe range, and instructs a blood drawing pump to be started to draw blood if the in-vivo blood component index is safe, and the blood component detection of the blood donor can be detected non-invasively once every 10ml of blood is drawn. Blood enters a blood separation unit from a blood drawing needle through a blood drawing blood pump, the blood separation unit separates the blood through a centrifuge, a blood separation component real-time detection device (detection circuit) of the component quality detection unit detects the separated blood components in real time, preferably detects the blood components which are just separated (newly separated) so as to feed back the separated blood components in time, preferably detects the separated blood components positioned in the separator if possible, also can detect the blood components in an output pipeline of the corresponding blood components of the separator, the detection point is preferably a position which is close to and far away from the separator, and according to the setting of the separator, the result is input into an automatic control unit of the centrifuge after being analyzed and processed by a central processing unit or the corresponding detection information is directly analyzed by the blood separation component real-time detection device and/or the automatic control unit of the centrifuge, the operation speed of the centrifuge is adjusted through an automatic control unit of the centrifuge, the optimal separation precision is achieved, various required blood components are stored in different blood storage bags under the action of blood storage pumps through different output pipelines after separation, the components which are not required after separation (blood components to be transfused back) are connected into a blood back-flow pump, the blood back-flow pump is instructed to stop by a computer, the blood back-flow pump is started, an output pipe ultrasonic bubble detection device (detection circuit) is started to carry out bubble, and the blood components to be transfused back are transfused back into a blood donor body.
Blood withdrawal is stopped when the desired blood component obtained meets a set collection volume or when the physiological indicators of the donor are checked to fall below a safety threshold.
When a donor needs to supplement the medicine, the computer instructs the blood-drawing blood pump 1 and the reinfusion blood pump to stop, and the fluid-supplementing blood pump is started to infuse the medicine.
The various blood pumps all adopt precision blood delivery pumps.
The various units of the invention, in addition to the explicitly described elements/devices with main and/or basic functions, may also comprise various corresponding mating and/or accessory elements/devices, such as mounting assemblies for said elements with main or basic functions, mating control circuits for said elements with main and/or basic functions, connecting pipes or other forms of connecting conduits for carrying out fluid transfer, etc., which mating and/or accessory elements/devices may be implemented according to the prior art.
The connection for the transport of blood or blood components according to the invention can be made by means of suitable tubing, such as rubber tubing, plastic tubing, metal tubing, etc., and can be provided with the necessary tubing connections, with or without a temporary storage space/container for the liquid.
The mechanical assembly or integration of the units of the invention can be according to the prior art.
The hardware architecture and/or communication mode of the central control unit for controlling the blood pumps and separators may be according to the prior art, and may be control interfaces respectively connected to the blood pumps and separators through control cables.
The communication connection with the central control unit or the information/data transmission between the central control unit and the central control unit is called as the communication connection with the central control computer or the central control data processor of the central control unit or the information/data transmission between the central control computer or the central control data processor of the central control unit in a direct or indirect mode, the central control computer or the central control data processor can be provided with a corresponding interface circuit or a data conversion circuit and the like to realize the communication connection or the information/data transmission, and the communication mode, the information/data transmission mode and a corresponding hardware architecture can be based on the prior art.
The present invention may be provided with various display, alarm and output/input devices in accordance with the prior art.
The preferred technical means disclosed by the invention can be combined arbitrarily to form a plurality of different technical schemes except for special description and further limitation that one preferred technical means is another technical means.
Claims (10)
1. A high-precision closed-loop blood component real-time separation and blood collection method includes separating blood extracted from a blood donor body into different blood components in real time, enabling the different blood components to comprise a blood component to be returned and one or more required blood components, returning the blood component to be returned to the blood donor body on site, storing the required blood components in corresponding required blood component containers, detecting blood component indexes in the blood donor body in a real-time non-invasive mode during blood extraction from the blood donor body, taking the blood component indexes in the blood donor body as independent indexes for limiting maximum blood collection amount, and stopping blood collection when the blood component indexes in the blood donor body are reduced to a safety threshold value.
2. The blood collecting method according to claim 1, wherein the blood components during and/or after the separation are detected in real time, the blood separating device is subjected to online real-time feedback control based on the detected information, and the operation speed of the blood centrifuge for blood separation is adjusted to achieve an optimal separation effect. For example: when the desired blood component comprises platelets, the real-time detection of the separated and/or isolated blood component comprises at least a purity detection of the separated and/or isolated platelets.
3. The blood collection method of claim 2, wherein:
the algorithm for real-time non-invasive detection of blood component indexes in a donor body adopts a dynamic spectrum integration self-normalization solution multivariate equation method, m spectrum frequencies f1 and f2.. fm are arranged in a full spectrum analysis range, corresponding spectrum powers are p1 and p2.. pm, for the ith power spectrum pi, the integration is respectively carried out at 0-fdc (such as 0.5Hz) and fac1 (such as 0.5Hz) -fac2 (such as 25Hz), namely pi dc and pi ac,
pidc＝∫ pidf f∈(0-fdc)
piac＝∫ pidf f∈(fac1-fac2)
for dynamic spectral integration with interference, the pic integration limit selects the half-power region of the pulse spectral distribution:
pi ac ═ pi df f epsilon (f0.51-f0.5h), wherein f0.51 and f0.5h are respectively an upper half-power point and a lower half-power point,
taking the logarithmic ratio of the two, ln (pic)/ln (pidc) ═ ri, column matrix equation:
the i-th component Ci ═ a1 ═ r1+ a2 ═ r2+. + an · rn
Solving n equations to obtain the component ci,
the algorithm for detecting the blood components in and/or after separation in real time adopts a spectral integral proportionality coefficient method to automatically control the running speed of a blood centrifugal separator system so as to achieve the purpose of controlling the precision, and specifically comprises the following steps:
let n be n components in blood, x1, x2.... times.n be the spectral density function of each component, the spectral density being related to the operating speed v when the system is operating, let xi be the spectral density function of the i-th useful component (e.g. hemoglobin), the ratio of the spectral energy of the useful component to the total spectral energy:
y ═ xidf/{ [ x1df + ] x2df +. ] x { [ n ] xndf }, where f is the spectral frequency
For the derivative of y, dy/dv { [ integral ] xidf/[ [ integral ] x1df + ] integral x2df +. ] integral ] xndf ] }/dv
Let dy/dv equal to 0, obtain the optimal running speed,
in the case that different components affect different weight considerations, the ratio of the spectral energy of the useful component to the total spectral energy is:
y ═ xidf/{ k1 × 1df + k2 × 2df +. kn ×. xndf }, where k1, k2... kn are weight coefficients and the other formulae are unchanged.
4. A high precision closed loop real time separation and blood sampling device for blood components using the method of any one of claims 1 to 3, comprising:
the blood drawing unit is provided with a blood drawing blood pump, and the blood drawing blood pump is provided with a blood drawing pipe;
a blood separation unit provided with a separator for separating blood components, preferably a blood centrifugal separator, for separating components of blood from the blood pump, and provided with a plurality of output pipes for outputting different blood components;
the storage unit is provided with one or more storage blood pumps and one or more storage containers for storing one or more required blood components matched with the one or more storage blood pumps, the inlet of the storage blood pump is connected with the corresponding blood component output pipeline of the separator, and the outlet of the storage blood pump is connected with the corresponding storage container for storing the required blood components;
the real-time physiological monitoring unit is used for collecting the physiological information of a blood donor in real time, and at least comprises an in-vivo blood component real-time noninvasive detection device, and the in-vivo blood component real-time noninvasive detection device is provided with a signal transmission cable and/or a wireless communication module and is used for being in communication connection with the central control unit;
and the central control unit is mainly composed of a central control computer or a central control data processor and is used for controlling the blood-drawing blood pump to work, receiving the physiological information of the blood donor from the physiological monitoring unit, analyzing and comparing the physiological information, controlling the blood-drawing blood pump to stop working when the physiological index of the blood donor is reduced to a blood-drawing safety threshold value (lower limit threshold value) or the collected blood component reaches a set amount, and the information of the blood donor at least comprises the index information of the blood component in the blood donor obtained by the real-time noninvasive detection device of the blood component in the body.
5. The lancing device according to claim 4, further comprising a component quality detecting unit having a real-time blood component detecting device for detecting a newly separated blood component in real time, wherein the real-time blood component detecting device transmits corresponding detection information to the CPU in a wired and/or wireless manner, and the CPU analyzes the detection information of the real-time blood component detecting device and controls the operation parameters of the separator according to the analysis result.
6. The blood collection device according to claim 4 or 5, further comprising a return unit, wherein the return unit is provided with a return blood pump, an inlet of the return blood pump is connected with an output pipeline of the separator, which is used for returning blood components, an outlet of the return blood pump is connected with a return pipe, and the central control unit controls the blood drawing blood pump to stop working and then controls the return blood pump to work during and/or after blood drawing is finished.
7. The blood collection device according to claim 6, further comprising a fluid infusion unit provided with a fluid infusion blood pump provided with a fluid inlet pipe and a fluid infusion pipe, wherein when fluid infusion to a donor is required, the central control unit controls the blood extraction blood pump to stop working and then controls the fluid infusion blood pump to work.
8. The blood collection device according to claim 7, wherein the fluid infusion tube and the return tube are connected to a same input tube, the input tube is provided with an ultrasonic bubble/pressure detection device for detecting bubble information and pressure information in the tube, and transmits corresponding detection information to the central processing unit in a wired and/or wireless manner, the central processing unit analyzes the detection information from the ultrasonic bubble/pressure detection device of the input tube, and when bubbles exist in the input tube, the central processing unit controls the fluid infusion blood pump or the return blood pump to stop working.
9. The blood collection device according to claim 8, wherein the storage unit is provided with a storage liquid level ultrasonic detection device for detecting the liquid level information in the storage container of the required blood component, the storage liquid level ultrasonic detection device transmits the corresponding detection information to the central processing unit in a wired and/or wireless manner, the central processing unit analyzes the detection information from the storage liquid level ultrasonic detection device, and when the liquid level in the storage container of the required blood component reaches a set height, the central processing unit controls the blood pump to stop working.
10. The lancing device according to claim 9, wherein said real-time non-invasive in vivo blood component measuring device is a real-time non-invasive in vivo blood component measuring device capable of measuring at least one of red blood cell, plasma and platelet concentrations in the blood of the subject, and said real-time separated blood component measuring device is a real-time measuring device capable of measuring at least platelet purity.
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