Background technology
Raising along with living standards of the people, unreasonable and China of the quickening of life speed and dietary structure progressively enters the impact of the problems such as aging society, the crowd who suffers from the diseases such as cerebral embolism, hyperlipidemia, cerebral hemorrhage is more old more, more seriously gradually to become younger, the future development of rejuvenation.Atherosclerosis and thromboembolia type complication thereof have all become human mortality and the main cause that disables in China and western countries, by World Health Organization's " monitoring of multinational cardiovascular diseases's development trend and determiner thereof " recent statistics in 2002 of (being called for short the MONICA scheme), annual nearly 1,700 ten thousand people die from various cardiovascular and cerebrovascular diseases, and prediction will reach 2,500 ten thousand people to the year two thousand twenty.The mortality rate of China's cardiovascular and cerebrovascular disease has increased by 3 times over nearly 30 years, and cardiovascular and cerebrovascular disease has become first cause of the death of urban and rural residents from the nineties in 20th century.Accounted at present nearly 40% of total death toll.Cardiovascular and cerebrovascular disease also is to cause the main cause that the labour force loses, quality of life descends and the disease burden increases, and annual medical expense reaches tens billion of, has seriously hindered the further raising of China's economic development and living standards of the people.As everyone knows, in case suffer from these diseases, the patient often loses ability to act and speech capability, needs relatives' daily treatment.So that patient itself is very painful, also so that the heavy financial burden of family numbers of patients back.Even can cause family quarrel to affect social cohesion.And used Therapeutic Method is at present: the means such as operation, interventional therapy, transfusion.But all in various degree serious problem arranged, the one, patient's voluntarily treatment of can't being in; The 2nd, also need accompanying of family members during treatment; The 3rd, above-mentioned treatment usual risks is higher; The 4th, treatment cost is high; The 5th, patient itself need bear very large misery.Particularly its recovery of the patient of cerebral embolism disease is a very long process, and simple operation, transfusion can not reach gradually rehabilitation.Therefore, study and a kind ofly externally can alleviate conditions of patients by smearing the method for this disease for the treatment of, also can alleviate family members' burden, and safety, convenience, medical expense are lower.
Lepirudin 023 ludon (r-HRD), along with the further investigation of the mankind to hirudin, show that more and more it has important exploitation and is worth, but the hirudin source is limited, the world of medicine all studies by genetic engineering emphatically and obtains lepirudin 023 ludon both at home and abroad, and succeeds respectively in escherichia coli and yeast.Compare with natural hirudin, not by tyrosine, active lower slightly, all the other character are basic identical on 63 amino acids (tyrosine) for lepirudin 023 ludon.Hirudin is the up-and-coming anticoagulant blood stasis dispelling of class medicine, and it can be used for the treatment of various thrombus diseases, especially the treatment of phlebothrombosis and the blood coagulation of diffusivity blood vessel; Also can be used for the formation of prevention of arterial thrombosis behind the surgical operation, the formation of thrombosis behind the prevention thrombus or behind the revascularization; Improve the cyclic process of extracorporeal circulation of blood hemodialysis, in microsurgery, Chang Yinwei anastomosis of blood vessel thromboembolism and leading to the failure adopts hirudin can promote wound healing.Research is proof also, and hirudin also can play a role in oncotherapy, and it can stop the transfer of tumor, has proved medicable tumor such as fibrosarcoma, osteosarcoma, blood sarcoma and leukemia.But hirudin is combined with chemotherapy and radiotherapy also, and blood flow increases curative effect in the tumor owing to increasing.Hirudin is strong, safe, the most effective thrombin natural inhibitor of finding up to now.
Characteristics according to lepirudin 023 ludon, lepirudin 023 ludon is combined with sha-syndrome scraping plate can makes things convenient for the patient to use, avoid traditional sha-syndrome scraping plate scrape therapy liquid or scrape therapy wet goods material need to be poured out with sha-syndrome scraping plate and dip the problem that pollutes easily scrape therapy liquid or scraping oil, simultaneously because user is the patient of the disease such as cerebral embolism, its action edge and action are dumb, may overturn the problems such as scrape therapy liquid, the amount that dips simultaneously also is difficult to control, if the amount of dipping is few, then successful is not enough, also can be owing to lubricated inadequate scratch skin.If the amount of dipping is many, then possible pollution clothes or bedding also can cause the waste of medicine to increase the spending that patient medical takes.The design of this product can be avoided above-mentioned problem, and scrape therapy liquid is combined with sha-syndrome scraping plate, can conveniently use the use amount that also can guarantee medicinal liquid, makes things convenient for patient's use.
Summary of the invention
The utility model discloses a kind of screeding device with liquid containing bottle, it is characterized in that it is by forming with hirudin liquid containing bottle 8, the rubber gasket 3 of draw-in groove 5, the plastic seal buckle 4 of inlaying scraper plate 2; The plastic seal buckle of wherein inlaying scraper plate is stuck on the liquid containing bottle with draw-in groove by rubber gasket.The material of described rubber gasket is silicone rubber.
0.1-2mm taper liquid outlet 1 is arranged in the middle of the screeding device with liquid containing bottle described in the utility model, the scraper plate of wherein inlaying.This design is can not flow out hirudin liquid in order to reach general inversion, and bottleneck pastille place and skin can be rubbed gently when using, utilize frictional force that bottle mouth position liquid is applied in the skin place, also bottleneck can be stood upside down and shake gently in the place of smearing, the hirudin conditioning liquid also can flow out.
Screeding device with liquid containing bottle described in the utility model, the scraper plate 2 of wherein inlaying in the plastic seal buckle is jade plate or the Cornu Bovis seu Bubali plate of 1-5cm for symmetrical length, its thickness is 0.5-2cm.Utilize the natural materials such as Cornu Bovis seu Bubali and jade both to guarantee the comfort level of using, this Cornu Bovis seu Bubali plate can well contact with skin with jade and can injured skin simultaneously.Its physicochemical property of the Cornu Bovis seu Bubali of what is more important natural material and jade is stable can not to affect the active and stable of hirudin without materials such as chemical constituent and heavy metals, use simultaneously natural Cornu Bovis seu Bubali and jade can also increase fully the subcutaneous absorption rate of hirudin as mediator, so that curative effect is more remarkable.The size of its length and thickness according to the state of an illness of user, use position, health etc. different and release different size, satisfy to greatest extent needs of patients.
Screeding device with liquid containing bottle described in the utility model, the scraper plate 2 of wherein inlaying in the plastic seal buckle be shaped as circle, square or rectangular.Purpose is for the patient can better utilize its features of shape for the scrape therapy of different affected parts, in addition because circle is different from square or rectangular effect dynamics, can select according to s own situation for the patient.
Screeding device with liquid containing bottle described in the utility model, the scraper plate of wherein inlaying on the plastic seal buckle 4 is fixed by binding agent.
Screeding device with liquid containing bottle described in the utility model, wherein the liquid of hirudin liquid containing bottle 8 is the high-purity lepirudin 023 ludon, molecule 7000 Dao Er, multiple micromolecule aminoacid forms, free from admixture, heavy metal free, without any side effects to human body.Described hirudin consumption is purity 93-98%, hirudin concentrated solution 1ml-20ml.
Screeding device with liquid containing bottle described in the utility model wherein can be changed with the hirudin liquid containing bottle of draw-in groove.The design of sha-syndrome scraping plate part is that top scrape therapy part can use for a long time, and the hirudin bottle of bottom then is disposable use, is finished as early as possible behind the Kaifeng to prevent bacteria effect hirudin effect.
The utlity model has following features: at first, this product has solved injury to human body by the percutaneous drug delivery approach, simultaneously also without any misery.Secondly, this product can farthest reduce medicine to the side effect of human body, so that product safety is reliable by percutaneous drug delivery.Again, this product can in unlimited time, the use in place, and need not family members' cooperation.At last, the price of this product is lower, and Most patients can be born.
The key technical indexes of the present utility model:
(1) high-purity lepirudin 023 ludon, molecule 7000 Dao Er, multiple micromolecule aminoacid forms, free from admixture, heavy metal free, without any side effects to human body.Described hirudin consumption is purity 93-98%, hirudin concentrated solution 1ml-20ml.
(2) zoopery and clinical research show, vein or subcutaneous injection hirudin are all without obvious toxic-side effects, no matter acute, subacute toxicity test, to blood pressure, heart rate, blood reach mutually the bleeding time, the hematochemistry composition is all unaffected, respiratory system is not impact also, without irritated reaction, generally find without specific antibody.The half lethal dose of hirudin (D50>50mgAg), be higher than treatment required therapeutic dose (1mgAg) far away.Especially it is worthy of note that hirudin can Transdermal absorption, this brings great convenience to medication; Because the hirudin physicochemical property is stable, trypsin and Chymotrypsin do not destroy its activity, so the hydrolyzed solution of hirudin still has the effect of Trombin inhibiting.
The using method of the disclosed screeding device with liquid containing bottle of this utility model is as follows:
(1) the sha-syndrome scraping plate device is stood upside down in the affected part, scrape gently several times, the hirudin in the bottle touches the affected part with frictional force, utilizes scraper plate that the hirudin that flows out is scraped all effects of even massage of coating of playing at skin repeatedly.Also this product can be stood upside down in the affected part, shake gently body, make hirudin be applied to the affected part, it is identical with last scheme that the recycling scraper plate scrapes its effect gently.The affected part body part that can be the patient determine according to self state of an illness, also can follow the doctor's advice is applied in this conditioning liquid on whole body meridian or the particular acupoint, massages gently the conditioning liquid that was glued in 5 minutes-10 minutes and all is absorbed.Maneuver is not wanted too not heavy in case the injured skin epidermis is scratched or hemorrhage should stopping using immediately such as epiderm skin.Bring into use phase suggestion early, evening each once (if conditions permit also can morning, noon, evening each massage once), change into once a day after 30 days and getting final product, the time of smearing is grasped voluntarily.Be specially adapted to subcutaneous absorption and carry out nursing behind the bolt, and safe ready is effective.Handicapped good nursing efficacy arranged for what cerebral embolism, cerebral hemorrhage, apoplexy caused.
(2) general 90 days-120 days handicapped nursing phase that causes for cerebral embolism, cerebral hemorrhage, apoplexy: the nursing of attaching most importance in front 30 days was general nursing, can reaches desirable nursing efficacy in 90 days-120 days in rear 60 days.
What (3) the cerebral infarction omen arranged also can use this product, can reach the appearance of avoiding initial stage cerebral infarction and secondary cerebral infarction.The suggestion first phase uses this product advise in the time of 30 days-60 days that user does brain CT one time, to understand the variation of brain bolt, smears number of times in order to grasp, and the observation nursing effect is adjusted nursing number of times and care cycle, increase or the minimizing consumption in the hope of reaching nursing efficacy.
Adopt the good effect of the screeding device with liquid containing bottle of the present utility model:
(1) this utility model adopts lepirudin 023 ludon r-HRD sha-syndrome scraping plate conditioning liquid (title of sha-syndrome scraping plate conditioning liquid is that the basic principle that classification is defined according to National Medical Devices is decided): product of the present utility model can effectively prevent venothrombotic formation, eliminates coagulation, reduces blood viscosity, blood fat reducing, dredging blood capillary, improves microcirculation, enhance metabolism.The biological thrombin inhibitor of the strongest, the most effective and safest this reversibility has been opened up and has been used for clinical medical inspection and treats clinical new purposes because of diseases such as subcutaneous hemorrhage or blood flow of the tip are not smooth.
(2) with high-purity lepirudin 023 ludon protein solution heavy metal free in the screeding device of liquid containing bottle, without any impurity, human body is had no effect, be specially adapted to pass through subcutaneous absorption.Albumen without any destruction and impact, without any injury, had the characteristics such as safe, credible, easy to use, successful to stomach, liver, intestinal.Filled up the blank of hemiplegia patient at rehabilitation course, for extensive patients provides Gospel.
(3) filled up the blank of hemiplegia patient at rehabilitation course with the screeding device of liquid containing bottle, for extensive patients provides Gospel.Be specially adapted to subcutaneous absorption and carry out nursing behind the bolt, and safe ready is effective.Handicapped good nursing efficacy arranged for what cerebral embolism, cerebral hemorrhage, apoplexy caused.
(4) this product is to have utilized China's tradition scrape therapy method to cooperate the perfect adaptation of modern biotechnology, on the one hand by unique product design, utilized the high-grade famous and precious materials such as Cornu rhinocerotis and jade to guarantee the comfort of this product, also simultaneously result of use has been strengthened greatly.Owing to the particularity of material, can be good at contact skin can not injuring skin in addition.
Adopt the screeding device with liquid containing bottle of the present utility model that typical cerebral embolism patient is tested: the sha-syndrome scraping plate device is stood upside down in the affected part, scrape gently several times, hirudin in the bottle touches the affected part with frictional force, utilizes scraper plate that the hirudin that flows out is scraped all effects of even massage of coating of playing at skin repeatedly.Also this product can be stood upside down in the affected part, shake gently body, make hirudin be applied to the affected part, it is identical with last scheme that the recycling scraper plate scrapes its effect gently.The affected part body part that can be the patient determine according to self state of an illness, also can follow the doctor's advice is applied in this conditioning liquid on whole body meridian or the particular acupoint, massages gently the conditioning liquid that was glued in 5 minutes-10 minutes and all is absorbed.The nursing of attaching most importance in front 30 days, beginning early, evening each once, got final product for general nursing changes into once a day in rear 60 days.90 days-120 days is a course for the treatment of.
Typical case: certain patient 45 years old, the male, operating pressure is large, and dinner party is many at ordinary times.Suffer from hypertension 100-180, hyperlipidemia (triglyceride 2.5mmol/L, T-CHOL 8.6mmol/L, HDL3 .5mmol/L, low density lipoprotein, LDL 6.0mmol/L), high blood viscosity denseness through hospital diagnosis and (play dizziness morning, bradyphrenia, generally will be after eating breakfast, it is clear-headed that brains just becomes gradually.Feel sleepy after the lunch, need to take a snap, otherwise whole afternoon is all listless.On the contrary, the mental status is good especially after the dinner, and high risk of stroke is arranged, and is typical three-hypers patient.By using this utility model product after 30 days, detect blood pressure through hospital and reduce to 90-140, blood fat (triglyceride 1.7mmol/L, T-CHOL 5.6mmol/L, HDL1 .5mmol/L, low density lipoprotein, LDL 3.9mmol/L) indices all is tending towards normal, energy is comparatively vigorous, brains is resourceful, and the symptoms such as the typical case of hyperlipidemia obviously alleviate.
Effect with respect to traditional sha-syndrome scraping plate is generally blood circulation promoting and blood stasis dispelling, through being usually used in edema, traumatic injury and the heat clearing away symptoms such as fire of dispelling, to typical cerebral embolism disease substantially without acting on.
This product has not only proved safe and effective by a large amount of use experiments; also have simple to operate; no pain, need not other people and assist the characteristics that to use; its positive effect is; usually can not get after the patient leaves hospital for various reasons system, in time, accurately treatment; and the expense of again being admitted to hospital is higher; the reasons such as family members' energy is limited; can only rely on the successive treatment of being in; but often the patient can't accomplish voluntarily; need other people to assist also can to exist that family members' energy and time is limited etc. that problems affect is in time treated, delay treatment even make the patient life danger occur.