CN102885693A - Recombinant hirudin liquid storing bottle with ball and spring retainer - Google Patents
Recombinant hirudin liquid storing bottle with ball and spring retainer Download PDFInfo
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- CN102885693A CN102885693A CN2012103658907A CN201210365890A CN102885693A CN 102885693 A CN102885693 A CN 102885693A CN 2012103658907 A CN2012103658907 A CN 2012103658907A CN 201210365890 A CN201210365890 A CN 201210365890A CN 102885693 A CN102885693 A CN 102885693A
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Abstract
The invention discloses a recombinant hirudin liquid storing bottle with a ball and a spring retainer. The liquid storing bottle comprises a bottle cap and a liquid storing bottle body, wherein a bottle cap extending part is connected below the bottle cap; an inwardly-concave bottle cap lock catch is formed close to a lower end on the inner side of the bottle cap, and is connected to a bump formed on the outer side of the bottle cap extending part; the bottle cap extending part is in threaded connection with the liquid storing bottle body through a liquid storing bottleneck; recombinant hirudin is filled into the liquid storing bottle body; a ball and a ball spring retainer are arranged in the bottle cap extending part; a liquid outlet cavity with a certain gap is formed between the ball spring support and the bottle cap extending part; and the lower end of the ball spring support is connected to the liquid storing bottleneck, and is supported by the surrounding walls of the liquid storing bottleneck. Through skin administration, the side effects of medicaments on human bodies can be reduced to the maximum extent, and a product is safe and reliable. Moreover, the recombinant hirudin liquid storing bottle can be used at any time and at any place, does not require cooperation of family members, and is good news for a large quantity of patients.
Description
Technical field
The invention belongs to technical field of medical instruments, relate to a kind of lepirudin 023 ludon r-HRD that adopts as a class apparatus of Transdermal absorption effect.More specifically say a kind of lepirudin 023 ludon liquid containing bottle with ball and latch bracket.
Background technology
Raising along with living standards of the people, unreasonable and China of the quickening of life speed and dietary structure progressively enters the impact of the problems such as aging society, the crowd who suffers from the diseases such as cerebral embolism, hyperlipidemia, cerebral hemorrhage is more old more, more seriously gradually to become younger, the future development of rejuvenation.Atherosclerosis and thromboembolia type complication thereof have all become human mortality and the main cause that disables in China and western countries, by World Health Organization's " monitoring of multinational cardiovascular diseases's development trend and determiner thereof " recent statistics in 2002 of (being called for short the MONICA scheme), annual nearly 1,700 ten thousand people die from various cardiovascular and cerebrovascular diseases, and prediction will reach 2,500 ten thousand people to the year two thousand twenty.The mortality rate of China's cardiovascular and cerebrovascular disease has increased by 3 times over nearly 30 years, and cardiovascular and cerebrovascular disease has become first cause of the death of urban and rural residents from the nineties in 20th century.Accounted at present nearly 40% of total death toll.Cardiovascular and cerebrovascular disease also is to cause the main cause that the labour force loses, quality of life descends and the disease burden increases, and annual medical expense reaches tens billion of, has seriously hindered the further raising of China's economic development and living standards of the people.As everyone knows, in case suffer from these diseases, the patient often loses ability to act and speech capability, needs relatives' daily treatment.So that patient itself is very painful, also so that the heavy financial burden of family numbers of patients back.Even can cause family quarrel to affect social cohesion.And used Therapeutic Method is at present: the means such as operation, interventional therapy, transfusion.But all in various degree serious problem arranged, the one, patient's voluntarily treatment of can't being in; The 2nd, also need accompanying of family members during treatment; The 3rd, above-mentioned treatment usual risks is higher; The 4th, treatment cost is high; The 5th, patient itself need bear very large misery.Particularly its recovery of the patient of cerebral embolism disease is a very long process, and simple operation, transfusion can not reach gradually rehabilitation.Therefore, study and a kind ofly externally can alleviate conditions of patients by smearing the method for this disease for the treatment of, also can alleviate family members' burden, and convenience, safety, medical expense are lower.
Lepirudin 023 ludon (r-HRD), along with the further investigation of the mankind to hirudin, show that more and more having important exploitation is worth, but the hirudin source is limited, the world of medicine all studies by genetic engineering emphatically and obtains lepirudin 023 ludon both at home and abroad, and succeeds respectively in escherichia coli and yeast.Compare with natural hirudin, not by tyrosine, active lower slightly, all the other character are basic identical on 63 amino acids (tyrosine) for lepirudin 023 ludon.Hirudin is the up-and-coming anticoagulant blood stasis dispelling of class medicine, and it can be used for the treatment of various thrombus diseases, especially the treatment of phlebothrombosis and the blood coagulation of diffusivity blood vessel; Also can be used for the formation of prevention of arterial thrombosis behind the surgical operation, the formation of thrombosis behind the prevention thrombus or behind the revascularization; Improve the cyclic process of extracorporeal circulation of blood hemodialysis, in microsurgery, Chang Yinwei anastomosis of blood vessel thromboembolism and leading to the failure adopts hirudin can promote wound healing.Research is proof also, and hirudin also can play a role in oncotherapy, and it can stop the transfer of tumor, has proved medicable tumor such as fibrosarcoma, osteosarcoma, blood sarcoma and leukemia.But hirudin is combined with chemotherapy and radiotherapy also, and blood flow increases curative effect in the tumor owing to increasing.Hirudin is strong, safe, the most effective thrombin natural inhibitor of finding up to now.
Characteristics according to lepirudin 023 ludon, lepirudin 023 ludon is combined with sha-syndrome scraping plate can makes things convenient for the patient to use, avoid traditional sha-syndrome scraping plate scrape therapy liquid or scrape therapy wet goods material need to be poured out with sha-syndrome scraping plate and dip the problem that pollutes easily scrape therapy liquid or scraping oil, simultaneously because user is the patient of the disease such as cerebral embolism, its action edge and action are dumb, may overturn the problems such as scrape therapy liquid, the amount that dips simultaneously also is difficult to control, if the amount of dipping is few, then successful is not enough, also can be owing to lubricated inadequate scratch skin.If the amount of dipping is many, then possible pollution clothes or bedding also can cause the waste of medicine to increase the spending that patient medical takes.The design of this product can be avoided above-mentioned problem, and scrape therapy liquid is combined with sha-syndrome scraping plate, can conveniently use the use amount that also can guarantee medicinal liquid, makes things convenient for patient's use.But, family members dip with hands and smear hirudin in patient's affected part, because the mechanism of hirudin is the positions such as relevant acupuncture point that act on local affected part or recommended by the doctor, and family members help the patient to smear with hands, hirudin can enter family members' hands and patient's affected part simultaneously, render a service so that hirudin reduces, act on not obvious.Match with sha-syndrome scraping plate with hirudin merely, hirudin poured out be applied in the affected part or specify the acupuncture point, use the sha-syndrome scraping plate scrape therapy, there is major defect in it, because hirudin is biological preparation, the as easy as rolling off a log bacteria effect that is subject to is in case be subject to the large tracts of land bacteria effect, hirudin activity then can occur and lower rapidly, even whole inactivation.And the stable and effective antibacterial means that guarantee hirudin activity are vital.In case after the hirudin vigor was reduced to less than 30% or whole inactivation, its effect also can corresponding attenuating even invalid.So guarantee that whether the curative effect of hirudin is subject to bacteria effect with activity is closely bound up.Concrete means are except strict control total number of bacteria in manufacturing engineering, and it is important means that the contact area of also should try one's best when the patient uses minimizing and air and the hirudin that will break a seal are finished as early as possible.
Summary of the invention
The present invention is the above-mentioned the problems of the prior art of solution, and a kind of lepirudin 023 ludon liquid containing bottle with ball and latch bracket is provided.
Technical scheme of the present invention is:
A kind of lepirudin 023 ludon liquid containing bottle with ball and latch bracket is characterized in that: this liquid containing bottle comprises bottle cap 1 and liquid storage bottle 8, and the below of bottle cap is connected with bottle cap extension 11, and the bottle cap extension is connected with the liquid storage bottle mouth position of liquid storage bottle top; Be loaded with lepirudin 023 ludon in the liquid storage bottle; Be provided with ball 4 and ball spring holder 5 in the bottle cap extension, the top of ball leans out from bottle cap extension top, and the bottom embeds in the rounded ball spring holder in cross section; Form between ball spring holder and the bottle cap extension inwall have a fixed gap go out sap cavity 3; The lower end of ball spring holder is connected on the liquid storage bottleneck 7, is supported by liquid storage bottleneck perisporium.
The inboard nearly lower end of described bottle cap is formed with the bottle cap snap close of indent, and bottle cap lock links on the jut that is connected on the formation of the bottle cap extension outside.
Described bottle cap extension and liquid storage bottleneck are threaded connection.
The lower end of described ball spring holder forms an annular base, arrange on the annular base a plurality of upwards hold up have certain elastic support bar, the upper end of support bar connects and is an annular brace holder.
Be formed with the liquid containing bottle base to lower process around the described liquid containing bottle bottom.
Described ball is made by jade material, Cornu Bovis seu Bubali material or plastic material.
High-purity lepirudin 023 ludon of the present invention, molecule 7000 Dao Er, multiple micromolecule aminoacid forms, free from admixture, heavy metal free, without any side effects to human body.Described hirudin consumption is purity 93-98%, lepirudin 023 ludon concentrated solution 1ml-20ml.
The key technical indexes of the present invention:
(1) high-purity lepirudin 023 ludon, molecule 7000 Dao Er, multiple micromolecule aminoacid forms, free from admixture, heavy metal free, without any side effects to human body.Described hirudin consumption is purity 93-98%, hirudin concentrated solution 1ml-20ml.
(2) zoopery and clinical research show, vein or subcutaneous injection hirudin are all without obvious toxic-side effects, no matter acute, subacute toxicity test, to blood pressure, heart rate, blood reach mutually the bleeding time, the hematochemistry composition is all unaffected, respiratory system is not impact also, without irritated reaction, generally find without specific antibody.The half lethal dose of hirudin (D50＞50mgAg), be higher than treatment required therapeutic dose (1mgAg) far away.Especially it is worthy of note that hirudin can Transdermal absorption, this brings great convenience to medication; Because the hirudin physicochemical property is stable, trypsin and Chymotrypsin do not destroy its activity, so the hydrolyzed solution of hirudin still has the effect of Trombin inhibiting.
The present invention has a clear superiority, and is easy to carry, uses simply, and the patient can use voluntarily and need not other people and assist.Special patent of the present invention is for symptom a common feature to be arranged, and the patient is owing to older and state of an illness impact, and self-care ability is usually relatively poor, needs family members to wait other people to assist.But social development speed is accelerated now, is commonly the only child in addition, and a pair of man and wife need look after 4 old men simultaneously, also needs work and fosters one's children, and bears heavy.Because family members busy is pressed for time, energy, muscle power all can't bear long-term nurse patient; Medical expense is very big; Operation risk is higher; The reasons such as the complication of expectant treatment and side effect are larger so that patient's the state of an illness worsens more, have in addition therefore and abandoning cure has caused great impact for people's life and health.And along with China progresses into aging society, this contradiction can be more and more outstanding.China people are badly in need of a kind of product namely can alleviate the pressure of accompanying and attending to that disease can alleviate again family members, reduces simultaneously economic spending and waits series of problems.By patented product of the present invention, just can significantly alleviate the appearance of this inconsistency.
The present invention further discloses with the lepirudin 023 ludon liquid containing bottle of ball and latch bracket as medical apparatus and instruments in the application aspect the prevention cerebral infarction omen medical apparatus and instruments.The particularly application aspect treatment cerebral embolism, cerebral hemorrhage, apoplexy medical apparatus and instruments.
Patent of the present invention has not only proved safe and effective by a large amount of use experiments; also have simple to operate; no pain; need not the characteristics that other people assistance can be used; its positive effect is; usually can not get system after the patient leaves hospital for various reasons; in time; accurately treatment; and the expense of again being admitted to hospital is higher; the reasons such as family members' energy is limited; can only rely on the successive treatment of being in; but often the patient can't accomplish voluntarily; need other people to assist also can to exist that family members' energy and time is limited etc. that problems affect is in time treated, delay treatment even make the patient life danger occur.
Conclusion:
This product have safety, effectively, have no side effect, easy to use, the advantage such as price is lower.Need not other people and assist and to use voluntarily, to relevant corollary equipment no requirement (NR)s such as place and facilities.This product design advantages of simple, can greatly solve its weak point by improving traditional sha-syndrome scraping plate, bring glad tidings to the patient.Can significantly alleviate simultaneously the burden of family numbers of patients, play positive role for the patient adheres to treatment, relieving the pain caused by diseases.
Good effect with ball and latch bracket lepirudin 023 ludon liquid containing bottle disclosed by the invention is:
(1) at first, this product has solved injury to human body by the percutaneous drug delivery approach, simultaneously also without any misery.Secondly, this product can farthest reduce medicine to the side effect of human body, so that product safety is reliable by percutaneous drug delivery.Again, this product can in unlimited time, the use in place, and need not family members' cooperation.At last, the price of this product is lower, and Most patients can be born.
(2) product of the present invention can effectively prevent venothrombotic formation, eliminates coagulation, reduces blood viscosity, blood fat reducing, dredging blood capillary, improves microcirculation, enhance metabolism.The biological thrombin inhibitor of the strongest, the most effective and safest this reversibility has been opened up and has been used for clinical medical inspection and treats clinical new purposes because of diseases such as subcutaneous hemorrhage or blood flow of the tip are not smooth.
(3) high-purity lepirudin 023 ludon protein solution heavy metal free in the liquid containing bottle, without any impurity, human body is had no effect, be specially adapted to pass through subcutaneous absorption.Albumen without any destruction and impact, without any injury, had the characteristics such as safe, credible, easy to use, successful to stomach, liver, intestinal.Filled up the blank of hemiplegia patient at rehabilitation course, for extensive patients provides Gospel.
(4) filled up the blank of hemiplegia patient at rehabilitation course with the lepirudin 023 ludon liquid containing bottle of ball and latch bracket, for extensive patients provides Gospel.Be specially adapted to subcutaneous absorption and carry out nursing behind the bolt, and safe ready is effective.Handicapped good nursing efficacy arranged for what cerebral embolism, cerebral hemorrhage caused.
(5) the use plastic material can be to general patient, in the hope of reducing treatment cost.Utilize the natural materials such as Cornu Bovis seu Bubali and jade both to guarantee the comfort level of using, this Cornu Bovis seu Bubali plate can well contact with skin with jade and can injured skin simultaneously.Its physicochemical property of the Cornu Bovis seu Bubali of what is more important natural material and jade is stable, can not affect the active and stable of hirudin without materials such as chemical constituent and heavy metals, use simultaneously natural Cornu Bovis seu Bubali and jade can also increase fully the subcutaneous absorption rate of hirudin as mediator, so that curative effect is more remarkable.Its size according to the state of an illness of user, use position, health etc. different and release different size, satisfy to greatest extent needs of patients.
Description of drawings
Fig. 1 is the structural representation of the lepirudin 023 ludon liquid containing bottle with ball and latch bracket of the present invention;
Fig. 2 is the perspective view of ball spring holder of the present invention.
Critical piece description of symbols among the figure:
1: bottle cap 2: the bottle cap snap close
3: go out sap cavity 4: ball
5: ball spring holder 6: screw thread
7: liquid storage bottleneck 8: the liquid storage bottle
9: liquid containing bottle 10: the liquid containing bottle base
11: the bottle cap extension.
The specific embodiment
Below in conjunction with embodiment the present invention is described, the scheme of embodiment described here, do not limit the present invention, one of skill in the art can make improvements and change according to spirit of the present invention, and described these improvement and variation all should be considered as within the scope of the invention.Lepirudin 023 ludon of the present invention has commercially available.
Fig. 1 is the structural representation of the lepirudin 023 ludon liquid containing bottle with ball and latch bracket of the present invention.As shown in Figure 1, lepirudin 023 ludon liquid containing bottle with ball and latch bracket of the present invention, this liquid containing bottle comprises bottle cap 1 and liquid storage bottle 8, the below of bottle cap 1 is connected with bottle cap extension 11, bottle cap 1 inboard nearly lower end is formed with the bottle cap snap close 2 of indent, and bottle cap snap close 2 is connected on the jut of bottle cap extension outside formation; Screw thread 6 by liquid storage bottleneck 7 places between bottle cap extension 11 and the liquid storage bottle 8 is connected.Be loaded with lepirudin 023 ludon in the liquid storage bottle 8; Be provided with ball 4 and ball spring holder 5 in the bottle cap extension 11, the top of ball 4 leans out from bottle cap extension 11 tops, and the bottom embeds in the rounded ball spring holder 5 in cross section.Form between ball spring holder 5 and bottle cap extension 11 inwalls have a fixed gap go out sap cavity 3.The lower end of ball spring holder 5 is connected on the liquid storage bottleneck 7, is supported by liquid storage bottleneck 7 perisporiums.The lower end of ball spring holder 5 forms an annular base, arrange on the annular base a plurality of upwards hold up have certain elastic support bar, the upper end of support bar connects and is an annular brace holder.Be formed with the liquid containing bottle base 10 to lower process around liquid containing bottle 9 bottoms.
The using method of the lepirudin 023 ludon liquid containing bottle with ball and latch bracket of the present invention is as follows:
When (1) using product of the present invention, pull up bottle cap 1, bottle cap snap close 2 and bottle cap extension 11 are thrown off.With the light nip drum pearl of skin, liquid can flow out with the rotation of ball.The ball spring holder is owing to there is the restriction of outer wall, and stroke limited (even that is to say that to make service pressure excessive, fluid is not too much yet for ball) can accurately be controlled liquid outlet quantity.Add on the ball in addition and join bottle cap, farthest fungi-proofing, dustproof.The design of spiral mouth can be replaced new hirudin liquid containing bottle and be continued to use, and avoids waste, and also can save patient's buying expenses simultaneously.
(2) after the lepirudin 023 ludon in the liquid containing bottle is finished, can twist-off closure extension 11 and being threaded of liquid storage bottleneck 7 places, more renew liquid containing bottle.
What (3) the cerebral infarction omen arranged also can use this product, can reach the appearance of avoiding initial stage cerebral infarction and secondary cerebral infarction.The suggestion first phase uses this product advise in the time of 30 days-60 days that user does brain CT one time, to understand the variation of brain bolt, smears number of times in order to grasp, and the observation nursing effect is adjusted nursing number of times and care cycle, increase or the minimizing consumption in the hope of reaching nursing efficacy.The ball design can at utmost both guarantee the easy to use of patient and reduce manufacturing cost, can effectively control again hirudin by the bacteria effect curative effect simultaneously.The simultaneously design of ball can also be by the control ball the parameters such as the position that goes out sap cavity, ball stage clip or ball and ball spring holder, distance, the accurate Calculation use amount for the order of severity of differentiation conditions of patients, at utmost satisfies the needs of patient treatment.The material of ball can be made by materials such as " jade, Cornu Bovis seu Bubali, plastics ".
Adopt product of the present invention that typical cerebral embolism patient is tested:, on the acupuncture point of doctor advised, to massage gently the conditioning liquid that was glued in 5 minutes-10 minutes and all be absorbed with the sticking a small amount of conditioning liquid of sha-syndrome scraping plate.The nursing of attaching most importance in front 30 days, beginning early, evening each once, got final product for general nursing changes into once a day in rear 60 days.90 days-120 days is a course for the treatment of.
Case 1:
Patient 45 years old, the male, operating pressure is large, and dinner party is many at ordinary times.Suffer from hypertension 100-180, hyperlipidemia (triglyceride 2.5mmol/L, T-CHOL 8.6mmol/L, HDL3 .5mmol/L, low density lipoprotein, LDL 6.0mmol/L), high blood viscosity denseness through hospital diagnosis and (play dizziness morning, bradyphrenia, generally will be after eating breakfast, it is clear-headed that brains just becomes gradually.Feel sleepy after the lunch, need to take a snap, otherwise whole afternoon is all listless.On the contrary, the mental status is good especially after the dinner, and high risk of stroke is arranged, and is typical three-hypers patient.Behind the application of the invention product 30 days, detect blood pressure through hospital and reduce to 90-140, blood fat (triglyceride 1.7mmol/L, T-CHOL 5.6mmol/L, HDL1 .5mmol/L, low density lipoprotein, LDL 3.9mmol/L) indices all is tending towards normal, energy is comparatively vigorous, brains is resourceful, and the symptoms such as the typical case of hyperlipidemia obviously alleviate.
Case 2:
Patient 64 years old, male, retirement.Without diseases such as hypertension, hyperlipidemia, high blood viscosity, cerebral embolism.Going out accidentally to fall, is fracture of femoral neck through hospital diagnosis, the cerebral embolism disease occurs through behind the operative treatment, and the left limb activity is not smooth, the language performance ambiguous, and forfeiture part speech capability and slobbering are usually said hemiplegia disease.Behind the application of the invention product 45 days, the left upper portion limb activity freely, lower extremity is owing to require bed behind the fracture operation, limitation of activity, slobbering is almost recovered, language performance is comparatively clear, has rosy cheeks, and is energetic.Obviously alleviate through brain CT examination thrombosis symptom.
Case 3:
Patient 78 years old, the women suffers from the cerebral hemorrhage disease.The patient happens suddenly the cerebral hemorrhage disease after hospital rescues, and life pulls through, but because the cerebral hemorrhage area is larger, in addition older, operation risk is high, and unconsciousness, right side disorder of limb ' s activity gatism appears, in the suggestion expectant treatment.Behind the application of the invention product 60 days, it is comparatively clear to realize, and defecation consciousness is recovered, and the right side limbs can simple activities, and through examination in hospital, infarct size obviously reduces.
Effect with respect to traditional sha-syndrome scraping plate is generally eliminating pathogens, dredging the meridian, Shujin is regulated the flow of vital energy, the wind dispelling cold expelling, removing damp-heat, blood circulation promoting and blood stasis dispelling, the symptoms such as reducing swelling and alleviating pain, to above-mentioned disease substantially without the effect.Also have in addition following deficiency: family members dip with hands and smear hirudin in patient's affected part, because the mechanism of hirudin is the positions such as relevant acupuncture point that act on local affected part or recommended by the doctor, and family members help the patient to smear with hands, hirudin can enter family members' hands and patient's affected part simultaneously, render a service so that hirudin reduces, act on not obvious.Traditional product does not reach at one's side the relatively poor crowd of self-care ability for working clan and empty nest old man or relatives and has following shortcoming:
1, a lot of medicines can not absorbing transmission from skin, and its external curative effect is very little.
2, dosage is inaccurate, determines according to the user custom fully.
3, the patient uses inconvenience, needs bimanualness, and also needing simultaneously has certain facility, needs at least the article such as a cover tables and chairs apparatus and towel.
4, carry inconvenience, need to carry simultaneously sha-syndrome scraping plate and scrape therapy liquid, cause easily omission.
Experimental Comparison:
Simple glass screen dress hirudin is smeared: hirudin is exposed in the air fully behind the open bottle cover, contacts with airborne antibacterial, even also can contact hands.It is exactly hands that common human body carries the maximum position of antibacterial.By above-mentioned situation describe used 3-5 time after, the bacterial number of water in bottle trematodiasis element significantly increases, because bacteria breed is on the impact of hirudin, with " activity of " chromogenic substrate method " test hirudin of current approval in the hirudin content ocular estimate of Chinese pharmacopoeia version record in 2010 and the industry, obtaining hirudin content is about 50% of labelled amount.After using 6-8 time, recording hirudin content is 20%.
Adopt product of the present invention: hirudin does not directly contact with air behind the open bottle cover, and this design has also been avoided contacting with hand, to such an extent as to increase the antibacterial risk of infection.During each the use, need press ball, so that liquid flows to the affected part.At utmost reduce the risk that hirudin is infected by antibacterial.By above-mentioned situation describe used 3-5 time after, the bacterial number of water in bottle trematodiasis element significantly increases, because bacteria breed is on the impact of hirudin, with " activity of " chromogenic substrate method " test hirudin of current approval in the hirudin content ocular estimate of Chinese pharmacopoeia version record in 2010 and the industry, obtaining hirudin activity is about 90% of labelled amount.After using 6-8 time, recording hirudin activity is 80%.
This product has not only proved safe and effective by a large amount of use experiments; also have simple to operate; no pain, need not other people and assist the characteristics that to use; its positive effect is; usually can not get after the patient leaves hospital for various reasons system, in time, accurately treatment; and the expense of again being admitted to hospital is higher; the reasons such as family members' energy is limited; can only rely on the successive treatment of being in; but often the patient can't accomplish voluntarily; need other people to assist also can to exist that family members' energy and time is limited etc. that problems affect is in time treated, delay treatment even make the patient life danger occur.
Claims (10)
1. lepirudin 023 ludon liquid containing bottle with ball and latch bracket, it is characterized in that: this liquid containing bottle comprises bottle cap (1) and liquid storage bottle (8), the below of bottle cap is connected with bottle cap extension (11), and the bottle cap extension is connected with the liquid storage bottle mouth position of liquid storage bottle top; Be loaded with lepirudin 023 ludon in the liquid storage bottle; Be provided with ball (4) and ball spring holder (5) in the bottle cap extension, the top of ball leans out from bottle cap extension top, and the bottom embeds in the rounded ball spring holder in cross section; Form between ball spring holder and the bottle cap extension inwall have a fixed gap go out sap cavity (3); The lower end of ball spring holder is connected on the liquid storage bottleneck (7), is supported by liquid storage bottleneck perisporium; The concentrated solution 1ml-20ml that described lepirudin 023 ludon consumption is purity 93-98%.
2. the lepirudin 023 ludon liquid containing bottle with ball and latch bracket according to claim 1 is characterized in that: the inboard nearly lower end of bottle cap (1) is formed with the bottle cap snap close (2) of indent, and bottle cap lock links and is connected on the jut that the bottle cap extension outside forms.
3. the lepirudin 023 ludon liquid containing bottle with ball and latch bracket according to claim 1, it is characterized in that: the bottle cap extension is connected by screw thread (6) with the liquid storage bottleneck.
4. the lepirudin 023 ludon liquid containing bottle with ball and latch bracket according to claim 1, it is characterized in that: the lower end of ball spring holder (5) forms an annular base, arrange on the annular base a plurality of upwards hold up have certain elastic support bar, the upper end of support bar connects and is an annular brace holder.
5. the lepirudin 023 ludon liquid containing bottle with ball and latch bracket according to claim 1 is characterized in that: be formed with the liquid containing bottle base (10) to lower process around the liquid containing bottle bottom.
6. the lepirudin 023 ludon liquid containing bottle with ball and latch bracket according to claim 1, it is characterized in that: described ball is made by jade material.
7. the lepirudin 023 ludon liquid containing bottle with ball and latch bracket according to claim 1, it is characterized in that: described ball is made by the Cornu Bovis seu Bubali material.
8. the lepirudin 023 ludon liquid containing bottle with ball and latch bracket according to claim 1, it is characterized in that: described ball is made by plastic material.
The described lepirudin 023 ludon liquid containing bottle with ball and latch bracket of claim 1 as medical apparatus and instruments in the application aspect preparation treatment cerebral embolism, cerebral hemorrhage, the apoplexy.
The described lepirudin 023 ludon liquid containing bottle with ball and latch bracket of claim 1 as medical apparatus and instruments in the application aspect the preparation prevention cerebral infarction omen.
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Application publication date: 20130123 |