CN106389709A - Medicinal liquor for treating cervical spondylosis and periarthritis humeroscapularis and preparation method thereof - Google Patents
Medicinal liquor for treating cervical spondylosis and periarthritis humeroscapularis and preparation method thereof Download PDFInfo
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- CN106389709A CN106389709A CN201611115066.0A CN201611115066A CN106389709A CN 106389709 A CN106389709 A CN 106389709A CN 201611115066 A CN201611115066 A CN 201611115066A CN 106389709 A CN106389709 A CN 106389709A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
- A61K36/605—Morus (mulberry)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/62—Nymphaeaceae (Water-lily family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/86—Violaceae (Violet family)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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Abstract
The invention discloses a medicinal liquor for treating cervical spondylosis and periarthritis humeroscapularis and a preparation method thereof. The medicinal liquor is prepared from the following active pharmaceutical ingredients in parts by weight: 10-40 parts of lotus leaf, 10-40 parts of mulberry leaf, 20-55 parts of Ligusticum wallichii, 30-80 parts of saffron, 50-150 parts of groundsel, 50-150 parts of Corydalis bungeana, 150-300 parts of Utricularia bifida and 2000-3000 parts of liquor. The medicinal liquor disclosed by the invention is simple and reasonable in formula, convenient to take, remarkable in curative effect and low in cost, has the advantages of no irritation to the gastrointestinal function, safety and no toxic or side effect, and has excellent curative effects on arthritis, periarthritis humeroscapularis, cervical spondylosis, lumbar disc herniation, hyperosteogeny and other neck/shoulder/waist/leg pain related diseases.
Description
Technical field
The invention belongs to the field of Chinese medicines is and in particular to a kind of medicinal liquor treating cervical spondylopathy and scapulohumeral periarthritis and preparation method thereof.
Background technology
Neck-shoulder pain, lumbago and leg pain is common clinical, frequently-occurring disease, is more common in the elderly, has a strong impact on work and the life of patient
Quality.Neck-shoulder pain, lumbago and leg pain belongs to the category of Chinese medical ' arthralgia syndrome ', and due to middle-aged and old weak or excessive strains, diseases caused by external factors wind, cold, wet is evil
Take advantage of a weak point, stagnate among muscle, muscles and bones and channels and collaterals, cause muscle, muscles and bones qi-blood-body fluid to be run not smooth, blockage of channel is not
Logical, long then turns to " cold phlegm ", mutually ties with hemostasis, streamer is in muscles and bones joint, thus polytype pain.Common disease
Sick type has arthritis, scapulohumeral periarthritis, cervical spondylopathy, protrusion of lumber intervertebral disc, osteoproliferation etc., when the coldest particularly in 1 year
Wait it is easier to show effect.Treatment to this kind of disease mainly has non-operative treatment and operative treatment two types at present.No operation is treated
Method mainly adopts acupuncture, massage, physiotherapy, traction, injection treatment, oral non-steroid anti-inflammatory drug etc..Operative treatment is then passed through
Analgesia, eliminates and stimulates, and promotes stable, prevents the principle of progressive injury from carrying out.But in operative treatment complication with
Contraindication is more, dangerous high, painful big, is just to select in the case that other therapies are all invalid.And in non-operative treatment,
Mainly pass through the Western medicine of the substantial amounts of antibiotic of long-term taking and steroids, thus can cause series of side effects, such as stomach work(
Energy disorder, nervous system disorders etc., and treatment cost is high, curative effect is not notable, easily recurs.
Traditional Chinese medicine thinks, cervical spondylopathy be formed as caused by liver and kidney deficiency, muscles and bones decline chronic accumulation strain in addition so that
Space between skin and muscles is empty, qi and blood declines less, muscles and bones loses, wind-cold damp pathogen intrusion foster in moistening, and numbness hinders channels and collaterals, caused by energy stagnation and blood stasis.This disease can be divided into
Neck type, numbness pain type, paralytic, vertiginous type, common with neck type and numbness pain type.
The method for the treatment of nerve root cervical vertebra sickness mainly has non-operative treatment treatment and operative treatment, non-operative treatment at present
Conventional method has：Physical treatment, traction therapeutic, various Chinese patent drug, Western medicine etc. although can be good at pain of alleviation, but
Effect is still undesirable, and it is long to there is treatment time, weak curative effect and have the defects such as side effect.
Content of the invention
The present invention is directed to the defect of above-mentioned treatment method, there is provided a kind for the treatment of cervical spondylopathy prepared by Chinese medicine material and shoulder
Medicinal liquor of Zhou Yan and preparation method thereof, rationally, preparation method is simple for its formula, and method of administration is convenient, with low cost, and curative effect shows
Write, no any stimulation, safe without toxic side effect to functions of intestines and stomach.
In order to realize the purpose of the present invention, adopt the following technical scheme that.
The treatment cervical spondylopathy of the present invention and the medicinal liquor of scapulohumeral periarthritis, are made up of the bulk drug of following weight portion：
Further, the treatment cervical spondylopathy of the present invention and the medicinal liquor of scapulohumeral periarthritis, are made up of the bulk drug of following weight portion：
It is an option that the treatment cervical spondylopathy of the present invention and the medicinal liquor of scapulohumeral periarthritis, by the bulk drug group of following weight portion
Become：
It is preferred that the treatment cervical spondylopathy of the present invention and the medicinal liquor of scapulohumeral periarthritis, it is made up of the bulk drug of following weight portion：
It is preferred that the treatment cervical spondylopathy of the present invention and the medicinal liquor of scapulohumeral periarthritis, it is made up of the bulk drug of following weight portion：
In the treatment cervical spondylopathy of the present invention and the medicinal liquor of scapulohumeral periarthritis, the described white wine number of degrees are 50-65 degree.
The preparation method of the medicinal liquor of the treatment cervical spondylopathy of the present invention and scapulohumeral periarthritis, is that all traditional Chinese medicinal components are added appearance jointly
In device, add white wine, sealing is soaked 7-15 days, isolated wine liquid and obtain final product.The usage of the medicinal liquor of the present invention and consumption are：Oral drink
With, 2 times a day, a 5-50ml.Also can external application, smear 5-10ml medicinal liquor in affected part, 3 times a day.It is administered orally and join with external application
Close and use, better.
The invention has the beneficial effects as follows：Provide a kind of formula advantages of simple, taking convenience, evident in efficacy, with low cost,
Non-stimulated to functions of intestines and stomach, the Traditional Chinese medicinal liquor of safe without toxic side effect.The present invention had both overcome western medicine toxic and side effect now
Greatly, dependence is big, easily recurs, the shortcoming of high cost, overcomes traditional Chinese medicine again and takes inconvenient shortcoming orally.This medicinal liquor is to joint
The neck-shoulder pain, lumbago and leg pain class disease such as inflammation, scapulohumeral periarthritis, cervical spondylopathy, protrusion of lumber intervertebral disc, osteoproliferation has splendid curative effect.The present invention
Only 8 taste Chinese medicine compositions, its prescription is simple, scientific and reasonable, and determined curative effect, it is easy to absorb, instant effect, has no toxic side effect, in addition
Patient's overall immunity can also be improved, improve the ability that body resists disease and evil.
Specific embodiment
With reference to embodiment, the present invention is described in further details.
Embodiment 1
Medicinal liquor in the present embodiment is made using the raw material of following weight：21 grams of lotus leaf, 26 grams of mulberry leaf, 38 grams of rhizome of chuanxiong, hide
68 grams of safflower, thousand 100 grams of time, 100 grams of Chinese violet, 200 grams of grass energetically, 2500 grams of white wine.
The preparation method of medicinal liquor of the present invention is：All traditional Chinese medicinal components are added in container jointly, adds 50 degree of white wine
2500g, sealing is soaked 10 days, isolates wine liquid and obtains final product.
Usage and consumption：It is administered orally plus applies outward and be used in combination, 3 times a day, a 60ml (applying 5-10 milliliter), 10 days is a course for the treatment of.
Embodiment 2
Medicinal liquor in the present embodiment is made using the raw material of following weight：40 grams of lotus leaf, 38 grams of mulberry leaf, 50 grams of rhizome of chuanxiong, hide
80 grams of safflower, thousand 150 grams of time, 150 grams of Chinese violet, 280 grams of grass energetically, 3000 grams of white wine.
The preparation method of medicinal liquor of the present invention is：All traditional Chinese medicinal components are added in container jointly, adds 62 degree of white wine
3000g, sealing is soaked 10 days, isolates wine liquid and obtains final product.
Usage and consumption：It is administered orally plus applies outward and be used in combination, 3 times a day, a 50ml, 10 days is a course for the treatment of.
Embodiment 3
Medicinal liquor in the present embodiment is made using the raw material of following weight：10 grams of lotus leaf, 12 grams of mulberry leaf, 22 grams of rhizome of chuanxiong, hide
30 grams of safflower, thousand 50 grams of time, 50 grams of Chinese violet, 150 grams of grass energetically, 2500 grams of white wine.
The preparation method of medicinal liquor of the present invention is：All traditional Chinese medicinal components are added in container jointly, adds 52 degree of white wine
2500g, sealing is soaked 7 days, isolates wine liquid and obtains final product.
Usage and consumption：Oral, 2 times a day, a 50ml, 10 days is a course for the treatment of.
Embodiment 4
Medicinal liquor in the present embodiment is made using the raw material of following weight：25 grams of lotus leaf, 29 grams of mulberry leaf, 34 grams of rhizome of chuanxiong, hide
45 grams of safflower, thousand 80 grams of time, 80 grams of Chinese violet, 150 grams of grass energetically, 2500 grams of white wine.
The preparation method of medicinal liquor of the present invention is：All traditional Chinese medicinal components are added in container jointly, adds 52 degree of white wine
2500g, sealing is soaked 7 days, isolates wine liquid and obtains final product.
Usage and consumption：Oral, 2 times a day, a 50ml, 10 days is a course for the treatment of.
Embodiment 5
For showing the therapeutic effect to the neck and shoulder ache disease such as scapulohumeral periarthritis, cervical spondylopathy for the present invention, the present inventor is to 198 cases
Carry out clinical observation, the wherein male sex 155 people, women 43 people, 20 years old -80 age after taking the medicinal liquor being obtained in above-described embodiment 1
Year, wherein scapulohumeral periarthritis 92, cervical spondylopathy 106.It is administered orally by using the medicinal liquor of the present invention and be combined with external application, general medication 1-3
The individual course for the treatment of, after 2 courses for the treatment of of medication, cures and effective 190, accounts for 95.9%；Invalid 8, account for 0.4%.
Typical clinical case
Case 1, Wang, man, 60 years old, right shoulder pain 6 years.Right shoulder pain simultaneously gradually increases limited by activity extremely, the right hand
Can not comb one's hair it is impossible to upper act, rear rotation, abduction, unbearably, especially night severe pain impact is slept such as accidentally to touch then severe pain
Sleep.Repeatedly fail to respond to any medical treatment in large hospital, fully recover after taking medicinal liquor 3 course for the treatment of of the present invention.
Case 2, Lin, female, 43 years old, unfavorable 18 months of cervicodynia, activity, aggravation in nearly 3 months, right side aching of shoulder and arm, food,
Middle finger is numb, has ant row sense；When head layback or to the right flex, electric shock sample string picotement is had to pass from neck root to right shoulder arm
Penetrate；When carrying shoulder, receiving arm, bend elbow, upper limbs aching and tired with numb mitigation.In many ways it is invalid to seek medical advice, and takes 2 courses for the treatment of of medicinal liquor of the present invention and fullys recover from an illness
More.
Case 3, Chen, man, 40 years old, suffer from cervical spondylopathy 10 years, whole nape part, bilateral margo vertebralis scapulae are sour, tired, heavy,
Overhead is sent out heavy, failure of memory, when have nausea, palpitaition, uncomfortable in chest, binocular vision to obscure, eyelid is felt nervous, right omarthralgia.No
Energy normal work, using western medical treatment DeGrain, takes 3 courses for the treatment of recoveries from illness of medicinal liquor of the present invention.
Embodiment 6：The irritant experiment to skin for the multiple dosing
Experimental technique：From healthy NZw 12, body weight 1.7～2.5kg, it is divided into normal skin group and skin
Each 6 of breakage group, using consubstantiality left and right sides self-contrast method, male and female half and half.Before test, 24h carries out depilation process to administration area,
Each one piece of left and right, unhairing scope 3cm × 3cm.Damaged skin group draws " well " word in agents area, to ooze out blood for degree.Every group left
The patch patch of embodiment of the present invention 1-3 at the depilation of side, right side compares.Application time 4h, three times a day, continuous 7d.Stick every time
After end, remove test sample and with warm water or nonirritant solvent cleaned medicine-feeding part.Examine at coating before coating every time
Skin has or not erythema, oedema, continues to observe 3d, carry out skin irritation by the requirement of new drug toxicity technical specification and comment after drug withdrawal
Valency.Take skin to do tissue pathology checking simultaneously.
Skin irritation is evaluated：
(1) standards of grading：Erythema：No 0 point of erythema；Slight 1 point of erythema (visible reluctantly)；The red class of moderate (clearly visible) 2
Point；3 points of severe erythema；Aubergine erythema forms 4 points to slight eschar.Oedema：No 0 point of oedema；Mild edema (visible reluctantly) 1
Point；2 points of intermediate edema (substantially swelling)；3 points of severe edema's (cutaneous protuberance 1mm, profile understands)；Severe edema (cutaneous protuberance>
Lmm simultaneously has expansion) 4 points.8 points of highest point total value.
(2) skin irritatin intensity evaluation standard：0-0.49 divides nonirritant；0.50～2.99 point of slight stimulation；3.00
～5.99 points of moderate excitants；6.00～8.00 points of strong and stimulatings.
Result：During test, two groups of rabbit spirit, signs are good, and appetite activity is normal；No dead, also have no any bad
Reaction；Hematological examination, biochemical investigation are showed no exception；System becomes celestial and each internal organs Histopathology no abnormality seen；Restorative
Observation has no retardance toxic reaction, with reference to the Testing index normal value of people and rabbit, result above all in normal range (NR), two
Organize more equal nonsignificance (P>0.05), show that rabbit does not produce toxic reaction with the coating of the embodiment of the present invention 1 for a long time.
Embodiment 7：Allergic experiment to skin
Experimental technique：Cavy 40, body weight 250-330g, it is divided into 30 of embodiment of the present invention 1-3, every group 10, right
According to group 10, water, male and female half and half, shave off skin of back.It is coated in hair removal section sensitization on the left of cavy by packet, weight after 4h after 24h
Overcoating once, to ensure medicament contact 8h, repeats to apply with a sensitization for the 7th day and the 14th day. press packet again in last dose 14d
Medicinal liquor is applied to hair removal section on the right side of cavy excite, after 8h, removes tested material, observe erythema and oedema situation, Continuous Observation 3d. presses
Cutaneous anaphylaxis standard is scored.
Skin irritation is evaluated：Carry out with reference to embodiment 5
Result：Then skin smooth, no erythema, no oedema (are 0 to the coating group of control group and embodiment of the present invention 1-3
Point), do not show any allergic reaction.
Claims (7)
1. a kind of medicinal liquor treating cervical spondylopathy and scapulohumeral periarthritis is it is characterised in that be made up of the bulk drug of following weight portion：
2. the medicinal liquor for the treatment of cervical spondylopathy according to claim 1 and scapulohumeral periarthritis is it is characterised in that former by following weight portion
Material medicine composition：
3. the medicinal liquor for the treatment of cervical spondylopathy according to claim 1 and scapulohumeral periarthritis is it is characterised in that former by following weight portion
Material medicine composition：
4. the medicinal liquor for the treatment of cervical spondylopathy according to claim 1 and scapulohumeral periarthritis is it is characterised in that former by following weight portion
Material medicine composition：
5. the medicinal liquor for the treatment of cervical spondylopathy according to claim 1 and scapulohumeral periarthritis is it is characterised in that former by following weight portion
Material medicine composition：
6. the medicinal liquor of the treatment cervical spondylopathy according to one of claim 1-5 and scapulohumeral periarthritis is it is characterised in that described white wine
The number of degrees are 50-65 degree.
7. the medicinal liquor of the treatment cervical spondylopathy according to one of claim 1-5 and scapulohumeral periarthritis preparation method it is characterised in that
All traditional Chinese medicinal components are added in container jointly, adds white wine, sealing is soaked 7-15 days, isolated wine liquid and obtain final product.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611115066.0A CN106389709A (en) | 2016-12-07 | 2016-12-07 | Medicinal liquor for treating cervical spondylosis and periarthritis humeroscapularis and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611115066.0A CN106389709A (en) | 2016-12-07 | 2016-12-07 | Medicinal liquor for treating cervical spondylosis and periarthritis humeroscapularis and preparation method thereof |
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| CN106389709A true CN106389709A (en) | 2017-02-15 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108042673A (en) * | 2018-01-15 | 2018-05-18 | 云南昆布生物科技有限公司 | A kind of medicinal liquor and its preparation method for treating cervical vertebra pain and shoulder and neck |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108042673A (en) * | 2018-01-15 | 2018-05-18 | 云南昆布生物科技有限公司 | A kind of medicinal liquor and its preparation method for treating cervical vertebra pain and shoulder and neck |
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Application publication date: 20170215 |